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    Method for assessing the condition of bone in-vivo
    1.
    发明申请
    Method for assessing the condition of bone in-vivo 审中-公开
    评估骨骼状态的方法

    公开(公告)号：US20060192965A1

    公开(公告)日：2006-08-31

    申请号：US11335072

    申请日：2006-01-18

    申请人： Bruce Tromberg ,  Anthony Durkin ,  David Cuccia ,  Albert Cerussi ,  Sean Merritt ,  Natasha Shah

    发明人： Bruce Tromberg ,  Anthony Durkin ,  David Cuccia ,  Albert Cerussi ,  Sean Merritt ,  Natasha Shah

    IPC分类号： G01N21/00

    CPC分类号： A61B5/4504 ,  A61B5/0059 ,  A61B5/1455 ,  A61B5/417 ,  A61B5/4509

    摘要： A method and apparatus for assessing bone tissue comprises the steps of and means for: exposing a sample to nonionizing radiation; detecting nonionizing radiation after transit in the bone tissue; measuring optical properties from the detected nonionizing radiation to characterize bone tissue across an entire selected spectral range using a continuous wave model, a frequency domain model or a combination of both wave model and frequency domain models; and determining composition, structure, physiology or a combination thereof of bone tissue from the measured optical properties.

    摘要翻译： 用于评估骨组织的方法和装置包括以下步骤和装置：将样品暴露于非离子辐照; 检测骨组织中过渡后的非放电辐射; 使用连续波模型，频域模型或波模型和频域模型的组合，从检测到的非离子化辐射测量光学特性以表征整个所选光谱范围内的骨组织; 以及根据测量的光学性质确定骨组织的组成，结构，生理学或其组合。

    Apparatus and method for monitoring deep tissue temperature using broadband diffuse optical spectroscopy
    2.
    发明申请
    Apparatus and method for monitoring deep tissue temperature using broadband diffuse optical spectroscopy 审中-公开
    使用宽带漫射光谱法监测深层组织温度的装置和方法

    公开(公告)号：US20060111622A1

    公开(公告)日：2006-05-25

    申请号：US11246369

    申请日：2005-10-07

    申请人： Sean Merritt ,  Bruce Tromberg ,  Albert Cerussi ,  Anthony Durkin

    发明人： Sean Merritt ,  Bruce Tromberg ,  Albert Cerussi ,  Anthony Durkin

    IPC分类号： G06F19/00 ,  A61B5/00

    CPC分类号： A61B5/01 ,  A61B5/0059

    摘要： A method for noninvasively determining deep tissue temperature comprises measuring data relating to spectral shifts of chromophore absorption in tissue using broadband diffuse optical spectroscopy and generating a temperature reading corresponding to the spectral shift of an absorption peak of the chromophore. A bound water correction is made to the spectral shift. A frequency domain measurement at multiple wavelengths is made to determine the absolute absorption and scattering values between 600 and 1050 nm. The measurement of an absolute absorption comprises measuring an absolute absorption coefficient of selected tissue and further comprising deducing concentrations of tissue composition including lipids, deducing information related to heterogeneity and integrity of tissue matrix, and deducing temperature heterogeneity related to vulnerable plaque in vascular tissue. The measurement comprises making a measurement in the range of 600-1100 nm to interrogate a vessel wall in the presence of blood.

    摘要翻译： 用于非侵入性地确定深部组织温度的方法包括使用宽带漫射光谱测量与组织中发色团吸收的光谱偏移有关的数据，并产生与发色团的吸收峰的光谱偏移相对应的温度读数。 对光谱偏移进行约束水校正。 进行多个波长的频域测量以确定600至1050nm之间的绝对吸收和散射值。 绝对吸收的测量包括测量所选择的组织的绝对吸收系数，并且还包括推导包括脂质的组织组合的浓度，推导与组织基质的异质性和完整性相关的信息，以及推导与血管组织中易损斑块相关的温度异质性。 测量包括在600-1100nm的范围内进行测量，以在存在血液的情况下询问血管壁。

    Method and apparatus for dynamically monitoring multiple in vivo tissue chromophores
    5.
    发明申请
    Method and apparatus for dynamically monitoring multiple in vivo tissue chromophores 有权
    用于动态监测多个体内组织发色团的方法和装置

