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公开(公告)号:US07612728B2
公开(公告)日:2009-11-03
申请号:US10593337
申请日:2005-03-16
CPC分类号: H01Q13/18 , H01Q1/2283 , H01Q1/38 , H01Q13/02 , H01Q13/0283 , H01Q19/32 , H01Q21/0093 , H01Q23/00
摘要: The invention relates to a microwave antenna for flip-chip semiconductor modules, comprising two semiconductor substrates which are metallized on the surface thereof. Patch antennas, i.e. metallized flat areas which are insulated from the rest of the circuit on an outer surface of a module with a supply line to the circuit, are already known per se. They result in vertical radiation at a relatively large angle. According to the invention, a closed group of bumps are arranged in such a way that the distance of the bumps (2) to each other is less than the half wavelength (λ/2) of the microsignal which is to be radiated or received and an open radiation slot arises in at least one pair of side walls (3,4) of the semiconductor substrates (a,b) and a bump, which is connected to the circuit of the semiconductor module, is arranged between the bumps (2) and the radiation slot, enabling the microwave antenna to be excited.
摘要翻译: 本发明涉及一种用于倒装芯片半导体模块的微波天线,包括在其表面上金属化的两个半导体衬底。 贴片天线,即在电路的外表面与电路的其余部分绝缘的金属化平坦区域,其电路具有电源线,本身已经是已知的。 它们导致相对较大角度的垂直辐射。 根据本发明,封闭的凸块组被布置成使得凸块(2)彼此的距离小于要被辐射或接收的微信号的半波长(λ/ 2),并且 在半导体基板(a,b)的至少一对侧壁(3,4)中产生开放的辐射狭槽,并且连接到半导体模块的电路的凸块布置在凸块(2)之间, 和辐射槽,使微波天线得以激发。
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公开(公告)号:US20060164124A1
公开(公告)日:2006-07-27
申请号:US10536699
申请日:2003-11-26
申请人: Reinhold Koch , Carsten Pampuch , Andreas Ney , Klaus Ploog
发明人: Reinhold Koch , Carsten Pampuch , Andreas Ney , Klaus Ploog
IPC分类号: H03K19/20
CPC分类号: H03K19/18
摘要: A method for operating a magnetic logic device (10) is described wherein at least one output variable O=F (IA, IB) is formed from input variables (IA, IB) by at least one logic operation with an operator function F of the magnetic logic device (10), whereby the logic device (10) is set at a starting state for executing the operator function F with a certain operator control signal (SET) before the operation, whereby the operator control signal is selected from a group of control signals with which various non-volatile starting states can be set in a controlled manner, each state being characteristic of a different logic function. Furthermore, a magnetic logic device (10) equipped for implementation of this method is also described.
摘要翻译: 描述了一种用于操作磁逻辑器件(10)的方法,其中至少一个输出变量O = F(I A,I B B)由输入变量(I 通过具有磁逻辑器件(10)的操作器功能F的至少一个逻辑运算,由此将逻辑器件(10)设置在一个或多个逻辑器件(10) 用于在操作之前用一定的操作员控制信号(SET)执行操作功能F的起动状态,从而从可以以受控的方式设置各种非易失性起动状态的一组控制信号中选择操作员控制信号, 每个状态是不同逻辑功能的特征。 此外,还描述了配备用于实现该方法的磁逻辑装置(10)。
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公开(公告)号:US20240350655A1
公开(公告)日:2024-10-24
申请号:US18556602
申请日:2022-04-22
发明人: Christian Ewald STIEGER , Christian Peter Richard HACKENBERGER , Marc-André KASPER , Philipp OCHTROP
IPC分类号: A61K47/68 , A61K47/54 , C07F9/32 , C07F9/6518 , C07F9/6524 , C07F9/653 , C07F9/6558 , C07F9/6561
CPC分类号: A61K47/6851 , A61K47/548 , A61K47/68031 , C07F9/3217 , C07F9/6518 , C07F9/6524 , C07F9/65324 , C07F9/65583 , C07F9/65586 , C07F9/6561
摘要: Disclosed are novel conjugates and methods for the preparation thereof. One of the methods for the preparation of a conjugate comprises a step of: acting a compound of formula (I), with a thiol-containing molecule of formula (II), wherein represents an amino acid, a peptide, a protein, an antibody, a nucleotide, an oligonucleotide, a saccharide, a polysaccharide, a polymer, a small molecule, an optionally substituted C1-C8-alkyl, an optionally substituted phenyl, or an optionally substituted aromatic 5- or 6-membered heterocyclic system; resulting in a compound of formula (III).
