公开(公告)号：US08080032B2

公开(公告)日：2011-12-20

申请号：US10674553

申请日：2003-09-30

Applicant: Erik J. van der Burg ,  Dino De Cicco ,  Andrew G. C. Frazier ,  Alexander K. Khairkhahan ,  Marc S. Kreidler ,  Michael D. Lesh ,  Chad C. Roue

Inventor： Erik J. van der Burg ,  Dino De Cicco ,  Andrew G. C. Frazier ,  Alexander K. Khairkhahan ,  Marc S. Kreidler ,  Michael D. Lesh ,  Chad C. Roue

IPC: A61M29/00

CPC classification number: A61B17/12122 ,  A61B17/0057 ,  A61B17/12022 ,  A61B17/12031 ,  A61B17/12136 ,  A61B17/12172 ,  A61B17/12186 ,  A61B17/12195 ,  A61B17/122 ,  A61B2017/00243 ,  A61B2017/00557 ,  A61B2017/00575 ,  A61B2017/00579 ,  A61B2017/00592 ,  A61B2017/00597 ,  A61B2017/00601 ,  A61B2017/00615 ,  A61B2017/00619 ,  A61B2017/00632 ,  A61B2017/00867 ,  A61B2017/081 ,  A61B2017/1205 ,  A61F2/01 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0069 ,  A61F2230/0071 ,  A61F2230/008 ,  A61M25/10 ,  A61M2025/1054 ,  A61M2210/125

Abstract: A device and method for obliterating or occluding a body cavity or passageway, in particular, the left atrial appendage of a patient's heart. The procedure can be carried out intraoperatively, but is preferably carried out percutaneously by use of a delivery catheter to position an occluding device adjacent a patient's left atrial appendage. The occluding device may prevent the passage of embolic or other material to or from the left atrial appendage by volumetrically filling the appendage, closing the opening of the appendage with an occluding member, or pulling the tissue around the opening of the appendage together and fixing it in a closed state.

Abstract translation: 用于消除或闭塞体腔或通道的装置和方法，特别是患者心脏的左心耳。 该程序可以在手术中进行，但是优选通过使用输送导管经皮进行以将闭塞装置定位在患者的左心耳附近。 闭塞装置可以阻止栓塞或其他材料通过体积方式填充附件，使闭塞构件闭合附件的开口，或将附件的开口附近的组织拉在一起并将其固定 处于关闭状态。

公开(公告)号：US20100249947A1

公开(公告)日：2010-09-30

申请号：US12413240

申请日：2009-03-27

Applicant: Michael D. Lesh ,  Stewart Kume ,  Randy J. Kesten ,  Leo Centeno ,  Jeff Zalewski

Inventor： Michael D. Lesh ,  Stewart Kume ,  Randy J. Kesten ,  Leo Centeno ,  Jeff Zalewski

IPC: A61F2/02 ,  B32B37/00

CPC classification number: B32B37/00 ,  A61L27/16 ,  A61L27/56 ,  A61L31/048 ,  A61L31/146 ,  C08L27/18

Abstract: The implant includes an outer layer of ePTFE which exhibits extensibility normally not associated with ePTFE. The ePTFE is reduced in length by deforming the fibrils between the nodes while maintaining the nodes in a substantially flat configuration. Various implant configurations that can include the outer layer described are also disclosed.

Abstract translation: 植入物包括ePTFE的外层，其表现出通常不与ePTFE相关的延展性。 通过使节点之间的原纤维变形，同时将节点保持在基本平坦的构型中，ePTFE的长度减小。 还公开了可以包括所描述的外层的各种植入物构造。

公开(公告)号：US20100249946A1

公开(公告)日：2010-09-30

申请号：US12412830

申请日：2009-03-27

Applicant: Michael D. Lesh ,  Stewart Kume ,  Randy J. Kesten ,  Geoffrey Willis ,  Leo Centeno ,  Jeff Christian

Inventor： Michael D. Lesh ,  Stewart Kume ,  Randy J. Kesten ,  Geoffrey Willis ,  Leo Centeno ,  Jeff Christian

IPC: A61F2/02

CPC classification number: A61F2/0059 ,  A61F2250/0003

Abstract: Disclosed are implantable tissue augmentation devices, methods, and associated tools. The devices include an inflatable body, having a self-sealing membrane operably attached to a wall of the implant. The self-sealing membrane provides access for filling the device, and includes a first layer comprising a fabric. The fabric has a first plurality of yarn strands positioned in a first direction, and a second plurality of yarn strands positioned in a second direction. The first and second plurality of yarn strands intersect to form a matrix pattern with cells defined by free spaces between yarn strands. The membrane also includes a first elastomeric material configured to fill the cells as well as form a coating over the first and second plurality of yarn strand, and a second layer comprising a second elastomeric material. The second elastomeric material has a lower durometer than the first elastomeric material. Kits and systems are also disclosed.

