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公开(公告)号：US5549551A
公开(公告)日：1996-08-27
申请号：US361825
申请日：1994-12-22
CPC分类号： A61M25/104 , A61F2/958 , A61M2025/1068 , A61M2025/1072 , A61M2025/1079 , A61M2025/1086
摘要： A dilatation catheter having a balloon with an inflated length than can be adjusted according to the length of stenosis to be dilated. In one embodiment an exterior sheath having an expandable distal tip is employed about a elongated balloon which can be longitudinally adjusted so as to expose a length of balloon which provides a working balloon length required to dilate the stenosis. In another embodiment, the balloon has independently inflatable chambers. In yet another embodiment, the balloon has longitudinal tubular sections which expand sequentially higher pressures. Other means are also described.
摘要翻译： 具有膨胀长度的气囊的扩张导管可以根据要扩张的狭窄长度进行调节。 在一个实施例中，具有可扩张的远侧末端的外部护套围绕细长的球囊使用，所述细长的球囊可以被纵向调节以便暴露一段长度的球囊，其提供扩张狭窄所需的工作气囊长度。 在另一个实施例中，气囊具有独立的可充气室。 在另一个实施例中，气囊具有纵向管状部分，其顺序地升高压力。 还描述了其它手段。
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公开(公告)号：US08541014B2
公开(公告)日：2013-09-24
申请号：US13357208
申请日：2012-01-24
IPC分类号： A61F2/02
CPC分类号： A61K48/005 , A61K31/355 , A61K45/06 , A61L31/16 , A61L2300/258 , A61L2300/416 , A61L2300/428
摘要： The present invention is directed to a drug eluting stent system, including: a stent; a tocopherol agent coupled to the stent; wherein the stent is adapted to elute the tocopherol agent into a surrounding lumenal wall tissue when implanted along the lumen within a body of a patient.
摘要翻译： 本发明涉及一种药物洗脱支架系统，包括：支架; 连接到支架的生育酚剂; 其中所述支架适于当沿着患者体内的内腔植入时将所述生育酚剂洗脱到周围的腔壁组织中。
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公开(公告)号：US07819826B2
公开(公告)日：2010-10-26
申请号：US10351450
申请日：2003-01-23
申请人： Chris J. Diederich , Jeffrey C. Lotz , Will Nau , David S. Bradford , John P. O'Banion , James C. Peacock, III
发明人： Chris J. Diederich , Jeffrey C. Lotz , Will Nau , David S. Bradford , John P. O'Banion , James C. Peacock, III
IPC分类号： A61B8/00
CPC分类号： A61B18/04 , A61B8/56 , A61B2017/00092 , A61B2017/00101 , A61B2017/00261 , A61B2018/00339 , A61B2090/374 , A61N7/00 , A61N7/02 , A61N7/022 , A61N2007/0078
摘要： A long-term implantable ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints. Various modes of operation provide for selective, controlled heating at different temperature ranges to provide different intended results in the target tissue, which ranges are significantly effected by pre-stressed tissues such as in-vivo intervertebral discs. In particular, treatments above 70 degrees C., and in particular 75 degrees C., are used for structural remodeling, whereas lower temperatures achieves other responses without appreciable remodeling.
摘要翻译： 提供了一种长期植入式超声治疗系统和方法，其向身体关节内诸如脊椎关节之间的组织的局部区域提供定向的聚焦超声。 将超声发射器或换能器输送到与关节相关联的身体内的位置，并从该位置加热与关节相关联的组织的目标区域。 用于超声换能器放置的这种位置可以包括例如在椎间盘内或周围，或骨结构，例如椎体或后椎体元件，例如小关节。 各种操作模式提供在不同温度范围内的选择性控制加热，以在目标组织中提供不同的预期结果，这些范围通过诸如体内椎间盘的预应力组织显着影响。 特别地，高于70摄氏度，特别是75摄氏度的处理被用于结构重塑，而较低的温度实现了其他响应而没有明显的重塑。
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公开(公告)号：US20090118810A1
公开(公告)日：2009-05-07
申请号：US12110217
申请日：2008-04-25
CPC分类号： A61F2/915 , A61F2/91 , A61F2/958 , A61F2002/826 , A61F2002/91508 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2230/0054 , A61F2250/0035 , A61F2250/0036 , A61F2250/0039 , A61F2250/0067 , A61F2250/0098
摘要： A stent is provided with modified ends (782, 786) and enhanced drug delivery. The stent assembly also provides for enhanced overlapping between adjacent stents.
