公开(公告)号：US5128248A

公开(公告)日：1992-07-07

申请号：US412904

申请日：1989-09-26

申请人： Jonathan S. Dordick ,  Andrew J. Hacking ,  Riaz A. Khan

发明人： Jonathan S. Dordick ,  Andrew J. Hacking ,  Riaz A. Khan

IPC分类号： C12P19/12 ,  C07H5/02 ,  C07H13/04 ,  C07H13/06 ,  C07H13/08

CPC分类号： C12P19/12 ,  C07H13/04 ,  C07H13/08 ,  C07H5/02

摘要： Sucrose or derivatives thereof such as esters are acylated at the 4'- and/or the 6-position by reaction with a donor acyl ester, e.g. a reactive ester of an alkanoic acid or benzoic acid, in the presence of lipase. Sucrose 6,4'-diesters so produced can be chlorinated and deacylated to produce the sweetener sucralose.

摘要翻译： 蔗糖或其衍生物如酯通过与供体酰基酯反应而在4'-和/或6-位被酰化。 在脂肪酶存在下的链烷酸或苯甲酸的反应性酯。 如此生产的蔗糖6,4'-二酯可以被氯化和脱酰基化以产生甜味剂三氯蔗糖。

公开(公告)号：US4826962A

公开(公告)日：1989-05-02

申请号：US921370

申请日：1986-10-20

申请人： Elner B. Rathbone ,  Khizar S. Mufti ,  Riaz A. Khan ,  Peter S. J. Cheetham ,  Andrew J. Hacking ,  Jonathan S. Dordick

发明人： Elner B. Rathbone ,  Khizar S. Mufti ,  Riaz A. Khan ,  Peter S. J. Cheetham ,  Andrew J. Hacking ,  Jonathan S. Dordick

IPC分类号： A23G3/38 ,  A23G3/34 ,  C07H1/00 ,  C07H3/04 ,  C07H5/02 ,  C12P19/00 ,  C12P19/14 ,  C12P19/20 ,  C12R1/645 ,  C12R1/685

CPC分类号： C07H5/02

摘要： The novel chlorinated sugar O-.alpha.-D-6-chloro-6-deoxygalactopyranosyl-(1.fwdarw.6)-.alpha.-D-4-chloro-4-deoxygalactopyranosyl-(1.fwdarw.2)-.beta.-D-1, 6-dichloro-1, 6-dideoxyfructofuranoside (TCR) can be used to prepare sucralose by incubating the TCR in solution in the presence of an enzyme serving to remove the 6-chloro-6-deoxygalactosyl moiety from the 6-position, especially an enzyme derived from a strain of Mortierella vinacea, Circinella muscae or Aspergillus niger. TCR is prepared by treating raffinose with thionyl chloride in the presence of triphenylphosphine oxide.

摘要翻译： 新型氯化糖O-α-D-6-氯-6-脱氧半乳糖吡喃糖基 - （1-> 6）-α-D-4-氯-4-脱氧半乳糖吡喃糖基 - （1-> 2）-β-D-1， 6-二氯-1,6-二脱氧呋喃果糖苷（TCR）可用于制备三氯蔗糖，通过在用于从6-位除去6-氯-6-脱氧半乳糖基部分的酶存在下，在溶液中温育TCR，特别是 衍生自高山被孢霉菌株，，蛇科或黑曲霉的酶。 通过在三苯基氧化膦存在下用亚硫酰氯处理棉子糖来制备TCR。

公开(公告)号：US4443538A

公开(公告)日：1984-04-17

申请号：US375179

申请日：1982-05-05

申请人： Peter S. J. Cheetham

发明人： Peter S. J. Cheetham

IPC分类号： C12N1/04 ,  C12N11/04 ,  C12N11/08 ,  C12N11/10 ,  C12P1/04 ,  C12P19/18

CPC分类号： C12N1/04 ,  C12N11/04

摘要： Enzyme-containing cells immobilized in an alginate gel are stabilized by contacting the gel with glycerol in a ratio of cellstoglycerol of 2:1 to 1:5. The enzyme-containing cells preferably convert sucrose to isomaltulose.

