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21.发明授权公开(公告)号：US06391296B1
公开(公告)日：2002-05-21
申请号：US09269833
申请日：1999-04-26
IPC分类号： A61K4500
CPC分类号： C07K14/555 , A61K38/00
摘要： A method of stabilizing a useful protein by mixing a useful protein and an aqueous solution of a compound having the basic structure of arabic acid, and a stabilizied useful protein compositon containing a useful protein and a compound having the basic structure of arabic acid; gum arabic is preferred as a compound having the basic structure of arabic acid, and examples of a useful protein include cytokine and interferon; and a production method for canine interferon-&ggr; and stabilization thereof.
摘要翻译： 通过混合有用蛋白质和具有阿拉伯酸碱性结构的化合物的水溶液和含有有用蛋白质的稳定化有用蛋白质组合物和具有阿拉伯酸碱性结构的化合物来稳定有用蛋白质的方法; 优选阿拉伯树胶作为具有阿拉伯酸碱性结构的化合物，有用的蛋白质的实例包括细胞因子和干扰素; 以及犬干扰素γ的制造方法及其稳定化。
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22.发明授权
公开(公告)号：US5342766A
公开(公告)日：1994-08-30
申请号：US3840
申请日：1993-01-11
CPC分类号： C12P13/08 , Y10S435/873
摘要： Higher amount of L-threonine can be accumulated by the cultivation of certain microorganism belonging to the genus Providencia, having a resistance to methionine antagonist and having capabilities of producing L-threonine.
摘要翻译： 可以通过培养属于普罗维登西亚属的某些微生物，具有对甲硫氨酸拮抗剂的抗性并具有产生L-苏氨酸能力的方式，可以积累更多量的L-苏氨酸。
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公开(公告)号：US10179924B2
公开(公告)日：2019-01-15
申请号：US14007438
申请日：2012-03-28
摘要： A method of producing a sugar liquid includes hydrolyzing with a filamentous fungus-derived cellulase a product obtained by adding a water-soluble inorganic salt(s) to a pretreated product of cellulose to a final concentration of 5 to 35 g/L; and subjecting the hydrolysate to solid-liquid separation and filtering the obtained solution component through an ultrafiltration membrane to recover the filamentous fungus-derived cellulase as a non-permeate and to obtain a sugar liquid as a permeate.
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公开(公告)号：US09598740B2
公开(公告)日：2017-03-21
申请号：US13984566
申请日：2012-02-17
CPC分类号： C13K13/007 , B01D61/025 , B01D61/027 , B01D61/145 , B01D2311/04 , B01D2311/25 , B01D2319/025 , C13B20/165 , C13K1/02
摘要： A method of producing a sugar liquid, includes filtering a cellulose-derived sugar liquid through one or more separation membranes selected from the group consisting of ultrafiltration membranes, nanofiltration membranes and reverse osmosis membranes, and washing the separation membrane(s) after filtration with warm water at a temperature of not less than 50° C.
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25.发明授权公开(公告)号：US09587253B2
公开(公告)日：2017-03-07
申请号：US12280197
申请日：2007-02-16
申请人： Hideki Sawai , Katsushige Yamada , Takashi Mimitsuka , Kenji Sawai , Tetsu Yonehara , Yohito Ito , Masahiro Henmi
发明人： Hideki Sawai , Katsushige Yamada , Takashi Mimitsuka , Kenji Sawai , Tetsu Yonehara , Yohito Ito , Masahiro Henmi
IPC分类号： C12P13/04 , C12P7/06 , C12M1/00 , C12M1/34 , C12P7/18 , C12P7/46 , C12P7/50 , C12P7/56 , C12P13/00 , C12P13/08 , C12P19/30
CPC分类号： C12P7/06 , C12M29/04 , C12M29/18 , C12M41/40 , C12M47/10 , C12P7/18 , C12P7/46 , C12P7/50 , C12P7/56 , C12P13/001 , C12P13/005 , C12P13/04 , C12P13/08 , C12P19/30 , Y02E50/17
摘要： The invention provides a method of producing a chemical product through continuous fermentation which includes filtering a culture of a microorganism or cultured cells with a separation membrane to recover a product from a filtrate and simultaneously retaining a nonfiltered fluid in, or refluxing it to, the culture, and adding fermentation materials to the culture, wherein a porous membrane having an average pore size of 0.01 μm or more to less than 1 μm is used as the separation membrane and the filtration is conducted with a transmembrane pressure difference in the range of 0.1 to 20 kPa. According to this method, the fermentation productivity of the chemical product can be largely elevated at high stability and a low cost.
