公开(公告)号：US5610257A

公开(公告)日：1997-03-11

申请号：US555046

申请日：1995-11-08

Applicant: Herve Richard ,  Madeleine Leduc ,  Alain Lagrange

Inventor： Herve Richard ,  Madeleine Leduc ,  Alain Lagrange

IPC: A61K8/60 ,  A61K8/00 ,  A61K8/06 ,  A61K8/58 ,  A61K8/72 ,  A61K8/89 ,  A61K8/891 ,  A61K8/896 ,  A61K8/898 ,  A61Q5/00 ,  A61Q17/04 ,  A61Q19/00 ,  C07F7/08 ,  C07F7/18 ,  C07F7/21 ,  C08G77/14 ,  C08G77/22 ,  C08G77/388 ,  C08L83/06 ,  C08G77/08

CPC classification number: A61K8/898 ,  A61K8/585 ,  A61Q17/04 ,  C07F7/0812 ,  C07F7/0854 ,  C07F7/21 ,  C08G77/388 ,  A61K2800/57

Abstract: Topically applicable sunscreen/cosmetic compositions well suited for enhanced photoprotection of human skin and/or hair against the damaging effects of UV-A and UV-B irradiation, particularly solar radiation, comprise a photoprotecting effective amount of a novel benzotriazole-substituted polyorganosiloxane/polyorganosilane having one of the formulae (1) to (3): ##STR1##A--Si(R').sub.3 (3)wherein A is a monovalent benzotriazole radical which comprises an acrylate or acrylamide functional group, which is bonded directly to a silicon atom, and which has the formula (4): ##STR2##

Abstract translation: 特别适用于对人类皮肤和/或头发进行增强光保护以防UV-A和UV-B照射特别是太阳辐射的破坏性影响的局部适用的防晒/美容组合物包含光保护有效量的新型苯并三唑取代的聚有机硅氧烷/聚有机硅烷 具有式（1）至（3）中的一个：其中A是包含丙烯酸酯或丙烯酰胺官能团的一价苯并三唑基团，其中A是（Si）（3） 其直接与硅原子键合，并具有式（4）：（4）

公开(公告)号：US5587173A

公开(公告)日：1996-12-24

申请号：US465105

申请日：1995-06-05

Applicant: Alex Junino ,  Alain LaGrange ,  Quang L. N'Guyen ,  Marie-Alix Bourboulon

Inventor： Alex Junino ,  Alain LaGrange ,  Quang L. N'Guyen ,  Marie-Alix Bourboulon

IPC: A61K8/30 ,  A61K8/00 ,  A61K8/04 ,  A61K8/11 ,  A61K8/14 ,  A61K8/33 ,  A61K8/365 ,  A61K8/37 ,  A61K8/42 ,  A61K8/49 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02 ,  C07C69/732 ,  C07C69/734 ,  C07C69/86 ,  C07C69/92 ,  C07C235/34 ,  A61K7/42

CPC classification number: C07C69/732 ,  A61K8/365 ,  A61K8/37 ,  A61K8/375 ,  A61K8/42 ,  A61Q17/04 ,  A61Q19/02 ,  Y10S514/844 ,  Y10S514/846 ,  Y10S514/937 ,  Y10S514/938 ,  Y10S514/943 ,  Y10S514/944 ,  Y10S977/926

Abstract: A cosmetic or dermatological composition with a depigmenting action comprises derivatives of 2,5-dihydroxyphenylcarboxylic acids, their homologs, and their salts, with the derivatives having the following structural formula: ##STR1## wherein: R.sub.1 represents OR.sub.5, OH, or ##STR2## R.sub.5 is a linear or branched C.sub.1 -C.sub.20 alkyl radical, a linear or branched C.sub.2 -C.sub.20 alkenyl radical, or a C.sub.1 -C.sub.20 alkyl radical substituted by one or more hydroxy or alkoxy groups;r' and r", identical or different, represent a hydrogen atom, a C.sub.1 -C.sub.20 alkyl radical, a C.sub.2 -C.sub.6 hydroxyalkyl radical, or a C.sub.3 -C.sub.6 polyhydroxyalkyl, or r' and r" taken together, with the nitrogen atom, form a heterocycle;the number of carbon atoms in the --(CH.sub.2).sub.n --COR.sub.1 chain is less than or equal to 21;R.sub.2 and R.sub.3, identical or different, represent a hydrogen atom, a linear or branched C.sub.1 -C.sub.4 alkyl radical, or a C.sub.1 -C.sub.4 alkoxy; R.sub.4 represents a hydrogen atom or a linear or branched C.sub.1 -C.sub.4 alkyl radical; andn is an integer from 0 to 20, provided that, when R.sub.2 and R.sub.3 represent a hydrogen atom, n is greater than or equal to 2.