Abstract translation: 公开了可植入组织增强装置，方法和相关联的工具。 所述装置包括可充气体，其具有可操作地附接到所述植入物的壁的自密封膜。 自密封膜提供用于填充装置的通路，并且包括包括织物的第一层。 织物具有沿第一方向定位的第一多根纱线和位于第二方向上的第二多根纱线。 第一和第二多根纱线相交以形成具有由纱线之间的自由空间限定的细胞的矩阵图案。 膜还包括构造成填充细胞并且在第一和第二多根纱线上形成涂层的第一弹性体材料，以及包含第二弹性体材料的第二层。 第二弹性体材料具有比第一弹性体材料低的硬度。 还披露了套件和系统。

公开(公告)号：US07799011B2

公开(公告)日：2010-09-21

申请号：US11809022

申请日：2007-05-30

Applicant: Michael D. Lesh

Inventor： Michael D. Lesh

IPC: A61M31/00

CPC classification number: A61M25/0136 ,  A61B17/22 ,  A61B2017/00243 ,  A61B2017/22082 ,  A61B2017/3488 ,  A61B2018/00273 ,  A61B2018/00815 ,  A61B2018/1425 ,  A61B2018/1435 ,  A61B2090/3784 ,  A61M25/0084 ,  A61M25/0133 ,  A61M25/0147 ,  A61N7/02

Abstract: This is a method and an apparatus for the treatment or introduction of contrast fluids into tissue, particularly cardiac tissue. The apparatus includes a catheter having an elongated flexible body and a tissue infusion apparatus including a hollow infusion needle configured to secure the needle into the tissue when the needle is at least partially inserted into the tissue to help prevent inadvertent removal of the needle from the tissue. This permits the selected treatment or contrast fluid to be confined to a specific site. The catheter may also include a visualization assembly including a transducer at the distal end of the body.

Abstract translation: 这是用于将对比流体治疗或引入组织，特别是心脏组织的方法和装置。 所述装置包括具有细长柔性体的导管和包括中空输液针的组织浸液装置，所述中空灌注针构造成当针至少部分插入组织中时将针固定到组织中，以帮助防止针头从组织中无意中移除 。 这允许所选择的治疗或造影剂被限制在特定部位。 导管还可以包括可视化组件，其包括在身体的远端处的换能器。

公开(公告)号：US07731681B2

公开(公告)日：2010-06-08

申请号：US10805738

申请日：2004-03-22

Applicant: Alan K. Schaer ,  Michael D. Lesh

Inventor： Alan K. Schaer ,  Michael D. Lesh

IPC: A61M35/00

CPC classification number: A61M25/0668 ,  A61B17/22012 ,  A61B18/1492 ,  A61B2017/003 ,  A61B2017/00867 ,  A61B2017/22038 ,  A61B2018/00214 ,  A61B2018/00285 ,  A61B2018/00577 ,  A61B2018/00839 ,  A61M2210/125 ,  A61N7/02 ,  C08L2201/12

Abstract: The present invention relates to a system adapted to position a medical device, such as an ablation catheter, at a location where a pulmonary vein extends from an atrium. The system optimally includes a deflectable catheter and a sheath. An ablation member is disclosed for use with the positioning system, wherein the deflectable catheter and the sheath cooperate so as to facilitate positioning of the ablation member at the location.

