公开(公告)号：US09612657B2

公开(公告)日：2017-04-04

申请号：US14775480

申请日：2013-03-14

Applicant: Brainlab AG

Inventor： Pascal Bertram ,  Dirk Staneker

IPC: G09G5/00 ,  G06F3/01 ,  G06F3/0481 ,  H04N13/00 ,  H04N13/04 ,  G06T15/08

CPC classification number: G06F19/321 ,  G06F3/013 ,  G06F3/04815 ,  G06F19/00 ,  G06T11/60 ,  G06T15/08 ,  G06T2210/41 ,  G16H30/20 ,  H04N13/156 ,  H04N13/344 ,  H04N13/383

Abstract: A medical image data processing method for determining a set of medical image data to be displayed, the data processing method being constituted to be executed by a computer and comprising the following steps: a) acquiring medical image data comprising three-dimensional medical image information describing an anatomical structure, and displaying the medical image information; b) acquiring navigation display feature data comprising navigation display feature information describing at least one graphical navigation feature; c) displaying the navigation display information simultaneously with the medical image information; d) acquiring viewing direction data comprising viewing direction information describing a spatial relationship of a viewing direction of a user relative to the position of the at least one graphical navigation feature; e) determining, based on the viewing direction data, image information subset data comprising image data subset information describing a subset of the medical image information to be selected for display.

公开(公告)号：US20170050050A1

公开(公告)日：2017-02-23

申请号：US15118724

申请日：2014-02-14

Applicant: Brainlab AG

Inventor： Kajetan Berlinger ,  Stephan Froehlich ,  Eva Maria Gronbach

IPC: A61N5/10 ,  G06T7/00 ,  A61B90/00 ,  A61B6/00 ,  A61B6/04 ,  A61B6/03

CPC classification number: A61B6/0492 ,  A61B6/032 ,  A61B6/0421 ,  A61B6/501 ,  A61B6/5211 ,  A61B6/547 ,  A61B90/14 ,  A61B90/39 ,  A61B2034/2055 ,  A61B2090/101 ,  A61B2090/364 ,  A61B2090/3937 ,  A61B2090/3983 ,  A61N5/1049 ,  A61N5/1069 ,  A61N2005/1061 ,  G01T7/005 ,  G06F19/00 ,  G06K9/00208 ,  G06K9/2054 ,  G06K9/2063 ,  G06K9/32 ,  G06K9/3216 ,  G06K9/6212 ,  G06K2009/2045 ,  G06K2009/3225 ,  G06K2009/3291 ,  G06T7/0014 ,  G06T7/74 ,  G06T2207/10081 ,  G06T2207/20221 ,  G06T2207/30004 ,  G06T2207/30204 ,  G06T2207/30208 ,  G06T2219/2004

Abstract: The presently described method is directed to determining a way of positioning a patient before execution of a medical procedure involving irradiating the patient with ionizing treatment radiation based on comparing medical images of the patient with a pre-acquired medical image. The planning computed tomography is searched for an image of the reference structure in order to determine the position of the patient relative to a patient support device. A retroreflective marker device, having a known and advantageously fixed position relative to the base plate, is detected by a navigation system operatively coupled to a motor of the support device. Based on the detected position of the marker device, the motor of the support device is activated to drive the patient into a desired position relative to beam direction along which the treatment radiation is to be issued towards the patient to execute the medical procedure.

Abstract translation: 目前描述的方法涉及确定在执行包括用患者的医疗图像与预先获取的医学图像进行比较的电离治疗辐射的医疗过程之前定位患者的方式。 搜索计划的计算机断层摄影以获得参考结构的图像，以便确定患者相对于患者支持装置的位置。 具有已知且有利地相对于基板的固定位置的回射标记装置由可操作地耦合到支撑装置的电动机的导航系统来检测。 基于检测到的标记装置的位置，启动支撑装置的电动机，以驱动患者进入相对于波束方向的期望位置，沿着该方向向治疗辐射发射治疗辐射以执行医疗程序。

