公开(公告)号：US08299676B2

公开(公告)日：2012-10-30

申请号：US12676062

申请日：2008-09-10

申请人： Koji Miyata ,  Minori Miyata, legal representative ,  Atsushi Miyata, legal representative ,  Hideki Kobayashi ,  Naoki Watanabe ,  Takehisa Minowa

发明人： Koji Miyata ,  Hideki Kobayashi ,  Naoki Watanabe ,  Takehisa Minowa

IPC分类号： H02K17/00

CPC分类号： H02K3/47 ,  H02K16/00 ,  H02K21/24

摘要： A high-output and highly efficient axial gap type rotating machine capable of reducing an eddy current generated in a winding wire and supplying a larger current is provided. The axial gap type rotating machine may include a housing, a rotating shaft rotatably supported in the housing; two rotors capable of rotating integrally with the rotating shaft, and a stator fixed to the housing, the stator disposed in an air gap formed by the rotating plates disposed to face each other, the stator including a fixing plate and coils disposed in a circle on the fixing plate so as to face the circles of the permanent magnets, wherein each of the coils includes a winding wire formed by a bundle of at least two coil conductors having rectangular cross sections by aligning at least one of long sides and short sides thereof, and the winding wire has an outer circumference covered with an insulating coating and is wound such that the long sides in cross section of the coil conductors are positioned perpendicular to the magnetic pole surfaces of the permanent magnets.

摘要翻译： 提供了能够减少绕组线中产生的涡电流并提供较大电流的高输出和高效率轴向间隙型旋转机。 轴向间隙型旋转机械可以包括壳体，可旋转地支撑在壳体中的旋转轴; 能够与旋转轴一体旋转的两个转子和固定到壳体的定子，定子设置在由彼此相对设置的旋转板形成的空气间隙中，定子包括固定板和设置成圆圈的线圈 所述固定板朝向所述永磁体的圆周，其中每个所述线圈包括由具有矩形横截面的至少两个线圈导体的束形成的绕组，所述绕组线具有通过对准其长边和短边中的至少一个， 并且绕组线具有覆盖有绝缘涂层的外周，并且被卷绕成使得线圈导体的横截面的长边垂直于永磁体的磁极表面定位。

公开(公告)号：US08182804B1

公开(公告)日：2012-05-22

申请号：US11662551

申请日：2005-09-12

申请人： James J Collins ,  Hideki Kobayashi ,  Mads Kearn ,  Michihiro Araki ,  Ari Friedland ,  Timothy Kuan-Ta Lu

发明人： James J Collins ,  Hideki Kobayashi ,  Mads Kearn ,  Michihiro Araki ,  Ari Friedland ,  Timothy Kuan-Ta Lu

IPC分类号： A01N63/00 ,  C12N15/74 ,  A61K48/00

CPC分类号： C12N9/2437 ,  A61L2/16 ,  C07K14/005 ,  C07K2319/00 ,  C12N7/00 ,  C12N2795/10222 ,  C12N2795/10243 ,  C12Y302/01004

摘要： The present invention provides engineered bacteriophages that express at least one biofilm degrading enzyme on their surface and uses thereof for degrading bacterial biofilms. The invention also provides genetically engineered bacteriophages expressing the biofilm degrading enzymes and proteins necessary for the phage to replicate in different naturally occurring biofilm producing bacteria. The phages of the invention allow a method of biofilm degradation by the use of one or only a few administration of the phage because the system using these phages is self perpetuating, and capable of degrading biofilm even when the concentration of bacteria within the biofilm is low.

