公开(公告)号：US12163934B2

公开(公告)日：2024-12-10

申请号：US17354234

申请日：2021-06-22

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Martin Gilar ,  Joseph D. Michienzi ,  Wade P. Leveille ,  Geoff C. Gerhardt ,  Jeffrey Musacchio ,  Jason F. Hill ,  Sylvain G. Cormier

IPC: G01N30/46 ,  G01N30/02 ,  G01N30/30 ,  G01N30/32 ,  G01N30/72 ,  G01N30/74

Abstract: The exemplary embodiments may provide a collective insulating sleeve for a plurality of chromatography columns or may provide separate insulating sleeve for each of the chromatography columns in a plurality. As a result, column ovens are not needed, and pre-heaters may not be required for each chromatography column in some exemplary embodiments. Thus, parallel column arrangements in the exemplary embodiments may be more compact than conventional arrangements.

公开(公告)号：US20210199624A1

公开(公告)日：2021-07-01

申请号：US17057361

申请日：2019-05-20

Applicant: Waters Technologies Corporation

Inventor： Martin Gilar ,  Thomas S. McDonald ,  Joseph D. Michienzi ,  Jeffrey Musacchio ,  Rachel Mumma ,  Keith Fadgen ,  Geoff C. Gerhardt

IPC: G01N30/06 ,  G01N1/40 ,  G01N30/54 ,  G01N30/60 ,  B01J20/24 ,  B01J20/28 ,  B01J20/288 ,  B01J20/32 ,  B01D15/38 ,  B01D15/22 ,  B01D15/16

Abstract: Sample preparation and separation can be performed using a sample cartridge (201). The cartridge includes a barrel (204) with a first and second end, a column segment (209) connected to the second end of the barrel, and a column (205) containing a sorbent material. The sorbent material includes particles that have antibodies attached to them to selectively retain analytes, proteins attached to them to retain certain classes of antibodies, or enzymes attached to them to perform specific modifications to certain classes of molecules. The column segment can be in thermal communication with a temperature control device in order to control the temperature of the column.

公开(公告)号：US09829470B2

公开(公告)日：2017-11-28

申请号：US14898272

申请日：2014-06-17

Applicant: Waters Technologies Corporation

Inventor： Geoff C. Gerhardt ,  Martin Gilar ,  Bernard Bunner

IPC: G01N30/20 ,  G01N30/86 ,  G01N30/60 ,  G01N30/02

CPC classification number: G01N30/8668 ,  G01N30/6095 ,  G01N30/8665 ,  G01N2030/027

Abstract: Provided are systems and methods for adapting to volume variations in microfluidic chromatography columns. A column is calibrated by comparing a parameter of the column with a same parameter of a reference column and generating, by a processor, an adjustment factor in response to the comparison between the parameter of the column with a same parameter of the reference column. Volume differences between the calibrated column and the reference column are compensated for by integrating the generated adjustment factor into a sample separation involving the calibrated column.

公开(公告)号：US09393504B2

公开(公告)日：2016-07-19

申请号：US14160678

申请日：2014-01-22

Applicant: Waters Technologies Corporation

Inventor： Geoff C. Gerhardt ,  Joseph A. Luongo

IPC: B01D15/16 ,  B01L3/00 ,  F04B13/02 ,  F04B23/04 ,  G01N30/32

CPC classification number: B01D15/163 ,  B01L3/50273 ,  B01L2200/143 ,  B01L2400/086 ,  F04B13/02 ,  F04B23/04 ,  F04B2205/09 ,  G01N30/32 ,  G01N2030/324

Abstract: A method and apparatus for monitoring and controlling nano-scale flow rate of fluid in the operating flow path of a HPLC system provide fluid flow without relying on complex calibration routines to compensate for solvent composition gradients typically used in HPLC. The apparatus and method are used to correct the flow output of a typical, analytical-scale (0.1-5 mL/min) HPLC pump to enable accurate and precise flow delivery at capillary (

Abstract translation: 用于监测和控制HPLC系统的操作流路中的纳米级流速的方法和装置提供流体流动，而不依赖于复杂的校准程序来补偿通常在HPLC中使用的溶剂组成梯度。 该装置和方法用于校正典型的分析型（0.1-5mL / min）HPLC泵的流量输出，以使毛细管（<0.1mL / min）和纳米级（< 1μL/ min）HPLC流速。

公开(公告)号：US20210199630A1

公开(公告)日：2021-07-01

申请号：US17057242

申请日：2019-05-20

Applicant: Waters Technologies Corporation

Inventor： Martin Gilar ,  Thomas S. McDonald ,  Joseph D. Michienzi ,  Jeffrey Musacchio ,  Rachel Mumma ,  Keith Fadgen ,  Geoff C. Gerhardt

IPC: G01N30/60 ,  G01N30/06

Abstract: Methods and devices for the washing, extraction, and separation of a sample in a disposable chromatography cartridge (201) comprising a barrel (204) and a column (205), and especially including reinforcement to the column permitting high-pressure separation.

