公开(公告)号：US09981003B2

公开(公告)日：2018-05-29

申请号：US15038557

申请日：2014-11-25

Applicant: STC.UNM

Inventor： Jeff Wade Hill

IPC: A61K38/06 ,  C07K5/097 ,  C07K14/715 ,  A61K45/06 ,  A61K38/00

CPC classification number: A61K38/06 ,  A61K38/00 ,  A61K45/06 ,  C07K5/0823 ,  C07K14/7158

Abstract: The present invention provides a novel class of medicament based on CXCR antagonistic peptides. Among other things, the present invention provides peptides, compositions and methods for treating diseases, disorders and conditions in which a CXCR mediated pathway is implicated. Compositions and methods for effective treatment of inflammation, stroke, traumatic brain injury, pancreatic cancer, and others are provided.

公开(公告)号：US20180143348A1

公开(公告)日：2018-05-24

申请号：US15877167

申请日：2018-01-22

Applicant: STC.UNM

Inventor： Anthony Robert Menicucci ,  Thomas P. Caudell ,  Andrea A. Mammoli

IPC: G01W1/10 ,  G01J5/00 ,  G06Q10/04

CPC classification number: G01W1/10 ,  G01J5/00 ,  G01J2001/4266 ,  G06Q10/04 ,  G06Q50/06 ,  H02J3/00 ,  H02J3/383 ,  H02J2003/007 ,  Y02E10/563 ,  Y02E60/76 ,  Y04S10/54 ,  Y04S40/22 ,  Y10T307/533 ,  Y10T307/604

Abstract: The present invention is an apparatus and method of forecasting solar energy irradiance potential and subsequent photovoltaic output in a region. The apparatus and method includes collecting meteorological data for a given region and then estimating irradiance levels using parameters collected from the meteorological data. Solar energy production is then simulated using the collected meteorological data, estimated irradiance levels, and physical characteristics of a solar generating system in the given region at a predetermined time.

公开(公告)号：US20180143138A1

公开(公告)日：2018-05-24

申请号：US15568029

申请日：2016-04-20

Applicant: STC.UNM

Inventor： Andrew P Shreve ,  Steven Wayde Graves ,  Bruce S Edwards ,  Jaime Javier Juarez

IPC: G01N21/64 ,  G01J3/02 ,  G01N15/14 ,  G01J3/28 ,  G01N15/02

CPC classification number: G01N21/6486 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0291 ,  G01J3/0294 ,  G01J3/2823 ,  G01J2003/2826 ,  G01N15/0211 ,  G01N15/14 ,  G01N15/147 ,  G01N2015/1006

Abstract: A method to simultaneously detect emission intensity or images at multiple distinct emission wavelengths in the analysis of parallel sample streams in a flow-based analysis system and apparatus for performing the described method.

公开(公告)号：US20180025131A1

公开(公告)日：2018-01-25

申请号：US15721277

申请日：2017-09-29

Applicant: STC.UNM

Inventor： Roy William Keyes ,  Christian Romano ,  Shuang Luan ,  Dorian C. Arnold

IPC: G06F19/00 ,  G06F9/50

CPC classification number: G06F19/3481 ,  G06F9/5083 ,  G06F19/00 ,  G16H50/50

Abstract: A method of calculating radiation fluence and energy deposition distributions on a networked virtual computational cluster is presented. With this method, complex Monte Carlo simulations that require expansive equipment, personnel, and financial resources can be done efficiently and inexpensively by hospitals and clinics requiring radiation therapy dose calculations.

公开(公告)号：US20180021357A1

公开(公告)日：2018-01-25

申请号：US15691977

申请日：2017-08-31

Applicant: Ball State Innovation Corporation ,  STC.UNM

Inventor： Susan A. McDowell ,  Robert E. Sammelson ,  Larry A. Sklar ,  Mark K. Haynes

IPC: A61K31/635

CPC classification number: A61K31/635

Abstract: The present disclosure relates to molecules that function as selective modulators (i.e., inhibitors and agonists) of the Ras-homologous (Rho) family of small GTPases and, in particular, CDC42 GTPase, and their use to treat bacterial infection including systemic infection from sources such as Staphylococcus aureus and Streptococcus pyogenes.

