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82 条记录 (耗时 0.039 秒)

    Method for identifying aptamers
    22.
    发明授权
    Method for identifying aptamers 有权

    公开(公告)号：US09903859B2

    公开(公告)日：2018-02-27

    申请号：US14354597

    申请日：2012-10-25

    申请人： HELMHOLTZ-ZENTRUM FUER UMWELTFORSCHUNG GMBH—UFZ ,  ALBERT-LUDWIGS-UNIVERSITAET FREIBURG

    发明人： Guenter Roth ,  Christine Reinemann ,  Beate Strehlitz

    IPC分类号： C12Q1/68 ,  C07H21/02 ,  C07H21/04 ,  G01N33/53 ,  C12N15/10 ,  C12N5/00

    CPC分类号： G01N33/5308 ,  C12N15/1048 ,  C12Q1/6811 ,  C12Q2525/205

    摘要： The invention relates to a method for identifying aptamers, having the following steps —bringing a mixture of oligonucleotides into contact with an aptamer target structure and binding at least some of the oligonucleotides to the target structure, —separating the oligonucleotides which have been bound to the aptamer target structure from the aptamer target structure and from oligonucleotides that are not bound to the aptamer target structure, —amplifying individual oligonucleotides which were bound to the aptamer target structure in a physically separate manner and producing a plurality of physically separate amplicons, each amplicon predominantly containing one type of oligonucleotides, —specifying a specific marker for a plurality of the physically separate amplicons such that each of the marked amplicons can be uniquely identified using the specified marker of the amplicon, —sequencing oligonucleotides in a plurality of marked amplicons and assigning the marker that is specific for the amplicon to the sequence of the type of oligonucleotides in the amplicon for each amplicon examined by means of the sequencing process —analyzing the binding properties of the types of oligonucleotides to the aptamer target structure and assigning the analyzed binding properties to the specific markers of the amplicons and to the sequences of the types of oligonucleotides.

    Covalently attached antimicrobial polymers
    26.
    发明授权
    Covalently attached antimicrobial polymers 有权
    共价附着的抗菌聚合物

    公开(公告)号：US09332755B2

    公开(公告)日：2016-05-10

    申请号：US13997444

    申请日：2011-12-22

    申请人： Thorsten Steinberg ,  Karen Lienkamp ,  Pascal Tomakidi ,  Ali Al-Ahmad

    发明人： Thorsten Steinberg ,  Karen Lienkamp ,  Pascal Tomakidi ,  Ali Al-Ahmad

    IPC分类号： A01N43/08 ,  A01N25/10 ,  C08F8/00 ,  C08F291/18 ,  C08F292/00 ,  A01N25/34

    CPC分类号： A01N43/08 ,  A01N25/10 ,  A01N25/34 ,  C08F8/00 ,  C08F291/18 ,  C08F292/00 ,  A01N33/12

    摘要： The present invention relates to substrates comprising covalently attached antimicrobial polymers, which act as synthetic mimics of antimicrobial peptides (SMAMPs) and are preferably obtained by ring opening metathesis polymerization (ROMP). The inventive antimicrobial polymers exhibit a molecular weight of more than 100,000 g mol−1 and are preferably covalently attached to the surface of a substrate, e.g. an implant, a medical device, medical equipment or a (tissue-supporting) biomaterial, etc. Covalent bonding may be carried out using a photoreactive crosslinker but also by “grafting onto” or “grafting from”. The present invention is also directed to uses of the inventive antimicrobial polymers as defined herein, e.g. for antimicrobially coating a surface of such a substrate with a layer of the inventive antimicrobial polymer.

    摘要翻译： 本发明涉及包含共价连接的抗微生物聚合物的底物，其作为抗微生物肽（SMAMP）的合成模拟物，并且优选通过开环易位聚合（ROMP）获得。 本发明的抗微生物聚合物显示出超过100,000g mol -1的分子量，并且优选共价连接到底物的表面，例如， 植入物，医疗装置，医疗设备或（组织支撑）生物材料等。共价键可以使用光反应性交联剂进行，而且可以通过“接枝”或“接枝”进行。 本发明还涉及本文定义的本发明的抗微生物聚合物的用途，例如， 用本发明的抗微生物聚合物的一层抗微生物涂覆这种基材的表面。

    HALL EFFECT SENSOR
    27.
    发明申请
    HALL EFFECT SENSOR 有权
    霍尔效应传感器

    公开(公告)号：US20160011281A1

    公开(公告)日：2016-01-14

    申请号：US14798887

    申请日：2015-07-14

    申请人： Micronas GmbH ,  Albert-Ludwigs-Universitaet Freiburg

    发明人： Christian SANDER ,  Oliver PAUL

    IPC分类号： G01R33/07 ,  H01L43/06

    CPC分类号： G01R33/077 ,  H01L43/065

    摘要： A Hall effect sensor with multiple Hall effect elements, each of the Hall effect elements having a first contact terminal, a second contact terminal, and a third contact terminal arranged along a straight line. The multiple Hall effect elements are electrically connected in series in a closed circuit. The second contact terminals of the Hall effect elements are supply voltage connections or Hall voltage pickoffs, and the applicable second contact terminal of the Hall effect element is a center contact of the Hall effect element. The Hall effect elements form two pairs, and the Hall effect elements of one pair each measure the same component of a magnetic field and an operating current is impressed on the series circuit in the two Hall effect elements of this one pair, and a supply voltage is applied to the Hall effect elements of the other pair.