公开(公告)号：US20160284082A1

公开(公告)日：2016-09-29

申请号：US15034077

申请日：2013-11-05

Applicant: BRAINLAB AG

Inventor： Bálint Varkuti

IPC: G06T7/00 ,  A61B5/00 ,  A61B5/055 ,  A61B6/00 ,  A61B8/08 ,  G06F17/16 ,  A61B6/03

CPC classification number: G06T7/0012 ,  A61B5/055 ,  A61B5/4064 ,  A61B6/032 ,  A61B6/037 ,  A61B6/481 ,  A61B6/501 ,  A61B8/0808 ,  A61B8/488 ,  G06F17/16 ,  G06F19/00 ,  G06F19/321 ,  G06T17/005 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/10092 ,  G06T2207/10104 ,  G06T2207/30016 ,  G06T2207/30241 ,  G06T2210/41 ,  G16H50/50

Abstract: The invention relates to a medical data processing method for determining a vulnerability field of a brain of a patient, the steps of the method being constituted to be executed by a computer and comprising: a) acquiring a nerve-indicating dataset comprising information about the brain of the patient suitable for identifying neural fibres in the brain of the patient; b) determining nodes within the brain preferably being neuron-rich grey matter parts of the brain; c) determining the axonal linkage of the nodes based on the nerve-indicating dataset to obtain edges connecting the nodes, the nodes and edges constituting a connectivity graph; d) determining a weight for each of the edges depending on centrality graph theoretical statistical measure of the respective edge in the connectivity graph; e) determining, for each of the edges, which voxels in a dataset of the brain of the patient belong to the edges or are passed by the edges and assigning or adding the determined weight of the respective edges to all of the voxels belonging to the respective edge to obtain a weighted voxel-based dataset of the brain of the patient defining the vulnerability field of the brain.

Abstract translation: 本发明涉及一种用于确定患者脑的脆弱性领域的医疗数据处理方法，该方法的步骤被构造为由计算机执行，并且包括：a）获取包含关于脑的信息的神经指示数据集 适合于鉴别患者脑部神经纤维的患者; b）确定脑内的节点优选地是脑的神经元丰富的灰质部分; c）基于神经指示数据集来确定节点的轴突连接，以获得连接节点，构成连通图的节点和边缘的边缘; d）根据连通性图中相应边缘的中心图理论统计量度确定每个边缘的权重; e）为每个边缘确定患者的脑的数据集中的哪些体素属于边缘或被边缘通过，并且将所确定的各个边的权重分配或添加到属于所述边缘的所有体素 相应的边缘以获得定义脑的脆弱性区域的患者的脑的加权基于体素的数据集。

公开(公告)号：US20160256223A1

公开(公告)日：2016-09-08

申请号：US15032158

申请日：2014-01-13

Applicant: BRAINLAB AG

Inventor： Martin Haimerl ,  Johannes Manus

IPC: A61B34/20 ,  A61B34/00

CPC classification number: A61B34/20 ,  A61B34/25 ,  A61B2034/2048 ,  A61B2034/2051 ,  A61B2034/2055 ,  A61B2034/2057 ,  A61B2034/2059 ,  A61B2034/2065 ,  G01S5/021

Abstract: A data processing method for generating a compensation information for hacking or for determining the position and/or orientation of an object in space, the method comprising the following steps performed by a computer: a) acquiring a predetermined constraint information defining one or more relative or absolute positions and/or orientations of the object in space; b) acquiring position and/or orientation data of the object while the object is positioned or moved while fulfilling the predetermined constraint; and c) determining the compensation information based on the predetermined constraint information and the acquired position and/or orientation data of the object.

Abstract translation: 一种用于生成用于黑客或确定空间中的对象的位置和/或方位的补偿信息的数据处理方法，所述方法包括由计算机执行的以下步骤：a）获取定义一个或多个相对或 物体在空间中的绝对位置和/或取向; b）在满足所述预定约束的同时在所述对象被定位或移动的同时获取所述对象的位置和/或取向数据; 以及c）基于所述预定约束信息和所获取的所述对象的位置和/或取向数据来确定所述补偿信息。

