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21.发明公开公开(公告)号：US20240062118A1
公开(公告)日：2024-02-22
申请号：US18499909
申请日：2023-11-01
Applicant: NeuroPace, Inc.
Inventor： Sharanya Arcot Desai , Thomas K. Tcheng , Benjamin E. Shanahan
IPC: G06N20/00 , G06N3/08 , G06F9/30 , G06F18/214 , G06F18/22 , G06F18/2321
CPC classification number: G06N20/00 , G06N3/08 , G06F9/30036 , G06F18/2155 , G06F18/22 , G06F18/2321 , G06V2201/031
Abstract: A deep learning model and dimensionality reduction are applied to each of a plurality of records of physiological information to derive a plurality of feature vectors. A similarities algorithm is applied to the plurality of feature vectors to form a plurality of clusters, each including a set of feature vectors. An output comprising information that enables a display of one or more of the plurality of clusters is provided, and a mechanism for selecting at least one feature vector within a selected cluster of the plurality of clusters is enabled. Upon selection of a feature vector, an output comprising information that enables a display of the record of physiological information corresponding to the selected feature vector is provided, and a mechanism for assigning a label to the displayed record is enabled. The assigned label is then automatically assigned to the records corresponding to the remaining feature vectors in the selected cluster.
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公开(公告)号：US11439826B2
公开(公告)日：2022-09-13
申请号：US16906914
申请日：2020-06-19
Applicant: NeuroPace, Inc.
Inventor： Sharanya Arcot Desai , Thomas K. Tcheng
Abstract: Information relevant to making clinical decisions for a patient is identified based on electrical activity records of the patient's brain and electrical activity records of other patients' brains. A deep learning algorithm is applied to an electrical activity record of the patient, i.e., an input record, and to a set of electrical activity records of other patients, i.e., a set of search records, to obtain an input feature vector of the patient and a set of search feature vectors, each including features extracted by the deep learning algorithm. A similarities algorithm is applied to the input feature vector and the set of search feature vectors to identify a subset of search records most like the input record. Clinical information associated with one or more search records in the identified subset of search records is extracted from a database and used to make decisions regarding the patient's neuromodulation therapies.
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23.发明授权公开(公告)号：US10966625B2
公开(公告)日：2021-04-06
申请号：US15838383
申请日：2017-12-12
Applicant: NeuroPace, Inc.
Inventor： Sharanya Arcot Desai , Thomas K. Tcheng , Stephen T. Archer
Abstract: A sensor of an implantable medical device senses electrical activity of the brain. A data analyzer of the device monitors an electrographic signal corresponding to the electrical activity of the sensed brain signal, and processes the brain signal to obtain a measure of phase-amplitude coupling. For a selected portion of the electrographic signal, the data analyzer detects first features and second features of the electrographic signal. The first features represent oscillations in a low frequency range, while the second features represent oscillations in a frequency range higher than the low frequency range. For example, the low frequency range may correspond to theta frequency and the higher frequency range may correspond to gamma frequency. The data analyzer determines a measure of phase-amplitude coupling between oscillations in the low frequency range and oscillations in the higher frequency range based on occurrences of second features which coincide with first features.
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公开(公告)号：US09878160B2
公开(公告)日：2018-01-30
申请号：US15246315
申请日：2016-08-24
Applicant: NeuroPace, Inc.
Inventor： Benjamin D. Pless , Thomas K. Tcheng
IPC: A61N1/00 , A61N1/36 , A61M5/142 , A61N1/05 , A61B5/00 , A61B5/04 , A61B5/0476 , A61B5/07 , A61B5/021 , A61B5/026 , A61B5/0488 , A61B5/145
CPC classification number: A61N1/36135 , A61B5/0006 , A61B5/0022 , A61B5/0031 , A61B5/021 , A61B5/026 , A61B5/04012 , A61B5/0476 , A61B5/0488 , A61B5/076 , A61B5/14542 , A61B5/14546 , A61B5/4812 , A61B5/4836 , A61B5/686 , A61B5/743 , A61M5/14276 , A61N1/0529 , A61N1/0531 , A61N1/0539 , A61N1/36064 , A61N1/36067 , A61N1/36078 , A61N1/36139
Abstract: An implantable neurostimulator system adapted to provide therapy for various neurological disorders is capable of varying therapy delivery strategies based on the context, physiological or otherwise, into which the therapy is to be delivered. Responsive and scheduled therapies can be varied depending on various sensor measurements, calculations, inferences, and device states (including elapsed times and times of day) to deliver an appropriate course of therapy under the circumstances.
