公开(公告)号：US20120165629A1

公开(公告)日：2012-06-28

申请号：US13249121

申请日：2011-09-29

申请人： Sean Merritt ,  Marcelo M. Lamego ,  Massi Joe E. Kiani

发明人： Sean Merritt ,  Marcelo M. Lamego ,  Massi Joe E. Kiani

IPC分类号： A61B5/1455 ,  A61B6/00

CPC分类号： A61B5/14551

摘要： FDPM processing provides an amplitude signal and a phase signal at a modulation frequency to improve measurement fidelity during measurement of one or more blood parameters. In an embodiment, a light source modulates light at a modulation frequency around 200 MHz to produce an amplitude and phase plethysmograph, usable to access clinical test data.

摘要翻译： FDPM处理以调制频率提供振幅信号和相位信号，以在测量一个或多个血液参数期间提高测量保真度。 在一个实施例中，光源以大约200MHz的调制频率调制光，以产生可用于访问临床测试数据的振幅和相位体积描记器。

公开(公告)号：US20150112169A1

公开(公告)日：2015-04-23

申请号：US14214633

申请日：2014-03-14

申请人： Marcelo M. Lamego ,  Hung The Vo ,  Cristiano Dalvi ,  Sean Merritt

发明人： Marcelo M. Lamego ,  Hung The Vo ,  Cristiano Dalvi ,  Sean Merritt

IPC分类号： A61B5/00 ,  A61B5/145 ,  A61B5/1495 ,  A61B5/1455

CPC分类号： A61B5/6838 ,  A61B5/02241 ,  A61B5/14532 ,  A61B5/14552 ,  A61B5/6826 ,  A61B5/6843

摘要： A finger-placement sensor fixture aligns and removably secures a finger to a sensor pad of a reusable finger-clip optical sensor so as to assure the finger is repeatably aligned between the sensors emitters and detectors and that the finger stays aligned during a test procedure. The sensor fixture has a sensor pad configured to removably install within a sensor clip. The sensor pad has a sensor cavity custom molded to the shape of an individual's fingertip. A plurality of metal strips are embedded within the sensor pad. A plurality of magnets are embedded within the sensor clip. The sensor pad metal strips are configured to align with the sensor clip magnets so that the sensor pad can be removed, disposed of, replaced and consistently aligned with the sensor clip.

摘要翻译： 手指放置传感器夹具将手指对准并可拆卸地固定到可重复使用的手指夹式光学传感器的传感器垫上，以确保手指在传感器发射器和检测器之间重复对准，并且手指在测试过程中保持对准。 传感器夹具具有被配置为可移除地安装在传感器夹内的传感器垫。 传感器垫具有定制模制成个人指尖形状的传感器腔。 多个金属条嵌入传感器垫内。 多个磁体嵌入在传感器夹中。 传感器焊盘金属条被配置成与传感器夹子磁体对准，使得传感器焊盘可以被移除，处置，替换并与传感器夹持一致地对准。

公开(公告)号：US20110028806A1

公开(公告)日：2011-02-03

申请号：US12511742

申请日：2009-07-29

申请人： Sean Merritt ,  Marcelo Lamego

发明人： Sean Merritt ,  Marcelo Lamego

IPC分类号： A61B5/1455

CPC分类号： A61B5/14532 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/1455

摘要： A noninvasive or minimally invasive procedure and system for measuring blood glucose levels is disclosed. A set of photodiodes detects the fluorescence and reflectance of light energy emitted from one or more emitters, such as LEDs, into a patient's skin. In an embodiment, small molecule metabolite reporters (SMMRs) that bind to glucose are introduced to the measurement area to provide more easily detected fluorescence.

摘要翻译： 公开了一种用于测量血糖水平的无创或微创手术和系统。 一组光电二极管检测从一个或多个发射器（例如LED）发射到患者皮肤中的光能的荧光和反射率。 在一个实施方案中，将结合葡萄糖的小分子代谢报告物（SMMR）引入测量区域以提供更容易检测的荧光。

公开(公告)号：US20090247984A1

公开(公告)日：2009-10-01

申请号：US12258280

申请日：2008-10-24

申请人： Marcelo Lamego ,  Sean Merritt ,  Grace Young

发明人： Marcelo Lamego ,  Sean Merritt ,  Grace Young

IPC分类号： A61M5/32 ,  A61M5/00 ,  G01N33/66

CPC分类号： A61K49/0021 ,  A61B5/14532 ,  A61K49/0004 ,  A61M37/00 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0046 ,  A61M2037/0053 ,  Y10T436/144444

摘要： Systems that can include a microneedle array and a small molecule metabolic reporter are disclosed. The systems can be used to penetrate the epidermis and monitor the change in concentration of one or more metabolite or analyte.