    公开(公告)号：US20050228246A1

    公开(公告)日：2005-10-13

    申请号：US11103963

    申请日：2005-04-12

    申请人： Jangwoen Lee ,  Bruce Tromberg ,  Albert Cerussi ,  Matthew Brenner

    发明人： Jangwoen Lee ,  Bruce Tromberg ,  Albert Cerussi ,  Matthew Brenner

    IPC分类号： A61B5/00 ,  G01J3/28 ,  G01N21/31 ,  G01N21/35 ,  G01N21/49

    CPC分类号： A61B5/14551 ,  A61B5/14552 ,  A61B5/412 ,  G01N21/31 ,  G01N21/359 ,  G01N21/49 ,  G01N2201/08

    摘要： A device and method utilizes a broadband diffuse optical spectroscopy (DOS) system to dynamically calculate the concentrations of multiple chromophores in vivo using a non-invasive probe. The device and method permit dynamic monitoring of multiple in vivo tissue chromophores non-invasively with sensitivities necessary for effective therapeutic monitoring. The device includes a probe containing first and second source optical fibers as well as first and second detector optical fibers. The probe is placed adjacent to a sample of interest and detects reflected light which is passed to a proximally located detector and spectrometer. The concentrations of multiple chromophores are determined in real time. In a preferred embodiment, the multiple tissue chromophores include at least two of methemoglobin (MetHb), deoxyhemoglobin (Hb-R), oxyhemoglobin (Hb-O2), water (H2O), and methylene blue (MB). The device and method can be used quantify and monitor methemoglobin formation in subjects suffering from methemoglobinemia.

    摘要翻译： 一种使用宽带漫射光谱（DOS）系统的装置和方法使用非侵入性探针来动态地计算体内多个发色团的浓度。 该装置和方法允许非侵入性地动态监测多个体内组织发色团，具有有效治疗监测所需的灵敏度。 该装置包括包含第一和第二源光纤以及第一和第二检测器光纤的探针。 将探针放置在感兴趣的样本附近，并检测反射光，其被传递到位于近端的检测器和光谱仪。 多个发色团的浓度实时测定。 在优选实施方案中，多组织发色团包括高铁血红蛋白（MetHb），脱氧血红蛋白（Hb-R），氧合血红蛋白（Hb-O 2 H），水（H 2 O 2） SUB）和亚甲基蓝（MB）。 该装置和方法可用于定量和监测患有高铁血红蛋白血症的受试者中的高铁血红蛋白形成。

    METHOD AND APPARATUS FOR THE DETERMINATION OF INTRINSIC SPECTROSCOPIC TUMOR MARKERS BY BROADBAND-FREQUENCY DOMAIN TECHNOLOGY
    6.
    发明申请
    METHOD AND APPARATUS FOR THE DETERMINATION OF INTRINSIC SPECTROSCOPIC TUMOR MARKERS BY BROADBAND-FREQUENCY DOMAIN TECHNOLOGY 审中-公开
    用于通过宽带频域技术确定内在光谱肿瘤标记物的方法和装置

    公开(公告)号：US20080009748A1

    公开(公告)日：2008-01-10

    申请号：US11749704

    申请日：2007-05-16

    申请人： Enrico Gratton ,  Shwayta Kukreti ,  Albert Cerussi ,  Bruce Tromburg

    发明人： Enrico Gratton ,  Shwayta Kukreti ,  Albert Cerussi ,  Bruce Tromburg

    IPC分类号： A61B6/00

    CPC分类号： A61B5/0059 ,  A61B5/06 ,  G01N21/359

    摘要： The illustrated embodiment is an improvement in a method of optically analyzing tissue in vivo in an individual to obtain a unique spectrum for the tissue of the individual, the improvement including the steps of optically measuring the tissue of the individual to obtain a spectrum of an optical parameter, and identifying a spectral signature specific to a metabolic or physiologic state in the tissue of the individual with a unique spectrum for the tissue by considering only the spectral differences between a first metabolic or physiologic state of the tissue of the individual and one or more other metabolic or physiologic states of the tissue of the individual such that identification of the spectral signature is self-referencing with respect to intra-individual metabolic or physiologic variations. The method also includes separating benign and malignant lesions only using the shape or a characteristic of the spectrum.

    摘要翻译： 所示实施例是在个体中在体内光学分析组织以获得个体组织的独特光谱的方法的改进，改进包括光学测量个体的组织以获得光学的光谱的步骤 参数，并且通过仅考虑个体组织的第一代谢或生理状态与一个或多个组织之间的光谱差异，通过组织的唯一光谱来识别特定于个体组织中代谢或生理状态的光谱特征 个体组织的其他代谢或生理状态，使得光谱特征的鉴定在个体内代谢或生理变化方面是自参照的。 该方法还包括仅使用光谱的形状或特征分离良性和恶性病变。