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公开(公告)号：US20250085525A1
公开(公告)日：2025-03-13
申请号：US18956363
申请日：2024-11-22
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Noam YORAV-RAPHAEL , Joseph Joel POLLAK , Sarah Levy SCHREIER , Yochay Shlomo ESHEL
Abstract: Apparatus and methods are described for determining a property of a bodily sample, using a microscope and optical-density-measurement apparatus. A sample carrier includes a microscopy sample chamber configured to receive a first portion of the sample and to facilitate imaging of the first portion of the sample by the microscope, and an optical-density-measurement chamber configured to receive a second portion of the sample, and to facilitate optical density measurements being performed by the optical-density-measurement apparatus upon the second portion of the sample. The sample carrier includes an upper surface and a lower surface. At least one of the upper surface and the lower surface of the sample carrier is defined by a glass sheet, and the other surface is defined by a molded component. Other applications are also described.
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公开(公告)号：US20240126060A1
公开(公告)日：2024-04-18
申请号：US18397324
申请日：2023-12-27
Applicant: S.D. SIGHT DIAGNOSTICS LTD
Inventor： Noam YORAV-RAPHAEL , Joseph Joel POLLAK , Sarah Levy , Yochay Shlomo ESHEL
CPC classification number: G02B21/0076 , G01N21/6456 , G02B21/36
Abstract: Apparatus and methods are described for determining a property of a bodily sample using a microscope and optical-density-measurement apparatus, the apparatus including a sample carrier that includes a plurality of microscopy sample chambers configured to receive a first portion of the sample and to facilitate imaging of the first portion of the sample by the microscope, each of the microscopy sample chambers having an upper and a lower surface, and having respective heights between the upper and lower surfaces that are different from each other. The sample carrier includes at least one optical-density-measurement chamber configured to receive a second portion of the sample, and to facilitate optical density measurements being performed optical-density-measurement apparatus upon the second portion of the sample. Other applications are also described.
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公开(公告)号：US20240029250A1
公开(公告)日：2024-01-25
申请号：US18376680
申请日：2023-10-04
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yuval GREENFIELD , Yonatan BILU , Joseph Joel POLLAK , Noam YORAV-RAPHAEL
CPC classification number: G06T7/0012 , G02B7/38 , G02B21/244 , G06T7/507 , G02B21/16 , G02B21/367 , G02B21/361 , G06T2207/10056 , G06T2207/30024
Abstract: Apparatus and methods are described for use with a cell sample that includes a plurality of cells. A series of images associated with a series of depth levels of the cell sample are acquired, by performing a depth scan of cell sample with a microscope. One of the depth levels is identified as being an optimum focal plane for imaging one or more entities within the cell sample using the microscope, under a first illumination condition. The cell sample is imaged under a second illumination condition that is different from the first illumination condition, using the microscope, by focusing the microscope at an investigative depth level that is based on the identified depth level. Other applications are also described.
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公开(公告)号：US20220390734A1
公开(公告)日：2022-12-08
申请号：US17882702
申请日：2022-08-08
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Joseph Joel POLLAK , Arnon HOURI YAFIN , Seth J. SALPETER
Abstract: Apparatus and methods are described including introducing a cell suspension comprising red blood cells into a carrier that is a closed cavity that includes a base surface and a closed top, via an inlet defined by the carrier. The cells in the cell suspension are allowed to settle on the base surface of the carrier to form a monolayer of cells on the base surface of the carrier. At least one microscope image of at least a portion of the monolayer of cells is acquired. Other applications are also described.
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公开(公告)号：US20220381672A1
公开(公告)日：2022-12-01
申请号：US17770365
申请日：2020-10-22
Applicant: S.D. SIGHT DIAGNOSTICS LTD.
Inventor： Sharon PECKER , Yochay Shlomo ESHEL , Amir ZAIT , Dan GLUCK , Noam YORAV-RAPHAEL , Arnon HOURI YAFIN , Sarah LEVY SCHREIER , Joseph Joel POLLAK , Daniel LEVNER , Yonatan HALPERIN , Natalie LEZMY , Itamar WEISS
Abstract: Apparatus and methods are described including placing at least a portion of a blood sample within a sample chamber (52), and acquiring microscopic images of the portion of the blood sample. Candidates of a given entity within the blood sample are identified, within the microscopic image. At least some of the candidates as being the given entity are validated, by performing further analysis of the candidates. A count of the candidates of the given entity is compared to a count of the validated candidates of the given entity, and at least the portion of the sample is invalidated from being used for performing at least some measurements upon the sample, at least partially based upon a relationship between the count of candidates and the count of validated candidates. Other applications are also described.
