公开(公告)号：US11169125B2

公开(公告)日：2021-11-09

申请号：US16384272

申请日：2019-04-15

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Michael O. Fogwill ,  Curt Devlin ,  Theodore A. Dourdeville ,  Jacob N. Fairchild ,  Geoff C. Gerhardt ,  Wade P. Leveille ,  Joseph D. Michienzi ,  Jeffrey Musacchio

IPC: G01N30/00 ,  G01N30/72

Abstract: Techniques and apparatus for ion source devices with minimized post-column volumes are described. In one embodiment, for example, an ion source assembly may include a chromatography column in fluid communication with an ion source device, the chromatography column arranged within a minimum distance of the ion source, the minimum distance comprising between about 60 mm and about 150 mm.

公开(公告)号：US11162517B2

公开(公告)日：2021-11-02

申请号：US16573311

申请日：2019-09-17

Applicant: Waters Technologies Corporation

Inventor： Jeffrey Musacchio ,  Joseph Michienzi

IPC: F16H3/54 ,  F15B15/14 ,  F15B1/04 ,  F15B15/18 ,  F16H3/02 ,  G01N30/02 ,  F16H3/44 ,  G01N30/32 ,  F16H3/64 ,  F16H15/56

Abstract: Disclosed is a liquid chromatography solvent pump including a motor, a first piston, a second piston, and a variable output drive system coupling the motor to at least one of the first piston and the second piston. The variable output drive system includes a gearbox configured to provide a non-equal ratio between an input from the motor and an output delivered to at least one of the first piston and the second piston. The first piston and the second piston are configured to deliver a flow of solvent in a liquid chromatography system.

公开(公告)号：US20210132012A1

公开(公告)日：2021-05-06

申请号：US17084998

申请日：2020-10-30

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Mark J. Basile ,  Jeffrey Musacchio ,  Michael O. Fogwill ,  Sebastien Besner ,  Joseph D. Michienzi ,  Wade P. Leveille

IPC: G01N30/74 ,  G01N30/30

Abstract: Techniques and apparatus for thermally controlled interfaces for separation devices and optical flow cell devices with minimized post-column volumes are described. In one embodiment, for example, a column-optical cell assembly may include an insulating device, a chromatography column arranged within the insulating device, and an optical flow cell in fluid communication with the chromatography column, the chromatography column arranged within a minimum distance of the optical flow cell.

公开(公告)号：US20200088220A1

公开(公告)日：2020-03-19

申请号：US16573311

申请日：2019-09-17

Applicant: Waters Technologies Corporation

Inventor： Jeffrey Musacchio ,  Joseph Michienzi

IPC: F15B15/14 ,  F16H3/02 ,  F15B1/04 ,  F15B15/18 ,  G01N30/02

Abstract: Disclosed is a liquid chromatography solvent pump including a motor, a first piston, a second piston, and a variable output drive system coupling the motor to at least one of the first piston and the second piston. The variable output drive system includes a gearbox configured to provide a non-equal ratio between an input from the motor and an output delivered to at least one of the first piston and the second piston. The first piston and the second piston are configured to deliver a flow of solvent in a liquid chromatography system.

公开(公告)号：US10465808B2

公开(公告)日：2019-11-05

申请号：US16323637

申请日：2017-08-07

Applicant: Waters Technologies Corporation

Inventor： Jeffrey Musacchio ,  Joseph D. Michienzi ,  Keith Fadgen

IPC: F16K15/14 ,  F04B53/10 ,  G01N30/02 ,  G01N30/20 ,  F16J15/3212

Abstract: A check valve includes a first valve body having a chamber in which second and third valve bodies are located. The check valve also includes a spring-energized seal disposed in the chamber. The spring-energized seal includes a compliant seal body having an annular shape and a resilient member, such as a cantered spring or O-ring, disposed in a pocket of the seal body. The resilient member applies a force to portions of the seal body to prevent the passage of fluid from a valve inlet port to a valve outlet port unless the differential fluid exceeds the cracking pressure of the check valve.