公开(公告)号：US09859677B1

公开(公告)日：2018-01-02

申请号：US15488088

申请日：2017-04-14

Applicant: STC.UNM

Inventor： Ladan Arissian ,  Jean-Claude Diels

IPC: G01N21/41 ,  H01S3/11 ,  H01S3/0957 ,  H01S3/106

CPC classification number: H01S3/1112 ,  G01N21/41 ,  G01N21/4133 ,  G01N2201/06113 ,  H01S3/0014 ,  H01S3/0957 ,  H01S3/105 ,  H01S3/1062 ,  H01S3/1106

Abstract: Apparatus, systems, and methods of generating multi combs can be used in a variety of applications. In various embodiments, a passive resonator can be disposed in the laser cavity of a mode-locked laser to generate a nested frequency comb. The passive resonator can be a sample under investigation, where a characteristic of the sample is determined using the generated nested frequency comb. Additional apparatus, systems, and methods are disclosed.

公开(公告)号：US09827446B2

公开(公告)日：2017-11-28

申请号：US15388201

申请日：2016-12-22

Applicant: STC.UNM ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Shuang Luan ,  Lijun Ma ,  Zhe Chen

IPC: A61N5/00 ,  A61N5/10 ,  A61B6/00

CPC classification number: A61N5/1084 ,  A61B6/4085 ,  A61N5/10 ,  A61N5/1031 ,  A61N5/1065 ,  A61N5/1067 ,  A61N5/1071 ,  A61N5/1081 ,  A61N2005/1074

Abstract: Photon-based radiosurgery is widely used for treating local and regional tumors. The key to improving the quality of radiosurgery is to increase the dose falloff rate from high dose regions inside the tumor to low dose regions of nearby healthy tissues and structures. Dynamic photon painting (DPP) further increases dose falloff rate by treating a target by moving a beam source along a dynamic trajectory, where the speed, direction and even dose rate of the beam source change constantly during irradiation. DPP creates dose gradient that rivals proton Bragg Peak and outperforms Gamma Knife® radiosurgery.

公开(公告)号：US09744292B2

公开(公告)日：2017-08-29

申请号：US14544032

申请日：2014-11-17

Applicant: STC.UNM

Inventor： Mark Hauswald

IPC: A61M5/14 ,  A61M5/142 ,  A61M5/315 ,  A61M5/168

CPC classification number: A61M5/14216 ,  A61M5/1422 ,  A61M5/16809 ,  A61M5/31535 ,  A61M5/31548 ,  A61M2202/048

Abstract: A mechanical infusion pump device for injecting medication into a patient's IV, includes an IV reservoir and a syringe communicated to the IV reservoir and having a syringe plunger which is moved in a first direction against a mechanical biasing element by engagement with a manually operable, independently movable filling plunger to fill the syringe with fluid medication. The mechanical biasing element is provided for exerting bias on the syringe plunger in a second syringe-discharging direction to dispense medication from the syringe into the patient's IV when the filling plunger is released. Only a calibrated amount of medicine can be discharged to the patent's IV over time as determined by calibration of the biasing element and a metering element located between the syringe and the patient's IV for a given viscosity of the medication.

公开(公告)号：US20170226595A1

公开(公告)日：2017-08-10

申请号：US15119506

申请日：2015-02-18

Applicant: STC.UNM

Inventor： Fu-Sen Liang ,  Wei Wang

IPC: C12Q1/68

CPC classification number: C12Q1/6897 ,  C12N2510/00

Abstract: This disclosure describes compositions and methods that involve a first modular component and a second modular component. The first modular component includes a first target molecule coupled to a first dimerizing moiety. The second modular component includes a second target molecule coupled to a second dimerizing moiety. The first dimerizing moiety dimerizes with the second dimerizing moiety when the first dimerizing moiety binds a chemical induced proximity (CIP) inducer.

公开(公告)号：US09717783B2

公开(公告)日：2017-08-01

申请号：US13946562

申请日：2013-07-19

Applicant: STC.UNM

Inventor： Bryce Chackerian ,  David S. Peabody ,  Ebenezer Tumban

IPC: A61K39/12 ,  A61K39/00

CPC classification number: A61K39/12 ,  A61K2039/5258 ,  A61K2039/58 ,  C12N2710/20034 ,  C12N2795/18023 ,  C12N2795/18071

Abstract: The invention provides immunotherapeutic and prophylactic bacteriophage viral-like particle (VLPs) which are useful in the treatment and prevention of human papillomavirus (HPV) infections and related disorders, including cervical cancer and persistent infections associated with HPV. Related compositions (e.g. vaccines), nucleic acid constructs, and therapeutic methods are also provided. VLPs and related compositions of the invention induce high titer antibody responses against HPV L2 and protect against HPV challenge in vivo. VLPs, VLP-containing compositions, and therapeutic methods of the invention induce an immunogenic response against HPV infection, confer immunity against HPV infection, protect against HPV infection, and reduce the likelihood of infection by HPV infection.