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公开(公告)号：US20130253087A1
公开(公告)日：2013-09-26
申请号：US13899357
申请日：2013-05-21
Applicant: MicroVention, Inc.
Inventor： Gregory M. Cruise , Michael J. Constant , Edward Michael Keeley , Terrance T. Tran
IPC: A61B17/12
CPC classification number: A61B17/12113 , A61B17/12181 , A61B90/39 , A61B2017/00004 , A61B2017/1205 , A61B2090/3966 , A61K49/0404 , A61L24/001 , A61L24/0031 , A61L24/046 , A61L27/16 , A61L27/18 , A61L27/56 , A61L31/048 , A61L31/06 , A61L31/146 , A61L31/18 , A61L2430/36 , C08L39/06 , C08L71/02
Abstract: Described herein are apparatus, compositions, systems and associated methods to occlude structures and malformations with radiopaque hydrogel filaments with delayed controlled rates of expansion permitting the repositioning of the device once inside the structure or malformation. Further described is a device for implantation in an animal comprising a difunctional, low molecular weight ethylenically unsaturated shapeable macromer; an ethylenically unsaturated monomer; and a radiopaque element, wherein said device contains no support members. Methods of forming such devices are also disclosed.
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公开(公告)号：US20130131716A1
公开(公告)日：2013-05-23
申请号：US13745258
申请日：2013-01-18
Applicant: MicroVention, Inc.
Inventor： Gregory M. Cruise , Michael J. Constant , Terrance Tran
IPC: A61B17/12
CPC classification number: A61B17/1219 , A61B17/12113 , A61B17/1214 , A61B17/12145 , A61B17/12154 , A61B17/12168 , A61L31/00 , A61L31/022 , A61L31/041 , A61L31/048 , A61L31/06 , A61L31/14 , A61L31/145 , A61L31/146 , A61L2400/04 , C08L71/02
Abstract: Devices for the occlusion of body cavities, such as the embolization of vascular aneurysms and the like, and methods for making and using such devices. The devices may be comprised of novel expansile materials, novel infrastructure design, or both. The devices provided are very flexible and enable deployment with reduced or no damage to bodily tissues, conduits, cavities, etceteras.
Abstract translation: 用于闭塞体腔的装置，例如血管动脉瘤栓塞等，以及制造和使用这些装置的方法。 这些装置可以由新颖的膨胀材料，新颖的基础设施设计或两者组成。 所提供的设备是非常灵活的，并且能够对身体组织，导管，空腔等进行减少或不损坏的部署。
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公开(公告)号：US11801326B2
公开(公告)日：2023-10-31
申请号：US17064434
申请日：2020-10-06
Applicant: MicroVention, Inc.
Inventor： Gregory M. Cruise , Michael J. Constant , Edward Michael Keeley , Rob Greene , Clayton Harris
CPC classification number: A61L24/06 , A61K49/0442 , A61K49/12 , A61L24/001 , A61L24/0015 , A61L2300/44 , A61L2400/06 , A61L2430/36 , A61L24/06 , C08L33/08 , A61L24/06 , C08L33/26
Abstract: Polymeric compositions are described comprising a biocompatible polymer including a biodegradable linkage to a visualization agent and a non-physiological solution; wherein the biocompatible polymer is soluble in the non-physiological solution and insoluble in a physiological solution. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.
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公开(公告)号：US10946100B2
公开(公告)日：2021-03-16
申请号：US16250878
申请日：2019-01-17
Applicant: MicroVention, Inc.
Inventor： Gregory M. Cruise , Clayton G. Harris , Michael J. Constant
IPC: A61K47/32 , A61K9/70 , A61K31/7068 , A61K31/787 , C07H19/06 , C07F15/00 , A61L31/14 , A61L31/16 , A61L31/18 , A61K9/00 , A61K49/04 , A61K47/58
Abstract: Polymers are described herein comprising: a reaction product of a prepolymer solution including at least one macromer and at least one visualization agent; and an active agent electrostatically bound to the polymer filament or chemically bound to the at least one monomer; wherein the polymer filament does not include metallic support members.
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公开(公告)号：US20210023261A1
公开(公告)日：2021-01-28
申请号：US17064434
申请日：2020-10-06
Applicant: MicroVention, Inc.
Inventor： Gregory M. Cruise , Michael J. Constant , Edward Michael Keeley , Rob Greene , Clayton Harris
Abstract: Polymeric compositions are described comprising a biocompatible polymer including a biodegradable linkage to a visualization agent and a non-physiological solution; wherein the biocompatible polymer is soluble in the non-physiological solution and insoluble in a physiological solution. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.
