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30 条记录 (耗时 0.026 秒)

    Control of cell arrangement
    23.
    发明授权
    Control of cell arrangement 失效
    细胞安排的控制

    公开(公告)号：US5202227A

    公开(公告)日：1993-04-13

    申请号：US531596

    申请日：1990-06-01

    申请人： Takehisa Matsuda ,  Kazuhiko Inoue ,  Nobutaka Tani

    发明人： Takehisa Matsuda ,  Kazuhiko Inoue ,  Nobutaka Tani

    IPC分类号： C12M3/04 ,  C12N5/00 ,  C12N5/071 ,  G03F7/00 ,  G03F7/008

    CPC分类号： G03F7/008 ,  C12N5/0068 ,  C12N5/069 ,  G03F7/00 ,  C12N2533/30 ,  C12N2533/52 ,  C12N2535/10

    摘要： A device for controlling cell arrangement having a pattern composed of a cell adhesive surface and a cell non-adhesive surface, which has a good selectivity of cell adhesion and which can provide a fine pattern of cells in high resolution by culturing cells in a usual manner. The device is prepared by a process which comprises applying a photosensitive, cell adhesive or cell non-adhesive polymer to a surface having a reverse cell adhesivity property to that of the applied polymer, and patternwise irradiating a light to the photosensitive polymer layer followed by development; a process which comprises patternwise irradiating UV or radiation to a cell non-adhesive surface to produce a cell adhesive functional group such as carboxyl group or amino group in the irradiated portion; or a process which comprises patternwise irradiating UV or radiation to a cell adhesive or non-adhesive surface made of plastics to produce a polymerization initiation site in the irradiated portion, and graft-polymerizing at least one monomer having the reverse cell adhesivity property to the plastic surface to produce a polymer on the irradiated portion of plastic surface.

    Biofilm formation inhibitor and treatment device thereof
    24.
    发明授权
    Biofilm formation inhibitor and treatment device thereof 有权

    公开(公告)号：US08123798B2

    公开(公告)日：2012-02-28

    申请号：US11719819

    申请日：2005-11-16

    申请人： Takehisa Matsuda ,  Ryo Maeyama

    发明人： Takehisa Matsuda ,  Ryo Maeyama

    IPC分类号： A61F2/06 ,  A61F2/00

    摘要： A treatment device such as a biliary stent, capable of effectively and continuously inhibiting biofilm formation, and a biofilm formation inhibitor suitable for coating on the treatment device by killing all bacteria including E. coli and by suppressing the growth of these bacteria, are provided. A biofilm formation inhibitor having an effective amount of catechin for inhibiting biofilm formation and a carrier that is suitable for adhesion of said catechin to a treatment device to be placed in the living body, are provided.

    BIOFILM FORMATION INHIBITOR AND TREATMENT DEVICE THEREOF
    25.
    发明申请
    BIOFILM FORMATION INHIBITOR AND TREATMENT DEVICE THEREOF 有权
    生物膜形成抑制剂及其处理装置

    公开(公告)号：US20090099646A1

    公开(公告)日：2009-04-16

    申请号：US11719819

    申请日：2005-11-16

    申请人： Takehisa Matsuda ,  Ryo Maeyama

    发明人： Takehisa Matsuda ,  Ryo Maeyama

    IPC分类号： A61F2/06 ,  A61K31/352

    CPC分类号： A01N25/10 ,  A01N43/16 ,  A01N65/08 ,  A61L31/16 ,  A61L2300/404 ,  A01N25/24

    摘要： A treatment device such as a biliary stent, capable of effectively and continuously inhibiting biofilm formation, and a biofilm formation inhibitor suitable for coating on the treatment device by killing all bacteria including E. coli and by suppressing the growth of these bacteria, are provided. A biofilm formation inhibitor having an effective amount of catechin for inhibiting biofilm formation and a carrier that is suitable for adhesion of said catechin to a treatment device to be placed in the living body, are provided.

    摘要翻译： 提供了能够有效连续地抑制生物膜形成的治疗装置，例如胆管支架，以及适用于通过杀死包括大肠杆菌在内的所有细菌并抑制这些细菌的生长而在治疗装置上涂覆的生物膜形成抑制剂。 提供了具有抑制生物膜形成的有效量的儿茶素的生物膜形成抑制剂和适合于将所述儿茶素粘附到待置于生物体中的治疗装置的载体。

    Polymer and process for producing polymer
    26.
    发明申请
    Polymer and process for producing polymer 审中-公开
    聚合物和生产聚合物的方法

