公开(公告)号：US06707051B2

公开(公告)日：2004-03-16

申请号：US10192329

申请日：2002-07-10

Applicant: Evgeny V. Shun'ko

Inventor： Evgeny V. Shun'ko

IPC: H01J4910

CPC classification number: H01J37/32091 ,  H01J37/32357 ,  H05H1/46 ,  H05H2001/466

Abstract: An RF loaded line type CCP source-having two collar type electrodes with an operating tube passing through these electrodes. One of the electrodes (high voltage electrode) is connected with the core of a feeding coaxial cable leading to a power supply, and another one is grounded by connection to a braid of the feeding coaxial cable, and the grounded electrode is further extended to form an outer cylindrical shield enveloping the operating tube with the high voltage electrode to provide a termination of an RF loaded line wherein the high voltage electrode with a plasma beam excited within the operating tube by action of an electric field between the electrodes form a core of this RF line. To provide effective contribution of RF energy in the plasma beam, the impedance of this line can be matched to the impedance of the plasma beam and matched also to the impedance of the feeding cable.

Abstract translation: RF负载线型CCP源，具有两个带有通过这些电极的工作管的环状电极。 电极（高压电极）中的一个与馈电同轴电缆的芯线连接，通向电源，另一个通过连接到馈电同轴电缆的编织物而接地，并且接地电极进一步延伸以形成 外圆筒形屏蔽件，其包围具有高电压电极的操作管，以提供RF负载线的端接，其中具有通过电极之间的电场作用而在操作管内激发的等离子体束的高压电极形成该电极的核心 射频线。 为了在等离子体束中提供RF能量的有效贡献，该线路的阻抗可以与等离子体束的阻抗匹配，并且也与馈电电缆的阻抗匹配。

公开(公告)号：US06677582B2

公开(公告)日：2004-01-13

申请号：US09941547

申请日：2001-08-30

Applicant: Masuyoshi Yamada ,  Yasuaki Takada ,  Masao Suga

Inventor： Masuyoshi Yamada ,  Yasuaki Takada ,  Masao Suga

IPC: H01J4910

CPC classification number: H01J49/168

Abstract: An apparatus for detecting the minor constituents of a sample with high efficiency in positive and negative ion monitoring modes. The directions in which the sample gas is forced to flow in the ionized region within the ion source are properly switched in the positive and negative ion monitoring modes, respectively, thereby enabling both positive ions and negative ions to be detected with high sensitivity.

Abstract translation: 一种用于在正离子和负离子监测模式下以高效率检测样品的次要成分的装置。 样品气体被迫在离子源内的离子化区域中流动的方向分别适当地在正离子和负离子监测模式中切换，从而能够以高灵敏度检测正离子和负离子。

公开(公告)号：US06649910B2

公开(公告)日：2003-11-18

申请号：US10232718

申请日：2002-09-03

Applicant: Minoru Sakairi

Inventor： Minoru Sakairi

IPC: H01J4910

CPC classification number: H01J49/168 ,  H01J49/0468

Abstract: For measuring dioxins and organic nitro compounds with high sensitivity while reducing complexity, efficiently ionize a sample using negative corona discharge; then, make use of a mass spectrometer to measure negatively charged ions produced.

公开(公告)号：US06483108B1

公开(公告)日：2002-11-19

申请号：US09293886

申请日：1999-04-19

Applicant: Minoru Sakairi

Inventor： Minoru Sakairi

IPC: H01J4910

CPC classification number: H01J49/168 ,  H01J49/0468

Abstract: For measuring dioxins and organic nitro compounds with high sensitivity while reducing complexity, efficiently ionize a sample using negative corona discharge; then, make use of a mass spectrometer to measure negatively charged ions produced.

Abstract translation: 为了在降低复杂性的同时测量高灵敏度的二恶英和有机硝基化合物，可以使用负电晕放电有效地离子化样品; 然后，使用质谱仪来测量产生的带负电荷的离子。

公开(公告)号：US06462337B1

公开(公告)日：2002-10-08

申请号：US09552962

申请日：2000-04-20

Applicant: Gangqiang Li ,  Hongfeng Yin

Inventor： Gangqiang Li ,  Hongfeng Yin

IPC: H01J4910

CPC classification number: H01J49/165 ,  C07D417/12 ,  C12P17/14 ,  C12P17/16

Abstract: A method of providing ions to a mass spectrometer having an interface member with an orifice through which ions are received for analysis. A fluid is provided at a capillary tip of an electrospray ionization source and a potential difference applied between the tip and the interface member so as to direct an ion beam from the tip toward and through the orifice. A field enhancing potential is applied at an auxiliary electrode so as to increase the electric field gradient from the capillary tip at least part way toward the interface member. A focussing potential may be applied to the auxiliary electrode to generate an electric field which decreases beam divergence from at least part way toward the interface member. Both the field enhancing and focusing potential may alternately be applied to the auxiliary electrode.

