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    METHOD AND APPARATUS FOR CARDIAC FUNCTION MONITORING
    21.
    发明申请
    METHOD AND APPARATUS FOR CARDIAC FUNCTION MONITORING 有权
    心脏功能监测的方法和装置

    公开(公告)号：US20130289430A1

    公开(公告)日：2013-10-31

    申请号：US13794898

    申请日：2013-03-12

    Applicant: MEDTRONIC, INC.

    Inventor： Zhendong Song ,  Xiaohong Zhou

    IPC: A61B5/0245 ,  A61N1/362

    CPC classification number: A61B7/04 ,  A61B5/02158 ,  A61B5/0245 ,  A61B6/12 ,  A61B6/487 ,  A61N1/056 ,  A61N1/362 ,  A61N1/36564 ,  A61N1/36578 ,  A61N1/36585

    Abstract: An implantable medical device that includes a first elongated lead body having an outer surface and an opening along the outer surface, a sensor positioned along the lead body and configured to receive acoustic signals through the opening of the first lead body and generate an electrical signal representative of sounds produced at a targeted location along a patient's cardiovascular system. A therapy delivery module is capable of delivering a cardiac therapy via predetermined electrodes of a plurality of electrodes, and a processor is configured to detect a cardiac event in response to the sensed cardiac electrical signals, determine a plurality of time intervals between the electrical signals and acoustic signals, determine a correlation between the electrical signals and the acoustic signals, and control the therapy delivery module to deliver therapy in response to the determined correlation.

    Abstract translation: 一种可植入医疗装置，其包括具有外表面和沿着外表面的​​开口的第一细长引线本体，沿着引线本体定位并被配置为通过第一引线体的开口接收声信号并产生电信号代表 在沿着患者心血管系统的目标位置产生的声音。 治疗递送模块能够通过多个电极的预定电极递送心脏治疗，并且处理器被配置为响应于所感测到的心脏电信号来检测心脏事件，确定电信号与电信号之间的多个时间间隔 声信号，确定电信号和声信号之间的相关性，并且响应于确定的相关性来控制治疗递送模块递送治疗。

    HEART SOUND MONITORING OF PULMONARY HYPERTENSION
    22.
    发明申请
    HEART SOUND MONITORING OF PULMONARY HYPERTENSION 审中-公开
    心脏超声心动图监测

    公开(公告)号：US20130237863A1

    公开(公告)日：2013-09-12

    申请号：US13786778

    申请日：2013-03-06

    Applicant: MEDTRONIC, INC.

    Inventor： Zhendong Song ,  Xiaohong Zhou

    IPC: A61N1/365 ,  A61M5/172 ,  A61B5/0205

    CPC classification number: A61B5/0205 ,  A61B5/021 ,  A61B5/0215 ,  A61B5/0456 ,  A61B5/7285 ,  A61B7/00 ,  A61B7/003 ,  A61M5/1723 ,  A61N1/36585

    Abstract: A medical device system and method that includes sensing a heart sound signal from a first external sensor, determining whether a pulmonary hypertension signature is detected in response to the sensed heart sound signal, sensing a lung sound signal from a second external sensor, determining whether a heart failure signature is detected in response to the sensed lung sound signal, and determining therapy parameters in response to determining whether a pulmonary hypertension signature is detected and determining whether a heart failure signature is detected.

    Abstract translation: 一种医疗装置系统和方法，其包括感测来自第一外部传感器的心音信号，确定是否响应于感测到的心音信号检测到肺动脉高压症特征，感测来自第二外部传感器的肺声信号， 响应于感测到的肺声信号检测心力衰竭特征，并且响应于确定是否检测到肺动脉高压症特征并确定是否检测到心力衰竭标记来确定治疗参数。

    IMPLANTABLE MEDICAL DEVICE HAVING OPTICAL FIBER FOR SENSING ELECTRICAL ACTIVITY
    23.
    发明申请
    IMPLANTABLE MEDICAL DEVICE HAVING OPTICAL FIBER FOR SENSING ELECTRICAL ACTIVITY 有权
    具有用于传感电活动的光纤的可植入医疗装置

    公开(公告)号：US20130197373A1

    公开(公告)日：2013-08-01

    申请号：US13794352

    申请日：2013-03-11

    Applicant: MEDTRONIC, INC.