    公开(公告)号：US20050131192A1

    公开(公告)日：2005-06-16

    申请号：US10499331

    申请日：2002-10-30

    申请人： Takehisa Matsuda ,  Tetsuo Itoh ,  Tatsuya Ohsumi

    发明人： Takehisa Matsuda ,  Tetsuo Itoh ,  Tatsuya Ohsumi

    IPC分类号： A61L24/04 ,  C08G18/10 ,  C08G18/48 ,  C08G18/50 ,  C08G18/77 ,  C08L71/02 ,  C09J175/04 ,  C08G18/00

    CPC分类号： C09J175/04 ,  A61L24/04 ,  A61L24/046 ,  C08G18/10 ,  C08G18/4837 ,  C08G18/5015 ,  C08G18/5021 ,  C08G18/5072 ,  C08G18/773 ,  C08L71/02 ,  C08L75/04 ,  C08G18/302

    摘要： The object of the present invention is to provide a polymer best suited for use as a medical adhesive excellent in wet adhesion strength (water-resistant adhesive strength). In the present invention, a polymer capable of forming a cured film and useful as a medical adhesive, which has a viscosity at 37° C. of 0.5 to 2,000 Pa·s and shows a saturated water absorption of 0.2 to 5 ml/g, is used. The above-mentioned polymer preferably shows an initial water absorption rate of 0.01 to 0.5 ml/g·min, the wet elongation percentage of the cured film is preferably 100 to 1,500%, and the wet 100% modulus of the cured film is preferably 0.01 to 10 MPa. Additionally, it is preferable that the above-mentioned polymer contains oxyethylene groups and in which the oxyethylene group content is 30 to 100% by weight based on the weight of the polymer.

    摘要翻译： 本发明的目的是提供一种最适合用作湿粘合强度（耐水粘合强度）优异的医用粘合剂的聚合物。 在本发明中，能够形成固化膜并用作医用粘合剂的聚合物在37℃下的粘度为0.5〜2,000Pa·s，饱和吸水倍数为0.2〜5ml / g， 用来。 上述聚合物优选初始吸水率为0.01〜0.5ml / g·min，固化膜的湿延伸率优选为100〜1500％，固化膜的湿100％模量优选为0.01 至10MPa。 此外，上述聚合物优选含有氧化乙烯基，其中氧乙烯基含量相对于聚合物的重量为30〜100重量％。

    Material to be worn on the eyeball
    27.
    发明授权
    Material to be worn on the eyeball 失效
    材料要佩戴在眼球上

    公开(公告)号：US6075066A

    公开(公告)日：2000-06-13

    申请号：US869983

    申请日：1997-06-05

    申请人： Takehisa Matsuda ,  Hiroshi Nakao

    发明人： Takehisa Matsuda ,  Hiroshi Nakao

    IPC分类号： G02C7/04 ,  A61K9/00 ,  G02B1/04

    CPC分类号： A61K9/0051 ,  G02B1/043

    摘要： The present invention provides semi-spherical materials to be worn on the eyeball, such as contact lenses for visual acuity correction or medical treatment use, cornea protecting materials, controlled drug release contact lenses and the like, which comprise, as a main component, a glycosaminoglycan existing in the living body as an extracellular matrix component of connective tissues and satisfy various requirements such as dimentional stability, transparency, surface water wettability, tissue compatibility, oxygen permeability and the like. In other words, the material to be worn on the eyeball has a shape of semi-spherical surface compatible in shape with the mammalian eyeball and has biological and surface-physical compatibilities with ophthalmic tissues and comprises, as a main component, a substantially transparent photocured crosslinked-glycosaminoglycan obtained by allowing photoreactive groups covalently bonded to a glycosaminoglycan to crosslink mutually by photoirradiation.

    摘要翻译： PCT No.PCT / JP95 / 00419 Sec。 371日期1996年3月1日 102（e）1996年3月1日PCT 1995年3月14日PCT PCT。 WO95 / 25287 PCT出版物 日期1995年9月21日本发明提供了要戴在眼球上的半球形材料，例如用于视力矫正或医疗治疗用途的隐形眼镜，角膜保护材料，受控药物释放隐形眼镜等，其包括： 主要成分，作为结缔组织的细胞外基质成分存在于生物体中的糖胺聚糖，满足各种要求，如维度稳定性，透明性，表面水润湿性，组织相容性，透氧性等。 换句话说，穿戴在眼球上的材料具有与哺乳动物眼球形状相容的半球形表面形状，并且与眼组织具有生物学和表面物理的相容性，并且包含作为主要成分的基本上透明的光固化 通过使与光聚合相互作用的光活性基团与糖胺聚糖相互交联而获得的交联糖胺聚糖。

    Control of cell arrangement
    28.
    发明授权
    Control of cell arrangement 失效
    细胞排列控制

