公开(公告)号：US20060192965A1

公开(公告)日：2006-08-31

申请号：US11335072

申请日：2006-01-18

申请人： Bruce Tromberg ,  Anthony Durkin ,  David Cuccia ,  Albert Cerussi ,  Sean Merritt ,  Natasha Shah

发明人： Bruce Tromberg ,  Anthony Durkin ,  David Cuccia ,  Albert Cerussi ,  Sean Merritt ,  Natasha Shah

IPC分类号： G01N21/00

CPC分类号： A61B5/4504 ,  A61B5/0059 ,  A61B5/1455 ,  A61B5/417 ,  A61B5/4509

摘要： A method and apparatus for assessing bone tissue comprises the steps of and means for: exposing a sample to nonionizing radiation; detecting nonionizing radiation after transit in the bone tissue; measuring optical properties from the detected nonionizing radiation to characterize bone tissue across an entire selected spectral range using a continuous wave model, a frequency domain model or a combination of both wave model and frequency domain models; and determining composition, structure, physiology or a combination thereof of bone tissue from the measured optical properties.

摘要翻译： 用于评估骨组织的方法和装置包括以下步骤和装置：将样品暴露于非离子辐照; 检测骨组织中过渡后的非放电辐射; 使用连续波模型，频域模型或波模型和频域模型的组合，从检测到的非离子化辐射测量光学特性以表征整个所选光谱范围内的骨组织; 以及根据测量的光学性质确定骨组织的组成，结构，生理学或其组合。

公开(公告)号：US20060111622A1

公开(公告)日：2006-05-25

申请号：US11246369

申请日：2005-10-07

申请人： Sean Merritt ,  Bruce Tromberg ,  Albert Cerussi ,  Anthony Durkin

发明人： Sean Merritt ,  Bruce Tromberg ,  Albert Cerussi ,  Anthony Durkin

IPC分类号： G06F19/00 ,  A61B5/00

CPC分类号： A61B5/01 ,  A61B5/0059

摘要： A method for noninvasively determining deep tissue temperature comprises measuring data relating to spectral shifts of chromophore absorption in tissue using broadband diffuse optical spectroscopy and generating a temperature reading corresponding to the spectral shift of an absorption peak of the chromophore. A bound water correction is made to the spectral shift. A frequency domain measurement at multiple wavelengths is made to determine the absolute absorption and scattering values between 600 and 1050 nm. The measurement of an absolute absorption comprises measuring an absolute absorption coefficient of selected tissue and further comprising deducing concentrations of tissue composition including lipids, deducing information related to heterogeneity and integrity of tissue matrix, and deducing temperature heterogeneity related to vulnerable plaque in vascular tissue. The measurement comprises making a measurement in the range of 600-1100 nm to interrogate a vessel wall in the presence of blood.

摘要翻译： 用于非侵入性地确定深部组织温度的方法包括使用宽带漫射光谱测量与组织中发色团吸收的光谱偏移有关的数据，并产生与发色团的吸收峰的光谱偏移相对应的温度读数。 对光谱偏移进行约束水校正。 进行多个波长的频域测量以确定600至1050nm之间的绝对吸收和散射值。 绝对吸收的测量包括测量所选择的组织的绝对吸收系数，并且还包括推导包括脂质的组织组合的浓度，推导与组织基质的异质性和完整性相关的信息，以及推导与血管组织中易损斑块相关的温度异质性。 测量包括在600-1100nm的范围内进行测量，以在存在血液的情况下询问血管壁。

公开(公告)号：US20060184043A1

公开(公告)日：2006-08-17

申请号：US11336065

申请日：2006-01-19

申请人： Bruce Tromberg ,  Anthony Durkin ,  David Cuccia ,  Frederic Bevilacqua

发明人： Bruce Tromberg ,  Anthony Durkin ,  David Cuccia ,  Frederic Bevilacqua

IPC分类号： A61B6/00

CPC分类号： G01N21/4795 ,  A61B5/0071 ,  A61B5/0073 ,  A61B5/0091 ,  A61B5/7257 ,  A61B5/726 ,  G01N21/6456 ,  G01N2021/6417 ,  G01N2021/6423 ,  G01N2021/6491

摘要： An improvement in a method for quantitative modulated imaging to perform depth sectioned reflectance or transmission imaging in a turbid medium, such as human or animal tissue is directed to the steps of encoding periodic pattern of illumination preferably with a fluorescent excitation wavelength when exposing a turbid medium to the periodic pattern to provide depth-resolved discrimination of structures within the turbid medium; and reconstructing a non-contact three dimensional image of the structure within a turbid medium. As a result, wide field imaging, separation of the average background optical properties from the heterogeneity components from a single image, separation of superficial features from deep features based on selection of spatial frequency of illumination, or qualitative and quantitative structure, function and composition information is extracted from spatially encoded data.