摘要翻译： 本发明提供了一种通过连续发酵生产化学产品的方法，包括用分离膜过滤微生物培养物或培养细胞，从滤液中回收产物，同时将非过滤液体保留在培养基中或将其回流至培养物中 将发酵材料添加到培养物中，其中使用平均孔径为0.01μm以上且小于1μm的多孔膜作为分离膜，并且以跨膜压差为0.1〜 20 kPa。 根据该方法，化学产品的发酵生产率可以在高稳定性和低成本的情况下大大提高。
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公开(公告)号：US20140158642A1
公开(公告)日：2014-06-12
申请号：US14235985
申请日：2012-07-27
CPC分类号： C12P19/14 , B01D61/04 , B01J20/24 , B01J20/28038 , B01J2220/4831 , C02F11/122 , C02F11/14 , C08B37/0057 , C08H8/00 , C08L1/02 , C08L5/14 , C12H1/063 , C12P19/02
摘要： A method of producing a filter aid includes: (A) obtaining a pretreated biomass by pulverization treatment and/or thermochemical treatment of a cellulose-containing biomass; (B) treating the pretreated biomass obtained in (A) with cellulase to obtain a cellulase-treated product; and (C) obtaining a solid content of the cellulase-treated product of (B).
摘要翻译： 助滤剂的制造方法包括：（A）通过粉碎处理和/或含有纤维素的生物质的热化学处理获得预处理的生物质; （B）用纤维素酶处理（A）中得到的预处理生物质，得到纤维素酶处理产物; （C）获得（B）的纤维素酶处理物的固体成分。
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公开(公告)号：US20130344543A1
公开(公告)日：2013-12-26
申请号：US14002383
申请日：2012-03-02
CPC分类号： C12P19/14 , C12P7/06 , C12P7/10 , C12P7/56 , C12P19/02 , C12P2203/00 , C12Y302/01004 , C13B20/165 , C13K1/02 , C13K13/002 , Y02E50/16 , Y02E50/17
摘要： A method produces a sugar liquid by adding a filamentous fungus-derived cellulase to a pretreated product of cellulose to obtain a hydrolysate; adding waste molasses to said hydrolysate to obtain a mixed sugar liquid; and subjecting said mixed sugar liquid to solid-liquid separation and filtering the obtained solution component through an ultrafiltration membrane, to recover the filamentous fungus-derived cellulase as a non-permeate and to obtain a sugar liquid as a permeate.
摘要翻译： 一种方法是通过将丝状真菌衍生的纤维素酶添加到纤维素的预处理产物中来产生糖液，得到水解产物; 向所述水解产物中加入废糖蜜以获得混合糖液; 并对所得混合糖液进行固液分离，并通过超滤膜过滤得到的溶液成分，回收作为非渗透物的丝状真菌衍生的纤维素酶，得到作为渗透液的糖液。
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公开(公告)号：US20130203117A1
公开(公告)日：2013-08-08
申请号：US13634961
申请日：2011-03-14
摘要： A method produces a sugar liquid by repeating a sugar liquid production process including (1) to (3): (1) adding a filamentous fungus-derived cellulase to cellulose to perform primary hydrolysis; (2) adding a fresh filamentous fungus-derived cellulase to the hydrolysate in Step (1) to perform secondary hydrolysis; and (3) subjecting the hydrolysate in Step (2) to solid-liquid separation to obtain a sugar liquid, from which a recovered enzyme is obtained; wherein the recovered enzyme obtained in Step (3) is used for Step (1) of the next and later sugar liquid production processes.