    公开(公告)号：US5593814A

    公开(公告)日：1997-01-14

    申请号：US308204

    申请日：1994-09-19

    申请人： Takehisa Matsuda ,  Kazuhiko Inoue ,  Nobutaka Tani

    发明人： Takehisa Matsuda ,  Kazuhiko Inoue ,  Nobutaka Tani

    IPC分类号： C12M3/04 ,  C12N5/00 ,  C12N5/071 ,  G03F7/00 ,  G03F7/008 ,  G03F7/012

    CPC分类号： G03F7/008 ,  C12N5/0068 ,  C12N5/069 ,  G03F7/00 ,  C12N2533/30 ,  C12N2533/52 ,  C12N2535/10

    摘要： A device for controlling cell arrangement having a pattern composed of a cell adhesive surface and a cell non-adhesive surface, which has a good selectivity of cell adhesion and which can provide a fine pattern of cells in high resolution by culturing cells in a usual manner. The device is prepared by a process which comprises applying a photosensitive, cell adhesive or cell non-adhesive polymer to a surface having a reverse cell adhesivity property to that of the applied polymer, and patternwise irradiating a light to the photosensitive polymer layer followed by development; a process which comprises patternwise irradiating UV or radiation to a cell non-adhesive surface to produce a cell adhesive functional group such as carboxyl group or amino group in the irradiated portion; or a process which comprises patternwise irradiating UV or radiation to a cell adhesive or non-adhesive surface made of plastics to produce a polymerization initiation site in the irradiated portion, and graft-polymerizing at least one monomer having the reverse cell adhesivity property to the plastic surface to produce a polymer on the irradiated portion of plastic surface.

    摘要翻译： 一种用于控制细胞排列的装置，其具有由细胞粘合剂表面和细胞非粘合剂表面组成的图案，其具有良好的细胞粘附选择性，并且可以通过以常规方式培养细胞而以高分辨率提供细胞图案 。 该装置通过一种方法制备，该方法包括将光敏，细胞粘合剂或细胞非粘合性聚合物施加到具有与施加的聚合物相反的反电池粘附性的表面，并将光图案照射到感光性聚合物层，随后显影 ; 包括将UV或辐射图案化地照射到细胞非粘合剂表面以在照射部分中产生诸如羧基或氨基的细胞粘附官能团的方法; 或包括以下步骤：将UV或辐射图案化地照射到由塑料制成的细胞粘合剂或非粘合剂表面，以在照射部分中产生聚合起始部位，并将至少一种具有反电池粘附性的单体接枝聚合到塑料 表面以在塑料表面的照射部分上产生聚合物。

    Method for manufacturing medical device having a highly biocompatible surface
    29.
    发明授权
    Method for manufacturing medical device having a highly biocompatible surface 失效
    用于制造具有高生物量表面的医疗装置的方法

    公开(公告)号：US5128170A

    公开(公告)日：1992-07-07

    申请号：US520902

    申请日：1990-05-09

    申请人： Takehisa Matsuda ,  Kazuhiko Inoue ,  Nobutaka Tani

    发明人： Takehisa Matsuda ,  Kazuhiko Inoue ,  Nobutaka Tani

    IPC分类号： A61L27/34 ,  A61L29/08 ,  A61L31/10 ,  A61L33/06

    CPC分类号： A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  A61L33/06

    摘要： A medical device having a highly biocompatible surface wherein hydrophilic polymer is bonded onto a surface of the medical device covalently through a nitrogen atom, and a method for manufacturing a medical device having a highly biocompatible surface comprising the steps of applying a hydrophilic polymer having azido group and/or a composition comprising a compound having at least two azido group and a hydrophilic polymer onto the surface of the medical device, and irradiating the biocompatible material with light so that the hydrophilic polymer is bonded to the medical device surface. The device has sufficient biocompatibility, medical functional capability and economical efficiency. The method easily provides a medical device with sufficient biocompatibility without impairing the device's medical functional capability and economical efficiency.

    Surgical adhesive
    30.
    发明授权
    Surgical adhesive 失效
    手术胶

    公开(公告)号：US4740534A

    公开(公告)日：1988-04-26

    申请号：US898710

    申请日：1986-08-21

    申请人： Takehisa Matsuda ,  Hiroo Iwata ,  Tetsuo Itoh

    发明人： Takehisa Matsuda ,  Hiroo Iwata ,  Tetsuo Itoh

    IPC分类号： A61L24/04 ,  A61L27/18 ,  C08G18/10 ,  C09J175/08

    CPC分类号： C09J175/08 ,  A61L24/046 ,  A61L27/18 ,  C08G18/10 ,  Y10S528/904

    摘要： Elastomeric or flexible surgical adhesives, comprising [A] NCO-terminated hydrophilic urethane prepolymer derived from hydrophilic polyether polyol of higher oxyethylene content, or combination of [A] with [B] unsaturated cyano compound containing cyano group attached to a carbon atom constituting the polymerizable double bond, are used for bonding of tissues, with rapid cure rate and sufficient bonding power.

    摘要翻译： 弹性体或柔性手术粘合剂，包含衍生自具有较高氧化乙烯含量的亲水性聚醚多元醇的[A] NCO封端的亲水性氨基甲酸酯预聚物，或[A]与[B]含氰基的不饱和氰基化合物的组合， 双键，用于粘合组织，具有快速固化速度和足够的粘合力。