公开(公告)号：US20160217567A1

公开(公告)日：2016-07-28

申请号：US14901289

申请日：2013-07-26

Applicant: BRAINLAB AG

Inventor： JENS KEUCHEL ,  DANIEL MODROW

IPC: G06T7/00

CPC classification number: G06T7/0012 ,  G06K9/6293 ,  G06K2209/05 ,  G06T7/11 ,  G06T7/174 ,  G06T7/70 ,  G06T2207/10081 ,  G06T2207/10084 ,  G06T2207/10088 ,  G06T2207/10104 ,  G06T2207/10116 ,  G06T2207/10132 ,  G06T2207/10136 ,  G06T2207/20104 ,  G06T2207/30008 ,  G06T2207/30061 ,  G06T2207/30096 ,  G06T2207/30196

Abstract: The invention relates to a medical data processing method of segmenting image features in medical images generated with different imaging modalities, wherein the image features represent a corresponding anatomical structure in each of the medical images, the method being constituted to be executed by a computer and comprising the following steps: a) acquiring (SI) first modality medical image data describing a first modality medical image containing a first modality image representation of the anatomical structure; b) acquiring (SI) second modality medical image data describing a second modality medical image containing a second modality image representation of the anatomical structure; c) determining, based on the first modality medical image data and the second modality medical image data, modality transformation data describing a mapping transformation between the image information in the first modality image data and the image information in the second modality image data; d) acquiring colour value data describing a colour value of the image elements in the first modality medical image and in the second modality medical image; e) determining (S2-S7), based on the first modality medical image data, first modality segmentation data describing the result of segmenting the first modality image representation from the first modality medical image data; f) determining (S8-S10), based on the first modality segmentation data and the modality transformation data and the colour value data, second modality segmentation data describing a result of segmenting the second modality image representation from the second modality medical image data.

Abstract translation: 本发明涉及一种分割不同成像模式生成的医学图像中的图像特征的医学数据处理方法，其中图像特征表示每个医学图像中的相应的解剖结构，该方法被构造为由计算机执行并且包括 以下步骤：a）获取（SI）描述包含解剖结构的第一模态图像表示的第一模态医学图像的第一模态医学图像数据; b）获取（SI）描述包含解剖结构的第二模态图像表示的第二模态医学图像的第二模态医学图像数据; c）基于第一模态医学图像数据和第二模态医学图像数据确定描述第一模态图像数据中的图像信息和第二模态图像数据中的图像信息之间的映射变换的模态变换数据; d）获取描述第一模态医学图像和第二模态医学图像中的图像元素的颜色值的颜色值数据; e）基于第一模态医学图像数据确定（S2-S7）第一模态分割数据，描述从第一模态医学图像数据分割第一模态图像表示的结果; f）基于第一模态分割数据和模态变换数据和颜色值数据来确定（S8-S10），第二模态分割数据描述从第二模态医学图像数据分割第二模态图像表示的结果。

公开(公告)号：USD761428S1

公开(公告)日：2016-07-12

申请号：US29517102

申请日：2015-02-10

Applicant: Brainlab AG

Designer： Rainer Birkenbach

公开(公告)号：US20160051842A1

公开(公告)日：2016-02-25

申请号：US14921363

申请日：2015-10-23

Applicant: Brainlab AG

Inventor： Pascal BERTRAM ,  Claus PROMBERGER ,  Thomas FLURSCHUETZ

IPC: A61N5/10 ,  G06T7/00 ,  G06T15/08

CPC classification number: A61N5/1039 ,  A61N5/103 ,  A61N5/1048 ,  A61N2005/1061 ,  A61N2005/1074 ,  G06F19/00 ,  G06F19/3481 ,  G06T7/0012 ,  G06T7/11 ,  G06T15/06 ,  G06T15/08 ,  G06T2200/04 ,  G06T2207/10072 ,  G06T2207/30024 ,  G06T2207/30096 ,  G06T2210/41 ,  G06T2211/40

Abstract: A method for generating planning data or control data for a radiation treatment, comprising the following steps: acquiring segmented data of an object which contains a treatment volume and a non-treatment volume; modelling at least some or all of the volume or surface of the treatment volume as a source of light or rays exhibiting a predefined or constant initial intensity; modelling the non-treatment volume as comprising volumetric elements or voxels which each exhibit an individually assigned feature or attenuation or transparency value (tmin≦t≦tmax) for the light or rays which feature is assigned to the light or ray or which attenuation or transparency maintains or reduces the intensity of the light or ray as it passes through the respective volumetric element or voxel, wherein the feature or attenuation or transparency value is individually assigned to each volumetric element or voxel of the non-treatment volume; defining a map surface which surrounds the treatment volume or the object; calculating an accumulated intensity value for points or areas on the map surface, the accumulated intensity being the sum of the intensities of all the rays which exhibit the predefined or constant initial intensity and are emitted from the volume or surface of the treatment volume and reach a respective point on the map surface preferably by following a straight line, wherein if the ray passes through a non-treatment volume or voxel, the intensity of the respective ray is reduced or attenuated by a factor which is determined by the individual feature or attenuation or transparency value of the respective non-treatment volume or voxel; and generating an intensity distribution on the map surface using the calculated accumulated intensities.

