公开(公告)号：US20100132909A1

公开(公告)日：2010-06-03

申请号：US12469804

申请日：2009-05-21

申请人： Thomas Meier

发明人： Thomas Meier

IPC分类号： B22D11/08

CPC分类号： B22D11/083 ,  B22D11/088

摘要： In a system for sealing a dummy bar head in a mould of a continuous casting plant for casting large-format preliminary sections, a flat gasket (6) to seal the gap between the dummy bar head and the mould is provided, which is held on a packing plate (7) contained on the dummy bar head. Said packing plate has approximately the cross-sectional shape of the mould profile and covers the flat gasket (6). The packing plate (7) is displaceable towards the centre of the mould by an amount which is a function of the conicity of the mould (3). To this end, it consists of two plate halves (7a, 7b) lying in one plane with respect to each other. This makes it possible, when inserting the dummy bar head, to compensate for the angled course of the mould with the contracting packing plate until the sealing gap between packing plate and mould remains uniform on all sides.

摘要翻译： 在用于铸造大型预备部分的连续铸造设备的模具中密封虚拟棒头的系统中，提供了用于密封虚拟棒头和模具之间的间隙的平垫圈（6），其保持在 包含在虚拟棒头上的包装板（7）。 所述包装板具有近似于模型轮廓的横截面形状并覆盖平垫圈（6）。 包装板（7）可以朝着模具的中心移动一定量，该量是模具（3）的锥度的函数。 为此，它由相对于彼此位于一个平面中的两个半板（7a，7b）组成。 这使得当插入虚拟棒头时，可以用收缩包装板补偿模具的成角度的过程，直到包装板和模具之间的密封间隙在所有方面保持均匀。

公开(公告)号：US20090071846A1

公开(公告)日：2009-03-19

申请号：US12175578

申请日：2008-07-18

申请人： Arnulf Staib ,  Thomas Meier ,  Reinhold Mischler ,  Harald Peschel ,  Martin Hajnsek

发明人： Arnulf Staib ,  Thomas Meier ,  Reinhold Mischler ,  Harald Peschel ,  Martin Hajnsek

IPC分类号： G01N27/26 ,  B05D5/12

CPC分类号： C12Q1/001 ,  G01N27/3272

摘要： The disclosure concerns a high efficiency electrochemical sensor with high signal yield for determining an analyte in a fluid medium comprising, at least one reference electrode, at least one working electrode having particles of an electrocatalyst in an electrode matrix, and an enzyme that is suitable for determining an analyte is selectively covalently bound to the particles of the electrocatalyst. The disclosure also describes a process for producing the electrochemical sensor and a method for determining an analyte in a fluid medium using the electrochemical sensor. have a high efficiency and thus achieve a high signal yield.

摘要翻译： 本公开涉及具有高信号收率的高效电化学传感器，用于确定流体介质中的分析物，所述流体介质包括至少一个参比电极，至少一个在电极基质中具有电催化剂颗粒的工作电极和适于 选择性地共价结合分析物与电催化剂的颗粒结合。 本公开还描述了用于生产电化学传感器的方法和使用电化学传感器确定流体介质中的分析物的方法。 具有高效率，从而达到高信号收率。

公开(公告)号：US07348423B2

公开(公告)日：2008-03-25

申请号：US10969624

申请日：2004-10-20

申请人： Eva Hoess ,  Thomas Meier ,  Gabriele Pestlin ,  Friedrich Popp ,  Klaus Reichert ,  Rainer Schmuck ,  Bernd Schneidinger ,  Christoph Seidel ,  Wilhelm Tischer

发明人： Eva Hoess ,  Thomas Meier ,  Gabriele Pestlin ,  Friedrich Popp ,  Klaus Reichert ,  Rainer Schmuck ,  Bernd Schneidinger ,  Christoph Seidel ,  Wilhelm Tischer

IPC分类号： A61K39/21

CPC分类号： C07K14/005 ,  C07K2319/00 ,  C12N2740/15022 ,  C12N2740/16122 ,  C12P21/02

摘要： A process is disclosed for the production of an antifusogenic peptide by producing a fusion peptide of a length of about 14 to 70 amino acids in a prokaryotic host cell, comprising the steps, under such conditions that inclusion bodies of said fusion peptide are formed, of: (a) expressing in said host cell a nucleic acid encoding said fusion peptide consisting of a first peptide which is an antifusogenic peptide of a length of about 10 to 50 amino acids and a second peptide of a length of about 4 to 30 amino acids, said first peptide being N-terminally linked to said second peptide; (b) cultivating said host cell to produce said inclusion bodies; and (c) recovering said antifusogenic peptide from said inclusion bodies, wherein said recovered antifusogenic peptide consists of said fusion peptide or a peptide comprising the antifusogenic peptide of about 10 to 50 amino acids and which is a fragment cleaved from said fusion peptide. Inclusion bodies of the peptides are disclosed. Also disclosed is a nucleic acid encoding the fusion peptide consisting of a first peptide which is an antifusogenic peptide selected from the group of SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 10, and said sequences further consisting of glycine at the C terminal end, N-terminally linked to the second peptide.

