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公开(公告)号：US07014861B2
公开(公告)日：2006-03-21
申请号：US10693047
申请日：2003-10-24
Applicant: Wouter E. Roorda , Vinayak D. Bhat , Paul M. Consigny
Inventor： Wouter E. Roorda , Vinayak D. Bhat , Paul M. Consigny
IPC: A61F2/02
CPC classification number: A61L31/16 , A61F2/91 , A61F2250/0067 , A61L2300/606
Abstract: A composition and a method for increasing the permeability of membrane junctions or cell membranes for delivery of a drug to target tissues are disclosed. Also disclosed are methods and devices for local drug delivery.
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公开(公告)号：US06544543B1
公开(公告)日：2003-04-08
申请号：US09752399
申请日：2000-12-27
Applicant: Evgenia Mandrusov , Christopher J. Buchko , Wouter E. Roorda
Inventor： Evgenia Mandrusov , Christopher J. Buchko , Wouter E. Roorda
IPC: A61F1300
CPC classification number: B82Y5/00 , A61F2/82 , A61F2250/0068 , A61K9/0009 , A61K9/1271 , A61K9/1647 , A61K9/1658 , A61K47/643 , A61K47/665 , A61K47/6911 , A61K47/6925 , A61L24/0015 , A61L24/0031 , A61L27/34 , A61L27/52 , A61L27/54 , A61L31/10 , A61L31/145 , A61L31/16 , A61L2300/40 , A61L2300/622 , A61M37/0092
Abstract: Brief periods of occlusion of blood flow in an otherwise open target vessel adjacent to vessels supplying blood to an ischemic region are caused by periodic administration of a therapeutically effective amount of a vasoconstrictor. It is anticipated these brief periods of occlusion will induce the enlargement of collateral vessels, causing increased blood flow to the ischemic region.
Abstract translation: 通过定期施用治疗有效量的血管收缩剂引起在与供血到缺血区域的血管相邻的另外开放的目标血管中血流阻塞的简单时期。 预计这些短暂的闭塞期将导致侧支血管扩大，导致血液流向缺血区域。
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公开(公告)号：US6071305A
公开(公告)日：2000-06-06
申请号：US976725
申请日：1997-11-24
Applicant: James E. Brown , Wouter E. Roorda
Inventor： James E. Brown , Wouter E. Roorda
IPC: A61F2/00 , A61F2/82 , A61F2/88 , A61F2/91 , A61F2/915 , A61L33/00 , A61L33/06 , A61L33/08 , A61F2/06
CPC classification number: A61F2/82 , A61F2/88 , A61F2/91 , A61F2/915 , A61L33/0005 , A61L33/0011 , A61L33/0064 , A61L33/066 , A61L33/068 , A61L33/08 , A61F2002/91541 , A61F2240/001 , A61F2250/0067 , A61F2250/0068 , A61M2005/14513
Abstract: The invention relates to a directional drug delivery stent which includes an elongated or tubular member having a cavity containing a biologically active agent. In one embodiment, the active agent is diffused from the reservoir directly to the walls of a body lumen, such as a blood vessel, through directional delivery openings arranged on an outer surface of the elongated member. Another variation of the stent includes an osmotic engine assembly for controlling the delivery of the active agent from the reservoir. The drugs which may be applied by the directional delivery stent include, but are not limited to, steroids, anti-inflammatory agents, restenosis preventing drugs, anti-thrombotic drugs, and tissue growth regulating drugs. The invention also relates to a method of using the directional drug delivery stent.
Abstract translation: 本发明涉及定向药物递送支架，其包括具有包含生物活性剂的空腔的细长管状构件。 在一个实施方案中，活性剂通过布置在细长构件的外表面上的定向输送开口从储存器直接扩散到体腔（例如血管）的壁。 支架的另一变体包括渗透引擎组件，用于控制活性剂从贮存器的输送。 可以由定向递送支架施用的药物包括但不限于类固醇，抗炎剂，预防再狭窄药物，抗血栓形成药物和组织生长调节药物。 本发明还涉及使用定向药物输送支架的方法。
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24.发明授权Erosion rate modifier for use in bioerodible drug delivery devices and method of use 失效用于生物蚀解药物输送装置的侵蚀速率调节剂及其使用方法
公开(公告)号：US5571525A
公开(公告)日：1996-11-05
申请号：US307845
申请日：1994-09-30
Applicant: Wouter E. Roorda , Fred Ehnow
Inventor： Wouter E. Roorda , Fred Ehnow
CPC classification number: C08K5/09 , A61K9/2013 , A61K9/204 , C08K5/0033 , C08K5/3435
Abstract: This invention resides in the field of bioerodible polymers for use as drug delivery vehicles. In particular, this invention addresses means for controlling the rate of biodegradation and degradation in general of such polymers.