Abstract translation: 一种用于产生辐射处理的规划数据或控制数据的方法，包括以下步骤：获取包含处理量和非处理量的对象的分段数据; 将处理体积的至少一部分或全部体积或表面建模为呈现预定义或恒定初始强度的光源或射线; 将非处理体积建模为包括体积元素或体素，其各自表现出分配给光或射线的特征的光或射线的单独赋予的特征或衰减或透明度值（tmin＆nlE; t＆nlE; tmax）或哪种衰减或透明度 当光或射线穿过相应的体积元素或体素时，维持或减小光或射线的强度，其中将特征或衰减或透明度值分别分配给非处理体积的每个体积元素或体素; 定义围绕处理体积或物体的地图表面; 计算地图表面上的点或区域的累积强度值，累积强度是表现出预定义或恒定初始强度的所有射线的强度之和，并且从处理体积的体积或表面发射并达到 优选地通过遵循直线的地图表面上的相应点，其中如果光线通过非处理体积或体素，则各个射线的强度由单个特征或衰减确定的因子减小或衰减，或 相应的非处理体积或体素的透明度值; 以及使用所计算的累积强度在所述地图表面上生成强度分布。

公开(公告)号：US20160026243A1

公开(公告)日：2016-01-28

申请号：US14775480

申请日：2013-03-14

Applicant: BRAINLAB AG

Inventor： Pascal Bertram ,  Dirk Staneker

IPC: G06F3/01 ,  G06T15/08 ,  H04N13/04 ,  G06F3/0481 ,  H04N13/00

CPC classification number: G06F19/321 ,  G06F3/013 ,  G06F3/04815 ,  G06F19/00 ,  G06T11/60 ,  G06T15/08 ,  G06T2210/41 ,  G16H30/20 ,  H04N13/156 ,  H04N13/344 ,  H04N13/383

Abstract: A medical image data processing method for determining a set of medical image data to be displayed, the data processing method being constituted to be executed by a computer and comprising the following steps: a) acquiring medical image data comprising three-dimensional medical image information describing an anatomical structure, and displaying the medical image information; b) acquiring navigation display feature data comprising navigation display feature information describing at least one graphical navigation feature; c) displaying the navigation display information simultaneously with the medical image information; d) acquiring viewing direction data comprising viewing direction information describing a spatial relationship of a viewing direction of a user relative to the position of the at least one graphical navigation feature; e) determining, based on the viewing direction data, image information subset data comprising image data subset information describing a subset of the medical image information to be selected for display.

Abstract translation: 一种用于确定要显示的一组医学图像数据的医学图像数据处理方法，所述数据处理方法被构造为由计算机执行，并且包括以下步骤：a）获取包括描述的三维医学图像信息的医学图像数据 解剖结构，并显示医学图像信息; b）获取包括描述至少一个图形导航特征的导航显示特征信息的导航显示特征数据; c）与医学图像信息同时显示导航显示信息; d）获取观看方向数据，所述观看方向数据包括描述用户相对于所述至少一个图形导航特征的位置的观看方向的空间关系的观看方向信息; e）基于观看方向数据确定包括描述要被选择用于显示的医学图像信息的子集的图像数据子集信息的图像信息子集数据。

公开(公告)号：US20160015951A9

公开(公告)日：2016-01-21

申请号：US13709429

申请日：2012-12-10

Applicant: Brainlab AG

Inventor： Christoph Pedain ,  Andreas Hartlep

IPC: A61M37/00

CPC classification number: A61M37/00 ,  A61B2034/2055 ,  A61M5/142 ,  A61M2005/14292 ,  A61M2210/1071

Abstract: A method for planning an infusion into hepatic tissue into a patient includes: obtaining anatomical and/or physiological patient data of the patient's liver or a region of the liver; determining at least one patient parameter from the patient data; planning the infusion using the anatomical patient data, physiological patient data, and/or at least one patient parameter, wherein planning includes determining how an administered substance is distributed in the tissue and/or how the administered substance influences physiological properties of the tissue; and determining a distribution and/or effectiveness of a therapeutic agent administered with the substance or after the substance.