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公开(公告)号:US11958880B2
公开(公告)日:2024-04-16
申请号:US17853591
申请日:2022-06-29
CPC分类号: C07K1/1075 , C12P21/005 , C12P21/02 , C12Y603/02025
摘要: The present invention provides means and methods for equipping a polypeptide of interest at its C-terminus with a versatile adaptor amino acid that allows the functionalization of the polypeptide of interest.
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公开(公告)号:US11926614B2
公开(公告)日:2024-03-12
申请号:US17253668
申请日:2019-06-19
发明人: Stefan Krauss , Marc Nazare , Lari Lehtio , Jo Waaler , Anita Wegert , Ruben Gerardus George Leenders
IPC分类号: C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04
CPC分类号: C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04 , C07B2200/07
摘要: The present invention relates to compounds of formula (I), tautomers, stereoisomers, pharmaceutically acceptable salts and pro-drugs thereof, to processes for their preparation, to pharmaceutical compositions containing such compounds and to their use in therapy wherein a dashed line indicates an optional bond; X represents: a 5- or 6-membered, unsaturated heterocyclic group optionally substituted by one or more (e.g. 1, 2 or 3) substituents independently selected from halogen (i.e. F, Cl, Br, I), C1-6 alkyl (e.g. C1-3 alkyl), C1-6 haloalkyl (e.g. C1-3 haloalkyl), C1-6 alkoxy (e.g. C1-3 alkoxy), —CN, —NO2, —N(R)2, and —SO2R (where each R is independently H or C1-6 alkyl, e.g. H or C1-3 alkyl); a C3-5 cycloalkyl group optionally substituted by one or more (e.g. 1 or 2) substituents independently selected from C1-6 alkyl (preferably C1-3 alkyl), C1-6 haloalkyl (e.g. C1-3 haloalkyl), and C1-6 alkoxy (e.g. C1-3 alkoxy); or an aryl group optionally substituted by one or more (e.g. 1, 2 or 3) substituents independently selected from halogen (i.e. F, Cl, Br, I), C1-6 alkyl (e.g C1-3 alkyl), C1-6 haloalkyl (e.g. C1-3 haloalkyl), and C1-6 alkoxy (e.g. C1-3 alkoxy); Y represents: an aryl or heteroaryl group optionally substituted by one or more (e.g. 1, 2 or 3) substituents independently selected from halogen (i.e. F, Cl, Br, I), C1-6 alkyl (e.g C1-3 alkyl), C1-6 haloalkyl (e.g. C1-3 haloalkyl), and C1-6 alkoxy (e.g. C1-3 alkoxy); a 5- or 6-membered, saturated heterocyclic group optionally substituted by one or more (e.g. 1, 2 or 3) substituents independently selected from C1-6 alkyl (preferably C1-3 alkyl), C1-6 haloalkyl (e.g. C1-3 haloalkyl), and C1-6 alkoxy (e.g. C1-3 alkoxy); or a C3-6 cycloalkyl group optionally substituted by one or more (e.g. 1 or 2) substituents independently selected from C1-6 alkyl (preferably C1-3 alkyl), C1-6 haloalkyl (e.g. C1-3 haloalkyl), and C1-6 alkoxy (e.g. C1-3 alkoxy); and Z represents: an aryl group optionally substituted by one or more (e.g. 1, 2 or 3) substituents independently selected from halogen (i.e. F, Cl, Br, I), C1-6 alkyl (e.g. C1-3 alkyl), C1-6 haloalkyl (e.g. C1-3 haloalkyl), C1-6 alkoxy (e.g. C1-3 alkoxy), —CN, —NO2, —N(R)2, and —SO2R (where each R is independently H or C1-6 alkyl, e.g. H or C1-3 alkyl); or an unsaturated, 5- to 10-membered mono- or bicyclic heterocyclic group optionally substituted by one or more (e.g. 1, 2 or 3) substituents independently selected from halogen (i.e. F, Cl, Br, I), C1-6 alkyl (e.g. C1-3 alkyl), C1-6 haloalkyl (e.g. C1-3 haloalkyl), C1-6 alkoxy (e.g. C1-3 alkoxy), —CN, —NO2, —N(R)2, and —SO2R (where each R is independently H or C1-6 alkyl, e.g. H or C1-3 alkyl). These compounds find particular use in the treatment and/or prevention of a disease or disorder responsive to inhibition of tankyrase 1 and/or 2, for example a disorder which is mediated by tankyrase 1 and/or 2 such as cancer.