    摘要翻译： 具有多个霍尔效应元件的霍尔效应传感器，每个霍尔效应元件具有沿直线布置的第一接触端子，第二接触端子和第三接触端子。 多个霍尔效应元件在闭合电路中串联电连接。 霍尔效应元件的第二接触端子是电源电压连接或霍尔电压检测，霍尔效应元件的适用的第二接触端子是霍尔效应元件的中心接触。 霍尔效应元件形成两对，一对的霍尔效应元件每个都测量相同的磁场分量，并且在该一对的两个霍尔效应元件中的串联电路上施加工作电流，并且电源电压 应用于另一对的霍尔效应元素。

    Method for the Automated Production Consisting of a Molecular Layer of Amphiphilic Molecules and a Device for Producing Said Molecular Layer
    28.
    发明申请
    Method for the Automated Production Consisting of a Molecular Layer of Amphiphilic Molecules and a Device for Producing Said Molecular Layer 审中-公开
    由两亲分子的分子层和产生所述分子层的装置构成的自动生产方法

    公开(公告)号：US20140044866A1

    公开(公告)日：2014-02-13

    申请号：US13979129

    申请日：2012-01-10

    申请人： Jan Behrends ,  Gerhard Baaken

    发明人： Jan Behrends ,  Gerhard Baaken

    IPC分类号： B81C1/00

    CPC分类号： B05D1/40 ,  B05C11/023 ,  B05C11/08 ,  B81C1/0038 ,  G01N33/5076

    摘要： The invention is related to a method and an apparatus for the automated fabrication of a molecular layer made from amphiphilic molecules, in particular lipids for a lipid bilayer membrane, in the apparatus, which has a support substrate for supporting the molecular layer, a rotation element, which can be rotated on top of the support substrate, and an actuator device, by means of which the rotation element can be automatically rotated, wherein the rotation element has an outer surface, which is formed hydrophobic at least in sections, the method having the following steps: placing a first solvent, which contains amphiphilic molecules, in a region above the support substrate; causing the automatic rotation of the rotation element above the support substrate; moving the first solvent between the support substrate and the rotation element by the interaction of the rotating rotation element with the first solvent, thus forming the molecular layer.

    摘要翻译： 本发明涉及一种用于自动制造由两亲分子，特别是用于脂双层膜的脂质制成的分子层的方法和装置，该装置具有用于支撑分子层的支撑基底，旋转元件 ，其可以在支撑基板的顶部上旋转;以及致动器装置，借助于该致动器装置，旋转元件可以自动旋转，其中旋转元件具有外表面，该外表面至少部分地形成为疏水性，该方法具有 以下步骤：将包含两亲分子的第一溶剂放置在载体基材上方的区域中; 使旋转元件自动旋转在支撑基板上方; 通过旋转旋转元件与第一溶剂的相互作用，在支撑基板和旋转元件之间移动第一溶剂，从而形成分子层。

    DETECTOR AND METHOD FOR DETECTING IONIZING RADIATION
    30.
    发明申请
    DETECTOR AND METHOD FOR DETECTING IONIZING RADIATION 审中-公开
    用于检测离子辐射的检测器和方法

    公开(公告)号：US20130134317A1

    公开(公告)日：2013-05-30

    申请号：US13684285

    申请日：2012-11-23

    申请人： Albert-Ludwigs-Universitaet Freiburg

    发明人： Alex FAULER ,  Christian DISCH ,  Andreas ZWERGER ,  Markus DAMBACHER ,  Michael FIEDERLE

    IPC分类号： G01T7/00

    CPC分类号： G01T7/00 ,  G01T1/241

    摘要： A detector and a method for the detection of ionising radiation are proposed. The detector (1) exhibits a detector body (2) made from a semiconductor material in which incident ionising radiation generates free electron-hole pairs, a cathode side (4) of the detector body (2) to which the free holes generated drift in an electric field, an anode side (3) of the detector body (2) to which the free electrons generated drift in an electric field, at least two electrodes (5, 6) on the anode side (3) and at least two electrodes (7, 8) on the cathode side (4). There is a potential difference between the electrodes (5, 6, 7, 8). The potential difference between the individual electrodes (7, 8) on the cathode side (4) is smaller than the potential difference between each of the electrodes (5, 6) on the anode side (3) on the one hand and each of the electrodes (7, 8) on the cathode side (4) on the other hand. As a result of irradiation of the detector body (2) with ionising radiation, electron-hole pairs are generated in the detector body (2). Signals are detected at the electrodes (7, 8) on the cathode side. The difference is calculated and evaluated from these signals.

    摘要翻译： 提出了一种用于检测电离辐射的检测器和方法。 检测器（1）表现出由半导体材料制成的检测器体（2），其中入射电离辐射产生自由电子 - 空穴对，检测器主体（2）的阴极侧（4）产生漂移的空穴 所述检测器主体（2）的阳极侧（3），所述自由电子在电场中产生漂移，所述阳极侧（3）上的至少两个电极（5,6）和至少两个电极 （7,8）在阴极侧（4）上。 电极之间存在电位差（5,6,7,8）。 阴极侧（4）上的各个电极（7,8）之间的电势差一方面小于阳极侧（3）上的每个电极（5,6）之间的电位差， 另一方面，阴极侧（4）上的电极（7,8）。 作为通过电离辐射照射检测器本体（2）的结果，在检测器主体（2）中产生电子 - 空穴对。 在阴极侧的电极（7,8）处检测信号。 从这些信号计算和评估差异。