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    COMPOSITIONS AND METHODS FOR DELIVERY OF HYDROPHOBIC ACTIVE AGENTS
    21.
    发明申请
    COMPOSITIONS AND METHODS FOR DELIVERY OF HYDROPHOBIC ACTIVE AGENTS 审中-公开
    用于输送疏水活性剂的组合物和方法

    公开(公告)号：US20140336571A1

    公开(公告)日：2014-11-13

    申请号：US14280170

    申请日：2014-05-16

    Applicant: SurModics, Inc.

    Inventor： Joram Slager ,  Dale G. Swan ,  Darin DuMez ,  Joseph Ventura ,  Shannon Wadman ,  Joseph Schmidt McGonigle ,  Robert W. Hergenrother

    IPC: A61K47/32 ,  A61K31/436 ,  A61L29/04 ,  A61M25/10 ,  A61L29/08 ,  A61L29/16 ,  A61K31/337 ,  A61K9/14

    CPC classification number: A61L29/041 ,  A61K9/0019 ,  A61K31/337 ,  A61K31/436 ,  A61K47/34 ,  A61L29/085 ,  A61L29/16 ,  A61L2300/416 ,  A61L2300/62 ,  A61L2300/63 ,  A61L2400/06 ,  A61L2420/06 ,  A61L2420/08 ,  A61M25/10 ,  A61M2025/105 ,  C08L79/02

    Abstract: Disclosed herein is a delivery composition for administering a hydrophobic active agent. In one embodiment, a delivery composition for local administration of a hydrophobic active agent to a tissue or organ of a patient is disclosed. In one embodiment, the delivery composition includes a cationic delivery agent, a therapeutically effective amount of a hydrophobic active agent and a pharmaceutically acceptable aqueous carrier. In one embodiment, the cationic delivery agent includes polyethyleneimine (PEI). In an embodiment, the invention includes a drug delivery device including a substrate; and coated therapeutic agent particles disposed on the substrate, the coated therapeutic agent particles comprising a particulate hydrophobic therapeutic agent; and a vinyl amine polymer. Methods of making the delivery composition, as well as kits and methods of use are also included herein.

    Abstract translation: 本文公开了用于施用疏水性活性剂的递送组合物。 在一个实施方案中，公开了用于向患者的组织或器官局部施用疏水性活性剂的递送组合物。 在一个实施方案中，递送组合物包括阳离子递送剂，治疗有效量的疏水活性剂和药学上可接受的水性载体。 在一个实施方案中，阳离子递送剂包括聚乙烯亚胺（PEI）。 在一个实施方案中，本发明包括药物递送装置，其包括基底; 以及设置在基材上的被覆治疗剂颗粒，所述涂敷的治疗剂颗粒包含颗粒状疏水性治疗剂; 和乙烯基胺聚合物。 制备递送组合物的方法以及试剂盒和使用方法也包括在本文中。

    COMPOSITION AND METHOD FOR DELIVERY OF HYDROPHOBIC ACTIVE AGENTS
    22.
    发明申请
    COMPOSITION AND METHOD FOR DELIVERY OF HYDROPHOBIC ACTIVE AGENTS 有权
    用于输送疏水活性剂的组合物和方法

    公开(公告)号：US20140142166A1

    公开(公告)日：2014-05-22

    申请号：US14072520

    申请日：2013-11-05

    Applicant: SurModics, Inc.

    Inventor： Joseph Ventura ,  Shannon Wadman ,  Joram Slager ,  Joseph Schmidt McGonigle ,  Robert W. Hergenrother

    IPC: A61K47/34 ,  A61K31/337

    CPC classification number: A61K47/34 ,  A61K9/0019 ,  A61K9/08 ,  A61K31/337 ,  A61L27/18 ,  A61L27/54 ,  A61L2300/416 ,  A61L2300/63 ,  A61L2400/06 ,  C08L79/02

    Abstract: Disclosed herein is a delivery composition for administering a hydrophobic active agent. In one embodiment, a delivery composition for local administration of a hydrophobic active agent to a tissue or organ of a patient is disclosed. In one embodiment, the delivery composition includes a cationic delivery agent, a therapeutically effective amount of a hydrophobic active agent and a pharmaceutically acceptable aqueous carrier. In one embodiment, the cationic delivery agent includes polyethyleneimine (PEI). In a more specific embodiment, the cationic delivery agent includes branched PEI. Methods of making the delivery composition, as well as kits and methods of use are also disclosed.

    Abstract translation: 本文公开了用于施用疏水性活性剂的递送组合物。 在一个实施方案中，公开了用于向患者的组织或器官局部施用疏水性活性剂的递送组合物。 在一个实施方案中，递送组合物包括阳离子递送剂，治疗有效量的疏水活性剂和药学上可接受的水性载体。 在一个实施方案中，阳离子递送剂包括聚乙烯亚胺（PEI）。 在更具体的实施方案中，阳离子递送剂包括支链PEI。 还公开了制备递送组合物的方法，以及试剂盒和使用方法。

    DELIVERY OF HYDROPHOBIC ACTIVE AGENT PARTICLES
    25.
    发明申请
    DELIVERY OF HYDROPHOBIC ACTIVE AGENT PARTICLES 审中-公开

    公开(公告)号：US20200237971A1

    公开(公告)日：2020-07-30

    申请号：US16847272

    申请日：2020-04-13

    Applicant: Surmodics, Inc.