Abstract translation: PCT No.PCT / US93 / 03003 Sec。 371日期1994年9月30日 102（e）1994年9月30日PCT 1993年3月30日PCT公布。 WO93 / 20134 PCT出版物 日期1993年10月14日本发明在于用作药物递送载体的生物可蚀解聚合物领域。 特别地，本发明涉及用于控制这些聚合物的生物降解和降解速率的方法。
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公开(公告)号：US5540912A
公开(公告)日：1996-07-30
申请号：US307843
申请日：1994-09-30
Applicant: Wouter E. Roorda , Fred Ehnow
Inventor： Wouter E. Roorda , Fred Ehnow
IPC: A61K9/10 , A61K9/16 , A61K31/165 , A61K31/245 , A61K31/445 , A61K31/47 , A61K47/38 , A61K9/70
CPC classification number: A61K9/0014 , A61K31/165 , A61K31/245 , A61K31/445 , A61K31/47 , A61K47/38 , A61K9/0019 , A61K9/10 , A61K9/1647 , Y10S514/818
Abstract: Controlled-release particles containing biologically effective agents such as therapeutic drugs and local anesthetics are suspended in a liquid suspending vehicle which has an elevated viscosity, the viscosity being substantially higher than that of water. Preferred vehicles are non-aqueous liquids and aqueous media which contain a dissolved polymer to increase the viscosity of the vehicle. Regardless of the composition of the media, however, the increased viscosity permits the use of particles of a relatively large size without a loss of suspension stability or localized application. The large particles offer the advantage of a longer release profile, and thus more prolonged activity of the agent.
Abstract translation: PCT No.PCT / US93 / 02992 Sec。 371日期1994年9月30日 102（e）1994年9月30日PCT 1993年3月30日PCT公布。 公开号WO93 / 19739 日期1993年10月14日将包含生物有效药剂（例如治疗药物和局部麻醉剂）的受控释放颗粒悬浮在具有升高粘度的液体悬浮液中，粘度显着高于水。 优选的载体是含有溶解的聚合物以增加载体粘度的非水性液体和水性介质。 然而，不管介质的组成如何，增加的粘度允许使用较大尺寸的颗粒，而不会失去悬浮稳定性或局部应用。 大颗粒提供了更长的释放曲线的优点，并且因此更加延长了该试剂的活性。
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Patent Agency Ranking
公开(公告)号：US09345475B2
公开(公告)日：2016-05-24
申请号：US13610602
申请日：2012-09-11
Applicant: Laveille Kao Voss , Stephanie Henze , Kristopher M. Konawalik , Leah M. Davis , Wouter E. Roorda
Inventor： Laveille Kao Voss , Stephanie Henze , Kristopher M. Konawalik , Leah M. Davis , Wouter E. Roorda
CPC classification number: A61B17/06161 , A61B17/0057 , A61B17/0469 , A61B17/0491 , A61B17/06061 , A61B17/062 , A61B50/3001 , A61B50/362 , A61B2017/00663 , A61B2017/047 , A61B2017/0472 , A61B2017/06142 , A61B2050/364 , A61B2090/0807 , A61M5/3278 , A61M2005/3284
Abstract: A needle removal device is provided for removing needles from suturing devices and/or systems. In an embodiment, the needle removal device may be intended for use with a suturing device having one or more needle lumens. The needle removal device may include a first member having a first plurality of needle receptacles extending therethrough. The first needle receptacles may be configured and positioned to correspond to one or more of the one or more needle lumens of the suturing device. The needle removal device may also include a second member having a second plurality of needle receptacles extending therethrough. At least one of the first member or the second member may be moveable between a first position, wherein the first needle receptacles and the second needle receptacles are substantially aligned, and a second position, wherein the first needle receptacles and the second needle receptacles substantially unaligned.
Abstract translation: 提供针去除装置用于从缝合装置和/或系统中去除针。 在一个实施例中，针去除装置可以用于具有一个或多个针管的缝合装置。 针去除装置可以包括具有延伸穿过其中的第一多个针插座的第一构件。 可以将第一针插槽配置和定位成对应于缝合装置的一个或多个针管腔中的一个或多个。 针去除装置还可以包括具有延伸穿过其中的第二多个针插座的第二构件。 第一构件或第二构件中的至少一个可以在第一位置和第二位置之间移动，第一位置和第二针座基本上对准，其中第一针座和第二针座基本上对准，其中第一针座和第二针座基本上不对齐 。
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公开(公告)号：US09241707B2
公开(公告)日：2016-01-26
申请号：US13485388
申请日：2012-05-31
Applicant: Wouter E. Roorda , Douglas H. Mehl , Rizza Garcia , Timothy C. Reynolds , Dinorah Merrill , Dawn Ma , David J. Milazzo , Aaron M. Fortson
Inventor： Wouter E. Roorda , Douglas H. Mehl , Rizza Garcia , Timothy C. Reynolds , Dinorah Merrill , Dawn Ma , David J. Milazzo , Aaron M. Fortson
CPC classification number: A61B17/0469 , A61B17/0485 , A61B17/06061 , A61B2017/00637 , A61B2017/00663 , A61B2017/00778 , A61B2017/0472
Abstract: A closure device for closing an opening in tissue is provided. The closure device includes an elongate member through which needles may be deployed. The closure device also includes a foot portion having one or more feet slidably mounted relative thereto. The feet are movable between a deployed position and a delivery position. The feet include cuffs removably mounted therein, with sutures connected between the cuffs. When the feet are in the deployed position and the needles are advanced, the needles securely engage the cuffs and draw the cuffs and suture through the lumen wall so that the opening in the lumen wall can be closed with the sutures.
