中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

2235 records (took 0.042 seconds)

    SYSTEM AND METHOD FOR DEVELOPING A MODEL INDICATIVE OF A SUBJECT'S EMOTIONAL STATE WHEN LISTENING TO MUSICAL PIECES
    371.
    发明申请
    SYSTEM AND METHOD FOR DEVELOPING A MODEL INDICATIVE OF A SUBJECT'S EMOTIONAL STATE WHEN LISTENING TO MUSICAL PIECES 有权
    用于发展音乐表演方面的主观特征的模式的系统和方法

    公开(公告)号：US20150235134A1

    公开(公告)日：2015-08-20

    申请号：US14428852

    申请日：2013-09-17

    Applicant: Agency for Science, Technology and Research

    Inventor： Cuntai Guan ,  Juanhong Yu ,  Yaozhang Pan

    IPC: G06N5/04 ,  G05B13/04 ,  G06F3/16

    CPC classification number: G06F3/165 ,  A61B5/0476 ,  A61B5/048 ,  A61B5/04845 ,  A61B5/165 ,  A61M2230/10

    Abstract: A method for deriving optimal discriminating features indicative of a subject state when the subject listens to one of a set of musical pieces, comprising a step of extracting frequency features from the subject's EEG signal when the subject is in a first subject state and a second subject state, the frequency features being extracted from more than one frequency band in one set of time segments; and identifying optimal discriminating features from the extracted frequency features, the optimal discriminating features indicative of characteristics of the EEG signal when the subject is in the first subject state and the second subject state, wherein one of the first subject state and the second subject state indicates that the subject likes a musical piece while the other state indicates that the subject does not like the musical piece.

    Abstract translation: 一种当主体听到一组音乐作品之一时，导出指示被摄体状态的最佳辨别特征的方法，包括当被摄体处于第一被摄体状态时从被摄体的EEG信号中提取频率特征的步骤，以及第二主体 状态，频率特征从一组时间段中的多于一个频带提取; 以及从所提取的频率特征中识别最佳鉴别特征，当所述对象处于所述第一对象状态和所述第二被摄体状态时指示所述EEG信号的特征的最佳识别特征，其中所述第一对象状态和所述第二对象状态中的一个指示 主体喜欢音乐作品，而另一个状态表示主体不喜欢音乐作品。

    IN VITRO ASSAY FOR PREDICTING RENAL PROXIMAL TUBULAR CELL TOXICITY
    374.
    发明申请
    IN VITRO ASSAY FOR PREDICTING RENAL PROXIMAL TUBULAR CELL TOXICITY 有权
    用于预测肾脏原发性管状细胞毒性的体外测定

    公开(公告)号：US20150219625A1

    公开(公告)日：2015-08-06

    申请号：US14416016

    申请日：2013-07-22

    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

    Inventor： Daniele Zink ,  Yao Li

    IPC: G01N33/50

    CPC classification number: G01N33/5014 ,  G01N33/5026 ,  G01N33/5044 ,  G01N2333/47 ,  G01N2333/4712 ,  G01N2458/00

    Abstract: There is provided an in vitro assay for screening a test compound for toxicity in renal proximal tubular cells. The method comprises contacting a test compound with a test population of renal proximal tubular cells; and examining one or more cell morphology features, examining one or more cytoskeleton features, and/or determining cell numbers of the renal proximal tubular cells in the test population and comparing such cell morphology, arrangement of cytoskeletal components and/or cell count with the respective features of a control population. A change in one or more cell morphology features, a change in arrangement of one or more cytoskeleton features or a decrease in cell numbers of the test population relative to the control population is indicative that the test compound is toxic for renal proximal tubular cells.