    Inventor： Joram Slager ,  Toni M. Heyer ,  David E. Babcock

    IPC: A61L29/08 ,  C12N15/113 ,  A61M25/10 ,  A61K47/34 ,  A61K31/713 ,  A61K31/337 ,  A61L29/14 ,  A61L29/16

    Abstract: Embodiments of the invention include drug delivery coatings and devices including the same. In an embodiment, the invention includes a drug delivery coating including a polymeric layer. The polymeric layer can include a hydrophilic outer surface. The coating can also include a matrix contacting the hydrophilic outer surface. The matrix can include a particulate hydrophobic therapeutic agent and a cationic agent. The polymeric layer can further include a hydrophilic polymer having pendent photoreactive groups and a photo-crosslinker including two aryl ketone functionalities. Other embodiments are also included herein.

    LOCALIZED TREATMENT OF TISSUES THROUGH TRANSCATHETER DELIVERY OF ACTIVE AGENTS
    28.
    发明申请
    LOCALIZED TREATMENT OF TISSUES THROUGH TRANSCATHETER DELIVERY OF ACTIVE AGENTS 审中-公开

    公开(公告)号：US20170281914A1

    公开(公告)日：2017-10-05

    申请号：US15470362

    申请日：2017-03-27

    Applicant: Surmodics, Inc.

    Inventor： Joram Slager

    IPC: A61M25/10 ,  A61M25/00 ,  A61K31/337

    Abstract: Embodiments herein include catheters and methods for the localized treatment of tissues through transcatheter delivery of active agents. In an embodiment, a method herein can include inserting a catheter into the lumen of a blood vessel. The catheter can include an inflatable balloon, a first lumen within the shaft for delivering a fluid to inflate the balloon, an active agent delivery port, and a second lumen disposed within the shaft for delivering the active agent composition through the shaft to the active agent delivery port. The method can include inflating the balloon to at least partially occlude the flow of blood through the blood vessel. The method can include ejecting the active agent composition from the active agent delivery port into the blood vessel. In an embodiment, a catheter for treating a localized region of the body with an active agent composition is included. Other embodiments are also included herein.

    MACROLIDE PARTICULATES, METHODS FOR PREPARATION, AND MEDICAL DEVICES ASSOCIATED THEREWITH
    30.
    发明申请
    MACROLIDE PARTICULATES, METHODS FOR PREPARATION, AND MEDICAL DEVICES ASSOCIATED THEREWITH 有权
    麦芽糖苷颗粒，制备方法和与之相关的医疗器械

    公开(公告)号：US20160374998A1

    公开(公告)日：2016-12-29

    申请号：US15262465

    申请日：2016-09-12

    Applicant: Surmodics, Inc.

    Inventor： Joram Slager

    IPC: A61K31/436 ,  A61K9/14 ,  A61K9/16

    CPC classification number: A61K31/436 ,  A61K9/0019 ,  A61K9/1075 ,  A61K9/145 ,  A61K9/1688 ,  A61K9/19 ,  A61K9/5123 ,  A61K9/5138 ,  A61K9/5146 ,  A61L29/085 ,  A61L29/16 ,  Y02A50/402 ,  Y02A50/478 ,  Y10T428/2982

    Abstract: The disclosure provides macrolide particulates including a macrolide therapeutic agent such as rapamycin at high concentration in the particulate. In one method the particulates are made by adding a composition containing an polyoxyethylene sorbitan n-acyl ester, poly(ethyleneimine), or alkylated quaternary ammonium salt to a composition including macrolide dissolved in an alcohol such as ethanol. In another method the particulates are made by adding a non-solvent composition to a composition including macrolide and an alkyl-substituted chromanol dissolved in an alcohol such as ethanol. The formed macrolide particulates have one or more desirable properties including sizes in the range of 0.1 μm to 10 μm, spherical or near spherical shapes, low polydispersity, and/or stability. The macrolide particulates can be used for therapeutic compositions, or in association with an implantable or insertable medical device, such as associated with a polymeric coating on a device.

    Abstract translation: 本公开提供了大环内酯颗粒，其包括大环内酯治疗剂，例如高浓度颗粒物中的雷帕霉素。 在一种方法中，颗粒通过将包含聚氧乙烯失水山梨糖醇n-酰基酯，聚（乙烯亚胺）或烷基化季铵盐的组合物加入到溶解在醇如乙醇中的大环内酯的组合物中来制备。 在另一种方法中，通过将非溶剂组合物加入到包含大环内酯和溶解在醇如乙醇中的烷基取代的苯并二氢苯并三氢吡喃的组合物中来制备颗粒。 形成的大环内酯颗粒具有一种或多种所需性质，包括0.1μm至10μm范围内的尺寸，球形或近球形，低分散性和/或稳定性。 大环内酯颗粒可用于治疗组合物，或与可植入或可插入的医疗装置相关联，例如与装置上的聚合物涂层相关联。

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