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公开(公告)号:US20110263599A1
公开(公告)日:2011-10-27
申请号:US13088206
申请日:2011-04-15
申请人: Xiaohong Song , Hong Ding , Steven W. Elmore , Milan Bruncko , David J. Madar , Andrew J. Souers , Cheol-Min Park , Zhi-Fu Tao , Xilu Wang , Aaron R. Kunzer
发明人: Xiaohong Song , Hong Ding , Steven W. Elmore , Milan Bruncko , David J. Madar , Andrew J. Souers , Cheol-Min Park , Zhi-Fu Tao , Xilu Wang , Aaron R. Kunzer
IPC分类号: A61K31/404 , C07D401/10 , A61K31/454 , C07D413/10 , A61K31/5377 , A61P35/00 , C07D403/04 , A61K31/4155 , C07D413/06 , C07D403/06 , A61K31/496 , C07D209/42 , A61K31/4439
CPC分类号: C07D209/42 , C07D403/04
摘要: Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mcl-1 protein are disclosed.
摘要翻译: 公开了抑制抗凋亡Mcl-1蛋白活性的化合物,含有该化合物的组合物,以及治疗涉及过表达或未调节的Mcl-1蛋白的疾病的方法。
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22.
公开(公告)号:US20100298321A1
公开(公告)日:2010-11-25
申请号:US12793418
申请日:2010-06-03
申请人: Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Todd M. Hansen
发明人: Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Todd M. Hansen
IPC分类号: A61K31/5377 , A61P35/04 , A61K31/497 , A61K31/4439 , A61K31/415 , A61K31/405 , A61K31/18 , C07D413/02 , C07D413/12 , C07D413/14 , C07D401/12 , C07D235/04 , C07D209/04 , C07C311/00 , A61P35/00
CPC分类号: C07D215/14 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/20 , C07D209/32 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D249/04 , C07D295/125 , C07D295/13 , C07D295/14 , C07D295/155 , C07D309/08 , C07D309/14 , C07D309/32 , C07D401/12 , C07D405/12 , C07D417/12 , C07D487/04
摘要: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.
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23.
公开(公告)号:US08586754B2
公开(公告)日:2013-11-19
申请号:US12793418
申请日:2010-06-03
申请人: Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Todd M. Hansen
发明人: Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Todd M. Hansen
IPC分类号: C07D209/32 , C07D401/10
CPC分类号: C07D215/14 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/20 , C07D209/32 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D249/04 , C07D295/125 , C07D295/13 , C07D295/14 , C07D295/155 , C07D309/08 , C07D309/14 , C07D309/32 , C07D401/12 , C07D405/12 , C07D417/12 , C07D487/04
摘要: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.
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24.APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 有权
标题翻译: 用于治疗癌症和免疫和自发性疾病的病毒诱导剂公开(公告)号:US20100298323A1
公开(公告)日:2010-11-25
申请号:US12793413
申请日:2010-06-03
申请人: Milan Bruncko , Yujia Dai , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Todd M. Hansen
发明人: Milan Bruncko , Yujia Dai , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron R. Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Todd M. Hansen
IPC分类号: A61K31/496 , C07D405/12 , C07D405/14 , C07D413/14 , C07D413/12 , C07D295/155 , C07D403/14 , C07D401/12 , C07D417/14 , A61K31/5377 , A61K31/495 , A61P35/00 , A61P35/02
CPC分类号: C07D213/76 , A61K31/495 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D211/06 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/14 , C07D295/30 , C07D309/04 , C07D309/32 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
摘要: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
摘要翻译: 公开了抑制抗凋亡Bcl-2蛋白活性的化合物,含有化合物的组合物和治疗疾病的方法,其中表达抗凋亡Bcl-2蛋白。
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公开(公告)号:US20090124616A1
公开(公告)日:2009-05-14
申请号:US12104319
申请日:2008-04-16
申请人: Xiaohong Song , Hong Ding , Steven W. Elmore , Milan Bruncko , David J. Madar , Andrew J. Souers , Cheol-Min Park , Zhi-Fu Tao , Xilu Wang , Aaron R. Kunzer
发明人: Xiaohong Song , Hong Ding , Steven W. Elmore , Milan Bruncko , David J. Madar , Andrew J. Souers , Cheol-Min Park , Zhi-Fu Tao , Xilu Wang , Aaron R. Kunzer
IPC分类号: A61K31/404 , C07D209/00 , C07D401/02 , C07D413/02 , C07D403/02 , A61K31/5377 , A61K31/454 , A61K31/4439 , A61K31/4155
CPC分类号: C07D209/42 , C07D403/04
摘要: Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mcl-1 protein are disclosed.