Abstract translation: 提供了用于封闭组织中的开口的闭合装置。 闭合装置包括细长构件，针可通过细长构件展开。 闭合装置还包括具有相对于其可滑动地安装的一个或多个脚的脚部。 脚可在展开位置和放置位置之间移动。 脚部包括可拆卸地安装在其中的袖口，缝合线连接在袖口之间。 当脚处于展开位置并且针被推进时，针牢固地接合袖口并且拉出袖口并缝合穿过管腔壁，使得可以用缝合线封闭管腔壁中的开口。
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公开(公告)号：US08753357B2
公开(公告)日：2014-06-17
申请号：US13111416
申请日：2011-05-19
Applicant: Wouter E. Roorda , Laveille K. Voss , David J. Milazzo , Aaron M. Fortson
Inventor： Wouter E. Roorda , Laveille K. Voss , David J. Milazzo , Aaron M. Fortson
CPC classification number: A61B17/0469 , A61B17/0057 , A61B17/0482 , A61B17/0483 , A61B2017/00663 , A61B2017/047 , A61B2017/0472 , A61B2017/0496
Abstract: A suture applying device includes a shaft which carries a pair of needles near its distal end. The needles are joined by a length of suture, and the shaft is used to both introduce the needles into a lumen of a body structure and to draw the needles back through tissue on either side of the puncture site. After the needles have passed through the tissue, they are captured by a needle receiver and drawn outward through the tract, leaving a loop of suture behind to close the puncture site near the body lumen. The suture can then be tied or otherwise secured to close the puncture site.
Abstract translation: 缝合施加装置包括在其远端附近承载一对针的轴。 针通过一定长度的缝合线连接，并且该轴用于将针引入体结构的内腔中，并且将针回穿穿刺部位两侧的组织。 针穿过组织后，它们被针头接收器捕获并向外穿过管道，留下一条缝合线，以闭合身体内腔附近的穿刺部位。 然后可以将缝合线绑定或以其他方式固定以关闭穿刺部位。
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公开(公告)号：US08715719B2
公开(公告)日：2014-05-06
申请号：US12816997
申请日：2010-06-16
Applicant: Wouter E. Roorda , Jill A. McCoy , Richard Seto , Eugene T. Michal
Inventor： Wouter E. Roorda , Jill A. McCoy , Richard Seto , Eugene T. Michal
IPC: A61K9/00 , A61K9/14 , A61P17/02 , A61K31/722
CPC classification number: A61K31/738 , A61L15/28 , A61L24/0021 , A61L24/08 , A61L26/0023 , A61L26/0071 , A61L27/20 , A61L2400/04 , C08L5/08
Abstract: A method of preparing a stable chitosan hemostatic implant including preparing a lyophilizable solution of chitosan polymers and freezing the solution to obtain a frozen chitosan composition. The method further includes placing the frozen chitosan composition under vacuum so as to substantially dry the chitosan composition and curing the dried chitosan composition by first exposing it to a relative humidity and then curing the dried chitosan composition under heat so as to crosslink the chitosan polymers.
Abstract translation: 一种制备稳定的壳聚糖止血植入物的方法，包括制备壳聚糖聚合物的可冻干溶液并冷冻溶液以获得冷冻的壳聚糖组合物。 该方法还包括将冷冻的壳聚糖组合物置于真空下，以基本上干燥壳聚糖组合物并固化干燥的壳聚糖组合物，首先将其暴露于相对湿度，然后在加热下固化干燥的壳聚糖组合物以交联壳聚糖聚合物。
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公开(公告)号：US20130053884A1
公开(公告)日：2013-02-28
申请号：US13219004
申请日：2011-08-26
Applicant: Wouter E. Roorda
Inventor： Wouter E. Roorda
IPC: A61B17/04
CPC classification number: A61B17/0057 , A61B17/0401 , A61B17/0467 , A61B17/0487 , A61B2017/00004 , A61B2017/00663 , A61B2017/0088 , A61B2017/00889 , A61B2017/0404 , A61B2017/0409 , A61B2017/0414 , A61B2017/0454 , A61B2017/0458 , A61B2017/0462 , A61B2017/0474 , A61B2017/0488
Abstract: A closure system for closing openings in tissue that includes a closure device and a fastener. The closure device includes shafts that are configured to deploy a fastener to close an opening in tissue. The closure device can deploy the fastener as a knot pusher to close the opening with sutures or as a knot replacement to close the opening with sutures.
Abstract translation: 用于封闭组织中的开口的封闭系统，其包括封闭装置和紧固件。 闭合装置包括构造成展开紧固件以关闭组织中的开口的轴。 闭合装置可以以扣子推动器的方式展开紧固件，以用缝合线或作为结更换来闭合开口，以用缝合线封闭开口。
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