公开(公告)号：US20190317062A1

公开(公告)日：2019-10-17

申请号：US16384272

申请日：2019-04-15

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Michael O. Fogwill ,  Curt Devlin ,  Theodore A. Dourdeville ,  Jacob N. Fairchild ,  Geoff C. Gerhardt ,  Wade P. Leveille ,  Joseph D. Michienzi ,  Jeffrey Musacchio

IPC: G01N30/72

Abstract: Techniques and apparatus for ion source devices with minimized post-column volumes are described. In one embodiment, for example, an ion source assembly may include a chromatography column in fluid communication with an ion source device, the chromatography column arranged within a minimum distance of the ion source, the minimum distance comprising between about 60 mm and about 150 mm.

公开(公告)号：US12259369B2

公开(公告)日：2025-03-25

申请号：US17057361

申请日：2019-05-20

Applicant: Waters Technologies Corporation

Inventor： Martin Gilar ,  Thomas S. McDonald ,  Joseph D. Michienzi ,  Jeffrey Musacchio ,  Rachel Mumma ,  Keith Fadgen ,  Geoff C. Gerhardt

IPC: G01N30/06 ,  B01D15/16 ,  B01D15/22 ,  B01D15/38 ,  B01J20/24 ,  B01J20/28 ,  B01J20/288 ,  B01J20/32 ,  G01N1/40 ,  G01N30/00 ,  G01N30/54 ,  G01N30/60 ,  G01N30/88

Abstract: Sample preparation and separation can be performed using a sample cartridge (201). The cartridge includes a barrel (204) with a first and second end, a column segment (209) connected to the second end of the barrel, and a column (205) containing a sorbent material. The sorbent material includes particles that have antibodies attached to them to selectively retain analytes, proteins attached to them to retain certain classes of antibodies, or enzymes attached to them to perform specific modifications to certain classes of molecules. The column segment can be in thermal communication with a temperature control device in order to control the temperature of the column.

公开(公告)号：US12247962B2

公开(公告)日：2025-03-11

申请号：US17057242

申请日：2019-05-20

Applicant: Waters Technologies Corporation

Inventor： Martin Gilar ,  Thomas S. McDonald ,  Joseph D. Michienzi ,  Jeffrey Musacchio ,  Rachel Mumma ,  Keith Fadgen ,  Geoff C. Gerhardt

IPC: G01N30/60 ,  G01N30/00 ,  G01N30/06

Abstract: Methods and devices for the washing, extraction, and separation of a sample in a disposable chromatography cartridge (201) comprising a barrel (204) and a column (205), and especially including reinforcement to the column permitting high-pressure separation.

公开(公告)号：US12222339B2

公开(公告)日：2025-02-11

申请号：US18491132

申请日：2023-10-20

Applicant: Waters Technologies Corporation

Inventor： Wade P. Leveille ,  Joseph D. Michienzi ,  Joseph D. Antocci ,  Jeffrey Musacchio

IPC: G01N30/60

Abstract: A clamp assembly includes a rail extending along the length and configured to receive a first fluidic assembly, and a carriage movably attachable to the rail such that the carriage moves along the rail, the carriage configured to receive a second fluidic assembly, the carriage including an actuator and a stop mechanism. The stop mechanism is configured to selectively prevent and allow movement of the carriage relative to the rail. The stop mechanism is configured to be independently operable from the actuator assembly, and the actuator is configured: to move a chromatography column received by the clamp assembly relative to the rail to create a first fluid tight seal between the chromatography column and the first fluidic assembly, and move the second fluidic assembly relative to the carriage body to create a second fluid tight seal between the second fluidic assembly and the chromatography column.

公开(公告)号：US12181453B2

公开(公告)日：2024-12-31

申请号：US17512864

申请日：2021-10-28

Applicant: Waters Technologies Corporation

Inventor： Wade P. Leveille ,  Joseph D. Michienzi ,  Jeffrey Musacchio ,  Michael O. Fogwill

IPC: G01N30/60 ,  B01D15/22 ,  G01N30/46

Abstract: The exemplary embodiments provide chromatography column positioning assemblies that can ensure that the distance between face seals or other sealing surfaces/mechanisms at the respective ends of a liquid chromatography column is a desired distance (i.e., the length of the liquid chromatography column). The exemplary embodiments can adjust the separation between the face seals to accommodate different length liquid chromatography columns. For example, a chromatography column positioning assembly of an exemplary embodiment can set the distance between face seals to accommodate a 25 mm column, a 50 mm column or a 100 mm column.