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公开(公告)号:US11324704B2
公开(公告)日:2022-05-10
申请号:US16082594
申请日:2017-03-06
Applicant: OSAKA UNIVERSITY , NATIONAL INSTITUTE FOR MATERIALS SCIENCE , NIPPON ZOKI PHARMACEUTICAL CO., LTD.
Inventor: Hiroyuki Tanaka , Kiyoshi Okada , Hideki Yoshikawa , Koji Suzuki , Mitsuhiro Ebara
IPC: A61K9/70 , A61K47/34 , A61K47/36 , A61K31/714 , A61K35/36 , A61K45/00 , A61K38/18 , A61P25/02 , A61K47/32
Abstract: Provided is a sustained release sheet that includes a drug for treating nerve injury, wherein the sheet is applied to a nerve injury site, can maintain a high concentration of the drug over a long period, and promotes nerve regeneration without stimulating the nerves, even when the sheet is implanted in the periphery of the nerve injury site. Also provided is a production method for the sheet. This sustained drug release sheet for treating nerve injury is a sheet comprising a non-woven fabric that is formed from nanofibers each containing a drug such as vitamin B12 and a biocompatible polymer such as a biodegradable aliphatic polyester, and is implanted in the periphery of the nerve injury site to promote nerve regeneration.
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公开(公告)号:US11203688B2
公开(公告)日:2021-12-21
申请号:US16318634
申请日:2017-07-11
Applicant: NATIONAL INSTITUTE FOR MATERIALS SCIENCE
Inventor: Masayoshi Higuchi , Miki Kanao
IPC: H01B1/12 , G02F1/15 , C08L101/00 , G02F1/1516 , C08G83/00 , G02F1/1523 , G02F1/155 , C09K9/02 , G02F1/1524
Abstract: The present invention relates to a composite having exceptional heat resistance and durability that exhibits quick response characteristics when used in an electrochromic device; an electrochromic device in which the composite is used; and a method for producing said composite and device. This composite contains an organic/metallic hybrid polymer that contains an organic ligand and a metal ion coordinated to the organic ligand, and an ionic liquid. The organic/metallic hybrid polymer forms ionic bonds with the ionic liquid. This electrochromic device comprises a first electrode, an electrochromic layer containing the composite, an electrolyte layer, and a second electrode.
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公开(公告)号:US20210372958A1
公开(公告)日:2021-12-02
申请号:US16644843
申请日:2018-08-24
Applicant: NATIONAL INSTITUTE FOR MATERIALS SCIENCE
Inventor: Shinsuke ISHIHARA , Jan LABUTA , Takashi NAKANISHI
IPC: G01N27/12
Abstract: [Object] To provide a formaldehyde detecting sensor capable of constantly monitoring formaldehyde selectively and with high accuracy.
[Solving Means] A formaldehyde detecting sensor according to the present invention includes: a reaction portion that contains at least a hydroxylamine salt and reacts with formaldehyde to generate an acid; and a response unit that includes an electrode carrying a carbon material, an electrical resistance value of the carbon material varying depending on the acid generated in the reaction portion, in which the hydroxylamine salt and the carbon material are separated from each other.-
公开(公告)号:US20210318261A1
公开(公告)日:2021-10-14
申请号:US17268715
申请日:2019-08-06
Applicant: NATIONAL INSTITUTE FOR MATERIALS SCIENCE
Inventor: Akihiro OKAMOTO , Wei-Peng LI
IPC: G01N27/406
Abstract: A measurement device according to one embodiment of the present invention, comprises: a voltage applying part for applying a voltage between electrodes of a biosensor, the biosensor comprising a solid electrolyte and at least two electrodes, and being configured such that the solid electrolyte and the electrodes are in contact with each other; a detection part for measuring a current value flowing between the electrodes when the voltage is applied; and a computing part for providing information resulting from the microorganisms by comparing the current value with a reference value stored in advance in which a current value and at least one type of factor selected from the group consisting of the presence or absence of the biological particles, a proliferative state of the microorganisms, and the presence or absence of expression of pathogenicity of the microorganisms are defined.
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公开(公告)号:US20210303601A1
公开(公告)日:2021-09-30
申请号:US17266591
申请日:2019-08-01
Applicant: NATIONAL INSTITUTE FOR MATERIALS SCIENCE
Inventor: Michiko YOSHITAKE
IPC: G06F16/28 , G06F16/2452 , G06F16/242 , G06F16/248 , G06F40/247
Abstract: To effectively utilize knowledge of relationship information among material property parameters the users tangibly and intangibly have in a search system that generates a graph in which material property parameters are nodes and relationships of the material property parameters are edges from a database of material property parameter pairs whose relationships are already known, and conducts a path search in the generated graph. A search system, which includes the database, a graph generator that generates the graph, and a graph searcher searches the graph, further includes a user interface and a user information storage unit corresponding to each user. The user conducts a search unique to the user by inputting relationship information between the material property parameters that he has to the user information storage unit and integrating the relationship information into the above graph. Further, by accumulating a history of searches conducted by the user in the user information storage unit and analyzing the search history, the user can be provided with new knowledge.