摘要翻译： 通过重复含有（1）〜（3）的糖液制造方法，可以得到糖液的方法：（1）向纤维素中加入丝状真菌衍生的纤维素酶进行初级水解; （2）在步骤（1）中向水解产物中加入新鲜的丝状真菌衍生的纤维素酶进行二次水解; 和（3）将步骤（2）中的水解产物进行固液分离，得到糖液，由此得到回收的酶; 其中步骤（3）中获得的回收酶用于下一个和后来的糖液生产过程的步骤（1）。
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29.发明申请POLYPEPTIDE HAVING D-LACTATE DEHYDROGENASE ACTIVITY, POLYNUCLEOTIDE ENCODING THE POLYPEPTIDE, AND PROCESS FOR PRODUCTION OF D-LACTIC ACID 有权具有D-脱水脱氢酶活性的多肽，编码多肽的多核苷酸以及D-乳酸的生产方法公开(公告)号：US20120070871A1
公开(公告)日：2012-03-22
申请号：US13375882
申请日：2010-06-02
申请人： Kenji Sawai , Kazumi Suda , Hideki Sawai , Katsushige Yamada , Junya Yamagishi
发明人： Kenji Sawai , Kazumi Suda , Hideki Sawai , Katsushige Yamada , Junya Yamagishi
CPC分类号： C12P7/56 , C12N9/0006
摘要： Highly productive D-lactic acid fermentation uses a transformant obtained by introducing into a host cell a polynucleotide encoding a polypeptide according to any one of the following (A) to (C) in such a manner that the polypeptide is expressed, which polypeptide has a D-lactate dehydrogenase activity higher than those of conventional polypeptides: (A) a polypeptide having the amino acid sequence shown in SEQ ID NO:1 or 2; (B) a polypeptide having the same amino acid sequence as shown in SEQ ID NO:1 or 2 except that one or several amino acids are substituted, deleted, inserted and/or added, which polypeptide has a D-lactate dehydrogenase activity; and (C) a polypeptide having an amino acid sequence which has a sequence identity of not less than 80% to the amino acid sequence shown in SEQ ID NO:1 or 2, which polypeptide has a D-lactate dehydrogenase activity.
摘要翻译： 高生产率D-乳酸发酵使用通过向宿主细胞中引入编码根据下列（A）至（C）中任一项所述的多肽的多核苷酸而获得的转化体，使得多肽表达， D-乳酸脱氢酶活性高于常规多肽的活性：（A）具有SEQ ID NO：1或2所示氨基酸序列的多肽; （B）具有与SEQ ID NO：1或2所示相同氨基酸序列的多肽，不同之处在于一个或几个氨基酸被取代，缺失，插入和/或添加，该多肽具有D-乳酸脱氢酶活性; 和（C）具有与SEQ ID NO：1或2所示的氨基酸序列具有不小于80％的序列同一性的氨基酸序列的多肽，该多肽具有D-乳酸脱氢酶活性。
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公开(公告)号：US20110053231A1
公开(公告)日：2011-03-03
申请号：US12865934
申请日：2009-02-03
IPC分类号： C12P7/56
CPC分类号： C12P7/56
摘要： A method of producing lactic acid continuous fermentation including filtering a culture of polyploid yeast having a capacity to produce lactic acid through a porous membrane having an average pore size of not less than 0.01 μm and less than 1 μm, and recovering the product from the filtrate while the unfiltered liquid is retained in or returned to the culture and a fermentation feedstock is added to the culture.
摘要翻译： 一种生产乳酸连续发酵的方法，包括通过平均孔径不小于0.01μm且小于1μm的多孔膜过滤具有生产乳酸能力的多倍体酵母的培养物，并从滤液中回收产物 而未过滤的液体保留在或返回到培养物中，并且向培养物中加入发酵原料。
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