Abstract translation: 具有脱色作用的化妆品或皮肤病学组合物包括2,5-二羟基苯基羧酸的衍生物，它们的同系物及其盐，其衍生物具有以下结构式：其中：R1表示OR5，OH或 R 5是直链或支链C 1 -C 20烷基，直链或支链C 2 -C 20烯基或被一个或多个羟基或烷氧基取代的C 1 -C 20烷基; r'和r“相同或不同，表示氢原子，C1-C20烷基，C2-C6羟基烷基或C3-C6多羟基烷基，或r'和r”与氮 原子，形成杂环; - （CH2）n-COR1链中的碳原子数小于或等于21; R2和R3相同或不同，表示氢原子，直链或支链C 1 -C 4烷基或C 1 -C 4烷氧基; R4表示氢原子或直链或支链C1-C4烷基; 并且n为0至20的整数，条件是当R 2和R 3表示氢原子时，n大于或等于2。

公开(公告)号：US5585105A

公开(公告)日：1996-12-17

申请号：US444276

申请日：1995-05-18

Applicant: Alex Junino ,  Alain Lagrange ,  Quang L. N'guyen ,  Marie-Alix Bourboulon

Inventor： Alex Junino ,  Alain Lagrange ,  Quang L. N'guyen ,  Marie-Alix Bourboulon

IPC: A61K8/30 ,  A61K8/00 ,  A61K8/04 ,  A61K8/11 ,  A61K8/14 ,  A61K8/33 ,  A61K8/365 ,  A61K8/37 ,  A61K8/42 ,  A61K8/49 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02 ,  C07C69/732 ,  C07C69/734 ,  C07C69/86 ,  C07C69/92 ,  C07C235/34 ,  A61K7/42

CPC classification number: C07C69/732 ,  A61K8/365 ,  A61K8/37 ,  A61K8/375 ,  A61K8/42 ,  A61Q17/04 ,  A61Q19/02 ,  Y10S514/844 ,  Y10S514/846 ,  Y10S514/937 ,  Y10S514/938 ,  Y10S514/943 ,  Y10S514/944 ,  Y10S977/926

Abstract: A cosmetic or dermatological composition with a depigmenting action comprises derivatives of 2,5-dihydroxyphenylcarboxylic acids, their homologs, and their salts, with the derivatives having the following structural formula: ##STR1## wherein: R.sub.1 represents OR.sub.5, OH, or ##STR2## R.sub.5 is a linear or branched C.sub.1 -C.sub.20 alkyl radical, a linear or branched C.sub.2 -C.sub.20 alkenyl radical, or a C.sub.1 -C.sub.20 alkyl radical substituted by one or more hydroxy or alkoxy groups;r' and r", identical or different, represent a hydrogen atom, a C.sub.1 -C.sub.20 alkyl radical, a C.sub.2 -C.sub.6 hydroxyalkyl radical, or a C.sub.3 -C.sub.6 polyhydroxyalkyl, or r' and r" taken together, with the nitrogen atom, form a heterocycle;the number of carbon atoms in the --(CH.sub.2).sub.n --COR.sub.1 chain is less than or equal to 21;R.sub.2 and R.sub.3, identical or different, represent a hydrogen atom, a linear or branched C.sub.1 -C.sub.4 alkyl radical, or a C.sub.1 -C.sub.4 alkoxy;R.sub.4 represents a hydrogen atom or a linear or branched C.sub.1 -C.sub.4 alkyl radical; andn is an integer from 0 to 20, provided that, when R.sub.2 and R.sub.3 represent a hydrogen atom, n is greater than or equal to 2.

Abstract translation: 具有脱色作用的化妆品或皮肤病学组合物包括2,5-二羟基苯基羧酸的衍生物，它们的同系物及其盐，其衍生物具有以下结构式：其中：R1表示OR5，OH或 R 5是直链或支链C 1 -C 20烷基，直链或支链C 2 -C 20烯基或被一个或多个羟基或烷氧基取代的C 1 -C 20烷基; r'和r“相同或不同，表示氢原子，C1-C20烷基，C2-C6羟基烷基或C3-C6多羟基烷基，或r'和r”与氮 原子，形成杂环; - （CH2）n-COR1链中的碳原子数小于或等于21; R2和R3相同或不同，表示氢原子，直链或支链C 1 -C 4烷基或C 1 -C 4烷氧基; R4表示氢原子或直链或支链C1-C4烷基; 并且n为0至20的整数，条件是当R 2和R 3表示氢原子时，n大于或等于2。