摘要翻译： 用于在诸如人或动物组织的混浊介质中进行深度切片反射或透射成像的定量调制成像方法的改进涉及以下步骤：当暴露混浊介质时，优选用荧光激发波长编码周期性图案 以提供在混浊介质内的结构的深度分辨鉴别的周期性图案; 以及在混浊介质内重构所述结构的非接触三维图像。 因此，宽场成像，将平均背景光学性质与异质性成分从单一图像分离，基于选择照明空间频率或定性和定量结构，功能和成分信息，将表面特征与深层特征分离 从空间编码数据中提取出来。

公开(公告)号：US20070241119A1

公开(公告)日：2007-10-18

申请号：US11730873

申请日：2007-04-04

申请人： Anthony Durkin ,  Desmond Regan

发明人： Anthony Durkin ,  Desmond Regan

IPC分类号： G07F11/00 ,  G08B21/00

CPC分类号： A61M39/02 ,  A61M1/0086 ,  A61M5/16886 ,  A61M39/223 ,  A61M39/285 ,  A61M2039/1077 ,  A61M2039/1088 ,  A61M2205/583 ,  A61M2210/101 ,  B29C45/14598 ,  B29C2045/14459 ,  B29K2083/00 ,  B29L2031/753 ,  F16L33/227

摘要： A fluid flow indicator (3) for use in a medical drainage device for draining fluid from a pleural cavity of a patient comprises an upper housing part (20), a lower housing part (21), a balloon member (22), a sampling port (23), and a control mechanism to selectively control flow of a body fluid through the balloon member (22) or through the sampling port (23). The balloon member (22) defines a lumen therethrough. Upon flow of a body fluid into the balloon member (22), for example upon inhalation of a patient, the balloon member (22) inflates from a deflated rest configuration to an inflated flow configuration. This inflation of the balloon member (22) provides a visual indication to an operator of the flow of the body fluid through the balloon member (22). When flow of the body fluid ceases, for example upon exhalation of a patient, the balloon member (22) deflates from the inflated flow configuration to the deflated rest configuration. This deflation of the balloon member (22) provides a visual indication to the operator of the cessation of the flow of the body fluid through the balloon member 22).

摘要翻译： 用于从患者胸膜腔排出液体的医用排液装置中的流体流量指示器（3）包括上部壳体部分（20），下部壳体部分（21），气囊部件（22），取样 端口（23），以及控制机构，用于选择性地控制体液通过球囊构件（22）或通过采样口（23）的流动。 球囊构件（22）限定通过其中的腔。 当身体流体进入球囊构件（22）时，例如在吸入患者时，球囊构件（22）从放气的静止构型膨胀到膨胀的流动构型。 球囊构件（22）的这种膨胀向操作者提供通过球囊构件（22）的体液流动的视觉指示。 当体液的流动停止时，例如在呼出患者时，气囊构件（22）从膨胀的流动构型放气到放气的静止构型。 球囊构件（22）的这种放气为操作者提供了通过球囊构件22）停止体液流动的视觉指示。

公开(公告)号：US20080091179A1

公开(公告)日：2008-04-17

申请号：US11777815

申请日：2007-07-13

申请人： Anthony Durkin ,  Dilip Paithankar ,  Yacov Domankevitz ,  James Hsia ,  Jayant Bhawalkar ,  Paul Lucchese

发明人： Anthony Durkin ,  Dilip Paithankar ,  Yacov Domankevitz ,  James Hsia ,  Jayant Bhawalkar ,  Paul Lucchese

IPC分类号： A61B18/18

CPC分类号： A61N5/0616 ,  A61B18/203 ,  A61B2017/00734 ,  A61B2018/00005 ,  A61B2018/00452 ,  A61B2018/1807 ,  A61B2018/2261 ,  A61N2005/0644 ,  A61N2005/066

摘要： A compact, handheld device can be used to treat a sebaceous follicle disorder in a preselected dermal region of mammalian skin. A treatment can ameliorate at least one symptom of a lesion characteristic of the disorder.

摘要翻译： 可以使用紧凑的手持装置来治疗哺乳动物皮肤预选皮肤区域中的皮脂腺卵泡病。 治疗可以改善病症特征的至少一种症状。

公开(公告)号：US20050030372A1

公开(公告)日：2005-02-10

申请号：US10818918

申请日：2004-04-07

申请人： Byungjo Jung ,  Bernard Choi ,  Anthony Durkin ,  J. Nelson

发明人： Byungjo Jung ,  Bernard Choi ,  Anthony Durkin ,  J. Nelson

IPC分类号： A61B5/00 ,  A61B5/103 ,  H04N7/18

CPC分类号： A61B5/444 ,  A61B5/0059 ,  A61B5/445 ,  A61B2560/0233

摘要： A digital imaging system provides color information of an entire port wine stain or other skin condition with a single image in CIE L*a*b* color space (L*, a*) derived from RGB pixel data (R, G, B). Cross-polarization optics produce marked reduction in specularly reflected light in the images. A patient positioning device allows for repeatable positioning of the patient's head or body portion. The digital nature of the system provides a near real-time mapping of melanin and erythema or other skin chromophore metrics. The cross-polarized diffuse reflectance color digital imaging system obtains subsurface skin color information and acquisition of facial images in a reproducible fashion at a fixed distance from an illumination source at optimized angles of view depending on the region of interest being imaged.