摘要翻译： 本发明提供了在其表面上表达至少一种生物膜降解酶的工程化噬菌体及其用于降解细菌生物膜的工程噬菌体。 本发明还提供表达生物膜降解酶和蛋白质在不同天然存在的生物膜产生细菌中复制的噬菌体所需的遗传工程化噬菌体。 本发明的噬菌体允许通过使用一种或仅少量的噬菌体施用来生物膜降解的方法，因为使用这些噬菌体的系统是自我延续的，并且即使当生物膜内的细菌浓度低时也能降解生物膜 。

公开(公告)号：US08178613B2

公开(公告)日：2012-05-15

申请号：US10547837

申请日：2004-03-05

申请人： Hisataka Nakashima ,  Mari Wakita ,  Hideki Kobayashi

发明人： Hisataka Nakashima ,  Mari Wakita ,  Hideki Kobayashi

IPC分类号： C08G77/28

CPC分类号： C08G77/42 ,  C08F283/12 ,  C08K5/0025 ,  C08L83/08 ,  C09D4/06 ,  C08L2666/04 ,  C08L2666/44

摘要： An acryloxy-functional silicone composition curable by high-energy radiation, which is characterized by excellent storage stability of the composition and by improved resistance to scratching, transparency, water repellency, and adhesiveness in a hard cured coating film produced from the aforementioned composition. This composition comprises (A) a polyfunctional acrylate of at least one type; an amino-modified organopolysiloxane (B) or a product (F) of a Michael addition reaction between at least one type of a polyfunctional acrylate and amino-modified organopolysiloxane; (C) an organoalkoxysilane having an aliphatic unsaturated bond, (D) a colloidal silica; and (E) an alcohol-containing organic solvent.

摘要翻译： 通过高能量辐射可固化的丙烯酰氧基官能的硅氧烷组合物，其特征在于组合物的优异的储存稳定性和由上述组合物制备的硬化固化涂膜中的耐擦伤性，透明性，拒水性和粘合性。 该组合物包含（A）至少一种类型的多官能丙烯酸酯; 至少一种多官能丙烯酸酯和氨基改性的有机聚硅氧烷之间的迈克尔加成反应的氨基改性的有机聚硅氧烷（B）或产物（F） （C）具有脂肪族不饱和键的有机烷氧基硅烷，（D）胶态二氧化硅; 和（E）含醇的有机溶剂。

公开(公告)号：US20120055556A1

公开(公告)日：2012-03-08

申请号：US13138656

申请日：2010-03-29

申请人： Hiroto Tokoshima ,  Hideki Kobayashi

发明人： Hiroto Tokoshima ,  Hideki Kobayashi

IPC分类号： F03B11/00

CPC分类号： C02F1/008 ,  C02F1/006 ,  C02F2103/04 ,  C02F2209/02 ,  C02F2209/04 ,  C02F2209/05 ,  C02F2209/11 ,  C02F2209/14 ,  C02F2209/20 ,  C02F2209/22 ,  G01N33/18 ,  G01N33/1846 ,  Y02A20/206 ,  Y10T137/0318 ,  Y10T137/8593

摘要： By reducing the amount of monitoring water required to measure and monitor the quality of ultrapure water with a plurality of measuring instruments, the size of an ultrapure water production system is reduced, whereby the system cost is reduced. When a portion of ultrapure water supplied from the ultrapure water production system to a use point is separated to monitor the water quality, the water is allowed to pass through a monitoring system consisting of two or more stages of different types of water quality measuring devices connected in series so that the water quality is monitored. Because the ultrapure water extracted from a supply pipe extending from the ultrapure water production system to the use point is allowed to pass, in series, through two or more stages of different types of water quality measuring devices connected in series, by making these measuring instruments use the same monitoring water, which is required for measuring the water quality, the amount of monitoring water can be reduced. As a result, the size of the ultrapure water production system can be reduced, and hence, the system cost can be reduced.

摘要翻译： 通过减少用多个测量仪器测量和监测超纯水质量所需的监测水量，减少了超纯水生产系统的尺寸，降低了系统成本。 当从超纯水生产系统供应到使用点的超纯水的一部分被分离以监测水质时，允许水通过由两级或更多级的不同类型的水质测量装置连接的监测系统 以便监测水质。 由于从从超纯水生产系统延伸到使用点的供给管提取的超纯水通过串联连接的两个或多个不同类型的水质测量装置通过制造这些测量仪器 使用相同的监测水，这是测量水质所需要的，可以减少监测水的量。 结果，可以减少超纯水生产系统的尺寸，从而可以降低系统成本。

