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公开(公告)号：US20060147982A1
公开(公告)日：2006-07-06
申请号：US11366001
申请日：2006-03-02
申请人： Steven Ruben , Craig Rosen , Kenneth Carter , Patrick Dillon , Gregory Endress , Guo-Liang Yu , Jian Ni , Ping Feng
发明人： Steven Ruben , Craig Rosen , Kenneth Carter , Patrick Dillon , Gregory Endress , Guo-Liang Yu , Jian Ni , Ping Feng
CPC分类号： C07K14/47 , A61K38/00 , C07K14/525 , G01N2500/04
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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公开(公告)号：US20060025574A1
公开(公告)日：2006-02-02
申请号：US11226657
申请日：2005-09-15
申请人： Steven Ruben , Craig Rosen , Kenneth Carter , Patrick Dillon , Gregory Endress , Guo-Liang Yu , Jian Ni , Ping Feng
发明人： Steven Ruben , Craig Rosen , Kenneth Carter , Patrick Dillon , Gregory Endress , Guo-Liang Yu , Jian Ni , Ping Feng
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
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公开(公告)号：US20070248593A1
公开(公告)日：2007-10-25
申请号：US11767824
申请日：2007-06-25
申请人： Steven Ruben , Craig Rosen , Kenneth Carter , Patrick Dillon , Gregory Endress , Guo-Liang Yu , Jian Ni , Ping Feng
发明人： Steven Ruben , Craig Rosen , Kenneth Carter , Patrick Dillon , Gregory Endress , Guo-Liang Yu , Jian Ni , Ping Feng
IPC分类号： A61K39/395 , A61K31/7052 , A61K48/00 , C07H21/04 , C07K14/00 , C07K16/18 , C12N15/00 , C12N5/06 , C12P1/04 , C12Q1/68 , G01N33/53
CPC分类号： C07K14/47 , A61K38/00 , C07K14/525 , G01N2500/04
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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公开(公告)号：US20070014787A1
公开(公告)日：2007-01-18
申请号：US11375555
申请日：2006-03-15
申请人： Steven Ruben , George Komatsoulis , D. Duan , Craig Rosen , Paul Moore , Yanggu Shi , David LaFleur , Reinhard Ebner , Henrik Olsen , Laurie Brewer , Kimberly Florence , Paul Young , Michael Mucenski , Gregory Endress , Daniel Soppet
发明人： Steven Ruben , George Komatsoulis , D. Duan , Craig Rosen , Paul Moore , Yanggu Shi , David LaFleur , Reinhard Ebner , Henrik Olsen , Laurie Brewer , Kimberly Florence , Paul Young , Michael Mucenski , Gregory Endress , Daniel Soppet
IPC分类号： A61K39/395 , C12Q1/68 , C07H21/04 , C12P21/06 , C07K14/705 , C07K16/28
CPC分类号： C07K14/47 , A61K38/00 , C07K2319/30
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US20050037467A1
公开(公告)日：2005-02-17
申请号：US10936773
申请日：2004-09-09
申请人： Steven Ruben , Ping Feng , David LaFleur , Paul Moore , Yanggu Shi , Hla Kyaw , Yi Li , ZhiZhen Zeng , Kenneth Carter , Gregory Endress , Ying-Fei Wei , Ping Fan , Craig Rosen
发明人： Steven Ruben , Ping Feng , David LaFleur , Paul Moore , Yanggu Shi , Hla Kyaw , Yi Li , ZhiZhen Zeng , Kenneth Carter , Gregory Endress , Ying-Fei Wei , Ping Fan , Craig Rosen
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US20050208619A1
公开(公告)日：2005-09-22
申请号：US10878523
申请日：2004-06-29
申请人： Craig Rosen , Steven Ruben , Reinhard Ebner , Roxanne Duan , Jian Ni , Daniel Soppet , Paul Moore , Yanggu Shi , David LaFleur , Henrik Olsen , Charles Birse , George Komatsoulis
发明人： Craig Rosen , Steven Ruben , Reinhard Ebner , Roxanne Duan , Jian Ni , Daniel Soppet , Paul Moore , Yanggu Shi , David LaFleur , Henrik Olsen , Charles Birse , George Komatsoulis
