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37 条记录 (耗时 0.163 秒)

    Partially hydrogenated 1H-indeno-[1,2-b]-pyridine derivatives
    22.
    发明授权
    Partially hydrogenated 1H-indeno-[1,2-b]-pyridine derivatives 失效
    部分氢化1H-茚并 - {8,1-b {9-吡啶衍生物

    公开(公告)号：US3980656A

    公开(公告)日：1976-09-14

    申请号：US470667

    申请日：1974-05-16

    申请人： Rudolf Kunstmann ,  Ernold Granzer

    发明人： Rudolf Kunstmann ,  Ernold Granzer

    IPC分类号： C07D221/16

    CPC分类号： C07D221/16

    摘要： Partially hydrogenated 1H-indeno[1,2-b]-pyridine derivatives of the general formula I ##SPC1##in whichR.sup.1 and R.sup.2, which may be identical or different, represent hydrogen, halogen or alkoxy of 1 to 4 carbon atoms,R.sup.3 represents pyridyl, phenyl, or phenyl mono- or di-substituted by halogen, nitro, amino, acylamino, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, or amino substituted by 1 or 2 aliphatic or aromatic hydrocarbon groups having 2 to 18 carbon atoms or substituted amino wherein the amino-nitrogen is included in a heterocycle,A represents a single or double bond, andX represents oxygen or sulfur,And their physiologically tolerated salts, process for preparing them and pharmaceutical preparations containing them.

    摘要翻译： R 1和R 2可以相同或不同，代表氢，卤素或1-4个碳原子的烷氧基的部分氢化的1H-茚并[1,2-b] - 吡啶衍生物，R 3表示吡啶基， 苯基或被卤素，硝基，氨基，酰氨基，具有1至4个碳原子的烷基，具有1至4个碳原子的烷氧基或被1或2个脂族或芳族烃基取代的氨基， 18个碳原子或取代的氨基，其中氨基氮被包括在杂环中，A表示单键或双键，X表示氧或硫，以及它们的生理学上可容忍的盐，其制备它们的方法和包含它们的药物制备方法。

    4-amino-2-(imidazolidin-2-on-1-yl)-5-(3-trifluoromet hyl-phenyllaminocarbonyl)pyrimidines for antithrombotic prophylaxis and treatment
    23.
    发明授权
    4-amino-2-(imidazolidin-2-on-1-yl)-5-(3-trifluoromet hyl-phenyllaminocarbonyl)pyrimidines for antithrombotic prophylaxis and treatment 失效
    4-氨基-2-（咪唑烷-2-基-1-基）-5-（3-三氟甲基 - 苯基氨基羰基）嘧啶，用于抗血栓预防和治疗

    公开(公告)号：US4705792A

    公开(公告)日：1987-11-10

    申请号：US878854

    申请日：1986-06-25

    申请人： Ernold Granzer ,  Klaus-Dieter Kampe

    发明人： Ernold Granzer ,  Klaus-Dieter Kampe

    IPC分类号： C07D403/04 ,  A61K31/505 ,  A61P7/02 ,  C07D239/42

    CPC分类号： A61K31/505

    摘要： 4-Amino-2-(imidazolidin-2-on-1-yl)-5-(3-trifluoromethylphenylaminocarbonyl)pyrimidine of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 have the indicated meanings, and their physiologically tolerated acid addition salts for the prophylaxis and therapy of thromboses, and the use of these compounds for the preparation of a medicament for the prophylaxis and therapy of thromboses are described.

    摘要翻译： 具有式I的4-氨基-2-（咪唑烷-2-基-1-基）-5-（3-三氟甲基苯基氨基甲酰基）嘧啶，其中R 1，R 2，R 3，R 4和R 5具有 描述了其用于预防和治疗血栓形成的生理学耐受的酸加成盐，以及这些化合物在制备用于预防和治疗血栓形成的药物中的用途。

    4-Phenoxy-phenoxy-alkane-carboxylic acid derivatives and process for their manufacture
    25.
    发明授权
    4-Phenoxy-phenoxy-alkane-carboxylic acid derivatives and process for their manufacture 失效
    4-苯氧基 - 苯氧基 - 烷烃 - 羧酸衍生物及其制备方法

    公开(公告)号：US4391995A

    公开(公告)日：1983-07-05

    申请号：US265902

    申请日：1981-05-21

    申请人： Helmut Nahm ,  Ernold Granzer

    发明人： Helmut Nahm ,  Ernold Granzer

    IPC分类号： A61K31/19 ,  C07C37/05 ,  C07C43/263 ,  C07C43/29 ,  C07C51/09 ,  C07C59/68 ,  C07C59/70 ,  C07C69/712 ,  C07C2/88