公开(公告)号：US08017610B2

公开(公告)日：2011-09-13

申请号：US12843348

申请日：2010-07-26

申请人： Akihiro Furukawa ,  Takehiro Fukuzaki ,  Yukari Onishi ,  Hideki Kobayashi ,  Takeshi Honda ,  Yumi Matsui ,  Masahiro Konishi ,  Kenjiro Ueda ,  Tetsuyoshi Matsufuji

发明人： Akihiro Furukawa ,  Takehiro Fukuzaki ,  Yukari Onishi ,  Hideki Kobayashi ,  Takeshi Honda ,  Yumi Matsui ,  Masahiro Konishi ,  Kenjiro Ueda ,  Tetsuyoshi Matsufuji

IPC分类号： A61K31/501 ,  A61K31/497 ,  A61K31/443 ,  A61K31/421 ,  C07D403/14 ,  C07D413/14 ,  C07D265/08

CPC分类号： C07D413/14 ,  C07D207/333 ,  C07D207/335 ,  C07D207/337 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04 ,  C07D417/04 ,  C07D417/14

摘要： The present invention relates to a compound or a pharmacologically acceptable salt thereof having superior glucokinase activating activity, and is a compound represented by general formula (I), or pharmacologically acceptable salt thereof: [wherein, A represents, for example, an oxygen atom or sulfur atom, R1 represents, for example, a C1-C6 alkyl group, a C1-C6 alkoxy group or a C1-C6 halogenated alkyl group, A and R1 together with the carbon atom bonded thereto form a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R2 represents a phenyl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group α or a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R3 represents a hydroxy group or a C1-C6 alkoxy group, and Substituent Group α consists of, for example, a halogen atom, a C1-C6 alkyl group, a C1-C6 alkyl group substituted with 1 or 2 hydroxy group(s), a C1-C6 alkylsulfonyl group, and a group represented by the formula —V—NR5R6 (wherein, V represents a carbonyl group or a sulfonyl group, and R5 and R6 may be the same or different and respectively represent a hydrogen atom or a C1-C6 alkyl group, or R5 and R6 together with the nitrogen atom bonded thereto form a 4- to 6-membered saturated heterocycle that may be substituted with 1 or 2 group(s) independently selected from a C1-C6 alkyl group and a hydroxy group, and the 4- to 6-membered saturated heterocycle may further contain one oxygen atom or nitrogen atom)].

摘要翻译： 本发明涉及具有优异的葡糖激酶活化活性的化合物或其药理学上可接受的盐，并且是通式（I）表示的化合物或其药理学上可接受的盐：[其中，A表示例如氧原子或 硫原子，R1表示例如C1-C6烷基，C1-C6烷氧基或C1-C6卤代烷基，A和R1与与其结合的碳原子一起形成可以被 1至3个独立地选自取代基组α的基团，R 2表示可以被独立地选自取代基组α的1至5个基团取代的苯基或可被1至3个基团取代的杂环基 独立地选自取代基组α，R3表示羟基或C1-C6烷氧基，取代基组α由例如卤素原子，C1-C6烷基，C1-C6烷基组成 取代 具有1或2个羟基，C1-C6烷基磺酰基和由式-V-NR5R6表示的基团（其中，V表示羰基或磺酰基，R5和R6可以相同） 或不同，分别表示氢原子或C1-C6烷基，或R5和R6与键合的氮原子一起形成可以被1或2个基团独立地取代的4至6元饱和杂环 选自C 1 -C 6烷基和羟基，并且4至6元饱和杂环可以进一步含有一个氧原子或氮原子）]。

公开(公告)号：US07595184B2

公开(公告)日：2009-09-29

申请号：US10539560

申请日：2003-12-15

申请人： Toshifumi Yamaki ,  Shinichi Banba ,  Kaori Matoishi ,  Kiyoshi Ito ,  Hideki Kobayashi ,  Eishi Tanaka ,  Toshihiro Oikawa

发明人： Toshifumi Yamaki ,  Shinichi Banba ,  Kaori Matoishi ,  Kiyoshi Ito ,  Hideki Kobayashi ,  Eishi Tanaka ,  Toshihiro Oikawa

