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21.发明申请Method and system implementing spatially modulated excitation or emission for particle characterization with enhanced sensitivity 有权实现空间调制激发或发射的方法和系统，用于增强灵敏度的粒子表征公开(公告)号：US20080181827A1
公开(公告)日：2008-07-31
申请号：US11698409
申请日：2007-01-26
CPC分类号： G01N21/6486 , G01N15/1427 , G01N15/147 , G01N2015/1447 , G01N2015/1454 , Y10T436/143333 , Y10T436/17
摘要： A method and system for using spatially modulated excitation/emission and relative movement between a particle (cell, molecule, aerosol, . . . ) and an excitation/emission pattern are provided. In at least one form, an interference pattern of the excitation light with submicron periodicity perpendicular to the particle flow is used. As the particle moves along the pattern, emission is modulated according to the speed of the particle and the periodicity of the stripe pattern. A single detector, which records the emission over a couple of stripes, can be used. The signal is recorded with a fast detector read-out in order to capture the “blinking” of the particles while they are moving through the excitation pattern. This concept enables light detection with high signal-to-noise ratio and high spatial resolution without the need of expensive and bulky optics.
摘要翻译： 提供了使用空间调制的激发/发射和颗粒（细胞，分子，气溶胶等）和激发/发射图案之间的相对运动的方法和系统。 在至少一种形式中，使用具有垂直于颗粒流的亚微米周期的激发光的干涉图案。 当颗粒沿着图案移动时，根据颗粒的速度和条纹图案的周期性来调制发射。 可以使用记录两条条纹上的发射的单个检测器。 用快速检测器读出来记录信号，以便在它们移动通过激励图案时捕获颗粒的“闪烁”。 这个概念能够实现高信噪比和高空间分辨率的光检测，而不需要昂贵和庞大的光学元件。
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22.发明授权Method and system implementing spatially modulated excitation or emission for particle characterization with enhanced sensitivity 有权实现空间调制激发或发射的方法和系统，用于增强灵敏度的粒子表征公开(公告)号：US08821799B2
公开(公告)日：2014-09-02
申请号：US11698409
申请日：2007-01-26
CPC分类号： G01N21/6486 , G01N15/1427 , G01N15/147 , G01N2015/1447 , G01N2015/1454 , Y10T436/143333 , Y10T436/17
摘要： A method and system for using spatially modulated excitation/emission and relative movement between a particle (cell, molecule, aerosol, . . . ) and an excitation/emission pattern are provided. In at least one form, an interference pattern of the excitation light with submicron periodicity perpendicular to the particle flow is used. As the particle moves along the pattern, emission is modulated according to the speed of the particle and the periodicity of the stripe pattern. A single detector, which records the emission over a couple of stripes, can be used. The signal is recorded with a fast detector read-out in order to capture the “blinking” of the particles while they are moving through the excitation pattern. This concept enables light detection with high signal-to-noise ratio and high spatial resolution without the need of expensive and bulky optics.
摘要翻译： 提供了使用空间调制的激发/发射和颗粒（细胞，分子，气溶胶等）和激发/发射图案之间的相对运动的方法和系统。 在至少一种形式中，使用具有垂直于颗粒流的亚微米周期的激发光的干涉图案。 当颗粒沿着图案移动时，根据颗粒的速度和条纹图案的周期性来调制发射。 可以使用记录两条条纹上的发射的单个检测器。 用快速检测器读出来记录信号，以便在它们移动通过激励图案时捕获颗粒的“闪烁”。 这个概念能够实现高信噪比和高空间分辨率的光检测，而不需要昂贵和庞大的光学元件。
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公开(公告)号：US08040526B2
公开(公告)日：2011-10-18
申请号：US12968115
申请日：2010-12-14
IPC分类号： G01B9/02
CPC分类号： G01N21/03 , A61B5/0075 , A61B5/0084 , A61B5/14532 , A61B5/1459 , G01N21/0303 , G01N21/274 , G01N21/31
摘要： An implantable product includes an optical cavity structure with first and second parts, each of which can operate as an optical cavity. The first part includes a container with at least one opening through which bodily fluid can transfer between the container's interior and exterior when the product is implanted in a body. The second part includes a container that is closed and contains a reference fluid. The implantable product can also include one or both of a light source component and a photosensing component. Photosensed quantities from the first part's output light can be adjusted based on photosensed quantities from the second part's output light. Both parts can have their light interface surfaces aligned so that they both receive input light from a light source component and both provide output light to a photosensing component.
