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    Apparatus and method for monitoring deep tissue temperature using broadband diffuse optical spectroscopy
    1.
    发明申请
    Apparatus and method for monitoring deep tissue temperature using broadband diffuse optical spectroscopy 审中-公开
    使用宽带漫射光谱法监测深层组织温度的装置和方法

    公开(公告)号：US20060111622A1

    公开(公告)日：2006-05-25

    申请号：US11246369

    申请日：2005-10-07

    申请人： Sean Merritt ,  Bruce Tromberg ,  Albert Cerussi ,  Anthony Durkin

    发明人： Sean Merritt ,  Bruce Tromberg ,  Albert Cerussi ,  Anthony Durkin

    IPC分类号： G06F19/00 ,  A61B5/00

    CPC分类号： A61B5/01 ,  A61B5/0059

    摘要： A method for noninvasively determining deep tissue temperature comprises measuring data relating to spectral shifts of chromophore absorption in tissue using broadband diffuse optical spectroscopy and generating a temperature reading corresponding to the spectral shift of an absorption peak of the chromophore. A bound water correction is made to the spectral shift. A frequency domain measurement at multiple wavelengths is made to determine the absolute absorption and scattering values between 600 and 1050 nm. The measurement of an absolute absorption comprises measuring an absolute absorption coefficient of selected tissue and further comprising deducing concentrations of tissue composition including lipids, deducing information related to heterogeneity and integrity of tissue matrix, and deducing temperature heterogeneity related to vulnerable plaque in vascular tissue. The measurement comprises making a measurement in the range of 600-1100 nm to interrogate a vessel wall in the presence of blood.

    摘要翻译： 用于非侵入性地确定深部组织温度的方法包括使用宽带漫射光谱测量与组织中发色团吸收的光谱偏移有关的数据，并产生与发色团的吸收峰的光谱偏移相对应的温度读数。 对光谱偏移进行约束水校正。 进行多个波长的频域测量以确定600至1050nm之间的绝对吸收和散射值。 绝对吸收的测量包括测量所选择的组织的绝对吸收系数，并且还包括推导包括脂质的组织组合的浓度，推导与组织基质的异质性和完整性相关的信息，以及推导与血管组织中易损斑块相关的温度异质性。 测量包括在600-1100nm的范围内进行测量，以在存在血液的情况下询问血管壁。

    Method for assessing the condition of bone in-vivo
    2.
    发明申请
    Method for assessing the condition of bone in-vivo 审中-公开
    评估骨骼状态的方法

    公开(公告)号：US20060192965A1

    公开(公告)日：2006-08-31

    申请号：US11335072

    申请日：2006-01-18

    申请人： Bruce Tromberg ,  Anthony Durkin ,  David Cuccia ,  Albert Cerussi ,  Sean Merritt ,  Natasha Shah

    发明人： Bruce Tromberg ,  Anthony Durkin ,  David Cuccia ,  Albert Cerussi ,  Sean Merritt ,  Natasha Shah

    IPC分类号： G01N21/00

    CPC分类号： A61B5/4504 ,  A61B5/0059 ,  A61B5/1455 ,  A61B5/417 ,  A61B5/4509

    摘要： A method and apparatus for assessing bone tissue comprises the steps of and means for: exposing a sample to nonionizing radiation; detecting nonionizing radiation after transit in the bone tissue; measuring optical properties from the detected nonionizing radiation to characterize bone tissue across an entire selected spectral range using a continuous wave model, a frequency domain model or a combination of both wave model and frequency domain models; and determining composition, structure, physiology or a combination thereof of bone tissue from the measured optical properties.