摘要翻译： 支架具有修改的末端（782,786）和增强的药物递送。 支架组件还提供相邻支架之间的增强的重叠。
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25.发明授权Endolumenal prosthesis and method of use in bifurcation regions of body lumens 失效腔内假体及其在体腔分叉区域的使用方法公开(公告)号：US06520988B1
公开(公告)日：2003-02-18
申请号：US08937130
申请日：1997-09-24
申请人： Antonio Colombo , Robert D. Lashinski , Matthew J. Birdsall , Dennis L. Brooks , Philip J. Haarstad , James C. Peacock, III
发明人： Antonio Colombo , Robert D. Lashinski , Matthew J. Birdsall , Dennis L. Brooks , Philip J. Haarstad , James C. Peacock, III
IPC分类号： A61F206
CPC分类号： A61F2/856 , A61F2/91 , A61F2/915 , A61F2/954 , A61F2/958 , A61F2002/065 , A61F2002/91541 , A61F2002/91558 , A61F2250/0039
摘要： An endolumenal medical device assembly is provided for use in a bifurcation region of a body lumen. An expandable prosthesis, such as a stent, is included in the assembly and is adjustable from a radially collapsed condition to a radially expanded condition. The expandable prosthesis includes a prosthesis passageway and a side port. A dilator or an access device is engaged within the prosthesis passageway and also through the side port while the expandable prosthesis is in the radially collapsed condition. The expandable prosthesis may be positioned in the bifurcation region such that its distal end portion is in a first branch lumen extending from the bifurcation, its proximal end portion is in a common proximal lumen of the bifurcation region, and the side port is aligned with an entrance zone to a second branch lumen extending from the bifurcation. When the expandable prosthesis is so positioned the access device maintains percutaneous translumenal access to the second branch lumen through the prosthesis passageway and the side port while the expandable prosthesis is adjusted from the radially collapsed condition to the radially expanded condition. A dilator may also to expand the bore formed by the side port from an initial inner diameter to a larger expanded inner diameter. A second, lateral expandable prosthesis can also be coupled to the first expandable prosthesis at a location adjacent to the side port and engaged by the dilator or access device extending through the side port.
摘要翻译： 提供了一种用于体腔分叉区域的腔内医疗装置组件。 可扩张假体，例如支架，被包括在组件中，并且可以从径向塌陷状态调节到径向扩张状态。 可扩张假体包括假体通道和侧端口。 扩张器或进入装置接合在假体通道内并且还可以通过侧端口，而可扩张假体处于径向折叠状态。 可扩张假体可以位于分叉区域中，使得其远端部分处于从分叉延伸的第一分支腔中，其近端部分位于分叉区域的共同的近侧内腔中，并且侧端口与 入口区到从分叉延伸的第二分支腔。 当可扩张假体如此定位时，进入装置通过假体通道和侧端口保持对第二分支腔的经皮腔内通路，同时将可扩张假体从径向折叠状态调节到径向扩张状态。 扩张器还可以将由侧口形成的孔从初始内径扩大到较大的扩大内径。 第二横向可膨胀假体还可以在与侧端口相邻的位置处联接到第一可扩张假体，并且通过延伸穿过侧端口的扩张器或进入装置接合。
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公开(公告)号：US20120323310A1
公开(公告)日：2012-12-20
申请号：US13357208
申请日：2012-01-24
IPC分类号： A61F2/82
CPC分类号： A61K48/005 , A61K31/355 , A61K45/06 , A61L31/16 , A61L2300/258 , A61L2300/416 , A61L2300/428
摘要： The present invention is directed to a drug eluting stent system, including: a stent; a tocopherol agent coupled to the stent; wherein the stent is adapted to elute the tocopherol agent into a surrounding lumenal wall tissue when implanted along the lumen within a body of a patient.