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公开(公告)号:US20220106356A1
公开(公告)日:2022-04-07
申请号:US17460791
申请日:2021-08-30
发明人: Christian Hackenberger , Marc André Kasper , Maria Glanz , Tom Sauer , Dominik Schumacher , Jonas Helma-Smets , Heinrich Leonhardt , Andreas Stengl
摘要: Disclosed are novel conjugates and processes for the preparation thereof. A process for the preparation of alkene- or alkyne-phosphonamidates comprises the steps of (I) reacting a compound of formula (III) with an azide of formula (IV) to prepare a compound of formula (V) (II) reacting a compound of formula (V) with a thiol-containing molecule of formula (VI) resulting in a compound of formula (VII)
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公开(公告)号:US20210040145A1
公开(公告)日:2021-02-11
申请号:US16993877
申请日:2020-08-14
摘要: The present invention provides means and methods for equipping a polypeptide of interest at its C-terminus with a versatile adaptor amino acid that allows the functionalization of the polypeptide of interest.
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公开(公告)号:US10596168B2
公开(公告)日:2020-03-24
申请号:US16096868
申请日:2017-04-26
发明人: Gerd Krause , Inna Hoyer , Edgar Specker , Jens Furkert , Patrick Marcinkowski , Jens-Peter Von Kries , Martin Neuenschwander , Marc Nazare
IPC分类号: A61K31/429 , A61K31/495 , A61P5/14 , A61P35/00
摘要: Chemical compounds are useful in the treatment of a subject afflicted by a thyroid disease. The compounds exhibit activity as thyroid-stimulating hormone receptor (TSHR) antagonists and can be used in the treatment of hyperthyroidism, Graves' disease, Graves' Ophthalmopathy and thyroid cancer.
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公开(公告)号:US10476517B2
公开(公告)日:2019-11-12
申请号:US16092883
申请日:2017-04-12
发明人: Florian Hühn
摘要: The present disclosure relates to a modulator for a digital amplifier and a device comprising such a modulator and a digital amplifier.The modulator includes a pulse shaper and a control unit for controlling the pulse shaper to convert an input signal into a bit stream configured for a digital amplifier which encodes an amplitude value per clock of a carrier signal. The pulse shaper can represent a respective amplitude value of the input signal with different bit patterns. The control unit includes an assignment of the control commands to associated amplitude values resulting from amplification of the associated bit patterns with the digital amplifier is stored or at least is provided in that the control unit selects a control command per clock by means of the assignment and the amplitude value of the input signal and drives the pulse shaper accordingly.
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公开(公告)号:US10416081B2
公开(公告)日:2019-09-17
申请号:US15725448
申请日:2017-10-05
发明人: Bernd Sumpf , Martin Maiwald
摘要: Optical systems and methods for spectroscopy are described. The optical system may be particularly suitable for Raman spectroscopy and includes a multispectral excitation source, designed to emit monochromatic excitation radiation successively at at least two different excitation wavelengths along a common beam axis; an elongated flow volume with a longitudinal axis, designed to direct a particle flow along the longitudinal axis; an excitation beam path, designed to irradiate the monochromatic excitation radiation into the flow volume at a first position and the second position that are located in the flow volume and the first position is spaced apart from the second position; and a detection device, designed to wavelength-selectively filter and detect a portion of a radiation scattered from the first position at a first filter wavelength and to wavelength-selectively filter and detect a portion of a radiation scattered from the second position at a second filter wavelength.
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