Abstract translation: 本发明涉及一种适于将医疗装置（例如消融导管）定位在肺静脉从心房延伸的位置处的系统。 该系统最佳地包括可偏转导管和护套。 公开了一种与定位系统一起使用的消融构件，其中可偏转导管和护套配合，以便于消融构件在该位置的定位。

公开(公告)号：US20080275569A1

公开(公告)日：2008-11-06

申请号：US11575493

申请日：2005-09-15

Applicant: Michael D. Lesh

Inventor： Michael D. Lesh

IPC: A61F2/10 ,  A61B17/3209 ,  A61M29/02

CPC classification number: A61B17/3468 ,  A61B90/02 ,  A61B2017/00539 ,  A61B2017/00747 ,  A61B2017/00792 ,  A61F2/0036 ,  A61F2/0059 ,  A61F2/12 ,  A61F2250/0003

Abstract: A medical device and methods for filling tissue are disclosed. The device has a first configuration for delivery into tissue to be filled and a second configuration in which the device either expands, or is forced to expand within the tissue to be filled. The exterior profile of the expanded device may be customized along its length, to achieve a desired result. The device is adapted to be placed in the skin, and may be used to reduce facial wrinkles or augment facial features such as the lips.

Abstract translation: 公开了用于填充组织的医疗装置和方法。 该装置具有用于输送到待填充的组织中的第一构造和第二构造，其中该装置在待填充的组织内膨胀或被迫膨胀。 扩展装置的外部轮廓可以沿其长度被定制，以实现期望的结果。 该装置适于放置在皮肤中，并且可用于减少面部皱纹或增加诸如嘴唇的面部特征。

公开(公告)号：US07340307B2

公开(公告)日：2008-03-04

申请号：US10996523

申请日：2004-11-24

Applicant: Mark A. Maguire ,  Michael D. Lesh ,  James C. Peacock, III ,  Edward L. Carcamo

Inventor： Mark A. Maguire ,  Michael D. Lesh ,  James C. Peacock, III ,  Edward L. Carcamo

IPC: A61B18/18

CPC classification number: A61N7/02 ,  A61B18/00 ,  A61B18/08 ,  A61B18/1492 ,  A61B2017/00243 ,  A61B2018/00011 ,  A61B2018/00065 ,  A61B2018/00101 ,  A61B2018/00148 ,  A61B2018/00214 ,  A61B2018/00232 ,  A61B2018/00238 ,  A61B2018/143 ,  A61B2018/1432 ,  A61B2218/002 ,  A61M25/1002

Abstract: This invention is related to a tissue ablation system and method that treats atrial arrhythmia by ablating a circumferential region of tissue at a location where a pulmonary vein extends from an atrium. The system includes a circumferential ablation member with an ablation element and also includes a delivery assembly for delivering the ablation member to the location. The circumferential ablation member is generally adjustable between different configurations to allow both the delivery through a delivery sheath into the atrium and the ablative coupling between the ablation element and the circumferential region of tissue.

Abstract translation: 本发明涉及组织消融系统和方法，其通过在肺静脉从心房延伸的位置烧蚀组织的周边区域来治疗心律失常。 该系统包括具有消融元件的圆周消融构件，并且还包括用于将消融构件输送到该位置的输送组件。 圆周消融部件通常在不同构型之间是可调节的，以允许通过输送护套输送到心房中，以及消融元件与组织的圆周区域之间的消融耦合。

公开(公告)号：US07089063B2

公开(公告)日：2006-08-08

申请号：US09858523

申请日：2001-05-16

Applicant: Michael D. Lesh ,  Michael R. Ross ,  James C Peakcock, III ,  Kevin J. Taylor

Inventor： Michael D. Lesh ,  Michael R. Ross ,  James C Peakcock, III ,  Kevin J. Taylor

IPC: A61F2/00

CPC classification number: A61B17/2202 ,  A61B18/1492 ,  A61B90/39 ,  A61B2017/00292 ,  A61B2018/00083 ,  A61B2018/00095 ,  A61B2018/00214 ,  A61B2018/00238 ,  A61B2018/00285 ,  A61B2018/00375 ,  A61B2018/00898 ,  A61M25/0108 ,  A61N7/02

Abstract: A deflectable tip catheter that is used in combination with a guidewire for delivery of an ablation element to target areas of a patient's vasculature. The deflectable tip catheter has a handle portion, an elongated shaft and a deflectable tip portion. A guidewire lumen extends through the elongated shaft and deflectable tip portion. A guidewire passes through the guidewire lumen and exits from a port in the distal end of the deflectable tip portion. The deflectable tip of the catheter is deflected by manipulation of the handle portion to direct the advancement of the guidewire as the guidewire is advanced out of the distal port. By using the deflectable tip portion to direct the advancement of the guidewire, the physician's ability to navigate sharp angles is greatly improved. The deflectable tip catheter is particularly suitable for delivering an ablation element to a pulmonary vein or pulmonary vein branch for performing circumferential ultrasound vein ablation to treat atrial fibrillation.

