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58 条记录 (耗时 0.038 秒)

    Bioadhesive nanoparticulate compositions having cationic surface stabilizers
    22.
    发明授权
    Bioadhesive nanoparticulate compositions having cationic surface stabilizers 有权
    具有阳离子表面稳定剂的生物粘附纳米颗粒组合物

    公开(公告)号：US07288267B2

    公开(公告)日：2007-10-30

    申请号：US10004808

    申请日：2001-12-07

    申请人： H. William Bosch ,  Eugene R. Cooper ,  Simon L. McGurk

    发明人： H. William Bosch ,  Eugene R. Cooper ,  Simon L. McGurk

    IPC分类号： A61K9/14 ,  A61K9/16

    CPC分类号： A01N25/12 ,  A01N25/24 ,  A01N25/30 ,  A61K8/0241 ,  A61K8/36 ,  A61K8/416 ,  A61K8/49 ,  A61K8/553 ,  A61K8/63 ,  A61K8/73 ,  A61K8/731 ,  A61K8/8147 ,  A61K8/8182 ,  A61K9/113 ,  A61K9/145 ,  A61K9/146 ,  A61K2800/413 ,  A61K2800/612 ,  A61K2800/614 ,  A61Q5/00 ,  A61Q19/00 ,  B82Y5/00

    摘要： Bioadhesive nanoparticulate compositions, comprising active agent particles and one or more cationic surface stabilizers, are described. The cationic surface stabilizers prevent aggregation of the nanoparticles and increase bioadhesion of the nanoparticles to biological substrates, such as an insect, teeth, bone, nails, chitin, feathers, scales, mucous, skin, hair, plant tissue, etc. The particles may consist of pharmacologically active compounds (e.g., drug compounds for human or veterinary use), agricultural chemicals (pesticides, herbicides, fertilizers, and the like), cosmetic agents, consumer products (coloring agents, flavors, or fragrances), or other materials which function by interacting with biological substrates. In addition, the invention relates to methods of preparing and using such bioadhesive nanoparticulate compositions.

    摘要翻译： 描述了包含活性剂颗粒和一种或多种阳离子表面稳定剂的生物粘附纳米颗粒组合物。 阳离子表面稳定剂防止纳米颗粒聚集并增加纳米颗粒对生物底物（如昆虫，牙齿，骨骼，指甲，甲壳质，羽毛，鳞屑，粘液，皮肤，毛发，植物组织等）的生物粘附。 化学药剂，消费品（着色剂，调味剂或香料）或其他材料的药物活性化合物（例如，用于人或兽用药物的化合物），农药（农药，除草剂，肥料等） 通过与生物底物相互作用起作用。 此外，本发明涉及制备和使用这些生物粘附纳米颗粒组合物的方法。

    Compositions of iodophenoxy alkanes and iodophenyl ethers in film-forming materials for visualization of the gastrointestinal tract
    23.
    发明授权
    Compositions of iodophenoxy alkanes and iodophenyl ethers in film-forming materials for visualization of the gastrointestinal tract 失效
    用于可视化胃肠道的成膜材料中碘苯氧基烷烃和碘苯基醚的组成

    公开(公告)号：US5326553A

    公开(公告)日：1994-07-05

    申请号：US12171

    申请日：1993-02-02

    申请人： Carl R. Illig ,  Eugene R. Cooper ,  John L. Toner ,  Donald A. Upson ,  Brent D. Douty ,  Thomas J. Caulfield ,  Bacon, Edward R. ,  Kimberly G. Estep ,  Kurt A. Josef ,  Shaughnessy Robinson ,  Paul P. Spara

    发明人： Carl R. Illig ,  Eugene R. Cooper ,  John L. Toner ,  Donald A. Upson ,  Brent D. Douty ,  Thomas J. Caulfield ,  Bacon, Edward R. ,  Kimberly G. Estep ,  Kurt A. Josef ,  Shaughnessy Robinson ,  Paul P. Spara

    IPC分类号： A61K49/04 ,  A61K31/075

    CPC分类号： A61K49/0433 ,  Y10S514/941 ,  Y10S514/942

    摘要： Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material capable of forming a coating on the gastrointestinal tract and an x-ray producing agent of the formula ##STR1## and methods for their use in diagnostic radiology of the gastrointestinal tract whereinZ=H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;R=C.sub.1 -C.sub.25 alkyl, cycloalkyl, or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxycarbonyloxy, (CR.sub.1 R.sub.2).sub.p-- (CR.sub.3 .dbd.CR.sub.4).sub.m Q, or (CR.sub.1 R.sub.2).sub.p --C.tbd.C--Q;R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently lower-alkyl, optionally substituted with halo;x is 1-4;n is 1-5;m is 1-15;p is 1-10; andQ is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkylin a pharmaceutically acceptable carrier.