    摘要翻译： 用于评估骨组织的方法和装置包括以下步骤和装置：将样品暴露于非离子辐照; 检测骨组织中过渡后的非放电辐射; 使用连续波模型，频域模型或波模型和频域模型的组合，从检测到的非离子化辐射测量光学特性以表征整个所选光谱范围内的骨组织; 以及根据测量的光学性质确定骨组织的组成，结构，生理学或其组合。

    FINGER-PLACEMENT SENSOR
    3.
    发明申请
    FINGER-PLACEMENT SENSOR 审中-公开
    手指放置传感器

    公开(公告)号：US20150112169A1

    公开(公告)日：2015-04-23

    申请号：US14214633

    申请日：2014-03-14

    申请人： Marcelo M. Lamego ,  Hung The Vo ,  Cristiano Dalvi ,  Sean Merritt

    发明人： Marcelo M. Lamego ,  Hung The Vo ,  Cristiano Dalvi ,  Sean Merritt

    IPC分类号： A61B5/00 ,  A61B5/145 ,  A61B5/1495 ,  A61B5/1455

    CPC分类号： A61B5/6838 ,  A61B5/02241 ,  A61B5/14532 ,  A61B5/14552 ,  A61B5/6826 ,  A61B5/6843

    摘要： A finger-placement sensor fixture aligns and removably secures a finger to a sensor pad of a reusable finger-clip optical sensor so as to assure the finger is repeatably aligned between the sensors emitters and detectors and that the finger stays aligned during a test procedure. The sensor fixture has a sensor pad configured to removably install within a sensor clip. The sensor pad has a sensor cavity custom molded to the shape of an individual's fingertip. A plurality of metal strips are embedded within the sensor pad. A plurality of magnets are embedded within the sensor clip. The sensor pad metal strips are configured to align with the sensor clip magnets so that the sensor pad can be removed, disposed of, replaced and consistently aligned with the sensor clip.

    摘要翻译： 手指放置传感器夹具将手指对准并可拆卸地固定到可重复使用的手指夹式光学传感器的传感器垫上，以确保手指在传感器发射器和检测器之间重复对准，并且手指在测试过程中保持对准。 传感器夹具具有被配置为可移除地安装在传感器夹内的传感器垫。 传感器垫具有定制模制成个人指尖形状的传感器腔。 多个金属条嵌入传感器垫内。 多个磁体嵌入在传感器夹中。 传感器焊盘金属条被配置成与传感器夹子磁体对准，使得传感器焊盘可以被移除，处置，替换并与传感器夹持一致地对准。

    Adaptive calibration system for spectrophotometric measurements
    5.
    发明授权
    Adaptive calibration system for spectrophotometric measurements 有权
    用于分光光度测量的自适应校准系统

    公开(公告)号：US08571618B1

    公开(公告)日：2013-10-29

    申请号：US12891428

    申请日：2010-09-27

    申请人： Marcelo Lamego ,  Sean Merritt ,  Massi Joe E. Kiani

    发明人： Marcelo Lamego ,  Sean Merritt ,  Massi Joe E. Kiani

    IPC分类号： A61B5/1455

    CPC分类号： A61B5/7221 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14551 ,  A61B5/1495 ,  A61B5/742 ,  A61B5/746

    摘要： This disclosure describes, among other features, systems and methods for customizing calibration curves, parameter algorithms, and the like to individual users. An initial calibration curve generated based on a population can be used as a starting point in an algorithm for measuring a physiological parameter such as glucose. The measurement algorithm can determine one or more initial measurement values for a user based on the initial calibration curve. In certain embodiments, one or more alternative measurements, such as invasive or minimally invasive measurements, can periodically or sporadically be input into the measurement algorithm. The algorithm can use the alternative measurements to adapt the calibration curve to the individual. As a result, measurements for the individual can more accurately reflect the individual's actual parameter values.

    摘要翻译： 本公开内容还描述了用于将校准曲线，参数算法等定制到个体用户的系统和方法。 基于群体生成的初始校准曲线可以用作用于测量诸如葡萄糖的生理参数的算法中的起始点。 测量算法可以基于初始校准曲线确定用户的一个或多个初始测量值。 在某些实施例中，可以周期地或偶尔地将一个或多个替代测量，例如侵入性或微创测量输入到测量算法中。 该算法可以使用替代测量来将校准曲线适应于个体。 因此，个人的测量可以更准确地反映个人的实际参数值。