Abstract translation: 向质谱仪提供离子的方法，所述质谱仪具有接口部件，所述接口部件具有接口用于分析的离子。 在电喷雾电离源的毛细管尖端处设置有流体，并且在尖端和界面部件之间施加电位差，以便将尖端的离子束引导并穿过孔口。 在辅助电极处施加场强增强电位，以便使毛细管尖端的电场梯度至少部分地向接口部件增加。 可以将辅助电极施加聚焦电位以产生电场，该电场将波束发散从至少部分地朝向接口部件减小。 场增强和聚焦电位都可以替代地施加到辅助电极。

公开(公告)号：US06770877B2

公开(公告)日：2004-08-03

申请号：US10457426

申请日：2003-06-10

Applicant: Toshihiko Ohta ,  Kenji Kusumoto ,  Yasuaki Takada ,  Hisashi Nagano

Inventor： Toshihiko Ohta ,  Kenji Kusumoto ,  Yasuaki Takada ,  Hisashi Nagano

IPC: H01J4910

CPC classification number: H01J49/145

Abstract: A method and apparatus for analyzing vapors generated from explosives in which vapors containing nitrogen monoxide and/or nitrogen dioxide are generated by decomposing explosives by increasing the temperature of the explosives, primary ions and neutral molecules are generated from air. The generated primary ions and the nitrogen monoxide and/or nitrogen dioxide contained in the generated vapors are allowed to react with each other in an area inhibited or prevented from being penetrated by the generated neutral molecules, and the nitrogen monoxide and/or nitrogen dioxide contained in the generated vapors is ionized. The ionized nitrogen monoxide and/or nitrogen dioxide is subjected to mass spectrometry, and an amount of the nitrogen monoxide and/or nitrogen dioxide contained in the generated vapors by decomposing the explosives is determined.

Abstract translation: 用于分析由爆炸物产生的蒸汽的方法和装置，其中通过从空气中产生爆炸物，初级离子和中性分子的温度来分解包含一氧化氮和/或二氧化氮的蒸气而产生的蒸气。 产生的初级离子和产生的蒸气中含有的一氧化氮和/或二氧化氮在被产生的中性分子渗透的区域中彼此反应，并且含有一氧化氮和/或二氧化氮 在产生的蒸气中电离。 对离子化的一氧化氮和/或二氧化氮进行质谱分析，并确定通过分解爆炸物而产生的蒸汽中所含的一氧化氮和/或二氧化氮的量。

公开(公告)号：US06765200B2

公开(公告)日：2004-07-20

申请号：US09792582

申请日：2001-02-23

Applicant: Akira Maekawa ,  Akira Owada ,  Yasushi Terui

Inventor： Akira Maekawa ,  Akira Owada ,  Yasushi Terui

IPC: H01J4910

CPC classification number: H01J49/105

Abstract: In order to provide an equipment that permits easy elimination of interference ions even in a low resolution mass spectrometer, the isotope mass number information and the isotope presence ratio information for each element are stored, and processing is done as is shown in FIG. 1 using such information and the measurement results, and the amount of target elemental ions is calculated by calculating and eliminating the amount of interference caused by other elemental isotopes to the target element. Because of this, when carrying out element analysis using a mass spectrometer with a relatively low resolution, the user can easily obtain the measurement result of the amount of any target elemental ions.