    摘要翻译： 公开了用于口腔或逆行检查胃肠道的x射线造影剂组合物，其包含能够在胃肠道上形成涂层的聚合物材料和具有式“IMAGE”的X射线产生剂及其用于诊断放射学的方法 的胃肠道，其中Z = H，卤素，C 1 -C 20烷基，环烷基，低级烷氧基，氰基，其中烷基和环烷基可被卤素或卤代低级烷基取代; 任选被卤素，氟 - 低级 - 烷基，芳基，低级 - 烷氧基，羟基，羧基，低级 - 烷氧基羰基或低级 - 烷氧基羰基氧基取代的C 1 -C 25烷基，环烷基或卤代低级烷基，（CR 1 R 2）p - （CR3 = CR4）mQ，或（CR1R2）pC 3BOND CQ; R 1，R 2，R 3和R 4独立地为低级烷基，任选被卤素取代; x为1-4; n为1-5; m为1-15; p为1-10; Q为药学上可接受的载体中的H，低级烷基，低级烯基，低级炔基，低级亚烷基，芳基或芳基 - 低级烷基。

    Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one
    24.
    发明授权
    Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one 失效
    含有1-十二烷基 - 氮杂环庚烷-2-酮的渗透性局部药物组合物

    公开(公告)号：US4557934A

    公开(公告)日：1985-12-10

    申请号：US506275

    申请日：1983-06-21

    申请人： Eugene R. Cooper

    发明人： Eugene R. Cooper

    IPC分类号： A61K9/06 ,  A61K9/70 ,  A61K31/52 ,  A61K31/57 ,  A61K47/08 ,  A61K47/22 ,  A01N59/26 ,  A61K33/42

    CPC分类号： A61K47/22 ,  A61K31/57 ,  A61K9/0014 ,  Y10S514/947

    摘要： Improved topical pharmaceutical compositions containing a pharmaceutically-active agent and the penetration enhancing agent 1-dodecylazacycloheptan-2-one are disclosed. This agent is used at selected levels in combination with certain C.sub.3 -C.sub.4 diols or a 1-substituted azacycloalkyl-2-one. This composition provides marked transepidermal and percutaneous delivery of the selected pharmaceutically-active agent. A method of treating certain pathologies and conditions responsive to the selected active, systemically or locally, is also disclosed.

    摘要翻译： 公开了含有药物活性剂和渗透促进剂1-十二烷基氮杂环庚烷-2-酮的改进的局部药物组合物。 该试剂与某些C3-C4二醇或1-取代的氮杂环烷基-2-酮组合使用。 该组合物提供所选择的药物活性剂的显着经皮和经皮递送。 还公开了对所选择的活性物质，系统地或局部反应的某些病理学和病症的治疗方法。

    Transscleral delivery
    26.
    发明授权
    Transscleral delivery 有权
    跨收运

    公开(公告)号：US07585517B2

    公开(公告)日：2009-09-08

    申请号：US10945682

    申请日：2004-09-20

    申请人： Eugene R. Cooper ,  David M. Kleinman ,  Thierry Nivaggioli ,  Philippe J M Dor ,  Sreenivasu Mudumba

    发明人： Eugene R. Cooper ,  David M. Kleinman ,  Thierry Nivaggioli ,  Philippe J M Dor ,  Sreenivasu Mudumba

    IPC分类号： A61F2/00 ,  C12P21/04 ,  A61K38/00 ,  A61K31/44 ,  A61K31/445

    CPC分类号： A61K9/0048 ,  A61K9/0019 ,  A61K31/436

    摘要： Diseases associated with the tissues in the posterior segment of the eye can be effectively treated by administering therapeutic agents transsclerally to those tissues. Compositions, devices, and methods for delivering therapeutic agents so that they cross the sclera and reach these tissues include injecting solutions or suspensions adjacent to or within the sclera and implanting solid structures containing the therapeutic agent adjacent to or within the sclera. These methods may be used for administering rapamycin or related compounds to treat choroidal neovascularization associated with age-related macular degeneration.