公开(公告)号：US07044135B2

公开(公告)日：2006-05-16

申请号：US10233157

申请日：2002-08-30

Applicant: Michael D. Lesh

Inventor： Michael D. Lesh

IPC: A61B19/00

CPC classification number: A61B18/10 ,  A61B18/08 ,  A61B18/1492 ,  A61B18/1815 ,  A61B2017/00243 ,  A61B2017/22038 ,  A61B2017/22054 ,  A61B2017/22067 ,  A61B2018/00011 ,  A61B2018/00083 ,  A61B2018/00107 ,  A61B2018/00148 ,  A61B2018/0016 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00273 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00351 ,  A61B2018/00369 ,  A61B2018/00375 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/00821 ,  A61B2018/00839 ,  A61B2018/00898 ,  A61B2018/00994 ,  A61B2018/1407 ,  A61B2218/002 ,  A61M25/1002 ,  A61M2025/1075 ,  A61M2210/125 ,  A61N7/022

Abstract: This invention is a method for treating a patient diagnosed with atrial arrhythmia by forming a circumferential conduction block along a circumferential path of tissue in a pulmonary vein wall that circumscribes the pulmonary vein lumen and transects the electrical conductivity of the pulmonary vein such that conduction is blocked along the longitudinal axis of the vein wall and into the left atrial wall. The method is performed to treat a patient with a focal arrythmogenic origin along the pulmonary vein wall by either ablating the focal origin or by isolating the focal origin from the atrial wall with the circumferential conduction block. The circumferential conduction block is also formed in a pulmonary vein in order to bridge the adjacent ends of two linear lesions, wherein each linear lesion is formed to extend between the pulmonary vein and another adjacent pulmonary vein in a less-invasive “maze”-type procedure. A circumferential ablation element in a circumferential ablation device assembly is used in a percutaneous translumenal catheter technique in order to form the circumferential conduction block in the pulmonary vein wall.

公开(公告)号：US06964660B2

公开(公告)日：2005-11-15

申请号：US10274742

申请日：2002-10-21

Applicant: Mark A. Maguire ,  Michael D. Lesh ,  James C. Peacock, III ,  Edward L. Carcamo

Inventor： Mark A. Maguire ,  Michael D. Lesh ,  James C. Peacock, III ,  Edward L. Carcamo

IPC: A61B17/00 ,  A61B18/00 ,  A61B18/08 ,  A61B18/14 ,  A61F2/958 ,  A61N7/02 ,  A61B18/18

CPC classification number: A61N7/02 ,  A61B18/00 ,  A61B18/08 ,  A61B18/1492 ,  A61B2017/00243 ,  A61B2018/00011 ,  A61B2018/00065 ,  A61B2018/00101 ,  A61B2018/00148 ,  A61B2018/00214 ,  A61B2018/00232 ,  A61B2018/00238 ,  A61B2018/143 ,  A61B2018/1432 ,  A61B2218/002 ,  A61M25/1002

Abstract: This invention is related to a tissue ablation system and method that treats atrial arrhythmia by ablating a circumferential region of tissue at a location where a pulmonary vein extends from an atrium. The system includes a circumferential ablation member with an ablation element and also includes a delivery assembly for delivering the ablation member to the location. The circumferential ablation member is generally adjustable between different configurations to allow both the delivery through a delivery sheath into the atrium and the ablative coupling between the ablation element and the circumferential region of tissue.

Abstract translation: 本发明涉及组织消融系统和方法，其通过在肺静脉从心房延伸的位置烧蚀组织的周边区域来治疗心律失常。 该系统包括具有消融元件的圆周消融构件，并且还包括用于将消融构件输送到该位置的输送组件。 圆周消融部件通常在不同构型之间是可调节的，以允许通过输送护套输送到心房中，以及消融元件与组织的圆周区域之间的消融耦合。