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公开(公告)号：US20170238832A1
公开(公告)日：2017-08-24
申请号：US15478168
申请日：2017-04-03
Applicant: NeuroPace, Inc.
Inventor： Thomas K. Tcheng
IPC: A61B5/0478 , A61B5/1455 , A61B5/00 , A61B5/0205 , A61B5/04 , A61N1/05 , A61N1/36 , A61N1/02 , A61B5/026 , A61B5/16
CPC classification number: A61B5/0478 , A61B5/0006 , A61B5/0031 , A61B5/0205 , A61B5/0261 , A61B5/04012 , A61B5/14553 , A61B5/165 , A61B5/4082 , A61B5/4094 , A61B5/4839 , A61B5/6868 , A61B5/7278 , A61B2562/0209 , A61B2562/028 , A61B2562/0285 , A61B2562/046 , A61B2562/063 , A61N1/025 , A61N1/0531 , A61N1/0534 , A61N1/36064 , A61N1/36067 , A61N1/36082 , A61N1/36132 , A61N1/36139
Abstract: A medical lead with at least a distal portion thereof implantable in the brain of a patient is described, together with methods and systems for using the lead. The lead is provided with at least two sensing modalities (e.g., two or more sensing modalities for measurements of field potential measurements, neuronal single unit activity, neuronal multi unit activity, optical blood volume, optical blood oxygenation, voltammetry and rheoencephalography). Acquisition of measurements and the lead components and other components for accomplishing a measurement in each modality are also described as are various applications for the multimodal brain sensing lead.
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Patent Agency Ranking
公开(公告)号：US09126042B2
公开(公告)日：2015-09-08
申请号：US14484701
申请日：2014-09-12
Applicant: NeuroPace, Inc.
Inventor： Thomas K. Tcheng , Robert E. Fischell , Benjamin D. Pless
CPC classification number: A61N1/36067 , A61N1/36135
Abstract: An implantable neurostimulator system for treating movement disorders includes a sensor, a detection subsystem capable of identifying episodes of a movement disorder by analyzing a signal received from the sensor, and a therapy subsystem capable of supplying therapeutic electrical stimulation to treat the movement disorder. The system treats movement disorders by detecting physiological conditions characteristic of an episode of symptoms of the movement disorder and selectively initiating therapy when such conditions are detected.
Abstract translation: 用于治疗运动障碍的可植入神经刺激器系统包括传感器，能够通过分析从传感器接收的信号来识别运动障碍发作的检测子系统，以及能够提供治疗性电刺激以治疗运动障碍的治疗子系统。 该系统通过检测运动障碍症状发作特征的生理条件来治疗运动障碍，并且当检测到这种病症时选择性地开始治疗。
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27.发明申请公开(公告)号：US20130184780A1
公开(公告)日：2013-07-18
申请号：US13784569
申请日：2013-03-04
Applicant: NeuroPace, Inc.
Inventor： Benjamin D. Pless , Thomas K. Tcheng
IPC: A61N1/36
CPC classification number: A61N1/36135 , A61B5/0006 , A61B5/0022 , A61B5/0031 , A61B5/021 , A61B5/026 , A61B5/04012 , A61B5/0476 , A61B5/0488 , A61B5/076 , A61B5/14542 , A61B5/14546 , A61B5/4812 , A61B5/4836 , A61B5/686 , A61B5/743 , A61M5/14276 , A61N1/0529 , A61N1/0531 , A61N1/0539 , A61N1/36064 , A61N1/36067 , A61N1/36078 , A61N1/36139
Abstract: An implantable neurostimulator system adapted to provide therapy for various neurological disorders is capable of varying therapy delivery strategies based on the context, physiological or otherwise, into which the therapy is to be delivered. Responsive and scheduled therapies can be varied depending on various sensor measurements, calculations, inferences, and device states (including elapsed times and times of day) to deliver an appropriate course of therapy under the circumstances.