    摘要翻译： 通过将这些组织交叉施用治疗剂，可以有效地治疗与眼后段组织相关的疾病。 用于递送治疗剂使得它们穿过巩膜并到达这些组织的组合物，装置和方法包括在巩膜附近或在巩膜附近注射溶液或悬浮液，并植入包含与巩膜内或巩膜内的治疗剂的固体结构。 这些方法可用于施用雷帕霉素或相关化合物以治疗与年龄相关的黄斑变性相关的脉络膜新生血管形成。

    Local anti-infective agent for treatment of nail fungal infections
    27.
    发明申请
    Local anti-infective agent for treatment of nail fungal infections 审中-公开
    用于治疗指甲真菌感染的局部抗感染药

    公开(公告)号：US20080193508A1

    公开(公告)日：2008-08-14

    申请号：US12028188

    申请日：2008-02-08

    申请人： David M. Cohen ,  Eugene R. Cooper

    发明人： David M. Cohen ,  Eugene R. Cooper

    IPC分类号： A61K31/195 ,  A61K31/20 ,  A61K31/19 ,  A61K9/70 ,  A61P31/00 ,  A61K31/135 ,  A61K31/192

    CPC分类号： A61Q17/005 ,  A61K8/36 ,  A61K8/361 ,  A61K8/368 ,  A61K8/4926 ,  A61Q3/00

    摘要： A topical composition for treating nail fungal infections that utilizes an acidic antifungal agent with a molecular weight no greater than 170 Daltons in a formulation having a pH less than or equal to the pKa of the acidic antifungal agent plus one. Possible antifungal agents include omadine, octanoic acid, sorbic acid, hexanoic acid, and benzoic acid. The antifungal agent can be combined with a delivery system such as a lacquer, a gel, a patch, or a hydrating system. A second therapeutic agent such as a 5-fluorocystine or terbinafine can be included.

    摘要翻译： 用于治疗指甲真菌感染的局部组合物，其在pH小于或等于酸性抗真菌剂的pKa加1的制剂中使用分子量不超过170道尔顿的酸性抗真菌剂。 可能的抗真菌剂包括奥马丁，辛酸，山梨酸，己酸和苯甲酸。 抗真菌剂可以与输送系统如漆，凝胶，贴剂或保湿系统组合。 可以包括第二种治疗剂如5-氟胞嘧啶或特比萘芬。

    Bioadhesive nanoparticulate compositions having cationic surface stabilizers
    29.
    发明授权
    Bioadhesive nanoparticulate compositions having cationic surface stabilizers 失效
    具有阳离子表面稳定剂的生物粘附纳米颗粒组合物

    公开(公告)号：US06428814B1

    公开(公告)日：2002-08-06

    申请号：US09414159

    申请日：1999-10-08

    申请人： H. William Bosch ,  Eugene R. Cooper ,  Simon L. McGurk

    发明人： H. William Bosch ,  Eugene R. Cooper ,  Simon L. McGurk

    IPC分类号： A61K950

    CPC分类号： A01N25/12 ,  A01N25/24 ,  A01N25/30 ,  A61K8/0241 ,  A61K8/36 ,  A61K8/416 ,  A61K8/49 ,  A61K8/553 ,  A61K8/63 ,  A61K8/73 ,  A61K8/731 ,  A61K8/8147 ,  A61K8/8182 ,  A61K9/113 ,  A61K9/145 ,  A61K9/146 ,  A61K2800/413 ,  A61K2800/612 ,  A61K2800/614 ,  A61Q5/00 ,  A61Q19/00 ,  B82Y5/00

    摘要： Bioadhesive nanoparticulate compositions, comprising active agent particles and one or more cationic surface stabilizers, are described. The cationic surface stabilizers prevent aggregation of the nanoparticles and increase bioadhesion of the nanoparticles to biological substrates, such as an insect, teeth, bone, nails, chitin, feathers, scales, mucous, skin, hair, plant tissue, etc. The particles may consist of pharmacologically active compounds (e.g., drug compounds for human or veterinary use), agricultural chemicals (pesticides, herbicides, fertilizers, and the like), cosmetic agents, consumer products (coloring agents, flavors, or fragrances), or other materials which function by interacting with biological substrates. In addition, the invention relates to methods of preparing and using such bioadhesive nanoparticulate compositions.

    摘要翻译： 描述了包含活性剂颗粒和一种或多种阳离子表面稳定剂的生物粘附纳米颗粒组合物。 阳离子表面稳定剂防止纳米颗粒聚集并增加纳米颗粒对生物底物（如昆虫，牙齿，骨骼，指甲，甲壳质，羽毛，鳞屑，粘液，皮肤，毛发，植物组织等）的生物粘附。 化学药剂，消费品（着色剂，调味剂或香料）或其他材料的药物活性化合物（例如，用于人或兽用药物的化合物），农药（农药，除草剂，肥料等） 通过与生物底物相互作用起作用。 此外，本发明涉及制备和使用这些生物粘附纳米颗粒组合物的方法。