    Abstract translation: 提供了用于在肾近端肾小管细胞中筛选测试化合物毒性的体外测定。 该方法包括使测试化合物与肾近端肾小管细胞的测试群体接触; 并检查一个或多个细胞形态特征，检查一个或多个细胞骨架特征，和/或确定测试群体中肾近端肾小管细胞的细胞数，并将细胞骨架成分和/或细胞计数与相应的细胞形态 控制人口的特点。 一个或多个细胞形态特征的改变，一个或多个细胞骨架特征的排列变化或测试群体相对于对照群体的细胞数量的减少表明该测试化合物对肾近端肾小管细胞有毒性。

    ANTIFUNGAL COMPOUND
    376.
    发明申请
    ANTIFUNGAL COMPOUND 有权
    抗菌化合物

    公开(公告)号：US20150203454A1

    公开(公告)日：2015-07-23

    申请号：US14420859

    申请日：2013-08-07

    Applicant: Agency for Science, Technology and Research

    Inventor： Yugen Zhang ,  Jackie Y. Ying ,  Lihong Liu ,  Hong Wu

    IPC: C07D233/61 ,  A01N43/50

    CPC classification number: C07D233/61 ,  A01N43/50 ,  A61K31/787

    Abstract: There is provided compound for use in therapy, the compound comprising repeating units of hydrophilic heterocyclic amine monomers that are coupled by hydrophobic linkers selected to confer a therapeutic effect. There is also provided the use of the above compound in the manufacture of a medicament for the treatment of a fungal infection and a method of treating a fungal infection using the above compound.

    Abstract translation: 提供用于治疗的化合物，所述化合物包含亲水性杂环胺单体的重复单元，所述亲水性杂环胺单体通过被选择赋予治疗效果的疏水性接头偶联。 还提供了上述化合物在制备用于治疗真菌感染的药物中的用途以及使用上述化合物治疗真菌感染的方法。

    METHOD USING FLUORESCENT TURN-ON PROBES FOR CELL-SPECIFIC DETECTION
    377.
    发明申请
    METHOD USING FLUORESCENT TURN-ON PROBES FOR CELL-SPECIFIC DETECTION 审中-公开
    使用荧光开启探针进行细胞特异性检测的方法

    公开(公告)号：US20150192589A1

    公开(公告)日：2015-07-09

    申请号：US14592381

    申请日：2015-01-08

    Applicant: Agency for Science, Technology and Research

    Inventor： Meng Gao ,  Bin Liu ,  Kai Li

    IPC: G01N33/58 ,  C12Q1/34 ,  G01N33/50 ,  C12Q1/44

    CPC classification number: G01N33/582 ,  C12Q1/34 ,  C12Q1/44 ,  G01N33/5079 ,  G01N2333/92 ,  G01N2333/938

    Abstract: The invention provides method for imaging the activity of enzymes or bioactive molecules in cells using fluorescent probes with aggregation-induced emission properties and excited-state intramolecular proton transfer properties. The fluorescent probes prepared according to the invention are those of formula (I), wherein W, X, Y, Z have the meaning as described in the description, R is a reactive group that can interact with enzymes and other bioactive molecules, Linker is a single bond or a combination of chemical bonds linking the targeting group T to the probe molecule, and T represents a targeting group that has an ability to interact with an organelle.

    Abstract translation: 本发明提供了使用具有聚集诱导的发射特性和激发态分子内质子转移特性的荧光探针对细胞中酶或生物活性分子的活性进行成像的方法。 根据本发明制备的荧光探针是式（I）的荧光探针，其中W，X，Y，Z具有描述中所述的含义，R是可与酶和其它生物活性分子相互作用的反应性基团，连接子是 单一键或将靶向基团T连接到探针分子的化学键的组合，T表示具有与细胞器相互作用的能力的靶向基团。

    AUTODIDACTIC COGNITIVE TRAINING DEVICE AND METHOD THEREOF
    378.
    发明申请
    AUTODIDACTIC COGNITIVE TRAINING DEVICE AND METHOD THEREOF 审中-公开
    自动识别训练装置及其方法

    公开(公告)号：US20150187227A1

    公开(公告)日：2015-07-02

    申请号：US14423614

    申请日：2013-08-22

    Applicant: Agency for Science, Technology and Research ,  National University of Singapore