摘要翻译： 公开了通过在原核宿主细胞中产生约14至70个氨基酸长度的融合肽来生产抗融合肽的方法，包括以下步骤：在形成所述融合肽的包涵体的条件下， （a）在所述宿主细胞中表达编码所述融合肽的核酸，所述融合肽由长度为约10至50个氨基酸的抗融合肽的第一肽和长度为约4-30个氨基酸的第二个肽组成 所述第一肽与所述第二肽N-末端连接; （b）培养所述宿主细胞以产生所述包涵体; 和（c）从所述包涵体中回收所述抗融合肽，其中所述回收的抗融合肽由所述融合肽或包含约10至50个氨基酸的抗融合肽的肽组成，并且是从所述融合肽切割的片段。 公开了肽的包涵体。 还公开了编码由第一肽组成的融合肽的核酸，第一肽是选自SEQ ID NO：7，SEQ ID NO：8，SEQ ID NO：9，SEQ ID NO：10的抗融合肽， 所述序列进一步由C末端的甘氨酸组成，N-末端与第二肽连接。

公开(公告)号：US20070062231A1

公开(公告)日：2007-03-22

申请号：US10579576

申请日：2004-11-15

申请人： Herbert Spindler ,  Ute Bauermeister ,  Thomas Meier ,  Michael Teske

发明人： Herbert Spindler ,  Ute Bauermeister ,  Thomas Meier ,  Michael Teske

IPC分类号： C05D9/02

CPC分类号： C05F17/0018 ,  C05C3/005 ,  C05D3/02 ,  C05F3/00 ,  Y02A40/205 ,  Y02E50/343 ,  Y02P20/145 ,  Y02W30/43 ,  C05D9/00 ,  C05F3/06

摘要： The invention relates to a method and a device for producing nitrogen fertilizer from organic waste products in the liquid phase (suspension, emulsion, solution) and for hygienizing the wastes or reducing the emissions by thermal treatment using mineral or organic additions. According to the invention, this is achieved by a method, wherein the waste product is heated at underpressure to temperatures between 40 and 90 ° C., the escaping gas containing carbon dioxide and ammonia is cooled down and introduced into an aqueous absorption agent, the nitrogen fertilizer formed thereby is discharged and the excess gas not having been absorbed and containing carbon dioxide is pumped back into the discharge container, wherein the underpressure generated at the beginning of the process by a vacuum pump is autogenously maintained by the progress of the process. Suitably, the return of the excess gas into the cycle is performed by either conducting it immediately above the waste product to be treated, or through a gas cooling system above the waste product to be treated, or dividing it and conducting a partial flow through the waste product and another partial flow above the waste product. Preferably, a gypsum suspension is used as an aqueous absorption agent.

摘要翻译： 本发明涉及一种用于从液相（悬浮液，乳液，溶液）中的有机废物生产氮肥的方法和装置，并且用于通过使用矿物或有机添加物的热处理来对废物进行卫生或减少排放。 根据本发明，这是通过一种方法实现的，其中将废物在负压下加热到40-90℃的温度，将含有二氧化碳和氨的逸出气体冷却并引入含水吸收剂中， 由此形成的氮肥被排出，并且未被吸收并含有二氧化碳的过量气体被泵送回排放容器中，其中通过真空泵开始生成的负压通过该过程的进行而被自动维持。 适当地，将过量气体返回循环是通过将其立即在要处理的废物上方进行，或者通过待处理的废物上方的气体冷却系统进行，或者将其分开并进行部分流过 废物和废物上方的另一部分流动。 优选使用石膏悬浮液作为水性吸收剂。

公开(公告)号：US07008006B2

公开(公告)日：2006-03-07

申请号：US10608447

申请日：2003-06-30

申请人： Dieter Steinhauser ,  Thomas Meier

发明人： Dieter Steinhauser ,  Thomas Meier

IPC分类号： B62D29/04

CPC分类号： B62D27/026 ,  B62D21/10 ,  B62D23/00 ,  B62D25/04 ,  B62D25/20

摘要： A structure is provided which is suitable for a passenger vehicle, containing a passenger cell with a windshield frame. For optimization of this structure with regard to advantageous manufacture and purposeful stability, panel structure and windshield frame consist of high-strength non-metallic material, e.g. fiber reinforced plastic, and are structurally joined.