摘要翻译： 可植入产品包括具有第一和第二部分的光学腔结构，每个部分可以作为光腔工作。 第一部分包括具有至少一个开口的容器，当产品植入体内时，体液可以通过该开口在容器的内部和外部之间转移。 第二部分包括封闭的容器并且包含参考流体。 可植入产品还可以包括光源组件和感光组件中的一个或两个。 可以根据第二部分输出指示灯的光线数量来调整第一部分输出光的照片数量。 两个部件可以使它们的光接口表面对准，使得它们都接收来自光源部件的输入光并且都向光敏部件提供输出光。
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公开(公告)号：US20090190121A1
公开(公告)日：2009-07-30
申请号：US12022485
申请日：2008-01-30
申请人： Alex Hegyi , Michael Bassler , Peter Kiesel , Noble M. Johnson
发明人： Alex Hegyi , Michael Bassler , Peter Kiesel , Noble M. Johnson
CPC分类号： G01N21/05 , B01L3/5027 , B01L3/502761 , G01N15/12 , G01N15/1429 , G01N15/1434 , G01N15/1463 , G01N15/1475 , G01N15/1484 , G01N2015/1037 , G01N2015/1075 , G01N2015/1093 , G01N2015/1254 , G01N2015/1472 , G01N2015/1486 , G01N2021/0346
摘要： Sensing results from moving objects, e.g. from photosensing emanating light or from impedance-based sensing, can indicate sensed time-varying waveforms with information about objects. For example, a sensed time-varying waveform can be compared with another waveform, such as a reference waveform produced by objects of a certain type, to obtain comparison results indicating motion-independent information about the object; time-scaling can adjust for displacement rate such as speed. Also, a modulation periodicity value can be obtained from a sensed time-varying waveform and used in obtaining information about an object; for example, a periodic modulation frequency can be used with a given time's chirp frequency to obtain phase information about an object's position. Or, where periodic modulation frequency indicates displacement rate, time scaling during comparison can use a scaling factor based on the frequency. Objects can move fluidically as in flow cytometry or through scanning movement, as in document scanning.
摘要翻译： 感测来自移动物体的结果，例如 从光敏发射光或基于阻抗的感测可以用关于对象的信息来指示感测的时变波形。 例如，可以将感测到的时变波形与诸如由某种类型的对象产生的参考波形的另一波形进行比较，以获得指示关于对象的运动无关信息的比较结果; 时间缩放可以调整速度等位移速率。 此外，可以从感测到的时变波形获得调制周期值，并用于获得关于对象的信息; 例如，可以使用周期调制频率与给定时间的啁啾频率来获得关于对象的位置的相位信息。 或者，在周期性调制频率表示位移速率的情况下，比较期间的时间缩放可以使用基于频率的缩放因子。 物体可以像流式细胞仪一样流动，也可以通过扫描运动进行流动，如文档扫描。
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公开(公告)号：US07852490B2
公开(公告)日：2010-12-14
申请号：US11702329
申请日：2007-02-05
IPC分类号： G01B9/02
CPC分类号： G01N21/03 , A61B5/0075 , A61B5/0084 , A61B5/14532 , A61B5/1459 , G01N21/0303 , G01N21/274 , G01N21/31
摘要： An implantable product includes an optical cavity structure with first and second parts, each of which can operate as an optical cavity. The first part includes a container with at least one opening through which bodily fluid can transfer between the container's interior and exterior when the product is implanted in a body. The second part includes a container that is closed and contains a reference fluid. The implantable product can also include one or both of a light source component and a photosensing component. Photosensed quantities from the first part's output light can be adjusted based on photosensed quantities from the second part's output light. Both parts can have their light interface surfaces aligned so that they both receive input light from a light source component and both provide output light to a photosensing component.