IPC分类号： G01N33/50 , A61K38/00 , A61K45/00 , A61P9/10 , A61P17/02 , A61P17/06 , A61P25/00 , A61P25/02 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/28 , A61P29/00 , A61P31/00 , A61P31/04 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/06 , C07H21/04 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N15/09 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566
CPC分类号： C07H21/04 , C07K14/47 , C07K16/18 , C07K2317/622 , C07K2319/30
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US20070190612A1
公开(公告)日：2007-08-16
申请号：US11738671
申请日：2007-04-23
申请人： Jian Ni , Steven Ruben , Craig Rosen , Reinhard Ebner , Kimberly Florence , Paul Young , Charles Birse , Kenneth Carter , George Komatsoulis
发明人： Jian Ni , Steven Ruben , Craig Rosen , Reinhard Ebner , Kimberly Florence , Paul Young , Charles Birse , Kenneth Carter , George Komatsoulis
CPC分类号： C07K14/47 , A01K2217/075 , A61K38/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US20050208602A1
公开(公告)日：2005-09-22
申请号：US10773236
申请日：2004-02-09
申请人： Craig Rosen , Kevin Baker , Charles Birse , Gil Choi , Michele Fiscella , George Komatsoulis , Paul Moore , Jian Ni , Henrik Olsen , Steven Ruben , Ping Wei , D. Roxanne Duan , Yanggu Shi
发明人： Craig Rosen , Kevin Baker , Charles Birse , Gil Choi , Michele Fiscella , George Komatsoulis , Paul Moore , Jian Ni , Henrik Olsen , Steven Ruben , Ping Wei , D. Roxanne Duan , Yanggu Shi
IPC分类号： A61K38/00 , A61K38/17 , G01N33/53 , G01N33/537 , G01N33/543 , G01N33/68
CPC分类号： G01N33/68 , A61K38/00 , G01N33/5005 , G01N33/5008 , G01N33/502 , G01N33/6845
摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to said human secreted proteins. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译： 本发明涉及人分泌多肽和编码所述多肽的分离的核酸分子，其可用于诊断和治疗与所述人分泌蛋白相关的疾病，病症和/或病症。 结合这些多肽的抗体也包括在本发明中。 本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。 本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。
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公开(公告)号：US20050042667A1
公开(公告)日：2005-02-24
申请号：US10935098
申请日：2004-09-08
申请人： David LaFleur , Daniel Soppet , Henrik Olsen , Steven Ruben , Jian Ni , Craig Rosen , Laurie Brewer , Roxanne Duan , Reinhard Ebner
发明人： David LaFleur , Daniel Soppet , Henrik Olsen , Steven Ruben , Jian Ni , Craig Rosen , Laurie Brewer , Roxanne Duan , Reinhard Ebner
IPC分类号： C12N15/09 , A61K31/711 , A61K38/00 , A61K39/395 , A61K48/00 , A61P5/00 , A61P7/00 , A61P11/06 , A61P19/02 , A61P29/00 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/00 , C07K14/435 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/21 , C12N5/10 , C12Q1/68 , C07H21/04 , C12N9/00
摘要： The present invention relates to 36 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译： 本发明涉及36种新型人分泌蛋白和含有编码这种蛋白质的基因的编码区的分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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公开(公告)号：US20080020969A1
公开(公告)日：2008-01-24
申请号：US11780874
申请日：2007-07-20
申请人： David LaFleur , Daniel Soppet , Henrik Olsen , Steven Ruben , Jian Ni , Craig Rosen , Laurie Brewer , Roxanne Duan , Reinhard Ebner
发明人： David LaFleur , Daniel Soppet , Henrik Olsen , Steven Ruben , Jian Ni , Craig Rosen , Laurie Brewer , Roxanne Duan , Reinhard Ebner
IPC分类号： A61K38/00 , A61K48/00 , C07H21/00 , C07K14/00 , C12N15/00 , C12N15/87 , C12N5/06 , C12P21/04 , G01N33/53
摘要： The present invention relates to 36 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译： 本发明涉及36种新型人分泌蛋白和含有编码这种蛋白质的基因的编码区的分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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