公开(公告)号：US20220257622A1

公开(公告)日：2022-08-18

申请号：US17738286

申请日：2022-05-06

申请人： Kimberly-Clark Worldwide, Inc.

发明人： Jingru Li ,  Lindsay Adrienne Peed ,  Cheryce Francina Joyner ,  Rebecca Ann Vongsa ,  David William Koenig ,  Ryan Daniel Bartell

IPC分类号： A61K31/702 ,  A61K31/7016 ,  A61K31/719 ,  A61K31/7004 ,  A61K31/194 ,  A61K31/192 ,  A61K31/19 ,  A61K31/191 ,  A61P15/02 ,  A61K9/00 ,  A61K47/12

摘要： The present invention provides compositions and formulations capable of maintaining or promoting the growth of certain strains of Lactobacilli spp. The compositions and formulations generally comprise only a single therapeutic agent selected from the group consisting of isomaltulose, maltitol, pullulan, maltotriose, 2-deoxy-D-ribose, 1-kestose and erlose. The single therapeutic agent is the sole source of carbon for bacterium when administered to a user. Despite comprising only a single therapeutic agent the compositions have been shown to promote the growth and maintenance of beneficial Lactobacilli and to effectively inhibit the growth of pathogens associated with urogenital infections. As such administration of the compositions maintain a healthy microflora balance in the urogenital area.

公开(公告)号：US11406653B2

公开(公告)日：2022-08-09

申请号：US17256950

申请日：2019-06-28

申请人： GREEN VALLEY (SHANGHAI) PHARMACEUTICALS CO., LTD. ,  SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Meiyu Geng ,  Xianliang Xin ,  Zhenqing Zhang ,  Jian Ding

IPC分类号： A61P25/06 ,  A61K31/715 ,  A61K31/7032 ,  A61K31/702 ,  A61P25/04 ,  A61K31/7004 ,  A61K31/7016

摘要： The present invention relates to the use of mannuronic diacid oligosaccharide composition in the treatment of pain.

公开(公告)号：US20220184151A1

公开(公告)日：2022-06-16

申请号：US17545777

申请日：2021-12-08

申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

发明人： Raina FICHOROVA ,  Andrew ONDERDONK ,  Hidemi YAMAMOTO ,  Mary DELANEY ,  Andrea DUBOIS

IPC分类号： A61K35/747 ,  A61K31/4164 ,  A61K31/7016 ,  A61K31/7056 ,  A61K31/7076 ,  A61K45/06 ,  A61K9/00 ,  C12N1/20

摘要： Described herein are methods and compositions for the use of treating and/or preventing vaginal bacterial infection and promoting healthy vaginal flora. Aspects of the invention relate to administering to a subject in need thereof a composition comprising a bacterial mixture of L. crispatus, L. gasseri, and L. jensenii.

公开(公告)号：US20220168327A1

公开(公告)日：2022-06-02

申请号：US17430756

申请日：2019-02-25

申请人： The Australian National University ,  Griffith University

发明人： Christopher Parish ,  Connor O'Meara ,  Lucy Coupland ,  Benjamin Ju Chye Quah ,  Farzaneh Kordbacheh ,  Anna Bezos ,  Anna Browne ,  Ross Stephens ,  Gregory David Tredwell ,  Lee Andrew Philip ,  Karen Knox ,  Laurence Mark von Itzstein ,  Chih-Wei Chang ,  Anne Brüstle ,  David Anak Simon Davis

IPC分类号： A61K31/7028 ,  A61K31/7016 ,  A61P37/06

摘要： The present invention relates to compounds with high chemical stability and methods for inhibiting the pathological activity of NETs in a subject. In particular, the invention relates to compounds with high chemical stability, uses thereof and methods for inhibiting or ameliorating NET mediated ailments (such as, for example, sepsis, systemic immune response syndrome (SIRS) and ischemia reperfusion injury (IRI)). More particularly, the invention relates to methods and uses of a polyanionic sulfated cellobioside modified with a small uncharged glycosidically linked substituent at its reducing terminus, wherein the presence of the substituent results in a molecule with high chemical stability without affecting the ability of the molecule to be effective in the therapy of NET mediated ailments. For example, the present invention relates to methods and uses of β-O-methyl cellobioside sulfate (mCBS) or a pharmaceutically acceptable salt thereof (e.g., mCBS.Na), in the therapy of a range of NET mediated ailments in subjects.

公开(公告)号：US11324765B2

公开(公告)日：2022-05-10

申请号：US17333614

申请日：2021-05-28

申请人： Children's Hospital Medical Center ,  The General Hospital Corporation ,  Instituto Nacional de Ciencias Medicas Y Nutricion

发明人： Ardythe L. Morrow ,  David S. Newburg ,  Guillermo M. Ruiz-Palacios

IPC分类号： A61K31/7016 ,  A61K47/62 ,  A23L33/00 ,  A61K31/702 ,  A61K35/20 ,  A61K47/50 ,  A61K47/61

摘要： A method of inhibiting inflammation with milk oligosaccharides or glycoconjugates containing the oligosaccharides.

公开(公告)号：US20220125717A1

公开(公告)日：2022-04-28

申请号：US16949376

申请日：2020-10-27

申请人： Uqora, Inc.

