公开(公告)号：US20170363590A1

公开(公告)日：2017-12-21

申请号：US15690614

申请日：2017-08-30

Applicant: Waters Technologies Corporation

Inventor： Theodore A. Dourdeville ,  Joshua A. Burnett ,  James E. Usowicz ,  Marc E. Lemelin ,  Lucas O. Tiziani

IPC: G01N30/80 ,  B01L3/02 ,  G01N30/02

CPC classification number: G01N30/80 ,  B01L3/0241 ,  B01L2300/0838 ,  B01L2300/165 ,  G01N2030/027

Abstract: Described is a dispensing needle for a fraction collector. The dispensing needle includes a conduit having a fluid channel to conduct a chromatographic flow, an interior wall that defines the fluid channel, an exterior surface and an endface through which the chromatographic flow is dispensed. The dispensing needle also includes a coating of a hydrocarbon material or a fluorocarbon material that is bonded to the endface. The coating is also bonded to at least a portion of the exterior surface that is adjacent to the endface and at least a portion of the interior wall that is adjacent to the endface. The coating operates to reduce a droplet volume of a liquid dispensed from the endface that may remain at the tip of the dispensing needle. Consequently, the concentration variation in a collected fraction due to a missing droplet or extra droplet is reduced.

公开(公告)号：US09618128B2

公开(公告)日：2017-04-11

申请号：US14529947

申请日：2014-10-31

Applicant: Waters Technologies Corporation

Inventor： Theodore A. Dourdeville ,  Russell L. Keene ,  Theodore D. Ciolkosz ,  James E. Usowicz

IPC: F16K11/085 ,  G01N30/20

CPC classification number: F16K11/0853 ,  G01N30/20 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/207 ,  Y10T137/0396 ,  Y10T137/86871

Abstract: The present invention provides a method and apparatus for substantially eliminating destructive transients of pressure or flow rate which can degrade the efficiency and useful lifetime of chromatography columns. The present invention enables a substantially constant flow of mobile phase liquid to be maintained through the chromatography system by eliminating the flow blockage interval associated with the actuation of sample injection valves. The present invention further provides a method to reduce the pressure and flow rate transients associated with pressurization of the sample loop contents when the sample loop is introduced to chromatography system delivery pressure.

公开(公告)号：US20160169843A1

公开(公告)日：2016-06-16

申请号：US15050929

申请日：2016-02-23

Applicant: Waters Technologies Corporation

Inventor： Bernard Bunner ,  Geoff C. Gerhardt ,  Theodore A. Dourdeville

IPC: G01N30/32 ,  G01L9/00 ,  B01L3/00 ,  G01N30/36

CPC classification number: G01N30/32 ,  B01D15/163 ,  B01L3/502746 ,  B01L2200/0605 ,  B01L2200/146 ,  B01L2300/0663 ,  B01L2300/0867 ,  B01L2300/0883 ,  B01L2300/14 ,  B01L2400/0487 ,  B01L2400/082 ,  B01L2400/086 ,  G01L9/0026 ,  G01L9/0042 ,  G01L9/0055 ,  G01L13/02 ,  G01L13/025 ,  G01L15/00 ,  G01L19/0023 ,  G01N30/00 ,  G01N30/34 ,  G01N30/36 ,  G01N2030/326 ,  G05D7/0676 ,  Y10T137/7762 ,  B01D15/40

Abstract: Flow through pressure sensors for use in fluid chromatography systems include a planar device formed from diffusion bonding of a plurality of metallic sheets and at least one sensing element. The planar device has a top surface, a bottom surface and a flow through channel. A diaphragm formed from a portion of one of the top or bottom surfaces is located adjacent to a sensing region of the flow through channel and is attached to the sensing element. The diaphragm is sized to deflect a distance in response to fluid pressure in the sensing region, which has an internal volume of less than about 25 microliters. The diaphragm and attached sensing element form a pressure sensor that measures strain or deflection of the diaphragm to calculate a pressure within the sensing region.

公开(公告)号：US20150047730A1

公开(公告)日：2015-02-19

申请号：US14529947

申请日：2014-10-31

Applicant: Waters Technologies Corporation

Inventor： Theodore A. Dourdeville ,  Russell L. Keene ,  Theodore D. Ciolkosz ,  James E. Usowicz

IPC: F16K11/085 ,  G01N30/20

CPC classification number: F16K11/0853 ,  G01N30/20 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/207 ,  Y10T137/0396 ,  Y10T137/86871

Abstract: The present invention provides a method and apparatus for substantially eliminating destructive transients of pressure or flow rate which can degrade the efficiency and useful lifetime of chromatography columns. The present invention enables a substantially constant flow of mobile phase liquid to be maintained through the chromatography system by eliminating the flow blockage interval associated with the actuation of sample injection valves. The present invention further provides a method to reduce the pressure and flow rate transients associated with pressurization of the sample loop contents when the sample loop is introduced to chromatography system delivery pressure.