摘要翻译： 本发明涉及一种药物洗脱支架系统，包括：支架; 连接到支架的生育酚剂; 其中所述支架适于当沿着患者体内的内腔植入时将所述生育酚剂洗脱到周围的腔壁组织中。
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公开(公告)号：US08101199B2
公开(公告)日：2012-01-24
申请号：US10595453
申请日：2004-10-21
IPC分类号： A61F2/02
CPC分类号： A61K48/005 , A61K31/355 , A61K45/06 , A61L31/16 , A61L2300/258 , A61L2300/416 , A61L2300/428
摘要： A stent is provided in combination with delivery of a tocopherol agent, and in particular a des-methyl tocopherol agent, and further beneficially a gamma-tocopherol agent, so as to reduce restenosis along the vessel or other lumenal wall where the stent is implanted. In particular applications, the stent is an endolumenal stent, and more specific beneficial applications is an endovascular stent, and the gamma-tocopherol elutes from a coating or carrier coupled with the stent. Certain combinations are provided with the des-methyl-tocopherol or phytyl substituted chromanol, e.g. gamma-tocopherol, combined with an additional agent such as an anti-restenosis agent, e.g. sirolimus, tacrolimus, everolimus, or paclitaxel, in order to provide synergistic benefit to tissues along the stented or recanalized regions. Other forms of tocopherol or tocotrienol, or other phytyl substituted chromanols, and other compounds such as palm oil, are also contemplated, for use to treat restenosis.
摘要翻译： 提供支架与生育酚试剂，特别是脱甲基生育酚试剂的输送结合，进一步有益地提供γ-生育酚试剂，以便减少沿植入支架的容器或其它内腔壁的再狭窄。 在具体应用中，支架是腔内支架，更具体的有益应用是血管内支架，并且γ-生育酚从与支架耦合的涂层或载体洗脱。 提供了去甲基 - 生育酚或植酰取代的色原烷醇的某些组合，例如。 γ-生育酚与另外的药物如抗再狭窄剂组合，如抗再狭窄剂。 西罗莫司，他克莫司，依维莫司或紫杉醇，以便为沿着支架或再通的区域的组织提供协同的益处。 还考虑了其它形式的生育酚或生育三烯酚或其它植烷基取代的色原醇，以及其它化合物如棕榈油，用于治疗再狭窄。
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28.发明申请MR SPECTROSCOPY SYSTEM AND METHOD FOR DIAGNOSING PAINFUL AND NON-PAINFUL INTERVERTEBRAL DISCS 有权MR光谱系统及其诊断方法，用于诊断阴性和非阴性椎间盘公开(公告)号：US20110087087A1
公开(公告)日：2011-04-14
申请号：US12579371
申请日：2009-10-14
IPC分类号： A61B5/05
CPC分类号： A61B5/055 , A61B5/407 , A61B5/4514 , A61B5/4824 , A61B5/7203 , G01R33/34069 , G01R33/3415 , G01R33/4616 , G01R33/485 , G01R33/565 , G01R33/56527 , G06F19/00
摘要： An MR Spectroscopy (MRS) system and approach is provided for diagnosing painful and non-painful discs in chronic, severe low back pain patients (DDD-MRS). A DDD-MRS pulse sequence generates and acquires DDD-MRS spectra within intervertebral disc nuclei for later signal processing & diagnostic analysis. An interfacing DDD-MRS signal processor receives output signals of the DDD-MRS spectra acquired and is configured to optimize signal-to-noise ratio (SNR) by an automated system that selectively conducts optimal channel selection, phase and frequency correction, and frame editing as appropriate for a given acquisition series. A diagnostic processor calculates a diagnostic value for the disc based upon a weighted factor set of criteria that uses MRS data extracted from the acquired and processed MRS spectra along regions associated with multiple chemicals that have been correlated to painful vs. non-painful discs. A diagnostic display provides a scaled, color coded legend and indication of results for each disc analyzed as an overlay onto a mid-sagittal T2-weighted MRI image of the lumbar spine for the patient being diagnosed. Clinical application of the embodiments provides a non-invasive, objective, pain-free, reliable approach for diagnosing painful vs. non-painful discs by simply extending and enhancing the utility of otherwise standard MRI exams of the lumbar spine.