IPC分类号： C12N9/88 ,  C12N5/10 ,  C12N1/21 ,  C07K14/00 ,  C12P21/00 ,  C12N15/00 ,  C12Q1/527 ,  C07H21/00

CPC分类号： C12Y402/01084 ,  C12N9/88

摘要： The amino acid sequence of a mutant which is obtained by introducing a novel mutation into a Pseudonocardia thermophila JCM3095-derived nitrile hydratase consisting of two types of heterogeneous subunits, and the base sequence of the gene are provided. The nitrile hydratase is modified by specifying the region to be modified in the stereostructure/amino acid sequence of the nitrile hydratase, and applying alteration such as substitution, insertion, deletion or the like, to the amino acids in the amino acid sequence which are corresponding to the amino acid residues forming the region. Also provided is a method for modifying an enzyme having a nitrile hydratase activity.

摘要翻译： 提供了通过将新突变引入由两种异质亚基组成的嗜热假诺卡氏菌JCM3095衍生的腈水合酶获得的突变体的氨基酸序列和该基因的碱基序列。 通过在腈水合酶的立体结构/氨基酸序列中指定待修饰的区域，并将替代，插入，缺失等的改变应用于氨基酸序列中相应的氨基酸序列中的氨基酸来修饰腈水合酶 到形成该区域的氨基酸残基。 还提供了修饰具有腈水合酶活性的酶的方法。

公开(公告)号：US07562733B2

公开(公告)日：2009-07-21

申请号：US11637244

申请日：2006-12-12

申请人： Toshiharu Watanabe ,  Hideki Kobayashi ,  Shinji Araki ,  Osamu Ito ,  Eiichi Mori

发明人： Toshiharu Watanabe ,  Hideki Kobayashi ,  Shinji Araki ,  Osamu Ito ,  Eiichi Mori

IPC分类号： B60K11/04

CPC分类号： B62D25/084

摘要： A radiator core support includes a radiator core support main body that is made of plastic material, a right fixing member and a left fixing member that are made of metal, and a first metal frame. The right fixing member and the left fixing member are fixed on a right side member and a left side member of a motor vehicle body, respectively. The first metal frame extends in a lateral direction of the motor vehicle body so as to connect the right fixing member and the left fixing member with each other and support the radiator core support main body.

摘要翻译： 散热器芯支撑件包括由塑料材料制成的散热器芯支撑主体，由金属制成的右固定构件和左固定构件，以及第一金属框架。 右固定构件和左固定构件分别固定在机动车身的右侧构件和左侧构件上。 第一金属框架沿着机动车体的横向方向延伸，以将右固定构件和左固定构件彼此连接并支撑散热器芯支撑主体。

公开(公告)号：US20090162067A1

公开(公告)日：2009-06-25

申请号：US12338184

申请日：2008-12-18

申请人： Hideki Kobayashi ,  Takehiro Fujita

发明人： Hideki Kobayashi ,  Takehiro Fujita

IPC分类号： H04J14/02

CPC分类号： H04J14/0221 ,  H04J14/0204 ,  H04J14/0209 ,  H04J14/0212

摘要： An optical apparatus includes a first optical amplifier for adjusting an output value to a constant level; an optical signal processor located before the first optical amplifier and processing the optical signal; a second optical amplifier located before the optical signal processor and subjected to automatic gain control for adjusting a gain constant; and a controller detecting a level of the optical signal at an output of the second optical amplifier. The controller adjusts a level of an output value of the first optical amplifier such that the level of the optical signal at the output of the second optical amplifier is held at the optimum value if the detected level of the optical signal differs from an optimum value, compensates for a loss caused in the optical signal processor and maintains the level of the optical signal at the output of the second optical amplifier at the optimum value.