摘要翻译： 数字成像系统在从RGB像素数据（R，G，B）得到的CIE L * a * b *颜色空间（L *，a *）中提供具有单个图像的整个端口葡萄酒渍或其它皮肤状况的颜色信息， 。 交叉偏振光学在图像中产生镜面反射光的显着减少。 患者定位装置允许患者的头部或身体部分的可重复定位。 该系统的数字性质提供了近乎实时的黑色素和红斑或其他皮肤发色团指标的绘图。 交叉偏振漫反射彩色数字成像系统根据所成像的感兴趣区域以优化的视角从照明源以固定的距离以可再现的方式获得地下皮肤颜色信息和面部图像。

公开(公告)号：US20080021415A1

公开(公告)日：2008-01-24

申请号：US11730808

申请日：2007-04-04

申请人： Anthony Durkin ,  Desmond Regan

发明人： Anthony Durkin ,  Desmond Regan

IPC分类号： A61M39/04

CPC分类号： A61M39/02 ,  A61M1/0086 ,  A61M5/16886 ,  A61M39/223 ,  A61M39/285 ,  A61M2039/1077 ,  A61M2039/1088 ,  A61M2205/583 ,  A61M2210/101 ,  B29C45/14598 ,  B29C2045/14459 ,  B29K2083/00 ,  B29L2031/753 ,  F16L33/227

摘要： A barb connector (2) for use in a medical drainage device for draining fluid from a pleural cavity of a patient comprises a gripping portion (10), two cylindrical tubular members (11) extending outwardly from the gripping portion (10), and a plurality of annular protrusions (13) spaced-apart along the external surface of each of the tubular members (11). Each tubular member (11) comprises a plurality of recesses spaced-apart along the external surface of the tubular member (11), and the protrusions (13) are mounted in the recesses. Each protrusion (13) is of a compressible material. Upon insertion of a tubular member (11) into a lumen defined through a drain tube of the medical drainage device, the protrusions (13) engage the internal surface of the drain tube and deform to sealingly engage the internal surface.

摘要翻译： 用于从患者胸膜腔排出液体的医用排液装置的倒钩连接器（2）包括夹持部分（10），从夹持部分（10）向外延伸的两个圆柱形管状构件（11），以及 沿着每个管状构件（11）的外表面间隔开的多个环形突起（13）。 每个管状构件（11）包括沿着管状构件（11）的外表面间隔开的多个凹部，并且突出部（13）安装在凹部中。 每个突起（13）都是可压缩材料。 在将管状构件（11）插入到通过医疗排泄装置的排水管限定的内腔中时，突起（13）接合排水管的内表面并变形以密封地接合内表面。

公开(公告)号：US20050226548A1

公开(公告)日：2005-10-13

申请号：US11104033

申请日：2005-04-12

申请人： Anthony Durkin ,  Sheng-Hao Tseng

发明人： Anthony Durkin ,  Sheng-Hao Tseng

IPC分类号： G01N21/31 ,  G01N21/35 ,  G01N21/49 ,  G02B6/00

CPC分类号： G01N21/49 ,  G01N21/31 ,  G01N21/3563 ,  G01N2201/08

摘要： A device and method for accurately performing quantitative diffuse optical spectroscopy on a sample includes a light source and a source optical fiber that is optically coupled to the light source. A diffuser material is interposed between the source optical fiber and the sample, the diffuser material comprising a high scattering, low absorption material. The diffuser material effectively increases the photon path length from the light source to the sample, which limits the depth of interrogation to superficial volumes despite the penetrating nature of the radiation typically used. A detector optical fiber is provided adjacent to or laterally disposed from the source optical fiber. The detector optical fiber is coupled to a detector which detects photons collected in the detector optical fiber. The detector optical fiber and the source optical fiber may be separated by a distance of less than 5 mm while still permitting the diffusion approximation to remain valid.

摘要翻译： 用于在样品上精确地进行定量扩散光谱的装置和方法包括光源和光学耦合到光源的源光纤。 漫射材料插入在源光纤和样品之间，漫射材料包含高散射低吸收材料。 扩散器材料有效地增加了从光源到样品的光子路径长度，这限制了询问到表面体积的深度，尽管通常使用的辐射的穿透性质。 检测器光纤被设置成与源光纤相邻或横向设置。 检测器光纤耦合到检测器，该检测器检测在检测器光纤中收集的光子。 检测器光纤和源光纤可以分开小于5mm的距离，同时仍允许扩散近似保持有效。