公开(公告)号：US20190111376A1

公开(公告)日：2019-04-18

申请号：US16157921

申请日：2018-10-11

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  James P. Murphy ,  Geoff C. Gerhardt

IPC: B01D53/02

Abstract: The present disclosure relates to methodologies, systems, apparatus, kits, and microfluidic separation devices based on separation columns and restrictors that are matched and bundled together for distribution as a unit, where the mobile phase flow rate and post-column pressure are specified based on this combination of matched separation column and restrictor.

公开(公告)号：US11169125B2

公开(公告)日：2021-11-09

申请号：US16384272

申请日：2019-04-15

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Michael O. Fogwill ,  Curt Devlin ,  Theodore A. Dourdeville ,  Jacob N. Fairchild ,  Geoff C. Gerhardt ,  Wade P. Leveille ,  Joseph D. Michienzi ,  Jeffrey Musacchio

IPC: G01N30/00 ,  G01N30/72

Abstract: Techniques and apparatus for ion source devices with minimized post-column volumes are described. In one embodiment, for example, an ion source assembly may include a chromatography column in fluid communication with an ion source device, the chromatography column arranged within a minimum distance of the ion source, the minimum distance comprising between about 60 mm and about 150 mm.

公开(公告)号：US20190317062A1

公开(公告)日：2019-10-17

申请号：US16384272

申请日：2019-04-15

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Michael O. Fogwill ,  Curt Devlin ,  Theodore A. Dourdeville ,  Jacob N. Fairchild ,  Geoff C. Gerhardt ,  Wade P. Leveille ,  Joseph D. Michienzi ,  Jeffrey Musacchio

IPC: G01N30/72

Abstract: Techniques and apparatus for ion source devices with minimized post-column volumes are described. In one embodiment, for example, an ion source assembly may include a chromatography column in fluid communication with an ion source device, the chromatography column arranged within a minimum distance of the ion source, the minimum distance comprising between about 60 mm and about 150 mm.

公开(公告)号：US20160139095A1

公开(公告)日：2016-05-19

申请号：US14898272

申请日：2014-06-17

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Geoff C. Gerhardt ,  Martin Gilar ,  Bernard Bunner

IPC: G01N30/86

CPC classification number: G01N30/8668 ,  G01N30/6095 ,  G01N30/8665 ,  G01N2030/027

Abstract: Provided are systems and methods for adapting to volume variations in microfluidic chromatography columns. A column is calibrated by comparing a parameter of the column with a same parameter of a reference column and generating, by a processor, an adjustment factor in response to the comparison between the parameter of the column with a same parameter of the reference column. Volume differences between the calibrated column and the reference column are compensated for by integrating the generated adjustment factor into a sample separation involving the calibrated column.

Abstract translation: 提供了适应微流体色谱柱体积变化的系统和方法。 通过将列的参数与参考列的相同参数进行比较来校准列，并且响应于列的参数与参考列的相同参数之间的比较，由处理器生成调整因子。 通过将生成的调整因子整合到涉及校准柱的样品分离中来补偿校准柱和参考柱之间的体积差异。

公开(公告)号：US20150144782A1

公开(公告)日：2015-05-28

申请号：US14552872

申请日：2014-11-25

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Joseph D. Michienzi ,  James P. Murphy ,  Geoff C. Gerhardt

IPC: H01J49/10 ,  H01J49/00 ,  H01J49/26 ,  H01J49/04

CPC classification number: H01J49/10 ,  H01J49/0431 ,  Y10T29/5313

Abstract: The invention provides interfaces between analytical instruments, e.g., between chromatography systems and mass spectrometers. In an exemplary embodiment, an ion source is provided for connecting a carbon dioxide-based chromatograph device to a mass spectrometer. The ion source includes a first conduit for receiving eluent from the chromatography device, a heater for heating at least a portion of said first conduit, a second conduit in fluid communication with the first conduit, an inlet for receiving eluent from said second conduit and introducing the eluent into an ion source region to form a plume of gas and/or liquid in the ion source region, and an ionization promoting inlet for injecting an ionization promoting fluid into the ion source region to interact with the plume to promote ionization of at least some of the plume.

Abstract translation: 本发明提供分析仪器之间的界面，例如在色谱系统和质谱仪之间。 在一个示例性实施例中，提供离子源用于将基于二氧化碳的色谱装置连接到质谱仪。 离子源包括用于从色谱装置接收洗脱液的第一管道，用于加热所述第一管道的至少一部分的加热器，与第一管道流体连通的第二管道，用于从所述第二管道接收洗脱液并引入 所述洗脱液进入离子源区域以在所述离子源区域中形成气体和/或液体的羽流;以及电离促进入口，用于将离子化促进流体注入到所述离子源区域中以与所述羽流相互作用以促进至少 一些羽流。