公开(公告)号：US10910794B2

公开(公告)日：2021-02-02

申请号：US15962600

申请日：2018-04-25

Applicant: Samsung Electronics Co., Ltd. ,  President and Fellows of Harvard College

Inventor： Jinseong Heo ,  Minhyun Lee ,  Seongjun Park ,  Philip Kim ,  Hongkun Park ,  Donhee Ham

IPC: H01S5/30 ,  H01S5/10 ,  H01S5/042 ,  H01S5/323 ,  H01L33/00 ,  H01S5/062

Abstract: A light-emitting device includes a substrate including a photonic cavity and configured to function as a gate, an active layer including a two-dimensional material, a first conductive contact, and a second conductive contact. The wavelength range of light generated by the light-emitting device may be narrowed based on the photonic cavity being included in the substrate, and the intensity and wavelength range of the generated light may be controlled based on the substrate functioning as a gate.

公开(公告)号：US10295636B2

公开(公告)日：2019-05-21

申请号：US15032241

申请日：2014-10-28

Applicant: SCHLUMBERGER TECHNOLOGY CORPORATION ,  PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Yi-qiao Song ,  Jeffrey Paulsen ,  Donhee Ham ,  Dongwan Ha

IPC: G01R33/54 ,  G01N24/08 ,  G01R33/36 ,  G01V3/32 ,  G01R33/3415

Abstract: An integrated circuit is provided for use in conjunction with an external antenna. The integrated circuit includes a memory circuit, a pulse sequencer, an NMR transmitter circuit and an NMR receiver circuit. The memory circuit is configured to store user-defined parameter data pertaining to an excitation period and an acquisition period that are part of an NMR pulse sequence. The pulse sequencer and the NMR transmitter circuit are configured to cooperate to generate RF signals in accordance the user-defined parameter data stored in the memory circuit, wherein such RF signals are supplied to the external antenna for emitting excitation signals from the external antenna during the excitation period of the NMR pulse sequence. The NMR receiver circuit is configured to receive electrical signals generated by the external antenna during the acquisition period of the NMR pulse sequence.

公开(公告)号：US20250160718A1

公开(公告)日：2025-05-22

申请号：US18839599

申请日：2023-03-24

Applicant: President and Fellows of Harvard College

Inventor： Donhee Ham ,  Jun Wang ,  Woo-Bin Jung ,  Hongkun Park

IPC: A61B5/294

Abstract: A device is provided for performing an electrical assessment in a biological environment. The device includes a substrate having an exposed surface having holes. At least one of the holes includes surfaces coated with a conductive material that is in electrical contact with an electrode. The device also includes circuitry controllable to apply a stimulus to the conductive material of the hole by applying the stimulus to the electrode in electrical contact with the hole. The hole may be disposed in a well structure that includes a wall surrounding the hole. The well structure may have a dimension such that a cell of interest in the biological environment is able to cover an entirety of a rim of the wall of the well structure. The wall of the well structure may surround one or more of the holes, which may be in electrical contact with a same electrode.

公开(公告)号：US20240280535A1

公开(公告)日：2024-08-22

申请号：US18569809

申请日：2022-06-13

Applicant: President and Fellows of Harvard College

Inventor： Donhee Ham ,  Woo-Bin Jung ,  Han Sae Jung ,  Jun Wang ,  Young-Ha Hwang ,  Henry Julian Hinton ,  Jeffrey T. Abbott ,  Hongkun Park

IPC: G01N27/416 ,  G01N27/27 ,  G01N27/30

CPC classification number: G01N27/4167 ,  G01N27/27 ,  G01N27/302

Abstract: Devices and methods for controlling the local pH of solutions (e.g., for parallelized polymer synthesis) are generally described. These may offer several advantages, including the ability to control pH using a plurality of pixels, and/or the ability to sense the pH associated with each pixel, according to certain embodiments. In some embodiments, such devices are used to selectively synthesize polymer sequences (e.g., DNA sequences) associated with each pixel. The pixels can, in some embodiments, comprise electrodes that can apply an electrical potential or current to a solution comprising an electrically sensitive pH modifier. In some cases, reaction of the electrically sensitive pH modifier may cause a change in pH. The pixels may comprise circuit components that can operate in multiple modes (e.g. as potentiostats, galvanostats, or open-circuit potential sensors capable of sensing local pH).