发明人： Spencer Gordon

IPC分类号： A61K9/06 ,  A61K9/02 ,  A61K33/40 ,  A61K31/191 ,  A61K35/747 ,  A61K31/7016 ,  A61K31/702

摘要： A gel and suppository and method to provide the gel and the suppository, are disclosed herein. The gel comprising: between 50 and 150 millimolar of lactic acid concentrate; and between 0.5 and 10 millimolar of hydrogen peroxide concentrate. The suppository comprising: between 22.5 and 67.5 milligrams of lactic acid concentrate; and between 1 and 20 milligrams of hydrogen peroxide concentrate.

公开(公告)号：US20220110959A1

公开(公告)日：2022-04-14

申请号：US17356082

申请日：2021-06-23

申请人： University of Louisville Research Foundation, Inc.

发明人： Tongalp H. Tezel ,  Andrea S. Gobin ,  Martin G. O'Toole

IPC分类号： A61K31/7016 ,  C08L1/28 ,  C08L5/02 ,  C08L5/08 ,  C08L5/10 ,  A61K9/00 ,  A61K47/32 ,  A61K47/38 ,  C08L33/14

摘要： Polymeric compositions are provided that include a poly(ethylene glycol), a viscoelastic polymer, and an antioxidant, where, in polymerized form, the compositions have a refractive index of about 1.30 to about 1.40. Methods of synthesizing the compositions are also provided and include the steps of heating an amount of water; adding a buffering agent to the water to form a buffer solution; mixing a poly(ethylene glycol) and a viscoelastic polymer into the buffer solution to form a reactive mixture; adding a plurality of antioxidant particles to the reactive mixture; and removing suspended gas bubbles from the reactive mixture. Methods of preventing oxidative damage to an eye lens of a subject are further provided and include administering the foregoing polymeric compositions to the eye lens of the subject.

公开(公告)号：US20220096524A1

公开(公告)日：2022-03-31

申请号：US17298194

申请日：2019-11-27

申请人： ABBOTT LABORATORIES

发明人： JOSÉ MARÍA LÓPEZ PEDROSA ,  RICARDO RUEDA CABRERA ,  MANUEL MANZANO MARTÍN ,  JORGE GARCÍA MARTINEZ ,  MARÍA CAMPRUBÍ ROBLES ,  PILAR BUENO VARGAS ,  JOSEPH WALTON ,  VIKKIE MUSTAD

IPC分类号： A61K31/718 ,  A61K31/702 ,  A61K31/7016 ,  A61K31/7004 ,  A61K31/733 ,  A61P3/02 ,  A23L33/125 ,  A23L33/00

摘要： A method of promoting healthy catch-up growth in a moderately malnourished individual is provided. The method includes administering to the moderately malnourished individual a nutritional composition that contains a carbohydrate blend, wherein the carbohydrate blend comprises a source of at least one carbohydrate that provides rapidly available glucose, a source of at least one carbohydrate that provides slowly available glucose, and a source of at least one non-digestible carbohydrate or resistant starch.

公开(公告)号：US11260086B2

公开(公告)日：2022-03-01

申请号：US16307857

申请日：2017-07-11

申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

发明人： Raina Fichorova ,  Andrew Onderdonk ,  Hidemi Yamamoto ,  Mary Delaney ,  Andrea Dubois

IPC分类号： A61K35/747 ,  A61K31/4164 ,  A61K31/7016 ,  A61K31/7056 ,  A61K31/7076 ,  A61K45/06 ,  A61K9/00 ,  C12N1/20 ,  A61K35/00 ,  A61K9/06 ,  C12R1/225

摘要： Described herein are methods and compositions for the use of treating and/or preventing vaginal bacterial infection and promoting healthy vaginal flora. Aspects of the invention relate to administering to a subject in need thereof a composition comprising a bacterial mixture of L. crispatus, L. gasseri, and L. jensenii.

公开(公告)号：US11229660B2

公开(公告)日：2022-01-25

申请号：US16883107

申请日：2020-05-26

申请人： Kaleido Biosciences, Inc.

发明人： Geoffrey A. von Maltzahn ,  Jared Silverman ,  Yvonne J. Yamanaka ,  John Miles Milwid ,  John M. Geremia

IPC分类号： A61K31/702 ,  A61K45/06 ,  A61K31/716 ,  A61K31/733 ,  A61P1/00 ,  A61K31/09 ,  A61K31/11 ,  A61K31/12 ,  A61K31/165 ,  A61K31/34 ,  A61K31/353 ,  A61K31/365 ,  A61K31/366 ,  A61K31/7034 ,  A61K31/7048 ,  A61K31/706 ,  A61K31/715 ,  A23L33/10 ,  A23P10/00 ,  A61K31/7004 ,  A61K31/7016 ,  A61K35/741 ,  A61K35/00

摘要： Preparations of glycan therapeutics, pharmaceutical compositions and medical foods thereof, optionally comprising micronutrients, polyphenols, prebiotics, probiotics, or other agents are provided and methods of making same. Also provided are methods of using said gycan therapeutics, e.g. for the modulation of human gastrointestinal microbiota and to treat dysbioses.