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Patent Agency Ranking
公开(公告)号：US20220299436A1
公开(公告)日：2022-09-22
申请号：US17836561
申请日：2022-06-09
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Amitai FRANKLIN , Trevor RUGGIERO , Sarah LEVY , Joseph Joel POLLAK , Aidan John CARROLL , Sharon PECKER , Yochay Shlomo ESHEL
IPC: G01N21/3577 , G02B21/36 , G02B21/02 , G01N21/31
Abstract: Apparatus and methods are described for use with a microscopy unit that comprises an objective lens and a microscope camera. A cantilever includes an objective lens housing. A motor moves the cantilever along a direction of the optical axis of the objective lens. The cantilever is configured, during the movement of the cantilever, to support the objective lens within the objective lens housing such that an optical axis of the objective lens is aligned with the camera, without the objective lens being directly connected to the camera. Other applications are also described.
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公开(公告)号：US20210327064A1
公开(公告)日：2021-10-21
申请号：US17362009
申请日：2021-06-29
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Noam YORAV-RAPHAEL , Uri WOLFOVITZ , Joseph Joel POLLAK
Abstract: Apparatus and methods are described for use with a digital microscope unit that includes a digital microscope. A biological cell sample that is disposed within a sample carrier is received into the digital microscope unit. It is determined that there is a variation in the focal depth of the biological sample with respect to the microscope due to curvature in the sample carrier and/or due to tolerance in setup of the microscope. In response to determining that there is the variation in the focal depth of the biological sample with respect to the microscope, the variation in the focal depth of the biological sample with respect to the microscope is accounted for. Other applications are also described.
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公开(公告)号：US20210072526A1
公开(公告)日：2021-03-11
申请号：US17083659
申请日：2020-10-29
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Noam YORAV-RAPHAEL , Joseph Joel POLLAK , Sarah LEVY SCHREIER , Yochay Shlomo ESHEL
Abstract: Apparatus and methods for determining a property of a bodily sample using a microscope are described. A sample carrier includes a plurality of microscopy sample chambers configured to receive a least a portion of the bodily sample, while the sample is imaged by the microscope. Each of the microscopy sample chambers has an upper and a lower surface, and the microscopy sample chambers have respective heights between the upper and lower surfaces that are different from each other. The sample carrier defines a microscopy sample chamber inlet hole, that is fluid communication with all of the microscopy sample chambers, such as to facilitate filling of all of the microscopy sample chambers with the portion of the bodily sample, via the microscopy sample chamber inlet hole. Other applications are also described.
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公开(公告)号：US20190145963A1
公开(公告)日：2019-05-16
申请号：US16099270
申请日：2017-05-11
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Amir ZAIT , Arnon HOURI YAFIN , Dan GLUCK , Sharon PECKER , Yochay Shlomo ESHEL , Sarah LEVY SCHREIER , Joseph Joel POLLAK
IPC: G01N33/50 , G01N33/49 , G01N33/569 , G01N15/06
Abstract: Apparatus and methods are described for use with a blood sample (48, 50), including measuring hemoglobin concentration within at least a portion (48) of the blood sample, by performing a first measurement on the blood sample. Mean corpuscular hemoglobin in the blood sample (48, 50) is measured, by performing a second measurement on the blood sample (48, 50). A parameter of the blood sample is determined, based on a relationship between the concentration of hemoglobin and the mean corpuscular hemoglobin. Other applications are also described.
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公开(公告)号：US20190002950A1
公开(公告)日：2019-01-03
申请号：US16106085
申请日：2018-08-21
Applicant: S.D. SIGHT DIAGNOSTICS LTD.
Inventor： Joseph Joel POLLAK , Arnon HOURI YAFIN , Seth J. SALPETER
Abstract: Apparatus and methods are described including introducing a cell suspension comprising red blood cells into a carrier that is a closed cavity that includes a base surface, via an inlet defined by the carrier. The cells in the cell suspension are allowed to settle on the base surface of the carrier to form a monolayer of cells on the base surface of the carrier. At least one microscope image of at least a portion of the monolayer of cells is acquired. Other applications are also described.
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