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公开(公告)号：US09133148B2
公开(公告)日：2015-09-15
申请号：US14599105
申请日：2015-01-16
Applicant: Abide Therapeutics, Inc. , The Scripps Research Institute
Inventor： Justin S. Cisar , Cheryl A. Grice , Todd K. Jones , Micah J. Niphakis , Jae Won Chang , Kenneth M. Lum , Benjamin F. Cravatt
IPC: A61K31/495 , A61K31/496 , C07D207/09 , C07D207/14 , C07D213/56 , C07D205/04 , C07D295/26 , C07D295/205 , C07D487/04 , C07D487/10 , C07D491/107 , C07D405/14 , C07D215/42 , C07D213/40 , C07C271/12 , C07D317/46 , C07D317/58 , C07D231/12 , C07D231/16 , C07D231/56 , C07D241/04 , C07D471/04 , C07D471/10 , C07D261/08 , C07D263/32 , C07D271/06 , C07D307/79 , C07D213/55 , C07D401/04 , C07D407/06 , C07D413/06 , C07C271/10
CPC classification number: C07D295/205 , C07C271/10 , C07C271/12 , C07D205/04 , C07D207/09 , C07D207/14 , C07D213/38 , C07D213/40 , C07D213/55 , C07D215/42 , C07D215/46 , C07D231/12 , C07D231/16 , C07D231/56 , C07D241/04 , C07D261/08 , C07D263/32 , C07D271/06 , C07D295/26 , C07D307/79 , C07D317/46 , C07D317/58 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/14 , C07D407/06 , C07D413/06 , C07D413/10 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/107
Abstract: This disclosure provides piperazine carbamates and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed piperazine carbamates as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from indications such as pain, solid tumor cancer and/or obesity comprising administering a disclosed compound or composition.
Abstract translation: 本公开提供哌嗪类氨基甲酸酯和可以是MAGL和/或ABHD6的调节剂的组合物及其作为药物的用途，其制备方法和包括公开的哌嗪氨基甲酸酯作为至少一种活性剂的药物组合物。 本公开还提供了治疗有需要的患者的方法，其中患者患有诸如疼痛，实体瘤癌症和/或肥胖的适应症，其包括施用所公开的化合物或组合物。
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公开(公告)号：US20150018335A1
公开(公告)日：2015-01-15
申请号：US14369982
申请日：2013-01-07
Applicant: ABIDE THERAPEUTICS, INC , THE SCRIPPS RESEARCH INSTITUTE
Inventor： Justin S. Cisar , Cheryl A. Grice , Todd K. Jones , Micah J. Niphakis , Jae Won Chang , Kenneth M. Lum , Benjamin F. Cravatt
IPC: C07D295/205 , C07D407/06 , C07D317/58 , C07D205/04 , C07D401/04 , C07D271/06 , C07D295/26 , C07D413/06 , C07D405/14 , C07D213/55
CPC classification number: C07D295/205 , C07C271/10 , C07C271/12 , C07D205/04 , C07D207/09 , C07D207/14 , C07D213/38 , C07D213/40 , C07D213/55 , C07D215/42 , C07D215/46 , C07D231/12 , C07D231/16 , C07D231/56 , C07D241/04 , C07D261/08 , C07D263/32 , C07D271/06 , C07D295/26 , C07D307/79 , C07D317/46 , C07D317/58 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/14 , C07D407/06 , C07D413/06 , C07D413/10 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/107
Abstract: This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from indications such as pain, solid tumor cancer and/or obesity comprising administering a disclosed compound or composition.
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公开(公告)号：US20210386734A1
公开(公告)日：2021-12-16
申请号：US17412102
申请日：2021-08-25
Applicant: Abide Therapeutics, Inc.
Inventor： Cheryl A. Grice , Justin S. Cisar , Katharine K. Duncan , Yu Feng , John J.M. Wiener , Olivia D. Weber
IPC: A61K31/496 , A61P25/04 , A61K31/506
Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds useful as modulators of MAGL and/or FAAH. The subject compounds and compositions are useful for the treatment of pain and neurological disorders.
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公开(公告)号：US20190256494A1
公开(公告)日：2019-08-22
申请号：US15777198
申请日：2016-11-18
Applicant: Abide Therapeutics, Inc.
Inventor： Olivia D. WEBER , Michael B. SHAGHAFI , Cheryl A. GRICE , Todd K. JONES
IPC: C07D401/14 , A61P25/04 , C07D487/10 , C07D413/14 , C07D491/08
Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of, for example, pain.
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公开(公告)号：US10350205B2
公开(公告)日：2019-07-16
申请号：US15919113
申请日：2018-03-12
Applicant: ABIDE THERAPEUTICS, INC.
Inventor： Cheryl A. Grice , Justin S. Cisar , Katharine K. Duncan , Yu Feng , John J. M. Wiener , Olivia D. Weber
IPC: A61K31/496 , A61K31/506 , A61P25/04
Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds useful as modulators of MAGL and/or FAAH. The subject compounds and compositions are useful for the treatment of pain and neurological disorders.