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公开(公告)号:US20210255142A1
公开(公告)日:2021-08-19
申请号:US17256832
申请日:2019-07-05
Applicant: NATIONAL INSTITUTE FOR MATERIALS SCIENCE
Inventor: Akihiro OKAMOTO , Divya NARADASU
IPC: G01N27/48 , G01N33/487 , G01N27/327
Abstract: [Object] An object of the present technology to provide a diagnosing apparatus capable of providing, more accurately and simply, information for determining at least one item selected from the group consisting of a type of an illness that has developed in a subject, and a state of progress of the illness that has developed in the subject. Another object of the present technology is to provide an analysis method.
[Solving Means] There is provided a diagnosing apparatus including: a cell into which a sample solution including collected body fluid is introduced; at least two electrodes that are disposed in the cell and come into contact with the sample solution; a voltage applying unit that applies a voltage between the electrodes; a measuring unit that measures an electrochemical response when the voltage is applied; a storage unit that stores a reference; and an analysis output unit that compares a numerical value obtained from the response with the reference, and provides information for determining at least one item selected from the group consisting of a type of an illness that has developed in a subject, and a state of progress of the illness that has developed in the subject.-
公开(公告)号:US11084980B2
公开(公告)日:2021-08-10
申请号:US16055343
申请日:2018-08-06
Applicant: MITSUBISHI CHEMICAL CORPORATION , NATIONAL INSTITUTE FOR MATERIALS SCIENCE , NICHIA CORPORATION , CITIZEN ELECTRONICS CO., LTD.
Inventor: Naoto Hirosaki , Kyota Ueda , Hajime Yamamoto
IPC: C09K11/77 , C01B21/06 , C01B21/082 , C04B35/447 , C04B35/58 , C04B35/581 , C04B35/584 , C04B35/597 , C09K11/08 , C09K11/64 , H01L33/50
Abstract: Phosphors include a CaAlSiN3 family crystal phase, wherein the CaAlSiN3 family crystal phase comprises at least one element selected from the group consisting of Mn, Ce, Pr, Nd, Sm, Eu, Tb, Dy, Ho, Er, Tm, and Yb.
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公开(公告)号:US20210205234A1
公开(公告)日:2021-07-08
申请号:US17163871
申请日:2021-02-01
Applicant: OSAKA UNIVERSITY , NATIONAL INSTITUTE FOR MATERIALS SCIENCE , NIPPON ZOKI PHARMACEUTICAL CO., LTD.
Inventor: Hiroyuki TANAKA , Kiyoshi OKADA , Hideki YOSHIKAWA , Koji SUZUKI , Mitsuhiro EBARA
IPC: A61K9/70 , A61K47/34 , A61K47/36 , A61K31/714 , A61K35/36 , A61K45/00 , A61K38/18 , A61P25/02 , A61K47/32
Abstract: A sustained release sheet that includes a drug for treating nerve injury, wherein the sheet is applied to a nerve injury site, can maintain a high concentration of the drug over a long period, and promotes nerve regeneration without stimulating the nerves, even when the sheet is implanted in the periphery of the nerve injury site. Also provided is a production method for the sheet. This sustained drug release sheet for treating nerve injury is a sheet including a non-woven fabric that is formed from nanofibers each containing a drug such as vitamin B12 and a biocompatible polymer such as a biodegradable aliphatic polyester, and is implanted in the periphery of the nerve injury site to promote nerve regeneration.
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公开(公告)号:US11052171B2
公开(公告)日:2021-07-06
申请号:US16396561
申请日:2019-04-26
Applicant: NATIONAL INSTITUTE FOR MATERIALS SCIENCE
Inventor: Tetsushi Taguchi
Abstract: A method of hemostasis includes the step of applying a hemostatic agent to an affected site of a subject, the hemostatic agent consisting of a first agent comprising a gelatin derivative having a hydrophobic group bonded to the gelatin via an imino group, wherein the gelatin derivative has (a) a weight average molecular weight of from 10,000 to 50,000, (b) the hydrophobic group, which is an alkyl group having 6 to 18 carbon atoms; and (c) a molar ratio of imino group/amino group of the gelatin derivative ranging from 1/99 to 30/70; and a second agent including a crosslinking agent for the gelatin derivative.
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公开(公告)号:US11008457B2
公开(公告)日:2021-05-18
申请号:US16303487
申请日:2017-05-26
Applicant: NATIONAL INSTITUTE FOR MATERIALS SCIENCE
Inventor: Masanobu Naito , Joginder Bansal , Debabrata Payra
IPC: C08L75/04 , C08G18/10 , C08G18/32 , C08G18/42 , C08G18/64 , C08G18/73 , C08J5/18 , C08J7/12 , C08L99/00
Abstract: A self-supporting multifunctional film is provided based on natural poly-phenols such as tannic acid. The self-supporting film composition of the invention contains a tannic acid derivative in which 12% to 24% of hydroxyl groups in tannic acid are bonded via urethane bonds that are formed by way of reactions with cyanate groups. Preferably, the film composition further includes a precursor polymer and 45 to 65% by mass of tannic acid and 55 to 35% by mass of the precursor polymer. Preferably, the precursor polymer has a second linear hydrocarbon compound urethane-bonded to both ends of a first linear hydrocarbon compound, and more preferably a diisocyanate group having an oligoethyene glycol as a spacer. Preferably, the ratio of the urethane bonds contained in the precursor polymer to the hydroxyl groups contained in the tannic acid is (12:88) to (24:76) inclusive in terms of molar ratio.
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