    Inventor： Vinod Sharma ,  Xiaohong Zhou

    IPC: A61B5/00

    CPC classification number: A61B5/0071 ,  A61B5/0084 ,  A61B5/0452

    Abstract: An implantable medical device for optically sensing action potential signals in excitable body tissue. The device includes an elongated tubular lead body carrying an optical fiber extending from a proximal lead end to a distal lead end to position the optical fiber at a target site. The lead body additionally carries a conduit for dispensing a voltage-sensitive fluorescent dye into tissue surrounding the target site. The optical fiber transmits excitation light to the fluorescent dye to cause the dye to fluoresce with varying intensity as the transmembrane potentials of local tissue cells vary due to passing depolarization wavefronts. The optical fiber transmits the fluorescence signal to the device to generate an action potential signal or fiducial points of an action potential signal for use in accurately measuring and characterizing electrical activity of excitable tissue.

    Abstract translation: 一种用于在可兴奋的身体组织中光学感测动作电位信号的可植入医疗装置。 该装置包括细长的管状引线体，其承载从近侧引线端延伸到远端引线端的光纤，以将光纤定位在目标部位。 引线体还带有用于将电压敏感的荧光染料分配到靶区域周围的组织中的导管。 光纤将激发光透射到荧光染料，以使得染料以不同的强度发荧光，因为局部组织细胞的跨膜电位由于通过去极化波前而变化。 光纤将荧光信号传输到设备以产生动作电位信号或动作电位信号的基准点，用于精确测量和表征可兴奋组织的电活动。

    MULTI-PARAMETER PREDICTION OF ACUTE CARDIAC EPISODES AND ATTACKS
    26.
    发明申请
    MULTI-PARAMETER PREDICTION OF ACUTE CARDIAC EPISODES AND ATTACKS 有权

    公开(公告)号：US20220273236A1

    公开(公告)日：2022-09-01

    申请号：US17663589

    申请日：2022-05-16

    Applicant: Medtronic, Inc.

    Inventor： Xiaohong Zhou

    IPC: A61B5/00 ,  A61B5/0205 ,  A61N1/39 ,  A61N1/05 ,  A61B5/08 ,  G16H50/30 ,  G16H50/20 ,  A61B5/316 ,  A61B5/363

    Abstract: In some examples, processing circuitry of a medical device system determines, for each of a plurality of patient parameters, a difference metric for a current period based on a value of a patient parameter determined for the current period and a value of the patient parameter determined for an immediately preceding period, and determines a score for the current period based on a sum of the difference metrics for at least some of the plurality of patient parameters. The processing circuitry determines a threshold for the current period based on scores determined for N periods that precede the current period, compares the score for the current period to the threshold, and determines whether to generate an alert indicating that an acute cardiac event of the patient, e.g., ventricular tachyarrhythmia, is predicted, and/or deliver a therapy configured to prevent the acute cardiac event, based on the comparison.

    Leadless pacing device for His bundle and bundle branch pacing
    27.
    发明授权
    Leadless pacing device for His bundle and bundle branch pacing 有权

    公开(公告)号：US11311734B2

    公开(公告)日：2022-04-26

    申请号：US16162998

    申请日：2018-10-17

    Applicant: Medtronic, Inc.