Abstract translation: 适用于为各种神经障碍提供治疗的可植入神经刺激器系统能够基于要递送治疗的上下文（生理或其他）改变治疗递送策略。 根据各种传感器测量，计算，推断和设备状态（包括经过时间和时间），在这种情况下提供适当的治疗方案，响应和预定的治疗方法可以不同。
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公开(公告)号：US11842255B2
公开(公告)日：2023-12-12
申请号：US17948947
申请日：2022-09-20
Applicant: NeuroPace, Inc.
Inventor： Sharanya Arcot Desai , Thomas K. Tcheng , Benjamin E. Shanahan
IPC: G06N20/00 , G06N3/08 , G06F9/30 , G06F18/214 , G06F18/22 , G06F18/2321
CPC classification number: G06N20/00 , G06F9/30036 , G06F18/2155 , G06F18/22 , G06F18/2321 , G06N3/08 , G06V2201/031
Abstract: A deep learning model and dimensionality reduction are applied to each of a plurality of records of physiological information to derive a plurality of feature vectors. A similarities algorithm is applied to the plurality of feature vectors to form a plurality of clusters, each including a set of feature vectors. An output comprising information that enables a display of one or more of the plurality of clusters is provided, and a mechanism for selecting at least one feature vector within a selected cluster of the plurality of clusters is enabled. Upon selection of a feature vector, an output comprising information that enables a display of the record of physiological information corresponding to the selected feature vector is provided, and a mechanism for assigning a label to the displayed record is enabled. The assigned label is then automatically assigned to the records corresponding to the remaining feature vectors in the selected cluster.
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公开(公告)号：US11690553B2
公开(公告)日：2023-07-04
申请号：US17313866
申请日：2021-05-06
Applicant: NeuroPace, Inc.
Inventor： Thomas K. Tcheng
IPC: A61B5/291 , A61N1/36 , A61B5/00 , A61B5/026 , A61B5/1455 , A61B5/16 , A61N1/05 , A61B5/316 , A61B5/0205 , A61N1/02
CPC classification number: A61B5/291 , A61B5/0006 , A61B5/0031 , A61B5/0205 , A61B5/0261 , A61B5/14553 , A61B5/165 , A61B5/316 , A61B5/4082 , A61B5/4094 , A61B5/4839 , A61B5/6868 , A61N1/025 , A61N1/0531 , A61N1/0534 , A61N1/36064 , A61N1/36067 , A61N1/36082 , A61N1/36132 , A61N1/36139 , A61B5/7278 , A61B2562/028 , A61B2562/0209 , A61B2562/0285 , A61B2562/046 , A61B2562/063
Abstract: A medical lead with at least a distal portion thereof implantable in the brain of a patient is described, together with methods and systems for using the lead. The lead is provided with at least two sensing modalities (e.g., two or more sensing modalities for measurements of field potential measurements, neuronal single unit activity, neuronal multi unit activity, optical blood volume, optical blood oxygenation, voltammetry and rheoencephalography). Acquisition of measurements and the lead components and other components for accomplishing a measurement in each modality are also described as are various applications for the multimodal brain sensing lead.
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公开(公告)号：US20230172529A1
公开(公告)日：2023-06-08
申请号：US18070902
申请日：2022-11-29
Applicant: NeuroPace, Inc.
Inventor： Sharanya Arcot Desai , Thomas K. Tcheng , Cairn G. Seale , Martha J. Morrell , David A. Greene
CPC classification number: A61B5/4094 , A61B5/7264 , G16H20/40 , A61B5/6868
Abstract: A method of assessing electrical activity of a brain includes, for each of a plurality of electrical-activity records of the brain, applying a machine-learned ESC model to the record to classify the record as one of a seizure record or a non-seizure record, wherein each of record is sensed by a corresponding one of a plurality of sensing channels of an implanted medical device; for each seizure record in a set of seizure records, applying the machine-learned ESC model to the seizure record to classify the seizure record as one of a local-seizure record or a spread-seizure record, wherein the seizure record comprises a first seizure record captured by a first sensing channel and a second seizure record captured by a second sensing channel; and for each spread-seizure record in a set of spread-seizure records, applying a machine-learned SSC model to the spread-seizure record to classify the spread-seizure record as a type of seizure spread pattern.
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