    Inventor： Hai Hong Zhang ,  Cuntai Guan ,  Ranga Krishnan ,  Tih Shih Lee ,  Zheng Yang Chin

    IPC: G09B19/00 ,  A61B5/16 ,  A61B5/0476 ,  A61B5/00

    CPC classification number: G09B19/00 ,  A61B5/0077 ,  A61B5/0476 ,  A61B5/162 ,  A61B5/4088 ,  A61B5/72 ,  A61B5/742 ,  A61B5/7475 ,  G02B6/12033 ,  G02F1/0147 ,  G02F1/025 ,  G02F1/225 ,  G02F2203/585

    Abstract: A cognitive training method has a step of obtaining sensor data of a subject during a memory exercise which in turns determining whether the sensor data includes predetermined information indicative of cognitive functions used for remembering. The step of advancing the memory exercise is carried out when it is determined that the sensor data includes predetermined information indicative of cognitive functions used for remembering. The step of calculating an objective cognitive assessment of the subject when the memory exercise is completed and a cognitive training is measured at least partially in response to the advancing the memory exercise. The fact that an objective cognitive assessment is calculated provides a method of using an autodidactic cognitive training device.

    Abstract translation: 认知训练方法具有在存储器锻炼期间获得被摄体的传感器数据的步骤，其进而确定传感器数据是否包括指示用于记忆的认知功能的预定信息。 当确定传感器数据包括指示用于记忆的认知功能的预定信息时，进行记忆练习的步骤。 记忆练习完成时计算对象的客观认知评估的步骤，并且至少部分地响应于进行记忆练习来测量认知训练。 计算客观认知评估的事实提供了使用自尊式认知训练装置的方法。

    CHROMATOGRAPHIC PURIFICATION OF IMMUNOGLOBULIN G PREPARATIONS WITH PARTICLES HAVING MULTIMODAL FUNCTIONALITIES
    379.
    发明申请
    CHROMATOGRAPHIC PURIFICATION OF IMMUNOGLOBULIN G PREPARATIONS WITH PARTICLES HAVING MULTIMODAL FUNCTIONALITIES 有权
    具有多种功能的颗粒的免疫球蛋白G制备的色谱纯化

    公开(公告)号：US20150183852A1

    公开(公告)日：2015-07-02

    申请号：US14555060

    申请日：2014-11-26

    Applicant: Agency for Science, Technology and Research

    Inventor： Peter Stanley Gagnon

    IPC: C07K16/00 ,  C07K1/16

    CPC classification number: C07K16/00 ,  B01D15/363 ,  C07K1/16 ,  C07K1/165 ,  C07K1/18 ,  C07K16/22 ,  C07K16/241 ,  C07K16/32

    Abstract: A method of purifying a sample containing a desired protein includes the steps of (i) providing a packed chromatographic column having positively charged porous particles, (ii) equilibrating the column to the conditions to which the desired protein in the sample is to elute, (iii) contacting the sample with the packed chromatographic column such that the sample volume applied to the packed chromatographic column is less than or equal to the interparticle space of the positively charged porous particles within the packed chromatographic column, (iv) eluting the desired protein from the packed chromatographic column, where the desired protein is in a purer state and in the conditions to which the packed chromatographic column was equilibrated; where the desired protein is an antibody, an antibody fragment, an antibody derivative, or an antibody fusion protein.

    Abstract translation: 纯化含有所需蛋白质的样品的方法包括以下步骤：（i）提供具有带正电荷的多孔颗粒的填充色谱柱，（ii）将色谱柱平衡至样品中所需蛋白质洗脱的条件（ iii）使样品与填充色谱柱接触，使得施加到填充色谱柱的样品体积小于或等于填充色谱柱中带正电荷的多孔颗粒的颗粒间间隔，（iv）从所需的蛋白质洗脱所需的蛋白质 填充色谱柱，其中所需的蛋白质处于更纯的状态和填充色谱柱平衡的条件下; 其中所需蛋白质是抗体，抗体片段，抗体衍生物或抗体融合蛋白。

Patent Agency Ranking