摘要翻译： 提供一种适用于乘客车辆的结构，其包含具有挡风玻璃框架的乘客舱。 为了在有利的制造和有目的的稳定性方面优化该结构，面板结构和挡风玻璃框架由高强度非金属材料，例如， 纤维增强塑料，并在结构上结合。

公开(公告)号：US20050222218A1

公开(公告)日：2005-10-06

申请号：US10519430

申请日：2003-07-01

申请人： Thomas Meier ,  Matthias Jauslin ,  Fabrice Schoumacher

发明人： Thomas Meier ,  Matthias Jauslin ,  Fabrice Schoumacher

IPC分类号： G01N33/68 ,  C12Q1/00 ,  A61K31/41

CPC分类号： G01N33/6896 ,  G01N2500/10 ,  G01N2800/2835

摘要： The present invention relates to a method for identifying and/or validating candidate substances for the treatment of Friedreich Ataxia (FRDA). Furthermore, the present invention relates to the use of selenium, Ebselen and Glutathione peroxidase (GPX) mimetics for the preparation of a medicament for the treatment of FRDA. Another aspect of the present invention relates to the use of cells with reduced frataxin expression for identifying and/or validating candidate substances for the treatment of Friedreich Ataxia.

摘要翻译： 本发明涉及用于鉴定和/或验证用于治疗弗里德赖希共济失调（FRDA）的候选物质的方法。 此外，本发明涉及硒，依布硒和谷胱甘肽过氧化物酶（GPX）模拟物在制备用于治疗FRDA的药物中的用途。 本发明的另一方面涉及具有降低的frataxin表达的细胞用于鉴定和/或验证用于治疗Friedreich共济失调的候选物质的用途。

公开(公告)号：US06905689B2

公开(公告)日：2005-06-14

申请号：US10624154

申请日：2003-07-21

申请人： Bernd Schneidinger ,  Thomas Meier ,  Rainer Schmuck ,  Zhixin Shao

发明人： Bernd Schneidinger ,  Thomas Meier ,  Rainer Schmuck ,  Zhixin Shao

IPC分类号： G01N33/573 ,  C12N9/14 ,  C12N9/16 ,  C12N15/09 ,  C12Q1/42 ,  G01N33/96 ,  A61K39/385 ,  C07H21/04 ,  C07K14/00

CPC分类号： G01N33/96 ,  C12N9/14 ,  C12Q1/42

摘要： A conjugate of a tissue non-specific alkaline phosphatase (tns-AP) and dextran which can be obtained by reacting unglycosylated tns-AP with activated dextran by incubation in aqueous solution, stopping the reaction and isolating the conjugate from the solution. The conjugate obtained in this manner is suitable as a standard for the determination of alkaline phosphatase.

摘要翻译： 组织非特异性碱性磷酸酶（tns-AP）和葡聚糖的缀合物，其可以通过在水溶液中温育而使未糖基化的tns-AP与活化的葡聚糖反应而获得，停止反应并从溶液中分离缀合物。 以这种方式获得的缀合物适合作为碱性磷酸酶测定的标准。

公开(公告)号：US06857695B2

公开(公告)日：2005-02-22

申请号：US10715858

申请日：2003-11-19

申请人： Oliver Stoffels ,  André Scholz ,  Thomas Meier

发明人： Oliver Stoffels ,  André Scholz ,  Thomas Meier

IPC分类号： B62D25/04 ,  B60J7/02 ,  B60J7/11 ,  B60R21/13

CPC分类号： B60J7/11

摘要： A body of a motor vehicle, particularly a passenger car of the sports car type, equipped with a windshield frame, a rollover bar system and a removable roof covering an area between the windshield frame and the rollover bar system. The roof on one side follows a convex shaping course of the windshield frame and, on the other side, follows a shaping course of the rollover bar system such that, viewed in the longitudinal direction of the passenger car, the roof has two lateral roof sections and a center roof section which extends between the lateral roof sections in the manner of a crease-type indentation shaped in the direction of the vehicle occupant compartment.