摘要翻译： 可植入产品包括具有第一和第二部分的光学腔结构，每个部分可以作为光腔工作。 第一部分包括具有至少一个开口的容器，当产品植入体内时，体液可以通过该开口在容器的内部和外部之间转移。 第二部分包括封闭的容器并且包含参考流体。 可植入产品还可以包括光源组件和感光组件中的一个或两个。 可以根据第二部分输出指示灯的光线数量来调整第一部分输出光的照片数量。 两个部件可以使它们的光接口表面对准，使得它们都接收来自光源部件的输入光并且都向光敏部件提供输出光。
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公开(公告)号：US07817254B2
公开(公告)日：2010-10-19
申请号：US12022485
申请日：2008-01-30
申请人： Alex Hegyi , Michael Bassler , Peter Kiesel , Noble M. Johnson
发明人： Alex Hegyi , Michael Bassler , Peter Kiesel , Noble M. Johnson
IPC分类号： G01P3/36
CPC分类号： G01N21/05 , B01L3/5027 , B01L3/502761 , G01N15/12 , G01N15/1429 , G01N15/1434 , G01N15/1463 , G01N15/1475 , G01N15/1484 , G01N2015/1037 , G01N2015/1075 , G01N2015/1093 , G01N2015/1254 , G01N2015/1472 , G01N2015/1486 , G01N2021/0346
摘要： Sensing results from moving objects, e.g. from photosensing emanating light or from impedance-based sensing, can indicate sensed time-varying waveforms with information about objects. For example, a sensed time-varying waveform can be compared with another waveform, such as a reference waveform produced by objects of a certain type, to obtain comparison results indicating motion-independent information about the object; time-scaling can adjust for displacement rate such as speed. Also, a modulation periodicity value can be obtained from a sensed time-varying waveform and used in obtaining information about an object; for example, a periodic modulation frequency can be used with a given time's chirp frequency to obtain phase information about an object's position. Or, where periodic modulation frequency indicates displacement rate, time scaling during comparison can use a scaling factor based on the frequency. Objects can move fluidically as in flow cytometry or through scanning movement, as in document scanning.
摘要翻译： 感测来自移动物体的结果，例如 从光敏发射光或基于阻抗的感测可以用关于对象的信息来指示感测的时变波形。 例如，可以将感测到的时变波形与诸如由某种类型的对象产生的参考波形的另一波形进行比较，以获得指示关于对象的运动无关信息的比较结果; 时间缩放可以调整速度等位移速率。 此外，可以从感测到的时变波形获得调制周期值，并用于获得关于对象的信息; 例如，可以使用周期调制频率与给定时间的啁啾频率来获得关于对象的位置的相位信息。 或者，在周期性调制频率表示位移速率的情况下，比较期间的时间缩放可以使用基于频率的缩放因子。 物体可以像流式细胞仪一样流动，也可以通过扫描运动进行流动，如文档扫描。
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公开(公告)号：US20090156917A1
公开(公告)日：2009-06-18
申请号：US11957610
申请日：2007-12-17
申请人： Jorg Martini , Jeffrey Roe , Peter Kiesel , Michael Bassler , Alan Bell , Richard H. Bruce , Noble M. Johnson
发明人： Jorg Martini , Jeffrey Roe , Peter Kiesel , Michael Bassler , Alan Bell , Richard H. Bruce , Noble M. Johnson
IPC分类号： A61B5/00
CPC分类号： A61B5/1459 , A61B5/14532 , G01N21/03 , G01N21/39 , G01N21/8507
摘要： An implantable product such as an article, device, or system can include analyte and non-analyte containers in parts that can be operated as optical cavities. The product can also include fluidic components such as filter assemblies that control transfer of objects that affect or shift spectrum features or characteristics such as by shifting transmission mode peaks or reflection mode valleys, shifting phase, reducing maxima or contrast, or increasing intermediate intensity width such as full width half maximum (FWHM). Analyte, e.g. glucose molecules, can be predominantly included in a set of objects that transfer more rapidly into the analyte container than other objects, and can have a negligible or zero rate of transfer into the non-analyte container; objects that transfer more rapidly into the non-analyte container can include objects smaller than the analyte or molecules of a set of selected types, including, e.g., sodium chloride. Output light from the containers accordingly includes information about analyte.