    Inventor： Xiaohong Zhou

    IPC: A61N1/368 ,  A61N1/39 ,  A61N1/365 ,  A61B5/283 ,  A61B5/349 ,  A61B5/366 ,  A61B5/00 ,  A61N1/37 ,  A61N1/375 ,  A61N1/372 ,  A61B5/24 ,  A61B5/363 ,  A61N1/05 ,  A61N1/362

    Abstract: The present disclosure relates generally to pacing of cardiac tissue, and more particularly to adjusting delivery of His bundle or bundle branch pacing in a cardiac pacing system to achieve synchronized ventricular activation. A leadless pacing device (LPD) may include a plurality of electrodes comprising a bundle pacing electrode leadlessly connected to the housing, which may be implanted proximate to or in the His bundle or bundle branch of the patient's heart. An electrical pulse generator may generate and deliver electrical His-bundle or bundle-branch stimulation pulses using the bundle pacing electrode based on sensing one or both of an atrial event and a ventricular event. The LPD may receive communication from another implantable device, such as a subcutaneously implanted device, and deliver His-bundle or bundle-branch pacing in response to the communication.

    ROTATABLE ADAPTER FOR CONNECTING IMPLANTABLE MEDICAL LEADS TO TEST DEVICES
    28.
    发明申请
    ROTATABLE ADAPTER FOR CONNECTING IMPLANTABLE MEDICAL LEADS TO TEST DEVICES 有权

    公开(公告)号：US20220088395A1

    公开(公告)日：2022-03-24

    申请号：US17348666

    申请日：2021-06-15

    Applicant: Medtronic, Inc.

    Inventor： Zhongping Yang ,  Thomas A. Anderson ,  Wade M. Demmer ,  Xiaohong Zhou

    IPC: A61N1/375

    Abstract: An adapter configured to electrically connect a test device to an implantable medical lead comprises a rotational electrical coupling. The rotational electrical coupling is configured to electrically connect a lead electrical connector to an adapter electrical connector. The rotational electrical coupling comprises a first conductive component configured to be electrically connected to the lead electrical connector and rotatable with a proximal portion of the implantable medical lead, and a second conductive component electrically connected to the first conductive component and the adapter electrical connector. The second conductive component may be rotationally fixed. The first and second conductive components may comprise graphite or another soft metal.

    Method and apparatus for cardiac function monitoring
    30.
    发明授权
    Method and apparatus for cardiac function monitoring 有权
    用于心脏功能监测的方法和装置

    公开(公告)号：US08926523B2

    公开(公告)日：2015-01-06

    申请号：US13794898

    申请日：2013-03-12

    Applicant: Medtronic, Inc.

    Inventor： Zhendong Song ,  Xiaohong Zhou

    IPC: A61B5/02 ,  A61N1/00 ,  A61B5/0215 ,  A61N1/365 ,  A61B5/0245 ,  A61N1/362 ,  A61B7/04 ,  A61N1/05

    CPC classification number: A61B7/04 ,  A61B5/02158 ,  A61B5/0245 ,  A61B6/12 ,  A61B6/487 ,  A61N1/056 ,  A61N1/362 ,  A61N1/36564 ,  A61N1/36578 ,  A61N1/36585

    Abstract: An implantable medical device that includes a first elongated lead body having an outer surface and an opening along the outer surface, a sensor positioned along the lead body and configured to receive acoustic signals through the opening of the first lead body and generate an electrical signal representative of sounds produced at a targeted location along a patient's cardiovascular system. A therapy delivery module is capable of delivering a cardiac therapy via predetermined electrodes of a plurality of electrodes, and a processor is configured to detect a cardiac event in response to the sensed cardiac electrical signals, determine a plurality of time intervals between the electrical signals and acoustic signals, determine a correlation between the electrical signals and the acoustic signals, and control the therapy delivery module to deliver therapy in response to the determined correlation.

    Abstract translation: 一种可植入医疗装置，其包括具有外表面和沿着外表面的​​开口的第一细长引线本体，沿着引线本体定位并被配置为通过第一引线体的开口接收声信号并产生电信号代表 在沿着患者心血管系统的目标位置产生的声音。 治疗递送模块能够通过多个电极的预定电极递送心脏治疗，并且处理器被配置为响应于所感测的心脏电信号来检测心脏事件，确定电信号与电信号之间的多个时间间隔 声信号，确定电信号和声信号之间的相关性，并且响应于确定的相关性来控制治疗递送模块递送治疗。

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