摘要翻译： 公开了可以包括微针阵列和小分子代谢报告物的系统。 该系统可用于穿透表皮并监测一种或多种代谢物或分析物的浓度变化。

公开(公告)号：US20060111622A1

公开(公告)日：2006-05-25

申请号：US11246369

申请日：2005-10-07

申请人： Sean Merritt ,  Bruce Tromberg ,  Albert Cerussi ,  Anthony Durkin

发明人： Sean Merritt ,  Bruce Tromberg ,  Albert Cerussi ,  Anthony Durkin

IPC分类号： G06F19/00 ,  A61B5/00

CPC分类号： A61B5/01 ,  A61B5/0059

摘要： A method for noninvasively determining deep tissue temperature comprises measuring data relating to spectral shifts of chromophore absorption in tissue using broadband diffuse optical spectroscopy and generating a temperature reading corresponding to the spectral shift of an absorption peak of the chromophore. A bound water correction is made to the spectral shift. A frequency domain measurement at multiple wavelengths is made to determine the absolute absorption and scattering values between 600 and 1050 nm. The measurement of an absolute absorption comprises measuring an absolute absorption coefficient of selected tissue and further comprising deducing concentrations of tissue composition including lipids, deducing information related to heterogeneity and integrity of tissue matrix, and deducing temperature heterogeneity related to vulnerable plaque in vascular tissue. The measurement comprises making a measurement in the range of 600-1100 nm to interrogate a vessel wall in the presence of blood.

摘要翻译： 用于非侵入性地确定深部组织温度的方法包括使用宽带漫射光谱测量与组织中发色团吸收的光谱偏移有关的数据，并产生与发色团的吸收峰的光谱偏移相对应的温度读数。 对光谱偏移进行约束水校正。 进行多个波长的频域测量以确定600至1050nm之间的绝对吸收和散射值。 绝对吸收的测量包括测量所选择的组织的绝对吸收系数，并且还包括推导包括脂质的组织组合的浓度，推导与组织基质的异质性和完整性相关的信息，以及推导与血管组织中易损斑块相关的温度异质性。 测量包括在600-1100nm的范围内进行测量，以在存在血液的情况下询问血管壁。

公开(公告)号：US20070282179A1

公开(公告)日：2007-12-06

申请号：US11757673

申请日：2007-06-04

申请人： Sean Merritt ,  Bruce J. Tromberg ,  Albert E. Cerussi ,  Anthony J. Durkin ,  So Hyun Chung

发明人： Sean Merritt ,  Bruce J. Tromberg ,  Albert E. Cerussi ,  Anthony J. Durkin ,  So Hyun Chung

IPC分类号： A61B5/00

CPC分类号： A61B5/0059 ,  A61B5/0064 ,  A61B5/0075 ,  A61B5/0091 ,  A61B5/441 ,  A61B5/4875

摘要： A method of optically analyzing tissue in vivo in an individual to obtain a unique spectrum for the tissue of the individual includes the steps of optically measuring the tissue of the individual using broadband diffuse optical spectroscopy (DOS) to measure a normalized tissue water spectrum of the individual or noninvasively optically line scanning a tissue site on the individual at a plurality of points, then determining spectral differences between the normalized tissue water spectrum and a pure water spectrum at each point of a line scan, generating a bound water index (BWI) corresponding to the spectral differences, and identifying a tissue state corresponding to the scanned tissue based on the BWI.

摘要翻译： 在个体中光学分析体内组织以获得个体组织的唯一光谱的方法包括以下步骤：使用宽带漫射光谱（DOS）光学测量个体的组织，以测量标准化组织水谱 个体或非侵入式光线在多个点上扫描个体上的组织部位，然后确定标准化组织水谱与在线扫描的每个点处的纯水谱之间的光谱差异，生成对应的结合水指数（BWI） 并且基于BWI识别与扫描的组织相对应的组织状态。

公开(公告)号：US20060192965A1

公开(公告)日：2006-08-31

申请号：US11335072

申请日：2006-01-18

申请人： Bruce Tromberg ,  Anthony Durkin ,  David Cuccia ,  Albert Cerussi ,  Sean Merritt ,  Natasha Shah

发明人： Bruce Tromberg ,  Anthony Durkin ,  David Cuccia ,  Albert Cerussi ,  Sean Merritt ,  Natasha Shah

IPC分类号： G01N21/00

CPC分类号： A61B5/4504 ,  A61B5/0059 ,  A61B5/1455 ,  A61B5/417 ,  A61B5/4509

摘要： A method and apparatus for assessing bone tissue comprises the steps of and means for: exposing a sample to nonionizing radiation; detecting nonionizing radiation after transit in the bone tissue; measuring optical properties from the detected nonionizing radiation to characterize bone tissue across an entire selected spectral range using a continuous wave model, a frequency domain model or a combination of both wave model and frequency domain models; and determining composition, structure, physiology or a combination thereof of bone tissue from the measured optical properties.

摘要翻译： 用于评估骨组织的方法和装置包括以下步骤和装置：将样品暴露于非离子辐照; 检测骨组织中过渡后的非放电辐射; 使用连续波模型，频域模型或波模型和频域模型的组合，从检测到的非离子化辐射测量光学特性以表征整个所选光谱范围内的骨组织; 以及根据测量的光学性质确定骨组织的组成，结构，生理学或其组合。