公开(公告)号：US5534037A

公开(公告)日：1996-07-09

申请号：US456814

申请日：1995-06-01

Applicant: Alex Junino ,  Alain Genet ,  Alain Lagrange

Inventor： Alex Junino ,  Alain Genet ,  Alain Lagrange

IPC: C07C233/03 ,  C07C323/32 ,  C07C323/36 ,  A61K7/13

CPC classification number: A61Q5/10 ,  A61K8/46 ,  C07C323/36

Abstract: The invention relates to a dye composition for keratinic fibers comprising an oxidation colorant precursor of the type ortho and/or para and a sulfured metaphenylenediamine having formula (I) ##STR1## wherein Z is alkyl, aralkyl, monohydroxyalkyl or polyhydroxyalkyl, aryl or aminoalkyl, as well as the acid salts thereof, with the condition that R.sub.1 and R.sub.2 do not represent simultaneously hydrogen when Z is alkyl or hydroxyalkyl, as well as the acid salts corresponding to the compounds of formula (I).

Abstract translation: 本发明涉及用于角蛋白纤维的染料组合物，其包含邻位和/或对位的氧化着色剂前体和具有式（I）的硫代偏苯二胺其中Z是烷基，芳烷基，单羟基烷基或多羟基烷基，芳基 或氨基烷基，以及其酸式盐，其中当Z是烷基或羟烷基时，R1和R2不同时代表氢，以及与式（I）化合物相应的酸式盐。

公开(公告)号：US5534036A

公开(公告)日：1996-07-09

申请号：US357745

申请日：1994-12-16

Applicant: Alex Junino ,  Alain Lagrange ,  Alain Genet

Inventor： Alex Junino ,  Alain Lagrange ,  Alain Genet

IPC: A61K8/00 ,  A61K8/33 ,  A61K8/40 ,  A61K8/41 ,  A61K8/46 ,  A61K8/49 ,  A61Q5/10 ,  C07C323/36 ,  C07C323/41 ,  A61K7/13

CPC classification number: A61Q5/10 ,  A61K8/411 ,  A61K8/46 ,  C07C323/36 ,  C07C323/41

Abstract: The present invention provides compositions of sulfated metaphenylenediamines for dyeing keratinous fibers and methods for their use.

Abstract translation: 本发明提供用于染色角质纤维的硫酸化偏苯二胺的组合物及其使用方法。

公开(公告)号：US5514188A

公开(公告)日：1996-05-07

申请号：US273148

申请日：1994-07-13

Applicant: Jean Cotteret ,  Marie P. Audousset ,  Alain Lagrange ,  Jean J. Vandenbosche

Inventor： Jean Cotteret ,  Marie P. Audousset ,  Alain Lagrange ,  Jean J. Vandenbosche

IPC: A45D19/00 ,  A61K8/00 ,  A61K8/22 ,  A61K8/34 ,  A61K8/35 ,  A61K8/41 ,  A61K8/46 ,  A61K8/49 ,  A61Q5/10 ,  C09B53/02 ,  C09B57/00 ,  D06P3/08 ,  D06P3/24 ,  A61K7/13

CPC classification number: A61Q5/10 ,  A61K8/411 ,  A61K8/415

Abstract: The invention relates to a dyeing composition for keratinous fibres and in particular for human keratinous fibres such as hair, comprising, in a suitable medium for dyeing, at least one oxidation dye precursor chosen from 3-methyl -para-aminophenol, 2-methyl-para-aminophenol and 2-hydroxymethyl-para-aminophenol, and their addition salts with an acid, as coupling agent, at least 2-methyl-5-aminophenol, or one of its addition salts with an acid; and at least one para-phenylenediamine and/or one bis-(phenylalkylenediamine) or one of their addition salts with an acid as oxidation dye precursor.

Abstract translation: 本发明涉及一种用于角质纤维，特别是人角质纤维如毛发的染色组合物，其包含在用于染色的合适的培养基中的至少一种选自3-甲基对氨基苯酚，2-甲基 - 对氨基苯酚和2-羟甲基 - 对氨基苯酚，以及它们与酸作为偶联剂与至少2-甲基-5-氨基苯酚或其与酸的加成盐之一的加成盐; 和至少一种对苯二胺和/或一种双 - （苯基亚烷基二胺）或其加成盐之一与酸作为氧化染料前体。

