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617 条记录 (耗时 0.021 秒)

    N-(phenyl) or N-(phenylcyclopropyl)-2,5-dihydro-2-oxo-4[(substituted phenyl)amino]-3-furancarboxamide derivatives
    32.
    发明授权
    N-(phenyl) or N-(phenylcyclopropyl)-2,5-dihydro-2-oxo-4[(substituted phenyl)amino]-3-furancarboxamide derivatives 失效
    N-（苯基）或N-（苯基环丙基）-2,5-二氢-2-氧代-4 [（取代的苯基）氨基] -3-呋喃甲酰胺衍生物

    公开(公告)号：US4625040A

    公开(公告)日：1986-11-25

    申请号：US839298

    申请日：1986-03-13

    申请人： Vassil S. Georgiev ,  Robert A. Mack

    发明人： Vassil S. Georgiev ,  Robert A. Mack

    IPC分类号： C07D307/66 ,  A61K31/365 ,  A61P37/08 ,  C07D307/68

    CPC分类号： C07D307/68

    摘要： Compounds which possess antiallergy activity have the formula: ##STR1## wherein R is selected from phenyl and phenyl mono or disubstituted with lower alkyl, nitro, halogenated methyl, halogen, lower alkoxy and combinations thereof;wherein R.sup.1 is selected from hydrogen and lower alkyl; andwhere R.sup.2 is selected from phenyl, phenyl monosubstituted with lower alkyl, nitro, halogenated methyl, halogen, and lower alkoxy, and trans-phenylcyclopropyl in which the phenyl group may be substituted with lower alkyl or halogen.

    摘要翻译： 具有抗过敏活性的化合物具有下式：其中R选自苯基和被低级烷基，硝基，卤代甲基，卤素，低级烷氧基及其组合单取代或二取代的苯基; 其中R1选自氢和低级烷基; 并且其中R 2选自苯基，被低级烷基，硝基，卤代甲基，卤素和低级烷氧基单取代的苯基，以及苯基可被低级烷基或卤素取代的反式苯基环丙基。

    Method and apparatus for sample retrieval from pharmaceutical dissolution testers
    34.
    发明授权
    Method and apparatus for sample retrieval from pharmaceutical dissolution testers 失效
    用于从药物溶解测试仪取样的方法和设备

    公开(公告)号：US4594902A

    公开(公告)日：1986-06-17

    申请号：US768596

    申请日：1985-08-23

    申请人： Bruce J. Compton ,  Orville N. Hinsvark

    发明人： Bruce J. Compton ,  Orville N. Hinsvark

    IPC分类号： G01N13/00 ,  G01N35/10 ,  G01N1/00

    CPC分类号： G01N35/109 ,  G01N13/00 ,  G01N2035/1006

    摘要： Discrete robotic sampling apparatus for withdrawing samples of pharmaceutical formulations having particulates therein contained within a plurality of dissolution vessels. The apparatus employs a single sampling probe utilizing a single in-line filter therein. Movement of the probe is guided by a robotic arm controlled by a programmable microprocessor which also controls a reversible pump for flushing the particulates retained by the filter, by means of filtered sample, back into the dissolution vessel, prior to dispensing a portion of the filtered sample into a sample container. The probe is then programmed to be washed with a wash solution prior to inserting of the probe into another dissolution vessel for withdrawing of sample therefrom.

    摘要翻译： 用于取出其中含有微粒的药物制剂的样品的离散机器人取样装置包含在多个溶解容器内。 该装置采用在其中使用单个在线滤波器的单个采样探针。 探头的移动由可编程微处理器控制的机器人手臂引导，该可编程微处理器还控制可逆泵，以便在分配一部分过滤的过滤器之前，通过过滤的样品将过滤的样品冲洗到溶解容器中 样品放入样品容器中。 然后将探针编程为在将探针插入另一溶解容器中之前用洗涤溶液洗涤以从中抽出样品。

    Dibenzo[b,d]pyranyloxyaminopropanols
    35.
    发明授权
    Dibenzo[b,d]pyranyloxyaminopropanols 失效
    二苯并[b，d]吡喃氧基氨基丙醇