公开(公告)号：US20230393103A1

公开(公告)日：2023-12-07

申请号：US18206989

申请日：2023-06-07

Applicant: Waters Technologies Corporation

Inventor： Matthew A. Lauber ,  Mathew H. DeLano ,  Scott A. McCall ,  Jonathan Belanger ,  Theodore A. Dourdeville ,  Kerri Smith ,  Paul Rainville ,  Dimple Shah ,  Stephen J. Shiner ,  Catalin Doneanu ,  Michael Donegan

IPC: G01N30/56 ,  B01J20/32 ,  B05D1/00 ,  B01J20/291 ,  C23C16/04 ,  C23C16/30 ,  C23C14/04 ,  C23C14/12 ,  C23C14/24 ,  G01N30/60

CPC classification number: G01N30/56 ,  B01J20/3272 ,  B05D1/60 ,  B01J20/291 ,  C23C16/045 ,  C23C16/30 ,  C23C14/046 ,  C23C14/12 ,  C23C14/24 ,  G01N30/6052 ,  B05D2518/10 ,  G01N30/7266

Abstract: A device for separating analytes is disclosed. The device has a sample injector, sample injection needle, sample reservoir container in communication with the sample injector, chromatography column downstream of the sample injector, and fluid conduits connecting the sample injector and the column. The interior surfaces of the fluid conduits, sample injector, sample reservoir container, and column form a flow path having wetted surfaces. A portion of the wetted surfaces of the flow path are coated with an alkylsilyl coating that is inert to at least one of the analytes. The alkylsilyl coating has the Formula I:






R1, R2, R3, R4, R5, and R6 are each independently selected from (C1-C6)alkoxy, —NH(C1-C6)alkyl, —N((C1-C6)alkyl)2, OH, ORA, and halo. RA represents a point of attachment to the interior surfaces of the fluidic system. At least one of R1, R2, R3, R4, R5, and R6 is ORA. X is (C1-C20)alkyl, —O[(CH2)2O]1-20, -(C1-C10)[NH(CO)NH(C1-C10)]1-20-, or -(C1-C10)[alkylphenyl(C1-C10)alkyl]1-20-.

公开(公告)号：US10001463B2

公开(公告)日：2018-06-19

申请号：US15690614

申请日：2017-08-30

Applicant: Waters Technologies Corporation

Inventor： Theodore A. Dourdeville ,  Joshua A. Burnett ,  James E. Usowicz ,  Marc E. Lemelin ,  Lucas O. Tiziani

IPC: G01N30/80 ,  B01L3/02 ,  G01N30/02

CPC classification number: G01N30/80 ,  B01L3/0241 ,  B01L2300/0838 ,  B01L2300/165 ,  G01N2030/027

Abstract: Described is a dispensing needle for a fraction collector. The dispensing needle includes a conduit having a fluid channel to conduct a chromatographic flow, an interior wall that defines the fluid channel, an exterior surface and an endface through which the chromatographic flow is dispensed. The dispensing needle also includes a coating of a hydrocarbon material or a fluorocarbon material that is bonded to the endface. The coating is also bonded to at least a portion of the exterior surface that is adjacent to the endface and at least a portion of the interior wall that is adjacent to the endface. The coating operates to reduce a droplet volume of a liquid dispensed from the endface that may remain at the tip of the dispensing needle. Consequently, the concentration variation in a collected fraction due to a missing droplet or extra droplet is reduced.

公开(公告)号：US12013380B2

公开(公告)日：2024-06-18

申请号：US17731318

申请日：2022-04-28

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Theodore A. Dourdeville

IPC: G01N30/38 ,  G01N30/16 ,  G01N30/32 ,  G01N30/60

CPC classification number: G01N30/38 ,  G01N30/16 ,  G01N30/32 ,  G01N30/6017 ,  G01N30/606 ,  G01N2030/326 ,  G01N2030/328 ,  G01N2030/385

Abstract: The present disclosure relates to methodologies, systems, and apparatus for controlling fluid flow within a chromatography system. The chromatography system includes a mobile phase pump configured to pump a liquid mobile phase through a column and a restrictor positioned downstream of the column and upstream of a detector. The system also includes a valve configured to operate in at least two positions. In a first position, the valve is configured to direct the output of the column to bypass the valve and reach the detector, while in the second position the valve directs the output of the column to waste.

公开(公告)号：US11709155B2

公开(公告)日：2023-07-25

申请号：US16133089

申请日：2018-09-17

Applicant: Waters Technologies Corporation

Inventor： Matthew A. Lauber ,  Mathew H. DeLano ,  Scott A. McCall ,  Jonathan L. Belanger ,  Theodore A. Dourdeville ,  Kerri M. Smith ,  Paul D. Rainville ,  Dimple D. Shah ,  Stephen J. Shiner ,  Catalin Doneanu ,  Michael Donegan

IPC: G01N30/56 ,  B01J20/32 ,  B05D1/00 ,  B01J20/291 ,  C23C16/04 ,  C23C16/30 ,  C23C14/04 ,  C23C14/12 ,  C23C14/24 ,  G01N30/60 ,  G01N30/72