摘要翻译： 提供MR光谱（MRS）系统和方法用于诊断慢性，严重腰痛患者（DDD-MRS）中的疼痛和非疼痛的椎间盘。 DDD-MRS脉冲序列产生并获取椎间盘核内的DDD-MRS光谱，用于后续信号处理和诊断分析。 接口DDD-MRS信号处理器接收所获得的DDD-MRS光谱的输出信号，并配置为通过选择性地进行最佳信道选择，相位和频率校正以及帧编辑的自动化系统来优化信噪比（SNR） 适用于给定的采集系列。 诊断处理器基于加权因子集合来计算盘的诊断值，该加权因子集合使用从与获得和处理的MRS光谱中提取的MRS数据沿着与多个化学物质相关联的区域，所述化学物质与疼痛与非痛苦盘相关。 诊断显示器提供经缩放的颜色编码的图例和针对被分析为被诊断的患者的腰椎的矢状T2加权MRI图像上的覆盖层的每个椎间盘的结果的指示。 实施例的临床应用提供了通过简单地扩展和增强腰椎否则的标准MRI检查的实用性来诊断疼痛与非痛性椎间盘的非侵入性，客观，无痛，可靠的方法。
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29.发明授权公开(公告)号：US07425217B2
公开(公告)日：2008-09-16
申请号：US10445400
申请日：2003-05-24
CPC分类号： A61K38/046
摘要： Systems and methods are described providing therapeutic preparations of tachykinins, and more specifically sialokinins, for treating various types of abnormal cellular proliferation conditions in regions of tissue associated with the body of a patient. The sialokinins may be isolated and purified from natural or bioengineered sources, or may be synthesized, and may be combined into, with, or on an implant for local elution or otherwise as a powder mixed in a carrier vehicle for injection delivery. Tumors, warts, and restenosis are abnormal cellular proliferation conditions treated by therapeutic doses of sialokinin. Size of the tissue structure to be treated is used to determine the therapeutic dose of sialokinin. The sialokinins are either locally or systemically delivered at therapeutic doses for the desired effect. Implants such as stents are coated with sialokinins for local elution at the site of injury or tissue otherwise vulnerable to harmful conditions treated by the sialokinin.
摘要翻译： 描述了系统和方法，其提供速激肽的治疗制剂，更具体地说是用于治疗与患者身体相关的组织区域中的各种类型的异常细胞增殖病症的治疗制剂。 唾液酸可以从天然或生物工程化来源分离和纯化，或者可以合成，并且可以与植入物组合成植入物，用于局部洗脱或以其它方式混合在用于注射递送的载体载体中的粉末。 肿瘤，疣和再狭窄是通过治疗剂量的sialokinin治疗的异常细胞增殖条件。 要处理的组织结构的大小用于确定sialokinin的治疗剂量。 可以以治疗剂量局部或全身递送sialokinin以获得所需效果。 诸如支架的植入物涂覆有唾液酸溶蛋白，以在损伤或组织的部位进行局部洗脱，否则易受由sialokinin处理的有害条件的影响。
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公开(公告)号：US06777644B2
公开(公告)日：2004-08-17
申请号：US10158374
申请日：2002-05-30
IPC分类号： B23K2638
CPC分类号： A61M25/104 , A61M25/0052 , A61M25/0053 , A61M25/0662 , A61M2025/0183
摘要： An intraluminal catheter which provides access to distal locations within a patient's body lumen and which is provided with a flexible distal section having an inner lining, an outer jacket or coating and a helical coil between the lining and jacket. The distal section of the catheter is quite flexible yet it has sufficient transverse or radial rigidity to prevent significant distortion of the transverse cross-sectional shape of the catheter.
摘要翻译： 一种管腔内导管，其提供进入患者体腔内的远侧位置，并且其设置有柔性远侧部分，该远端部分具有内衬，外护套或涂层以及衬里和护套之间的螺旋线圈。 导管的远端部分是相当灵活的，但它具有足够的横向或径向刚度，以防止导管的横截面形状的显着变形。
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