摘要翻译： 光学装置包括用于将输出值调整到恒定水平的第一光学放大器; 位于第一光放大器之前并处理光信号的光信号处理器; 位于光信号处理器之前并经受用于调节增益常数的自动增益控制的第二光放大器; 以及控制器，其检测所述第二光放大器的输出处的所述光信号的电平。 控制器调节第一光放大器的输出值的电平，使得如果检测到的光信号的电平与最佳值不同，则将第二光放大器的输出处的光信号的电平保持在最佳值， 补偿在光信号处理器中造成的损耗，并将第二光放大器的输出处的光信号的电平保持在最佳值。

公开(公告)号：US07542883B2

公开(公告)日：2009-06-02

申请号：US11082101

申请日：2005-03-17

申请人： Toshimitsu Kumazawa ,  Hideki Kobayashi

发明人： Toshimitsu Kumazawa ,  Hideki Kobayashi

IPC分类号： G06F19/00 ,  G06F7/60 ,  G06F17/10

CPC分类号： G06Q90/00 ,  G06Q30/0283

摘要： An evaluation apparatus which evaluates environmental load of circulated life cycle in which group of products recovered from one of markets which differ from each other in value lifetime of group is introduced into another of markets, cost thereof and profit thereof generates attribute data of group, attribute data of group including remaining useful lifetime and product age, determinates introduction order and introduction rule which are used for introducing group into markets, based on remaining useful lifetime at point in time when group is recovered from one of markets and remaining value lifetime of group which is obtained by subtracting product age at point in time when group is recovered from one of markets from value lifetime of another of markets, and evaluates environmental load of circulated life cycle in which group is introduced into markets in accordance with introduction order and rule, cost thereof and profit thereof.

摘要翻译： 评估装置，评估循环寿命周期的环境负荷，其中从组中的价值寿命中彼此不同的市场中回收的一组产品被引入另一个市场，其成本和利润产生组的属性数据，属性 基于剩余使用寿命和产品年龄的数据，确定引入顺序和引入规则，用于将组引入市场，基于当从市场中的一个市场恢复的时间段的剩余使用寿命和组的剩余寿命 通过减去当从另一市场的价值生命周期中的一个市场中恢复的时间点的产品年龄，并根据引入顺序和规则，成本来评估组被引入市场的循环生命周期的环境负荷 并获利。

公开(公告)号：US20080255321A1

公开(公告)日：2008-10-16

申请号：US11722826

申请日：2005-12-22

申请人： Hisataka Nakashima ,  Hideki Kobayashi

发明人： Hisataka Nakashima ,  Hideki Kobayashi

IPC分类号： C08L83/04 ,  C08L63/00

CPC分类号： C08L63/00 ,  B29C35/02 ,  B29C65/14 ,  B29C66/71 ,  B29K2063/00 ,  B29K2083/00 ,  B32B25/20 ,  B32B27/38 ,  C08J5/12 ,  C08J2363/00 ,  C08J2383/04 ,  C08L83/04 ,  C08L83/00 ,  B29C65/00

摘要： An firmly bonded composite of a silicone resin and an epoxy resin comprising: (A) a curable silicone resin composition comprising: (A1) an organopolysiloxane resin that has a refractory index of above 1.45 but below 1.60 and contains at least two silicon-bonded alkenyl groups having 2 to 12 carbon atoms, and no less than 30 mole percent of total siloxane units is phenylsiloxane units represented by the following formula: C6H5—SiO3/2, (A2) an organopolysiloxane that contains at least two silicon-bonded hydrogen atoms and (A3) hydrosilylation catalyst, and (B) a curable epoxy resin composition comprising: (B1) an epoxy resin that contains at least two epoxy groups in one molecule, (B2) a curing agent, and (B3) a curing catalyst. The firmly bonded composite is obtained only by curing composition (A) and composition (B) in tight contact with each other.

摘要翻译： 一种有机硅树脂和环氧树脂的牢固粘合复合物，其包含：（A）可固化的有机硅树脂组合物，其包含：（A1）有机聚硅氧烷树脂，其难熔指数高于1.45但低于1.60，并且含有至少两个硅键合的烯基 具有2至12个碳原子且不少于30摩尔％的总硅氧烷单元的基团是由下式表示的苯基硅氧烷单元：C 6 H 5 -SiO （A2）包含至少两个与硅键合的氢原子的有机聚硅氧烷和（A3）氢化硅烷化催化剂，和（B）可固化环氧树脂组合物，其包含：（B1）环氧树脂，其包含 一个分子中至少有两个环氧基，（B2）固化剂，和（B3）固化催化剂。 仅通过使组合物（A）和组合物（B）彼此紧密接触而获得牢固粘合的复合材料。