CPC classification number: G01N30/56 ,  B01J20/291 ,  B01J20/3272 ,  B05D1/60 ,  C23C14/046 ,  C23C14/12 ,  C23C14/24 ,  C23C16/045 ,  C23C16/30 ,  G01N30/6052 ,  B05D2518/10 ,  G01N30/7266 ,  G01N2030/567

Abstract: A device for separating analytes is disclosed. The device has a sample injector, sample injection needle, sample reservoir container in communication with the sample injector, chromatography column downstream of the sample injector, and fluid conduits connecting the sample injector and the column. The interior surfaces of the fluid conduits, sample injector, sample reservoir container, and column form a flow path having wetted surfaces. A portion of the wetted surfaces of the flow path are coated with an alkylsilyl coating that is inert to at least one of the analytes. The alkylsilyl coating has the Formula I:




R1, R2, R3, R4, R5, and R6 are each independently selected from (C1-C6)alkoxy, —NH(C1-C6)alkyl, —N((C1-C6)alkyl)2, OH, ORA, and halo. RA represents a point of attachment to the interior surfaces of the fluidic system. At least one of R1, R2, R3, R4, R5, and R6 is ORA. X is (C1-C20)alkyl, —O[(CH2)2O]1-20—, —(C1-C10)[NH(CO)NH(C1-C10)]1-20—, or —(C1-C10)[alkylphenyl(C1-C10)alkyl]1-20-.

公开(公告)号：US09470664B2

公开(公告)日：2016-10-18

申请号：US13939731

申请日：2013-07-11

Applicant: Waters Technologies Corporation

Inventor： Theodore A. Dourdeville ,  Charles Phoebe ,  Rolf Grigat

IPC: G01V3/00 ,  G01N30/04 ,  G01R33/30 ,  G01R33/44 ,  G01N30/82 ,  G01N24/08 ,  G01N30/78 ,  G01N30/84 ,  G01R33/46

CPC classification number: G01N30/04 ,  G01N24/08 ,  G01N24/084 ,  G01N24/085 ,  G01N30/78 ,  G01N30/82 ,  G01N2030/8411 ,  G01R33/302 ,  G01R33/307 ,  G01R33/44 ,  G01R33/46

Abstract: A chromatographic interface for sample handling and manipulation between separations or analyses is provided. The interface has an interfacing unit, a sample acquisition unit, and a sample trapping unit. The sample acquisition unit includes an inflow selector valve, an outflow selector valve, and one or more collection loops. The sample trapping unit includes a trap in fluid communication with the loop and having a stationary phase. The stationary phase can trap an analyte of interest from a fraction of the chromatographic sample separation flow. The tapping unit also has a scavenging gas source and a vacuum source; both can be used to substantially dry the stationary phase.

Abstract translation: 提供了色谱界面，用于分离或分析之间的样品处理和操作。 接口具有接口单元，采样单元和采样单元。 样品采集单元包括流入选择阀，流出选择阀和一个或多个收集回路。 样品捕集单元包括与环流体连通并具有固定相的阱。 固定相可从一部分色谱样品分离流中捕获感兴趣的分析物。 攻丝单元还具有清除气源和真空源; 两者都可用于基本干燥固定相。

公开(公告)号：US09952186B2

公开(公告)日：2018-04-24

申请号：US15050929

申请日：2016-02-23

Applicant: Waters Technologies Corporation

Inventor： Bernard Bunner ,  Geoff C. Gerhardt ,  Theodore A. Dourdeville

IPC: G01L13/02 ,  G01N30/32 ,  B01L3/00 ,  G01N30/34 ,  G01N30/00 ,  G01L15/00 ,  G01L19/00 ,  G05D7/06 ,  G01N30/36 ,  G01L9/00 ,  B01D15/16

CPC classification number: G01N30/32 ,  B01D15/163 ,  B01L3/502746 ,  B01L2200/0605 ,  B01L2200/146 ,  B01L2300/0663 ,  B01L2300/0867 ,  B01L2300/0883 ,  B01L2300/14 ,  B01L2400/0487 ,  B01L2400/082 ,  B01L2400/086 ,  G01L9/0026 ,  G01L9/0042 ,  G01L9/0055 ,  G01L13/02 ,  G01L13/025 ,  G01L15/00 ,  G01L19/0023 ,  G01N30/00 ,  G01N30/34 ,  G01N30/36 ,  G01N2030/326 ,  G05D7/0676 ,  Y10T137/7762 ,  B01D15/40

Abstract: Flow through pressure sensors for use in fluid chromatography systems include a planar device formed from diffusion bonding of a plurality of metallic sheets and at least one sensing element. The planar device has a top surface, a bottom surface and a flow through channel. A diaphragm formed from a portion of one of the top or bottom surfaces is located adjacent to a sensing region of the flow through channel and is attached to the sensing element. The diaphragm is sized to deflect a distance in response to fluid pressure in the sensing region, which has an internal volume of less than about 25 microliters. The diaphragm and attached sensing element form a pressure sensor that measures strain or deflection of the diaphragm to calculate a pressure within the sensing region.