公开(公告)号：US20160183858A1

公开(公告)日：2016-06-30

申请号：US15061924

申请日：2016-03-04

Applicant: DexCom, Inc.

Inventor： Naresh C. Bhavaraju ,  Arturo Garcia ,  Hari Hampapuram ,  Apurv Ullas Kamath ,  Aarthi Mahalingam ,  Dmytro Sokolovskyy ,  Stephen J. Vanslyke

IPC: A61B5/145

CPC classification number: G01N33/48792 ,  A61B5/14532 ,  A61B5/1495 ,  A61B5/7221 ,  A61B2560/0223 ,  A61B2560/0266 ,  A61B2560/0276 ,  A61B2560/028 ,  G01M99/008 ,  G01N33/49 ,  G01N33/66 ,  G16C20/80 ,  G16C99/00

Abstract: Systems and methods for processing sensor data and end of life detection are provided. In some embodiments, a method for determining the end of life of a continuous analyte sensor includes evaluating a plurality of risk factors using an end of life function to determine an end of life status of the sensor and providing an output related to the end of life status of the sensor. The plurality of risk factors may be selected from the list including the number of days the sensor has been in use, whether there has been a decrease in signal sensitivity, whether there is a predetermined noise pattern, whether there is a predetermined oxygen concentration pattern, and error between reference BG values and EGV sensor values.

公开(公告)号：US09320466B2

公开(公告)日：2016-04-26

申请号：US14058091

申请日：2013-10-18

Applicant: DexCom, Inc.

Inventor： Peter C. Simpson ,  Robert J. Boock ,  Apurv Ullas Kamath ,  Matthew D. Wightlin ,  Michael J. Estes

IPC: A61B5/00 ,  A61B5/1473 ,  A61B5/145 ,  A61B5/1486 ,  B05C3/10

CPC classification number: A61B5/1473 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B2560/0223 ,  A61B2562/0209 ,  A61B2562/043 ,  A61B2562/125 ,  B05C3/10

Abstract: Devices and methods are provided for continuous measurement of an analyte concentration. The device can include a sensor having a plurality of sensor elements, each having at least one characteristic that is different from other sensor(s) of the device. In some embodiments, the plurality of sensor elements are each tuned to measure a different range of analyte concentration, thereby providing the device with the capability of achieving a substantially consistent level of measurement accuracy across a physiologically relevant range. In other embodiments, the device includes a plurality of sensor elements each tuned to measure during different time periods after insertion or implantation, thereby providing the sensor with the capability to continuously and accurately measure analyte concentrations across a wide range of time periods. For example, a sensor system 180 is provided having a first working electrode 150 comprising a first sensor element 102 and a second working electrode 160 comprising a second sensor element 104, and a reference electrode 108 for providing a reference value for measuring the working electrode potential of the sensor elements 102, 104.

Abstract translation: 提供了用于连续测量分析物浓度的装置和方法。 该装置可以包括具有多个传感器元件的传感器，每个传感器元件具有与装置的其它传感器不同的至少一个特性。 在一些实施例中，多个传感器元件各自被调谐以测量分析物浓度的不同范围，从而为器件提供在生理学相关范围内实现基本一致的测量精度水平的能力。 在其他实施例中，该装置包括多个传感器元件，每个传感器元件在插入或植入之后的不同时间期间被调整以测量，从而为传感器提供在宽范围的时间段内连续且精确地测量分析物浓度的能力。 例如，传感器系统180被提供有具有包括第一传感器元件102的第一工作电极150和包括第二传感器元件104的第二工作电极160以及用于提供用于测量工作电极电位的参考值的参考电极108 的传感器元件102,104。

公开(公告)号：US20160098540A1

公开(公告)日：2016-04-07

申请号：US14874334

申请日：2015-10-02

Applicant: DexCom, Inc.