    CPC分类号： C07C323/00 ,  C07C51/09 ,  C07C59/68

    摘要： Novel 4-phenoxy-phenoxy-alkane-carboxylic acid derivatives of the formula I ##STR1## in which R.sub.1 stands for hydrogen, methylithio, cyclopentyl, cyclohexyl, phenyl, methylcycylohexyl, ethylcyclohexyl, or R.sub.1 and R.sub.3 together stand for a --CH.dbd.CH--CH.dbd.CH-- bridge or--unless at least one of the substituents R.sub.2 to R.sub.8 stands for hydrogen, or if R.sub.9 stands for a radical having at least 2 carbon atoms--for chlorine,R.sub.2 and R.sub.3, independent of one another, each stands for hydrogen, chlorine or alkyl of 1 to 4 carbon atoms,R.sub.4 stands for hydrogen, chlorine, alkyl of 1 to 4 carbon atoms, cyclopentyl, cyclohexyl, methylcyclohexyl or R.sub.3 and R.sub.4 together stand for a --CH.dbd.CH--CH.dbd.CH-- bridge,R.sub.5, R.sub.6 and R.sub.7, independent of one another, each stands for hydrogen or alkyl of 1 to 4 carbon atoms,R.sub.8 stands for hydrogen, alkyl of 1 to 4 carbon atoms or allyl,R.sub.9 stands for alkyl of 1 to 10 carbon atoms or phenyl andX stands for hydrogen, the cation of a physiologically acceptable inorganic or organic base of a hydrocarbon radical of 1 to 10 carbon atoms, having a strong action on the lipide and cholesterine metabolism and a process for this manufacture.

    摘要翻译： 式I的新型4-苯氧基 - 苯氧基 - 烷 - 羧酸衍生物，其中R1代表氢，甲硫基，环戊基，环己基，苯基，甲基氰基己基，乙基环己基或R1和R3一起代表-CH = CH -CH = CH-桥或 - 除非取代基R2至R8中的至少一个代表氢，或者如果R9表示具有至少2个碳原子的基团，则对于氯，R 2和R 3彼此独立地，各自独立地 对于氢，氯或1至4个碳原子的烷基，R4代表氢，氯，1至4个碳原子的烷基，环戊基，环己基，甲基环己基或R3和R4一起代表-CH = CH-CH = CH- 桥，R5，R6和R7彼此独立，各代表氢或1-4个碳原子的烷基，R8代表氢，1-4个碳原子的烷基或烯丙基，R9代表1-10个碳原子的烷基 原子或苯基，X代表氢，生物学上可接受的无机或有机碱基的阳离子 具有1至10个碳原子的自由基，对脂质和胆固醇代谢具有强烈的作用和用于该制造的方法。

    Pharmaceutical composition containing 1-(imidazole-1-yl)-isoquinolines and method of treating hyperlipemia
    28.
    发明授权
    Pharmaceutical composition containing 1-(imidazole-1-yl)-isoquinolines and method of treating hyperlipemia 失效
    含有1-（咪唑-1-基） - 异喹啉的药物组合物和治疗高脂血症的方法

    公开(公告)号：US3961062A

    公开(公告)日：1976-06-01

    申请号：US562048

    申请日：1975-03-26

    申请人： Ulrich Lerch ,  Ernold Granzer

    发明人： Ulrich Lerch ,  Ernold Granzer

    IPC分类号： C07D521/00 ,  A61K31/47

    CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08

    摘要： This application discloses pharmaceutical compositions containing, and a method of treatment with, 1-(1-imidazolyl)-isoquinolines of the general formula I and their physiologically tolerated salts, ##SPC1##In which R.sub.1, R.sub.2 and R.sub.3 represent hydrogen, alkyl of 1 to 4 carbon atoms or phenyl, R.sub.1, R.sub.2 and R.sub.3 may be identical or different, R.sub.4 represents hydrogen, alkyl of 1 to 4 carbon atoms, phenyl or chlorine, and R.sub.5 represents hydrogen, alkyl of 1 to 6 carbon atoms, cycloalkyl of 5 to 8 carbon atoms, phenyl or chlorine.

    摘要翻译： 本申请公开了含有通式I的1-（1-咪唑基） - 异喹啉及其生理耐受盐的药物组合物，其中R 1，R 2和R 3表示氢，1至4个碳原子的烷基 原子或苯基，R 1，R 2和R 3可以相同或不同，R 4表示氢，1-4个碳原子的烷基，苯基或氯，R 5表示氢，1至6个碳原子的烷基，5至8个碳原子的环烷基 原子，苯基或氯。