    公开(公告)号：US4569994A

    公开(公告)日：1986-02-11

    申请号：US749321

    申请日：1985-06-27

    申请人： Ronald C. Griffith

    发明人： Ronald C. Griffith

    IPC分类号： C07D311/80 ,  C07D407/12 ,  C07D521/00 ,  C07D413/12

    CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D311/80 ,  C07D407/12

    摘要： Dibenzopyran derivatives which possess antihypoxia activity are 7,8,9,10-tetrahydro-6H-dibenzo[b,d]pyranyloxyaminopropanols having the formula: ##STR1## Where X is oxygen or dialkyl in which each alkyl group contains one to seven carbons (C.sub.1 -C.sub.7); R is hydrogen or alkyl containing one to seven carbons (C.sub.1 -C.sub.7); and A is --NR.sub.1 R.sub.2 where R.sub.1 and R.sub.2 may independently be hydrogen, C.sub.1 -C.sub.7 alkyl, C.sub.3 -C.sub.7 cycloalkyl, phenyl, C.sub.7 -C.sub.10 phenylalkyl, C.sub.7 -C.sub.10 phenoxyalkyl, C.sub.2 -C.sub.6 alkanol, 6-oxo-6H-dibenzo[b,d]pyran-3-yl, 2-hydroxy-3-(7,8,9,10-tetrahydro-6-oxo-6H-dibenzo[b,d]pyranyl-3-oxy)-propyl; or A is a heterocyclic ring of structure: ##STR2## where n=2 or 3; or A is a substituted heterocyclic ring of structure: ##STR3## where Y and Z may be independently hydrogen or methyl and B represents a single bond, methylene, ethylene, propylene, CH-phenyl, CHCH.sub.2 -phenyl, oxygen, sulfur, or N--R.sub.4 where R.sub.4 is hydrogen, C.sub.1 C.sub.4 alkyl, formyl, phenyl, or benzyl and where the phenyl rings may additionally be substituted with halogen, methoxy, methyl, CF.sub.3, or various combinations thereof; or where A is an unsaturated heterocyclic ring taken to be 1-imidazolyl, 1-pyrrolyl, 1-pyrazolyl or 1-[1,2,4-triazolyl].

    摘要翻译： 具有抗缺氧活性的二苯并吡喃衍生物是具有下式的7,8,9,10-四氢-6H-二苯并[b，d]吡喃氧基氨基丙醇，其中X是氧或二烷基，其中每个烷基含有1至7个碳（ C1-C7）; R是氢或含有1至7个碳的烷基（C 1 -C 7）; 并且A是-NR 1 R 2，其中R 1和R 2可以独立地是氢，C 1 -C 7烷基，C 3 -C 7环烷基，苯基，C 7 -C 10苯基烷基，C 7 -C 10苯氧基烷基，C 2 -C 6链烷醇，6-氧代-6H-二苯并[b ，d]吡喃-3-基，2-羟基-3-（7,8,9,10-四氢-6-氧代-6H-二苯并[b，d]吡喃基-3-氧基） - 吡咯烷基; 或A是具有以下结构的杂环：其中n = 2或3; 或者A是结构如下的取代杂环：其中Y和Z可以独立地是氢或甲基，B代表单键，亚甲基，亚乙基，丙烯，CH-苯基，CHCH 2 - 苯基，氧，硫或N -R4，其中R4是氢，C1C4烷基，甲酰基，苯基或苄基，并且其中苯环可以另外被卤素，甲氧基，甲基，CF 3或其各种组合取代; 或其中A是不饱和杂环为1-咪唑基，1-吡咯基，1-吡唑基或1- [1,2,4-三唑基]。

    Low gold dental alloys
    38.
    发明授权
    Low gold dental alloys 失效
    低金牙合金

    公开(公告)号：US4539176A

    公开(公告)日：1985-09-03

    申请号：US607093

    申请日：1984-05-04

    申请人： Paul J. Cascone

    发明人： Paul J. Cascone

    IPC分类号： A61K6/04 ,  C22C5/04

    CPC分类号： A61K6/046 ,  C22C5/04

    摘要： A silverless low gold dental alloy contains, by weight, 10-40% gold; 3-8% gallium; 0.5-10% indium and/or tin; 0.1 to 1.5% ruthenium, or iridium, or rhenium; balance palladium. The alloy is non-staining and bondable to and compatible with porcelain.

    摘要翻译： 无银低金牙科合金含有重量的10-40％的金; 3-8％镓; 0.5-10％的铟和/或锡; 0.1至1.5％的钌，或铱或铼; 平衡钯。 该合金是无染色的，可与瓷器粘合并兼容。

    Encapsulated phase change thermal energy storage materials and process
    40.
    发明授权
    Encapsulated phase change thermal energy storage materials and process 失效
    封装相变热能储存材料及工艺

    公开(公告)号：US4513053A

    公开(公告)日：1985-04-23

    申请号：US609672

    申请日：1984-05-14

    申请人： Johnson C. H. Chen ,  John L. Eichelberger

    发明人： Johnson C. H. Chen ,  John L. Eichelberger

    IPC分类号： F28D20/02 ,  F24D5/10 ,  F24D19/02

    CPC分类号： F28D20/023 ,  Y02E60/145 ,  Y10S106/03 ,  Y10T428/249921 ,  Y10T428/249953

    摘要： A thermal energy storage composite pellet-shaped product of about 1/8 inch to 1 inch in size, formed of an outer seamless shell member which defines a cavity that permanently encases a phase-change composition, the composition being present in a quantity such that the total volume of the composition, whether in its solid form, liquid form, or both forms as in its transition state, never exceeds the volume of the cavity; and a process for making the product which includes using the phase-change composition in a compacted powder form as cast about which the shell member is formed by roll-coating steps.

    摘要翻译： 大约1/8英寸至1英寸的热能储存复合颗粒状产品由外部无缝壳体构件形成，所述外部无缝壳体构件限定永久包围相变组合物的空腔，所述组合物的存在量使得 组合物的总体积，无论是其固体形式，液体形式还是二者形式，如其过渡状态，不会超过腔的体积; 以及制造该产品的方法，其包括使用压粉粉末形式的相变组合物，其中通过辊涂步骤形成壳构件。