Inventor： Georgios Zamanakos ,  Daniel Justin Wiedeback ,  Jeffrey Grant Stewart ,  Eli Reihman ,  David Price ,  Lauren C. Miller ,  Keri Leone ,  Dan Kraemer ,  Katherine Eng Kirby ,  Greg Kida ,  Apurv Ullas Kamath ,  Adam R. Greene ,  Rebecca Gimenez ,  Sarah Paige Elli ,  Rian Draeger ,  Shane Philip Delmore ,  Leif N. Bowman

IPC: G06F19/00

CPC classification number: G06T11/206 ,  A61B5/0022 ,  A61B5/14532 ,  A61B5/7275 ,  A61B5/7282 ,  A61B5/742 ,  G06T2200/24 ,  G16H10/40 ,  G16H15/00 ,  G16H20/17 ,  G16H40/63 ,  Y02A90/26

Abstract: Systems and methods are described that provide a dynamic reporting functionality that can identify important information and dynamically present a report about the important information that highlights important findings to the user. The described systems and methods are generally described in the field of diabetes management, but are applicable to other medical reports as well. In one implementation, the dynamic reports are based on available data and devices. For example, useless sections of the report, such as those with no populated data, may be removed, minimized in importance, assigned a lower priority, or the like.

Abstract translation: 描述了系统和方法，其提供动态报告功能，其可以识别重要信息并且动态地呈现关于向用户突出重要发现的重要信息的报告。 所描述的系统和方法通常在糖尿病管理领域中描述，但也适用于其他医疗报告。 在一个实现中，动态报告基于可用的数据和设备。 例如，报告中的无用部分（例如没有填充数据的部分）可能会被删除，重要性最小化，分配较低优先级等。

公开(公告)号：US20160081632A1

公开(公告)日：2016-03-24

申请号：US14960127

申请日：2015-12-04

Applicant: DexCom, Inc.

Inventor： Apurv Ullas Kamath ,  Jack Pryor ,  Alexandra Lynn Carlton ,  Kristin Koenekamp Cote ,  Leif N. Bowman ,  Michael Robert Mensinger

IPC: A61B5/00 ,  A61B5/1495 ,  A61B5/145

Abstract: Methods and systems for encouraging interactions with a glucose monitoring system include incrementing a score and/or providing a reward based on a variety of different interactions with the glucose monitoring system. The interactions which improve the score may include initiating or changing displays, downloading data, setting operational parameters and other interactions that are independent of a user's glucose measurements. Encouraging these interactions can enhance success in maintaining healthy glucose concentrations.

公开(公告)号：US20160081597A1

公开(公告)日：2016-03-24

申请号：US14862079

申请日：2015-09-22

Applicant: DexCom, Inc.

Inventor： Naresh C. Bhavaraju ,  Michael A. Bloom ,  Leif N. Bowman ,  Alexandra Lynn Carlton ,  Katherine Yerre Koehler ,  Hari Hampapuram ,  Jonathan Hughes ,  Lauren Hruby Jepson ,  Apurv Ullas Kamath ,  Anna Leigh Rack-Gomer ,  Peter c. Simpson ,  Stephen J. Vanslyke

IPC: A61B5/145 ,  A61M5/172 ,  A61B5/00 ,  A61B5/1455 ,  A61B5/1486

CPC classification number: A61B5/14532 ,  A61B5/0002 ,  A61B5/0004 ,  A61B5/14503 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/6898 ,  A61B5/72 ,  A61B5/7221 ,  A61B5/7275 ,  A61B5/7282 ,  A61B5/742 ,  A61B5/7435 ,  A61B5/746 ,  A61B5/7475 ,  A61B2560/0223 ,  A61B2560/0487 ,  A61M5/1723 ,  A61M2230/005 ,  A61M2230/201 ,  G16H40/40 ,  G16H40/63 ,  Y02A90/26

Abstract: Systems and methods described provide dynamic and intelligent ways to change the required level of user interaction during use of a monitoring device. The systems and methods generally relate to real time switching between a first or initial mode of user interaction and a second or new mode of user interaction. In some cases, the switching will be automatic and transparent to the user, and in other cases user notification may occur. The mode switching generally affects the user's interaction with the device, and not just internal processing. The mode switching may relate to calibration modes, data transmission modes, control modes, or the like.