摘要翻译： 诸如制品，装置或系统的可植入产品可以包括可以作为光腔操作的部件中的分析物和非分析物容器。 该产品还可以包括流体组件，例如过滤器组件，其控制影响或移动光谱特征或特性的物体的转移，例如通过移动透射模式峰值或反射模式谷，移动相位，减小最大值或对比度，或增加中等强度宽度， 作为全宽半最大值（FWHM）。 分析物，例如 葡萄糖分子可以主要包括在一组物体中，其比其它物体更快地转移到分析物容器中，并且可以具有可忽略或零速率的转移到非分析物容器中; 将更快速地转移到非分析物容器中的物体可以包括比分析物小的物体或一组选定类型的分子，包括例如氯化钠。 因此，来自容器的输出光包括关于分析物的信息。
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28.发明授权Method and apparatus for improved light distribution in an anti-resonant waveguide sensor 有权用于改善反谐振波导传感器中的光分布的方法和装置公开(公告)号：US07456953B2
公开(公告)日：2008-11-25
申请号：US11777976
申请日：2007-07-13
CPC分类号： G02B6/10 , G01N21/03 , G01N21/0303 , G01N21/33 , G01N21/35 , G01N21/3577 , G01N21/64 , G01N21/65 , G01N2021/651 , G02B6/032 , G02B6/34
摘要： An improved method of analyzing target analytes in a sample is described. The method is based on creating an approximately homogeneous distribution of light in an anti-resonant guided optical waveguide to improve light-target interaction in a target-containing medium. The light-target interaction can be monitored by many different means to determine characteristics of the target analyte.
摘要翻译： 描述了一种分析样品中目标分析物的改进方法。 该方法基于在反谐振引导光波导中产生大致均匀的光分布，以改善含靶介质中的光 - 目标相互作用。 光靶相互作用可以通过许多不同的手段来监测，以确定目标分析物的特征。
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公开(公告)号：US20080186483A1
公开(公告)日：2008-08-07
申请号：US11702329
申请日：2007-02-05
IPC分类号： G01N1/10
CPC分类号： G01N21/03 , A61B5/0075 , A61B5/0084 , A61B5/14532 , A61B5/1459 , G01N21/0303 , G01N21/274 , G01N21/31
摘要： An implantable product includes an optical cavity structure with first and second parts, each of which can operate as an optical cavity. The first part includes a container with at least one opening through which bodily fluid can transfer between the container's interior and exterior when the product is implanted in a body. The second part includes a container that is closed and contains a reference fluid. The implantable product can also include one or both of a light source component and a photosensing component. Photosensed quantities from the first part's output light can be adjusted based on photosensed quantities from the second part's output light. Both parts can have their light interface surfaces aligned so that they both receive input light from a light source component and both provide output light to a photosensing component.
摘要翻译： 可植入产品包括具有第一和第二部分的光学腔结构，每个部分可以作为光腔工作。 第一部分包括具有至少一个开口的容器，当产品植入体内时，体液可以通过该开口在容器的内部和外部之间转移。 第二部分包括封闭的容器并且包含参考流体。 可植入产品还可以包括光源组件和感光组件中的一个或两个。 可以根据第二部分输出指示灯的光线数量来调整第一部分输出光的照片数量。 两个部件可以使它们的光接口表面对准，使得它们都接收来自光源部件的输入光并且都向光敏部件提供输出光。
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30.发明授权公开(公告)号：US07830517B2
公开(公告)日：2010-11-09
申请号：US12205730
申请日：2008-09-05
申请人： Markus Beck , Peter Kiesel , Michael Bassler , Tobias Burgel
发明人： Markus Beck , Peter Kiesel , Michael Bassler , Tobias Burgel
IPC分类号： G01N21/00
CPC分类号： G01N21/645 , B01L3/502715 , B01L3/502776 , B01L2200/0636 , B01L2300/0654 , B01L2300/0816 , B01L2300/087 , B01L2300/0877 , B01L2400/086 , G01N15/1434 , G01N21/05 , G01N2015/1411 , G01N2021/0346 , G01N2021/0378 , G01N2021/6467 , G01N2021/6482
摘要： An embodiment is a fluidic channel to enhance light-target interaction. A first channel portion receives a first excitation light, an analyte flow, and a sheath flow. The analyte flow and the first excitation light are separated while in the first channel portion. The sheath flow flows on two sides or surrounds the analyte flow. A second channel portion has a first redirection structure to redirect the analyte flow by the sheath flow into the first excitation light at a first detection area.
摘要翻译： 一个实施例是用于增强光 - 目标相互作用的流体通道。 第一通道部分接收第一激发光，分析物流和鞘流。 分析物流和第一激发光在第一通道部分分离。 鞘流在两侧流动或围绕分析物流。 第二通道部分具有第一重定向结构，以将分析物流通过鞘流重定向到第一检测区域的第一激发光。
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