利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

131 条记录 (耗时 0.043 秒)

    Synthetic microfluidic systems for wound healing and hemostasis
    26.
    发明授权
    Synthetic microfluidic systems for wound healing and hemostasis 有权
    用于伤口愈合和止血的合成微流体系统

    公开(公告)号：US09291614B2

    公开(公告)日：2016-03-22

    申请号：US14202721

    申请日：2014-03-10

    申请人： CFD Research Corporation

    发明人： Balabhaskar Prabhakarpandian ,  Kapil Pant

    IPC分类号： C12M3/00 ,  G01N33/50 ,  G01N33/86 ,  B01L3/00

    CPC分类号： G01N33/5029 ,  B01L3/5027 ,  G01N33/5005 ,  G01N33/5011 ,  G01N33/5061 ,  G01N33/5088 ,  G01N33/86 ,  G01N2333/4703 ,  G01N2333/70525

    摘要： A method of assaying wound healing can include: growing cells on the matrix in the first flow channel; introducing an agent that removes the matrix from the junction; introducing a matrix material into the second flow channel so as to form the second matrix in the second flow channel and junction; and detecting cellular migration into the junction onto the second matrix. The agent that removes the matrix can include a biomolecule or chemical agent. The method can include removing cells in the matrix in the junction before introducing the matrix material into the second flow channel. A bioactive agent can be introduced into the junction to determine if it modulates cellular migration and/or clot formation into the intersection openings of tissue and vascular channels.

    摘要翻译： 测定伤口愈合的方法可以包括：在第一流动通道中在基质上生长细胞; 引入从接合处去除基质的试剂; 将基质材料引入到第二流动通道中，以便在第二流动通道和结中形成第二基质; 并检测细胞迁移到第二基质上的结。 去除基质的试剂可以包括生物分子或化学试剂。 该方法可以包括在将基质材料引入第二流动通道之前去除接合中的基体中的细胞。 可以将生物活性剂引入接头以确定其是否调节细胞迁移和/或凝块形成到组织和血管通道的交叉开口中。