公开(公告)号：US20150351683A1

公开(公告)日：2015-12-10

申请号：US14830568

申请日：2015-08-19

Applicant: DexCom, Inc.

Inventor： James H. Brauker ,  Mark A. Tapsak ,  Sean T. Saint ,  Apurv Ullas Kamath ,  Paul V. Neale ,  Peter C. Simpson ,  Michael Robert Mensinger ,  Dubravka Markovic

IPC: A61B5/00 ,  A61M5/172 ,  A61M11/00 ,  A61B5/1486 ,  A61M15/00 ,  A61B5/145 ,  A61M5/315

CPC classification number: A61M5/31525 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/4839 ,  A61B2560/0443 ,  A61M5/1723 ,  A61M11/00 ,  A61M15/0001 ,  A61M2005/1726 ,  A61M2205/18 ,  A61M2205/3303 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3468 ,  G16H20/17 ,  G16H40/63

Abstract: Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.

公开(公告)号：US20150289823A1

公开(公告)日：2015-10-15

申请号：US14659500

申请日：2015-03-16

Applicant: DexCom, Inc.

Inventor： Anna Leigh Rack-Gomer ,  Hari Hampapuram ,  Apurv Ullas Kamath ,  Eli Reihman ,  Leif N. Bowman ,  Arturo Garcia ,  Katherine Yerre Grubstein ,  Naresh C. Bhavaraju ,  Rian Draeger ,  Paul Kramer ,  Paul Noble-Campbell

IPC: A61B5/00 ,  G06F3/0484 ,  A61M5/50 ,  A61B5/145 ,  A61M5/172 ,  G06F3/0481 ,  G06F19/00

CPC classification number: A61B5/7282 ,  A61B5/01 ,  A61B5/1112 ,  A61B5/1118 ,  A61B5/14532 ,  A61B5/165 ,  A61B5/168 ,  A61B5/4306 ,  A61B5/4839 ,  A61B5/4866 ,  A61B5/6898 ,  A61B5/7239 ,  A61B5/7275 ,  A61B5/7405 ,  A61B5/742 ,  A61B5/743 ,  A61B5/7435 ,  A61B5/746 ,  A61B5/7475 ,  A61B2505/07 ,  A61B2560/0295 ,  A61B2560/0475 ,  A61M5/1723 ,  A61M5/5086 ,  A61M2005/1726 ,  G06F3/04817 ,  G06F3/04847 ,  G06F19/3468 ,  G16H40/63

Abstract: Systems and methods are disclosed that employ several or numerous factors in the determination of a glycemic urgency index (GUI), which may be based on a measured blood glucose level as well as other factors. The other factors may include time derivatives of the glucose level and/or other factors, e.g., user-entered data, data measured by other sensors or received from a network source, or historical data. The GUI is then presented to the user in an interesting way, e.g., via a background color or other inconspicuous notifier, e.g., on a mobile device such as a smart phone. The GUI may also be employed in the triggering of actionable alerts and alarms on an electronic device for the user. The GUI, or another index calculated from combinations of the variables and parameters described, may further be employed to drive a medicament delivery device such as a pump.

Abstract translation: 公开了在确定血糖紧急指数（GUI）中的几个或多个因素的系统和方法，其可以基于测量的血糖水平以及其他因素。 其他因素可以包括葡萄糖水平的时间导数和/或其他因素，例如用户输入的数据，由其他传感器测量或从网络源接收的数据或历史数据。 然后，以有趣的方式，例如通过背景颜色或其他不显眼的通知器（例如，诸如智能电话的移动设备）将GUI呈现给用户。 GUI也可以用于在用户的电子设备上触发可操作的警报和警报。 GUI或由所述变量和参数的组合计算出的另一指标可进一步用于驱动药物输送装置例如泵。

公开(公告)号：US20150250429A1

公开(公告)日：2015-09-10

申请号：US14720668

申请日：2015-05-22

Applicant: DexCom, Inc.