公开(公告)号：US20240210380A1

公开(公告)日：2024-06-27

申请号：US18365045

申请日：2023-08-03

Applicant: President and Fellows of Harvard College

Inventor： Donhee Ham ,  Jeffrey T. Abbott ,  Wenxuan Wu ,  Tianyang Ye ,  Han Sae Jung ,  Hongkun Park

IPC: G01N33/487 ,  B01L3/00 ,  G01N15/01 ,  G01N15/1031 ,  G01N33/50

CPC classification number: G01N33/48728 ,  B01L3/502715 ,  G01N15/1031 ,  G01N33/5005 ,  B01L2300/0645 ,  G01N15/01

Abstract: Disclosed herein are an apparatus for electrically assessing and/or manipulating cells. One aspect is directed to electrically mapping cells on the surface of the semiconductor substrate via cross-electrode impedance measurements. Further according to some aspects, the electrode array allows for spatially addressable electrical stimulation and/or recording of electrical signals in real-time using the CMOS circuitry. Some of these aspects are directed to using an electrode array to perform cell patterning through electrochemical gas generation, and extracellular electrochemical mapping.

公开(公告)号：US11747321B2

公开(公告)日：2023-09-05

申请号：US17877702

申请日：2022-07-29

Applicant: President and Fellows of Harvard College

Inventor： Donhee Ham ,  Jeffrey T. Abbott ,  Wenxuan Wu ,  Tianyang Ye ,  Han Sae Jung ,  Hongkun Park

IPC: G01N33/487 ,  B01L3/00 ,  G01N15/10 ,  G01N33/50 ,  G01N15/00

CPC classification number: G01N33/48728 ,  B01L3/502715 ,  G01N15/1031 ,  G01N33/5005 ,  B01L2300/0645 ,  G01N2015/0065

Abstract: Disclosed herein are an apparatus for electrically assessing and/or manipulating cells. One aspect is directed to electrically mapping cells on the surface of the semiconductor substrate via cross-electrode impedance measurements. Further according to some aspects, the electrode array allows for spatially addressable electrical stimulation and/or recording of electrical signals in real-time using the CMOS circuitry. Some of these aspects are directed to using an electrode array to perform cell patterning through electrochemical gas generation, and extracellular electrochemical mapping.

公开(公告)号：US20200292482A1

公开(公告)日：2020-09-17

申请号：US16760723

申请日：2018-10-30

Applicant: President and Fellows of Harvard College

Inventor： Donhee Ham ,  Hongkun Park ,  Keith Krenek ,  Tianyang Ye ,  Jeffrey T. Abbott ,  Wenxuan Wu

IPC: G01N27/327 ,  C12M1/34 ,  C12N13/00 ,  G01N27/416

Abstract: Methods and systems for monitoring the activity of electrogenic networks are described. One representative system includes an array of electrode coupled to an analyzer having a stimulator and a receiver. The electrode is placed in contact with an electrogenic cell. The electrodes can be shaped as nanowires, tubes, cavities and/or cones. The analyzer may be configured to operate in a voltage stimulation mode, in which the cells are stimulated via voltages and monitored via current, or in a current stimulation mode, in which the cells are stimulated via currents and monitored via voltages. The analyzers may be arranged as single-stage amplifiers, and may include a feedback loop shared between the stimulation signal path and the sensing signal path. The feedback loop may be arranged to provide overlapping stimulation and sensing of the electrogenic network's cells.

公开(公告)号：US20160274204A1

公开(公告)日：2016-09-22

申请号：US15032241

申请日：2014-10-28

Applicant: SCHLUMBERGER TECHNOLOGY CORPORATION ,  PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Yi-qiao Song ,  Jeffrey Paulsen ,  Donhee Ham ,  Dongwan Ha

IPC: G01R33/54 ,  G01V3/32

CPC classification number: G01R33/543 ,  G01N24/081 ,  G01R33/3415 ,  G01R33/3607 ,  G01R33/3614 ,  G01R33/3621 ,  G01R33/3635 ,  G01V3/32

Abstract: An integrated circuit is provided for use in conjunction with an external antenna. The integrated circuit includes a memory circuit, a pulse sequencer, an NMR transmitter circuit and an NMR receiver circuit. The memory circuit is configured to store user-defined parameter data pertaining to an excitation period and an acquisition period that are part of an NMR pulse sequence. The pulse sequencer and the NMR transmitter circuit are configured to cooperate to generate RF signals in accordance the user-defined parameter data stored in the memory circuit, wherein such RF signals are supplied to the external antenna for emitting excitation signals from the external antenna during the excitation period of the NMR pulse sequence. The NMR receiver circuit is configured to receive electrical signals generated by the external antenna during the acquisition period of the NMR pulse sequence.

Abstract translation: 提供与外部天线结合使用的集成电路。 集成电路包括存储器电路，脉冲序列发生器，NMR发射器电路和NMR接收器电路。 存储器电路被配置为存储关于作为NMR脉冲序列的一部分的激励周期和获取周期的用户定义的参数数据。 脉冲序列器和NMR发射器电路被配置为根据存储在存储器电路中的用户定义的参数数据进行协作以产生RF信号，其中这样的RF信号被提供给外部天线，用于在外部天线期间发射来自外部天线的激励信号 NMR脉冲序列的激发期。 NMR接收器电路被配置为在NMR脉冲序列的采集周期期间接收由外部天线产生的电信号。