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72 条记录 (耗时 0.047 秒)

    Antibody and use of the same
    21.
    发明申请
    Antibody and use of the same 有权
    抗体和使用相同

    公开(公告)号：US20060275286A1

    公开(公告)日：2006-12-07

    申请号：US11498439

    申请日：2006-08-02

    申请人： Hirokazu Matsumoto ,  Yasuko Horikoshi ,  Chieko Kitada ,  Tetsuya Ohtaki

    发明人： Hirokazu Matsumoto ,  Yasuko Horikoshi ,  Chieko Kitada ,  Tetsuya Ohtaki

    IPC分类号： A61K39/395 ,  G01N33/53 ,  C12P21/04 ,  C12N5/06 ,  C07K16/26

    CPC分类号： G01N33/689 ,  C07K16/18 ,  G01N33/6857 ,  G01N2800/368

    摘要： The present invention aims at providing an antibody, by which metastin or its derivative can be quantified specifically with a high sensitivity, a method of detecting/quantifying metastin or its derivative using the antibody, and a diagnostic agent (e.g., a diagnostic for pregnancy) the same. Specifically, an antibody capable of specifically reacting with a partial peptide at the N-terminus or C-terminus of a polypeptide having the amino acid sequence represented by SEQ ID NO: 1 or its derivative, and a method of detecting/quantifying metastin or its derivative using the antibody as well as a diagnostic agent using the same.

    摘要翻译： 本发明的目的在于提供抗体，通过该抗体可以以高灵敏度特异性地定量分析蛋白或其衍生物，使用抗体检测/定量分析蛋白或其衍生物的方法，以及诊断剂（例如，怀孕诊断） 一样。 具体而言，能够与具有SEQ ID NO：1所示的氨基酸序列的多肽的N末端或C末端的部分肽特异性反应的抗体或其衍生物，以及检测/定量分析的方法 衍生物以及使用该抗体的诊断剂。

    Anti-metasin antibodies and their methods of use
    22.
    发明授权
    Anti-metasin antibodies and their methods of use 有权
    抗metasin抗体及其使用方法

    公开(公告)号：US07112662B2

    公开(公告)日：2006-09-26

    申请号：US10490125

    申请日：2002-09-18

    申请人： Hirokazu Matsumoto ,  Yasuko Horikoshi ,  Chieko Kitada ,  Tetsuya Ohtaki

    发明人： Hirokazu Matsumoto ,  Yasuko Horikoshi ,  Chieko Kitada ,  Tetsuya Ohtaki

    IPC分类号： C07K16/00

    CPC分类号： G01N33/689 ,  C07K16/18 ,  G01N33/6857 ,  G01N2800/368

    摘要： The present invention aims at providing an antibody, by which metastin or its derivative can be quantified specifically with a high sensitivity, a method of detecting/quantifying metastin or its derivative using the antibody, and a diagnostic agent (e.g., a diagnostic for pregnancy) the same.Specifically, an antibody capable of specifically reacting with a partial peptide at the N-terminus or C-terminus of a polypeptide having the amino acid sequence represented by SEQ ID NO: 1 or its derivative, and a method of detecting/quantifying metastin or its derivative using the antibody as well as a diagnostic agent using the same.

    摘要翻译： 本发明的目的在于提供抗体，通过该抗体可以以高灵敏度特异性地定量分析蛋白或其衍生物，使用抗体检测/定量分析蛋白或其衍生物的方法，以及诊断剂（例如，怀孕诊断） 一样。 具体而言，能够与具有SEQ ID NO：1所示的氨基酸序列的多肽的N末端或C末端的部分肽特异性反应的抗体或其衍生物，以及检测/定量分析的方法 衍生物以及使用该抗体的诊断剂。

    Peptide, production and use thereof
    25.
    发明授权
    Peptide, production and use thereof 失效
    肽，生产和使用