摘要翻译: 公开了抑制抗凋亡Mcl-1蛋白活性的化合物,含有该化合物的组合物,以及治疗涉及过表达或未调节的Mcl-1蛋白的疾病的方法。
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公开(公告)号:US20050272744A1
公开(公告)日:2005-12-08
申请号:US11138717
申请日:2005-05-26
申请人: Steven Elmore , Milan Bruncko , Cheol-Min Park
发明人: Steven Elmore , Milan Bruncko , Cheol-Min Park
IPC分类号: A61K31/445 , A61K31/495 , C07D211/14 , C07D211/18 , C07D211/32 , C07D211/46 , C07D211/48 , C07D241/04 , C07D295/155 , C07D295/205 , C07D409/06
CPC分类号: C07D211/14 , C07D211/18 , C07D211/46 , C07D211/48 , C07D295/155 , C07D295/205 , C07D409/06
摘要: Compounds having the formula are apoptosis promoters. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译: 具有下式的化合物是凋亡启动子。 还公开了制备化合物,含有化合物的组合物和使用该化合物的处理方法的方法。
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公开(公告)号:US20060074085A1
公开(公告)日:2006-04-06
申请号:US11288997
申请日:2005-11-29
申请人: Steven Elmore , Cheol-Min Park , Xilu Wang
发明人: Steven Elmore , Cheol-Min Park , Xilu Wang
IPC分类号: A61K31/5377 , A61K31/496 , A61K31/4545 , A61K31/44 , C07D413/02 , C07D401/02
CPC分类号: C07D295/215 , A61K31/4025 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/553 , A61K31/554 , C07D211/16 , C07D211/18 , C07D211/26 , C07D211/58 , C07D211/82 , C07D295/205
摘要: Compounds having the formula are apoptosis promoters. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
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公开(公告)号:US07585858B2
公开(公告)日:2009-09-08
申请号:US11138717
申请日:2005-05-26
申请人: Steven W. Elmore , Milan Bruncko , Cheol-Min Park
发明人: Steven W. Elmore , Milan Bruncko , Cheol-Min Park
IPC分类号: A61K31/5377 , A61K31/451 , C07D211/14 , C07D211/48 , C07D211/70 , C07D413/12 , A61K31/495 , C07D295/195
CPC分类号: C07D211/14 , C07D211/18 , C07D211/46 , C07D211/48 , C07D295/155 , C07D295/205 , C07D409/06
摘要: Compounds having the formula are apoptosis promoters. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译: 具有下式的化合物是凋亡启动子。 还公开了制备化合物,含有化合物的组合物和使用该化合物的处理方法的方法。
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公开(公告)号:US20100035879A1
公开(公告)日:2010-02-11
申请号:US12474610
申请日:2009-05-29
申请人: Steven W. Elmore , Milan Bruncko , Cheol-Min Park
发明人: Steven W. Elmore , Milan Bruncko , Cheol-Min Park
IPC分类号: A61K31/445 , C07D211/40 , C07D241/04 , C07D413/12 , A61K31/495 , A61K31/5377 , A61P35/00
CPC分类号: C07D211/14 , C07D211/18 , C07D211/46 , C07D211/48 , C07D295/155 , C07D295/205 , C07D409/06
摘要: Compounds having the formula are apoptosis promoters. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译: 具有下式的化合物是凋亡启动子。 还公开了制备化合物,含有化合物的组合物和使用该化合物的处理方法的方法。
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公开(公告)号:US20080146572A1
公开(公告)日:2008-06-19
申请号:US12037608
申请日:2008-02-26
申请人: Steven W. Elmore , Cheol-Min Park , Xilu Wang
发明人: Steven W. Elmore , Cheol-Min Park , Xilu Wang
IPC分类号: C07D211/06 , C07D413/00 , A61K31/5377 , A61K31/496 , A61P43/00 , C07D241/04 , A61K31/445
CPC分类号: C07D295/215 , A61K31/4025 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/553 , A61K31/554 , C07D211/16 , C07D211/18 , C07D211/26 , C07D211/58 , C07D211/82 , C07D295/205
摘要: Compounds having the formula are apoptosis promoters. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译: 具有下式的化合物是凋亡启动子。 还公开了制备化合物,含有化合物的组合物和使用该化合物的处理方法的方法。
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