Abstract translation: 一种用于规划将肝组织输注入患者的方法包括：获得患者肝脏或肝脏区域的解剖学和/或生理学患者数据; 从所述患者数据确定至少一个患者参数; 使用解剖患者数据，生理学患者数据和/或至少一个患者参数来计划输注，其中规划包括确定给药物质如何分布在组织中和/或所施用的物质如何影响组织的生理特性; 以及确定施用该物质或物质后的治疗剂的分布和/或有效性。

公开(公告)号：US20150379718A1

公开(公告)日：2015-12-31

申请号：US14766471

申请日：2013-04-03

Applicant: BRAINLAB AG

Inventor： Mario SCHUBERT ,  Melanie WEGNER ,  Sabine KLING

IPC: G06T7/00 ,  G06K9/52 ,  G06T7/60 ,  G06T3/60 ,  G01B11/14

CPC classification number: A61B5/1079 ,  A61B5/0077 ,  A61B5/1072 ,  A61B5/1075 ,  A61B5/1121 ,  A61B5/1127 ,  A61B5/4538 ,  A61B5/7278 ,  A61B34/20 ,  A61B2034/2048 ,  A61B2034/2055 ,  A61B2034/2068 ,  A61B2090/3937 ,  A61B2562/0219 ,  A61B2576/00 ,  G01B11/14 ,  G06F19/00 ,  G06K9/52 ,  G06T3/60 ,  G06T7/0014 ,  G06T7/30 ,  G06T7/60 ,  G06T7/73 ,  G06T7/74 ,  G06T2207/30004 ,  G06T2207/30204

Abstract: A data processing method for determining the relative orientation of an object coordinate system of an anatomical object in a global co-ordinate system, comprising the steps of: acquiring a reference direction dataset representing a first reference direction of a line between a first anatomical landmark of a reference object and a second anatomical landmark of the reference object, and a second reference direction of a line between a third anatomical landmark of the reference object and a fourth anatomical landmark of the reference object, wherein the first and second reference directions are given in a reference coordinate system and the reference object corresponds to the anatomical object; acquiring an object direction dataset representing a first object direction of a line between the first anatomical landmark of the anatomical object and the second anatomical landmark of the anatomical object, and a second object direction of a line between the third anatomical landmark of the anatomical object and the fourth anatomical landmark of the anatomical object, wherein the first and second object directions are given in the global co-ordinate system and the landmarks of the anatomical object correspond to the landmarks of the reference object; calculating the orientation of the reference co-ordinate system relative to the global co-ordinate system which results in the best match between each of the reference directions and the respectively corresponding object direction; and—using the orientation of the reference co-ordinate system in the global co-ordinate system as the relative orientation of the object co-ordinate system.

Abstract translation: 一种用于确定全局坐标系中的解剖学对象的物体坐标系的相对取向的数据处理方法，包括以下步骤：获取基准方向数据集，所述参考方向数据集表示第一解剖学标记之间的线的第一参考方向， 参考对象的参考对象和第二解剖学标记，以及参考对象的第三解剖标记与参考对象的第四解剖学标记之间的线的第二参考方向，其中第一和第二参考方向在 参考坐标系和参考对象对应于解剖对象; 获取表示解剖学对象的第一解剖学标记与解剖学对象的第二解剖学标记之间的线的第一对象方向的对象方向数据集，以及解剖对象的第三解剖学标记之间的线的第二对象方向和 解剖学对象的第四解剖学标记，其中在全局坐标系中给出第一和第二对象方向，并且解剖对象的界标对应于参考对象的界标; 计算参考坐标系相对于全局坐标系的取向，其导致每个参考方向和相应的对象方向之间的最佳匹配; 并使用全局坐标系中参考坐标系的方向作为对象坐标系的相对方向。