Abstract translation: 为了提供即使在低分辨率质谱仪中也容易消除干扰离子的设备，存储每个元件的同位素质量数信息和同位素存在比信息，并且如图1所示进行处理。 使用这样的信息和测量结果，并且通过计算和消除由其他元素同位素对目标元素引起的干扰量来计算目标元素离子的量。 因此，当使用分辨率相对较低的质谱仪进行元素分析时，用户可以容易地获得任何目标元素离子的量的测量结果。

公开(公告)号：US06649909B2

公开(公告)日：2003-11-18

申请号：US10081780

申请日：2002-02-20

Applicant: Charles W. Russ, IV ,  Steven M. Fischer

Inventor： Charles W. Russ, IV ,  Steven M. Fischer

IPC: H01J4910

CPC classification number: H01J49/0009 ,  H01J49/004

Abstract: An apparatus and method for calibrating a mass spectrometer by internally introducing calibration masses at a post-source stage of the mass spectrometer is provided. A source of lock mass ions adjacent the ion optics creates lock mass ions within the ion optics. Lock mass ions mix with the analyte ions in the ion optics prior to mass analysis. The source of lock mass ions may include various means for ionizing lock mass molecules including but not limited to photoionization, field desorption-ionization, electron ionization, and thermal ionization means. An apparatus and method of mass calibrating a tandem mass spectrometer is also provided. The mass calibration apparatus includes a collision cell for fragmenting analyte ions and a source of lock mass ions adjacent said collision cell for creating lock mass ions in the collision cell.

Abstract translation: 提供了通过在质谱仪的后源阶段内部引入校准质量来校准质谱仪的装置和方法。 与离子光学器件相邻的锁定质量离子源产生离子光学器件内的锁定质子离子。 在质量分析之前，将质子离子与离子光学中的分析物离子混合。 锁定质量离子的来源可以包括用于电离锁定质量分子的各种装置，包括但不限于光电离，场解吸电离，电子离子化和热电离装置。 还提供了质量校准串联质谱仪的装置和方法。 质量校准装置包括用于碎裂分析物离子的碰撞单元和邻近所述碰撞室的锁定质量离子源，用于在碰撞室中产生锁定质量离子。

公开(公告)号：US06624409B1

公开(公告)日：2003-09-23

申请号：US10208441

申请日：2002-07-30

Applicant: Alex Mordehai ,  Jian Bai

Inventor： Alex Mordehai ,  Jian Bai

IPC: H01J4910

CPC classification number: H01J49/164 ,  G01N33/54393 ,  H01J49/0418

Abstract: A substrate for matrix assisted laser desorption ionization mass spectrometry. The substrate has a layer of a nitride composition on the surface of the substrate. The nitride composition is a major amount by weight from the group of titanium nitride, zirconium nitride and hafnium nitride.

Abstract translation: 基质辅助激光解吸电离质谱法。 衬底在衬底的表面上具有氮化物组合物层。 氮化物组合物是来自氮化钛，氮化锆和氮化铪的重量的主要量。

公开(公告)号：US06569324B1

公开(公告)日：2003-05-27

申请号：US09703005

申请日：2000-10-31

Applicant: James E. Moon ,  Timothy J. Davis ,  Gregory J. Galvin ,  Gary A. Schultz ,  Thomas N. Corso ,  Stephen Lowes

Inventor： James E. Moon ,  Timothy J. Davis ,  Gregory J. Galvin ,  Gary A. Schultz ,  Thomas N. Corso ,  Stephen Lowes

IPC: H01J4910

CPC classification number: G01N30/6095 ,  G01N30/7266 ,  G01N2030/6013 ,  H01J49/0018 ,  H01J49/167 ,  Y10T436/24 ,  Y10T436/2575

Abstract: An electrospray device, a liquid chromatography device and an electrospray-liquid chromatography system are disclosed. The electrospray device comprises a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electrode for application of an electric potential to the substrate to optimize and generate an electrospray; and, optionally, additional electrode(s) to further modify the electrospray. The liquid chromatography device comprises a separation substrate defining an introduction channel between an entrance orifice and a reservoir and a separation channel between the reservoir and an exit orifice, the separation channel being populated with separation posts perpendicular to the fluid flow; a cover substrate bonded to the separation substrate to enclose the reservoir and the separation channel adjacent the cover substrate; and, optionally, electrode(s) for application of a electric potential to the fluid. The exit orifice of the liquid chromatography device may be homogeneously interfaced with the entrance orifice of the electrospray device to form an integrated single system. An array of multiple systems may be fabricated in a single monolithic chip for rapid sequential fluid processing and generation of electrospray for subsequent analysis, such as by positioning the exit orifices of the electrospray devices near the sampling orifice of a mass spectrometer.