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Patent Agency Ranking
公开(公告)号：US10201562B2
公开(公告)日：2019-02-12
申请号：US15924028
申请日：2018-03-16
Applicant: MicroVention, Inc.
Inventor： Gregory M. Cruise , Michael J. Constant , Joshua Garretson
Abstract: Compositions are described comprising a polymer; a non-physiological pH solution; and a visualization agent; wherein the polymer is soluble in the non-physiological pH solution and insoluble at a physiological pH. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.
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公开(公告)号：US20180200288A1
公开(公告)日：2018-07-19
申请号：US15924028
申请日：2018-03-16
Applicant: MicroVention, Inc.
Inventor： Gregory M. Cruise , Michael J. Constant , Joshua Garretson
CPC classification number: A61K31/785 , A61K9/0024 , A61K31/78 , A61K47/32 , A61L24/0089 , A61L24/046 , A61L2430/36
Abstract: Compositions are described comprising a polymer; a non-physiological pH solution; and a visualization agent; wherein the polymer is soluble in the non-physiological pH solution and insoluble at a physiological pH. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.
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公开(公告)号：US20160166258A1
公开(公告)日：2016-06-16
申请号：US14990676
申请日：2016-01-07
Applicant: MicroVention, Inc.
Inventor： Gregory M. Cruise , Michael J. Constant , Terrance Tran
CPC classification number: A61B17/1219 , A61B17/12113 , A61B17/1214 , A61B17/12145 , A61B17/12154 , A61B17/12168 , A61L31/00 , A61L31/022 , A61L31/041 , A61L31/048 , A61L31/06 , A61L31/14 , A61L31/145 , A61L31/146 , A61L2400/04 , C08L71/02
Abstract: Devices for the occlusion of body cavities, such as the embolization of vascular aneurysms and the like, and methods for making and using such devices. The devices may be comprised of novel expansile materials, novel infrastructure design, or both. The devices provided are very flexible and enable deployment with reduced or no damage to bodily tissues, conduits, cavities, etceteras.
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公开(公告)号：US20150306227A1
公开(公告)日：2015-10-29
申请号：US14678514
申请日：2015-04-03
Applicant: MicroVention, Inc.
Inventor： Gregory M. Cruise , Clayton G. Harris , Michael J. Constant
IPC: A61K47/32 , A61K9/70 , C07F15/00 , A61K47/48 , A61K47/02 , C07H19/06 , A61K31/7068 , A61K31/787
CPC classification number: A61K47/32 , A61K9/0092 , A61K31/7068 , A61K31/787 , A61K47/58 , A61K49/04 , A61L31/145 , A61L31/148 , A61L31/16 , A61L31/18 , A61L2430/36 , C07F15/0093 , C07H19/06
Abstract: Polymers are described herein comprising: a reaction product of a prepolymer solution including at least one macromer and at least one visualization agent; and an active agent electrostatically bound to the polymer filament or chemically bound to the at least one monomer; wherein the polymer filament does not include metallic support members.
Abstract translation: 本文描述了聚合物，其包含：包含至少一种大分子单体和至少一种可视化试剂的预聚物溶液的反应产物; 和与所述聚合物长丝静电结合或化学结合至所述至少一种单体的活性剂; 其中聚合物长丝不包括金属支撑构件。
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公开(公告)号：US09078950B2
公开(公告)日：2015-07-14
申请号：US14054515
申请日：2013-10-15
Applicant: MicroVention, Inc.
Inventor： Gregory M. Cruise , Michael J. Constant , Edward Michael Keeley , Rob Greene , Clayton Harris
CPC classification number: A61L24/06 , A61K49/0442 , A61K49/12 , A61L24/001 , A61L24/0015 , A61L2300/44 , A61L2400/06 , A61L2430/36 , C08L33/08 , C08L33/26
Abstract: Polymeric compositions are described comprising a biocompatible polymer including a biodegradable linkage to a visualization agent and a non-physiological pH solution; wherein the biocompatible polymer is soluble in the non-physiological pH solution and insoluble at a physiological pH. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.
Abstract translation: 描述了包含生物相容性聚合物的聚合物组合物，其包括与可视化试剂和非生理pH溶液的生物可降解连接; 其中所述生物相容性聚合物可溶于非生理pH溶液中，并且在生理pH下不溶。 公开了形成溶液和聚合物的方法以及治疗用途的方法。
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