摘要翻译： 通过使凝胶与甘油以2:1至1:5的比例的细胞分离甘油接触来固定固定在藻酸盐凝胶中的含酶细胞。 含酶细胞优选将蔗糖转化成异麦芽酮糖。

公开(公告)号：US07868101B2

公开(公告)日：2011-01-11

申请号：US11753302

申请日：2007-05-24

申请人： David Neal Lewis ,  Gerrit Schutte ,  Henk Westerhof ,  Jane Janssen ,  William E. Kelly

发明人： David Neal Lewis ,  Gerrit Schutte ,  Henk Westerhof ,  Jane Janssen ,  William E. Kelly

IPC分类号： C08G63/08

CPC分类号： C08G63/08 ,  C08G63/06 ,  C08L67/04 ,  C09D167/04 ,  C09J167/04 ,  Y10T428/2826

摘要： The invention is directed to a method for preparing an environmentally degradable polymeric compound as well as to such a compound per se and to its use. A compound of the present invention includes a polycondensated lactic acid containing polymer, having a molecular weight (Mw) of from 500 to 50,000 g/mol, to which a flexibilizing aliphatic polyester having a molecular weight of from 500 to 50,000 g/mol is coupled. The amount of lactic acid including groups in the polymeric compound ranges from 50 to 99% and the amount of flexibilizing polyester groups ranges from 1 to 50%.

摘要翻译： 本发明涉及一种制备环境可降解的聚合物以及这种化合物本身及其用途的方法。 本发明的化合物包括分子量（Mw）为500〜50,000g / mol的聚缩醛的缩聚乳酸，分子量为500〜50,000g / mol的柔性脂肪族聚酯与其结合 。 聚合物中包含基团的乳酸的含量为50〜99％，增韧聚酯基的量为1〜50％。

公开(公告)号：US07018667B2

公开(公告)日：2006-03-28

申请号：US10011120

申请日：2001-11-13

申请人： Carolyn M. Merkel ,  Ning Wang ,  Jean Lee

发明人： Carolyn M. Merkel ,  Ning Wang ,  Jean Lee

IPC分类号： A23L1/236

CPC分类号： A23L27/37 ,  A23V2002/00 ,  A23V2250/264 ,  A23V2250/242

摘要： The present invention provides a meltable sucralose and acesulfame-k sweetener. This sweetener may be incorporated in a wide variety of reduced calorie food products such as cooked and hard candies, microwaveable food products, glazed food products, deep fried food products and as a substitute for sugar in applications that require melt sugar.

公开(公告)号：US5141860A

公开(公告)日：1992-08-25

申请号：US412670

申请日：1989-09-26

申请人： Stephen Bornemann ,  John M. Cassells ,  Clive L. Combes ,  Jonathan S. Dordik ,  Andrew J. Hacking

发明人： Stephen Bornemann ,  John M. Cassells ,  Clive L. Combes ,  Jonathan S. Dordik ,  Andrew J. Hacking

IPC分类号： C12P19/12 ,  C07H5/02 ,  C07H13/04 ,  C07H13/06 ,  C12P19/14

CPC分类号： C07H5/02 ,  C07H13/04

摘要： Sucrose derivatives partially acylated in each ring can be obtained by treating a fully or partially acylated sucrose derivative with an enzyme having sucrose esterase activity capable of removing at least one acyl group from each ring, generally comprising or being a component of a lipase, esterase, amylase, .alpha.-galactosidase or protease preparation, the enzyme treatment being effected in an aqueous system. Sucralose can be obtained by using this method to obtain a sucrose 2,3,6,3',4'-penta ester which can then be chlorinated and de-esterfied. Some of the penta acetates, tetraacetates and mixed acetates/butyrates are new compounds.