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Patent Agency Ranking
公开(公告)号：US20190202801A1
公开(公告)日：2019-07-04
申请号：US16334335
申请日：2017-09-18
Applicant: ABIDE THERAPEUTICS, INC.
Inventor： Cheryl A. GRICE , Daniel J. BUZARD , Michael B. SHAGHAFI , Olivia D. WEBER
IPC: C07D401/10 , C07D403/10 , C07D413/10 , C07D403/14 , C07D405/10 , C07D471/06 , C07D241/04 , A61P23/00 , A61P29/00 , A61P1/00 , A61P25/28
CPC classification number: C07D401/10 , A61K45/06 , A61P1/00 , A61P23/00 , A61P25/28 , A61P29/00 , C07D205/04 , C07D207/09 , C07D207/16 , C07D211/26 , C07D211/58 , C07D211/60 , C07D211/62 , C07D231/12 , C07D241/04 , C07D265/30 , C07D295/205 , C07D309/08 , C07D333/38 , C07D333/40 , C07D401/04 , C07D403/10 , C07D403/14 , C07D405/10 , C07D413/10 , C07D471/06 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10
Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
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公开(公告)号：US10266497B2
公开(公告)日：2019-04-23
申请号：US15986747
申请日：2018-05-22
Applicant: ABIDE THERAPEUTICS, INC.
Inventor： Cheryl A. Grice , John J. M. Wiener , Olivia D. Weber , Katharine K. Duncan
IPC: C07D231/14 , C07D401/06 , C07D403/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D403/06 , C07D487/04 , C07D471/10 , C07D451/02 , C07D491/048 , C07D401/12 , C07D519/00 , C07D403/14 , C07D413/14
Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of monoacylglycerol lipase (MAGL). Furthermore, the subject compounds and compositions are useful for the treatment of pain.
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公开(公告)号：US20190046668A1
公开(公告)日：2019-02-14
申请号：US15999117
申请日：2017-02-17
Applicant: ABIDE THERAPEUTICS, INC.
Inventor： Cheryl A Grice , Todd K Jones , Justin S Cisar , Iain Peter Fraser
IPC: A61K51/04 , C07D295/205 , C12N9/20 , A61B6/03
CPC classification number: A61K51/0459 , A61B6/037 , C07B59/002 , C07B2200/05 , C07D295/205 , C12N9/20 , C12Y301/01023
Abstract: Provided herein are monoacylglycerol lipase (MGLL) occupancy probes comprising a MGLL inhibitor containing a positron emission tomography (PET) tracer radionuclide. Also provided are methods of assessing MGLL enzyme occupancy of a MGLL inhibitor using the radiolabeled occupancy probes described herein.
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公开(公告)号：US10093630B2
公开(公告)日：2018-10-09
申请号：US15312998
申请日：2015-05-20
Applicant: ABIDE THERAPEUTICS, INC. , THE SCRIPPS RESEARCH INSTITUTE
Inventor： Dale L. Boger , Katerina Otrubova , Justin S. Cisar , Cheryl A. Grice , Todd K. Jones
IPC: C07D231/14 , C07D491/107 , C07D403/12 , C07D417/12 , C07D405/12 , C07D401/12
Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of one or more of MAGL, ABHD6, and FAAH. Furthermore, the subject compounds and compositions are useful for the treatment of, for example, pain, solid tumors and/or obesity.
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公开(公告)号：US20180208568A1
公开(公告)日：2018-07-26
申请号：US15925517
申请日：2018-03-19
Applicant: ABIDE THERAPEUTICS, INC. , THE SCRIPPS RESEARCH INSTITUTE
Inventor： Justin S. CISAR , Cheryl A. GRICE , Todd K. JONES , Micah J. NIPHAKIS , Jae Won CHANG , Kenneth M. LUM , Benjamin F. CRAVATT
IPC: C07D295/205 , C07D491/107 , C07C271/10 , C07D471/10 , C07D471/04 , C07D413/10 , C07D413/06 , C07D407/06 , C07D405/14 , C07D403/10 , C07D401/10 , C07D401/04 , C07D317/58 , C07D317/46 , C07D307/79 , C07D295/26 , C07D271/06 , C07D263/32 , C07D261/08 , C07D241/04 , C07D231/56 , C07D231/16 , C07D231/12 , C07D215/46 , C07D215/42 , C07D213/55 , C07D213/40 , C07D213/38 , C07D207/14 , C07D207/09 , C07D205/04 , C07C271/12 , C07D487/04
CPC classification number: C07D295/205 , C07C271/10 , C07C271/12 , C07D205/04 , C07D207/09 , C07D207/14 , C07D213/38 , C07D213/40 , C07D213/55 , C07D215/42 , C07D215/46 , C07D231/12 , C07D231/16 , C07D231/56 , C07D241/04 , C07D261/08 , C07D263/32 , C07D271/06 , C07D295/26 , C07D307/79 , C07D317/46 , C07D317/58 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/14 , C07D407/06 , C07D413/06 , C07D413/10 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/107
Abstract: This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from indications such as pain, solid tumor cancer and/or obesity comprising administering a disclosed compound or composition.
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