    公开(公告)号：US5614497A

    公开(公告)日：1997-03-25

    申请号：US992131

    申请日：1992-12-17

    申请人： Chieko Kitada ,  Tetsuya Ohtaki ,  Masahiko Fujino

    发明人： Chieko Kitada ,  Tetsuya Ohtaki ,  Masahiko Fujino

    IPC分类号： A61K38/00 ,  C07K5/02 ,  C07K7/02 ,  C07K14/575 ,  C07K5/10 ,  C07K7/00 ,  C07K7/06

    CPC分类号： C07K5/021 ,  C07K14/57536 ,  C07K5/0202 ,  C07K7/02 ,  A61K38/00

    摘要： A peptide represented by the formula: ##STR1## wherein R.sub.1 represents an oil-soluble group; R.sub.2 and R.sub.5 represent a hydrogen atom or a lower alkyl group; R.sub.3 represents an aliphatic group which may have O or S; R.sub.4 represents a heterocyclic-substituted lower alkyl group; R.sub.6 represents a hydrogen atom, a lower alkyl group or an aromatic cyclic group; X represents a group having an aromatic ring; n represents an integer of 0 or more and m represents an integer of 2 or more, or a salt thereof exhibits a marked endothelin receptor-antagonistic action, and the peptide [I] is pharmaceutically useful as a therapeutic agent for hypertension, cardiovascular disease and renal disease, for instance.

    摘要翻译： 由下式表示的肽：其中R1表示油溶性基团; R2和R5表示氢原子或低级烷基; R3表示可具有O或S的脂族基团; R4表示杂环取代的低级烷基; R6代表氢原子，低级烷基或芳族环状基团; X表示具有芳环的基团; n表示0以上的整数，m表示2以上的整数，或其盐表现出显着的内皮素受体拮抗作用，肽[I]作为高血压，心血管疾病和 肾脏病例如。

    Polypeptides and use thereof
    26.
    发明授权
    Polypeptides and use thereof 失效
    多肽及其用途

    公开(公告)号：US5801147A

    公开(公告)日：1998-09-01

    申请号：US766725

    申请日：1996-12-13

    申请人： Chieko Kitada ,  Takuya Watanabe

    发明人： Chieko Kitada ,  Takuya Watanabe

    IPC分类号： A61K38/00 ,  C07K1/00 ,  C07K14/575 ,  C07K14/00

    CPC分类号： C07K1/006 ,  C07K14/57563 ,  A61K38/00

    摘要： Disclosed are (1) a polypeptide represented by formula (I), or a pharmaceutically acceptable amide, ester or salt thereof: His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-NH-CHX-CO-Ala-Val-Lys-Lys-Tyr-Y SEQ ID NO:13 (I) wherein X is hydrogen atom; or a lower alkyl group which may be substituted with a member selected from the group consisting of hydroxy group, substituted or unsubstituted amino group, carboxyl group, carbamoyl group, and substituted or unsubstituted aromatic group; and Y is one of amino acids or peptides consisting of 1 to 16 amino acid residues counted from the N-terminal side of Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys SEQ ID NO:20, and (2) a pharmaceutical composition comprising a polypeptide represented by formula (I), or a pharmaceutically acceptable amide, ester or salt thereof, which has remarkable c-AMP activity and is useful as a nerve activating agent.

    摘要翻译： 公开了（1）式（I）表示的多肽或其药学上可接受的酰胺，酯或其盐：His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr -Arg-Lys-Gln-NH-CHX-CO-Ala-Val-Lys-Lys-Tyr-Y SEQ ID NO：13（I）其中X是氢原子; 或可以被选自羟基，取代或未取代的氨基，羧基，氨基甲酰基和取代或未取代的芳基的成员取代的低级烷基; Y是从Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val的N-末端计数的1至16个氨基酸残基组成的氨基酸或肽之一 -Lys-Asn-Lys SEQ ID NO：20，和（2）包含由式（I）表示的多肽或其药学上可接受的酰胺，酯或其盐的药物组合物，其具有显着的c-AMP活性并且是有用的 作为神经活化剂。

    Polypeptide having c-AMP-producing activity
    28.
    发明授权
    Polypeptide having c-AMP-producing activity 失效
    具有C-AMP生产活性的多肽

    公开(公告)号：US5208320A

    公开(公告)日：1993-05-04

    申请号：US732059

    申请日：1991-07-18

    申请人： Chieko Kitada ,  Takuya Watanabe

    发明人： Chieko Kitada ,  Takuya Watanabe

    IPC分类号： A61K38/00 ,  C07K14/575

    CPC分类号： C07K14/57563 ,  A61K38/00

    摘要： A polypeptide or a pharmaceutically acceptable salt thereof having c-AMP-producing activity is disclosed, the polypeptide being represented by the following general formula:X-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Y (X-SEQ ID NO:2-Y)wherein X represents any amino acid residue or an acyl group, and Y represents NH.sub.2, OH, Ala-NH.sub.2, Ala-OH, Ala-Ala-NH.sub.2, Ala-Ala-OH, Ala-Ala-Val-NH.sub.2 or Ala-Ala-Val-OH.