摘要翻译： 通过用能够从每个环除去至少一个酰基的蔗糖酯酶活性的酶处理完全或部分酰化的蔗糖衍生物，通常包含或作为脂肪酶，酯酶的组分，可以获得在每个环中部分酰化的蔗糖衍生物， 淀粉酶，α-半乳糖苷酶或蛋白酶制剂，酶处理在水系统中进行。 可以通过使用该方法获得三氯蔗糖，得到蔗糖2,3,6,3'，4'-五酯，然后可以将其氯化和脱酯化。 一些五乙酸酯，四乙酸酯和混合乙酸酯/丁酸酯是新的化合物。

公开(公告)号：US4918182A

公开(公告)日：1990-04-17

申请号：US73454

申请日：1987-07-15

申请人： Graham Jackson ,  Michael R. Jenner

发明人： Graham Jackson ,  Michael R. Jenner

IPC分类号： A23L27/00 ,  A23L27/30 ,  B02C19/00 ,  B02C19/06 ,  C07H5/02

CPC分类号： A23L27/37

摘要： Crystalline sucralose having a mean particle size of at most 10 microns, the maximum particle size being no more than twice the mean, exhibits enhanced stability to heat. Preferably the sucralose has a mean particle size of at most 5 microns and a maximum particle size of at most 10 microns. A method of enhancing the thermal stability of crystalline sucralose comprises jet milling the sucralose to reduce the particle size, and render the size distribution such that the maximum size is no more than twice the mean.

公开(公告)号：US4640717A

公开(公告)日：1987-02-03

申请号：US712256

申请日：1985-03-15

申请人： Dipak P. Shukla ,  Keith Sinclair ,  Kevin A. Smith

发明人： Dipak P. Shukla ,  Keith Sinclair ,  Kevin A. Smith

IPC分类号： C13B25/00 ,  C13B30/02 ,  C13K1/10 ,  C13F1/02

CPC分类号： C13B30/022 ,  C13K1/10

摘要： Sugar (sucrose or glucose) is crystallized by passing a hot supersaturated syrup to a continuous screw extruder such that progressive nucleation of the syrup is induced during a mean residence time of below 25 seconds and then discharging the nucleated syrup onto a surface, e.g. a conveyor belt, to crystallise without agitation.

摘要翻译： 糖（蔗糖或葡萄糖）通过将热过饱和糖浆通过连续螺杆挤出机结晶，使得在平均停留时间低于25秒时诱导糖浆的逐渐成核，然后将成核浆液排出到表面，例如， 输送带，以不搅拌结晶。

公开(公告)号：US06998480B2

公开(公告)日：2006-02-14

申请号：US10092730

申请日：2002-03-08

申请人： Steven J. Catani ,  James E. Wiley ,  Nicholas M. Vernon ,  Carolyn M. Merkel ,  Edward Micinski

发明人： Steven J. Catani ,  James E. Wiley ,  Nicholas M. Vernon ,  Carolyn M. Merkel ,  Edward Micinski

IPC分类号： C07H13/02

CPC分类号： C07H1/06 ,  C07H5/02 ,  C07H13/08

摘要： This invention relates to processes for purifying sucralose by the use of an initial non-crystallization purification procedure followed by three or more sequential crystallization steps and recycle of the mother liquor remaining from each crystallization step to the feed of another crystallization or purification step. This invention also relates to sucralose compositions as well as compositions comprising the sucralose compositions of the present invention. These compositions may be highly pure and have a superior taste profile.

公开(公告)号：US06943248B2

公开(公告)日：2005-09-13

申请号：US10426387

申请日：2003-04-30

申请人： Steven J. Catani ,  Carolyn M. Merkel ,  Nicholas M. Vernon

发明人： Steven J. Catani ,  Carolyn M. Merkel ,  Nicholas M. Vernon

IPC分类号： C07H1/06 ,  C07H5/02 ,  C07H1/00 ,  C07H3/04

CPC分类号： C07H5/02 ,  C07H1/06

摘要： A crystalline form of sucralose, and a method of making it. The method involves continuously crystallizing sucralose from an aqueous solution by a process providing continuous removal and recirculation of the vessel contents, and providing a long residence time for sucralose in the system. The crystals thus formed are of a relatively low length/diameter ratio, have an unsymmetrical shape, and exhibit good stability. The larger crystals in particular are tapered as compared to the rod-like larger crystals in prior art product.