摘要翻译： 一种机动车辆，特别是跑车类型的客车，配备有挡风玻璃框架，翻车杆系统和覆盖挡风玻璃框架和翻车杆系统之间的区域的可移除屋顶。 一侧的屋顶遵循挡风玻璃框架的凸形成形过程，另一侧遵循翻车杆系统的成形过程，使得从客车的纵向方向看，屋顶具有两个侧顶部段 以及中心屋顶部分，其以在车辆乘员舱的方向上成形的折痕式凹陷的方式在侧顶部分之间延伸。

公开(公告)号：US06769767B2

公开(公告)日：2004-08-03

申请号：US09845425

申请日：2001-04-30

申请人： Gregory Swab ,  James E. Malackowski ,  Mikal Greaves ,  Rolf Milesi ,  Christiaan Ligtenberg ,  Thomas Meier

发明人： Gregory Swab ,  James E. Malackowski ,  Mikal Greaves ,  Rolf Milesi ,  Christiaan Ligtenberg ,  Thomas Meier

IPC分类号： G02C100

CPC分类号： G02C11/10 ,  G01N30/02 ,  G02C5/146 ,  G02C5/22 ,  G06F1/163 ,  H04W4/80 ,  H04W52/248 ,  H04W56/0015 ,  H04W84/18 ,  Y10T16/526 ,  B01D2015/3895

摘要： A wireless ad hoc pico network is formed by eyewear and other devices such as a computer, a bracelet and a telephone having similar transceivers mounted on them. Master slave relationships are configurable. Other devices, such as a radio, a CD player, a hand held global positioning satellite system and a heart rate monitor, having similar transceivers, can also be connected with the transceiver of the eyewear. The transceivers operate on globally available, unlicensed radio band, 2.45 gigahertz (GHz) and conforms to the Bluetooth standard. The power consumption of Bluetooth enabled devices is less than three percent of the power consumption of a mobile phone. The eyewear includes a frame and connected to the frame are two temples. Temples are connected to frame via hinges. Temples have a male portion of a connector incorporated in them. Female portion of the connector is made integral with the hinges. When the male portion is inserted in the female portion the temple is attached to the frame. The temples can be removed by pulling the connector apart, and a temple with different apparatus within it can be inserted in place of the removed temples. The temple may have co-molded within its body, an apparatus such as an audio device, a camera, a speaker, and a microphone, and a display device such as liquid crystal or an alarm. In another embodiment, eyewear constitutes a distance alarm to monitor the movement of, for example, a child. A device in form of, for example, a bracelet is worn by the child. The transceivers in the eyewear and the bracelet form a small-range wireless network, i.e., piconet, wherein the eyewear and the bracelet communicate using signals conforming to the Bluetooth technology. The transceiver in the eyewear is configured to generate an alarm when the bracelet exceeds a predetermined distance from eyewear.

摘要翻译： 无线特设微微网络由眼镜和诸如计算机，手镯和具有安装在其上的类似收发器的电话的其他设备形成。 主从关系是可配置的。 具有类似收发器的其他设备，例如无线电，CD播放器，手持式全球定位卫星系统和心率监测器也可以与眼镜的收发器连接。 收发器在全球可用的无符号无线电频段（2.45千兆赫兹（GHz））上运行，符合蓝牙标准。 蓝牙设备的功耗小于手机功耗的3％。 眼镜包括框架并连接到框架上是两个寺庙。 寺庙通过铰链连接到框架。 寺庙具有并入其中的连接器的阳性部分。 连接器的母头部分与铰链成一体。 当阳部插入阴部时，镜腿与框架相连。 可以通过将连接器分开拉出来去除镜腿，并且可以插入具有不同装置的镜腿以代替去除的镜腿。 镜子可以在其主体内共模塑，诸如音频设备，照相机，扬声器和麦克风之类的装置，以及诸如液晶或报警器的显示装置。 在另一个实施例中，眼镜构成监视例如儿童的运动的距离警报。 例如，手镯的形式的装置由小孩佩戴。 眼镜和手镯中的收发器形成小范围无线网络，即微微网，其中眼镜和手镯使用符合蓝牙技术的信号进行通信。 眼镜上的收发器配置为当手链超过眼镜预定距离时产生报警。

公开(公告)号：US06587071B2

公开(公告)日：2003-07-01

申请号：US09958564

申请日：2002-02-08

申请人： Thomas Meier

发明人： Thomas Meier

IPC分类号： G01S1393

CPC分类号： G01S13/18 ,  G01S13/12

摘要： A device which can accurately detect even objects in very close proximity to a vehicle and at the same time can reliably detect more distant objects has means (MM) that can execute a selection of those reception pulses (EI) whose chronological offset in comparison to the respective transmission pulses (SI) emitted is of such a magnitude that these reception signals (EI) result exclusively from reflections against objects from a selected distance range correlating to the chronological offset. Means (DG) are also provided that permit the transmission pulse power to be increased and decreased as the distance range rises and falls.