Inventor： Hari Hampapuram ,  Anna Leigh Rack-Gomer ,  Naresh C. Bhavaraju ,  Apurv Ullas Kamath ,  Claudio Cobelli ,  Giovanni Sparacino ,  Andrea Facchinetti ,  Chiara Zecchin

IPC: A61B5/00 ,  A61B5/145

CPC classification number: A61B5/746 ,  A61B5/0004 ,  A61B5/002 ,  A61B5/0022 ,  A61B5/0031 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/4848 ,  A61B5/4866 ,  A61B5/7221 ,  A61B5/7275 ,  G06F19/00

Abstract: Systems and methods for providing sensitive and specific alarms indicative of glycemic condition are provided herein. In an embodiment, a method of processing sensor data by a continuous analyte sensor includes: evaluating sensor data using a first function to determine whether a real time glucose value meets a first threshold; evaluating sensor data using a second function to determine whether a predicted glucose value meets a second threshold; activating a hypoglycemic indicator if either the first threshold is met or if the second threshold is predicted to be met; and providing an output based on the activated hypoglycemic indicator.

Abstract translation: 本文提供了用于提供指示血糖状况的敏感和特定警报的系统和方法。 在一个实施例中，通过连续分析物传感器处理传感器数据的方法包括：使用第一函数来评估传感器数据，以确定实时葡萄糖值是否满足第一阈值; 使用第二功能评估传感器数据，以确定预测的葡萄糖值是否满足第二阈值; 如果满足第一阈值或者如果预测到第二阈值被满足则激活低血糖指示剂; 并提供基于激活的低血糖指标的输出。

公开(公告)号：US09119529B2

公开(公告)日：2015-09-01

申请号：US13742841

申请日：2013-01-16

Applicant: DexCom, Inc.

Inventor： Hari Hampapuram ,  Anna Leigh Rack-Gomer ,  Naresh C. Bhavaraju ,  Apurv Ullas Kamath ,  Claudio Cobelli ,  Giovanni Sparacino ,  Andrea Facchinetti ,  Chiara Zecchin

IPC: G08B21/00 ,  A61B5/00 ,  A61B5/145

CPC classification number: A61B5/746 ,  A61B5/0004 ,  A61B5/002 ,  A61B5/0022 ,  A61B5/0031 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/4848 ,  A61B5/4866 ,  A61B5/7221 ,  A61B5/7275 ,  G06F19/00

Abstract: Systems and methods for providing sensitive and specific alarms indicative of glycemic condition are provided herein. In an embodiment, a method of processing sensor data by a continuous analyte sensor includes: evaluating sensor data using a first function to determine whether a real time glucose value meets a first threshold; evaluating sensor data using a second function to determine whether a predicted glucose value meets a second threshold; activating a hypoglycemic indicator if either the first threshold is met or if the second threshold is predicted to be met; and providing an output based on the activated hypoglycemic indicator.

Abstract translation: 本文提供了用于提供指示血糖状况的敏感和特定警报的系统和方法。 在一个实施例中，通过连续分析物传感器处理传感器数据的方法包括：使用第一函数来评估传感器数据，以确定实时葡萄糖值是否满足第一阈值; 使用第二功能评估传感器数据，以确定预测的葡萄糖值是否满足第二阈值; 如果满足第一阈值或者如果预测到第二阈值被满足则激活低血糖指示剂; 并提供基于激活的低血糖指标的输出。

公开(公告)号：US20150087942A1

公开(公告)日：2015-03-26

申请号：US14552398

申请日：2014-11-24

Applicant: DexCom, Inc.

Inventor： James H. Brauker ,  Apurv Ullas Kamath

IPC: A61B5/1473 ,  A61B5/1495 ,  A61B5/00 ,  A61B5/145

CPC classification number: A61B5/1473 ,  A61B5/0004 ,  A61B5/002 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/15142 ,  A61B5/72 ,  A61B5/742 ,  A61B5/746

Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.