公开(公告)号：US5055452A

公开(公告)日：1991-10-08

申请号：US378792

申请日：1989-07-12

Applicant: Serge Forestier ,  Alain Lagrange ,  Gerard Lang ,  Braham Shroot

Inventor： Serge Forestier ,  Alain Lagrange ,  Gerard Lang ,  Braham Shroot

IPC: C07D307/93 ,  A61K8/04 ,  A61K8/25 ,  A61K8/31 ,  A61K8/36 ,  A61K8/49 ,  A61K8/65 ,  A61K8/73 ,  A61K8/86 ,  A61K31/34 ,  A61K31/343 ,  A61P17/00 ,  A61P27/02 ,  A61P27/14 ,  A61P29/00 ,  A61P37/08 ,  A61Q5/00 ,  A61Q5/02 ,  C07D307/94

CPC classification number: A61K8/4973 ,  A61K8/671 ,  A61Q19/00 ,  C07D307/94 ,  A61Q17/04

Abstract: A benzofuran derivative which is a compound of formula (I): ##STR1## wherein a to d each are 0 or 1, with a+b+c+d.gtoreq.2; R.sub.1 to R.sub.6 are each H or C.sub.1 -C.sub.6 alkyl; R.sub.7 is --CH.sub.2 OR.sub.8 (R.sub.8 =H, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 mono- or polyhydroxyalkyl), --COR.sub.9 (R.sub.9 =H, C.sub.1 -C.sub.6 alkyl, ##STR2## which is an amino acid or amino sugar residue or where R' and R" are H, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 mono- or polyhydroxyalkyl, C.sub.3 -C.sub.6 alkenyl or form a heterocycle) or OR.sub.10 (where R.sub.10 is H, C.sub.1 -C.sub.20 alkyl, C.sub.2 -C.sub.6 mono- or polyhydroxyalkyl or --OR.sub.10 is derived from a sugar) has retinoid type action and can be used in cosmetics (body and hair hygiene) and in medicine (treatment of dermatological conditions; atopy; degenerative diseases of connective tissue; or corneopathies).

公开(公告)号：US4952391A

公开(公告)日：1990-08-28

申请号：US253970

申请日：1988-10-05

Applicant: Gerard Lang ,  Serge Forestter ,  Alain LaGrange ,  Claudine Moire ,  Andre DeFlandre

Inventor： Gerard Lang ,  Serge Forestter ,  Alain LaGrange ,  Claudine Moire ,  Andre DeFlandre

IPC: C07C49/683 ,  A21D2/14 ,  A61K8/00 ,  A61K8/04 ,  A61K8/11 ,  A61K8/30 ,  A61K8/34 ,  A61K8/92 ,  A61K9/00 ,  A61K31/12 ,  A61K31/125 ,  A61Q1/00 ,  A61Q5/02 ,  A61Q5/04 ,  A61Q5/08 ,  A61Q5/10 ,  A61Q17/04 ,  A61Q19/00 ,  C07C45/00 ,  C07C45/45 ,  C07C45/72 ,  C07C45/74 ,  C07C49/657 ,  C07C49/743 ,  C07C49/747 ,  C07C49/753 ,  C07C67/00 ,  C09K3/00 ,  C09K15/06 ,  C09K15/08

CPC classification number: A61Q17/04 ,  A61K8/35 ,  C07C45/74 ,  C07C49/747 ,  C07C49/753 ,  Y10S514/88 ,  Y10S514/886 ,  Y10S514/937

Abstract: New tert-butyl derivatives of benzylidenecamphor, process for preparing them, their use as antioxidant agents and cosmetic and pharmaceutical compositions containing them.The invention relates to benzylidenecamphor derivatives of formula: ##STR1## where R is hydrogen or a tert-butyl residue, R.sub.1 is a C.sub.1 -C.sub.8 alkyl or alkoxy residue, and R.sub.2 and R.sub.3 denote hydrogen or hydroxyl, at least one of the two being hydroxyl, to a process for preparing them and to their uses as antioxidants, broad-band sunscreens and medicinal products for the preventive treatment of skin allergies and inflammations as well as for the prevention of certain cancers.

Abstract translation: 亚苄基樟脑的新叔丁基衍生物，其制备方法，它们作为抗氧化剂的用途以及含有它们的化妆品和药物组合物。 本发明涉及下式的亚苄基or or衍生物：其中R是氢或叔丁基残基，R 1是C 1 -C 8烷基或烷氧基残基，R 2和R 3表示氢或羟基，其中至少一个是 两者是羟基，制备它们的方法和用作抗氧化剂，宽带防晒剂和药用产品，用于预防皮肤过敏和炎症以及预防某些癌症。

公开(公告)号：US4918176A

公开(公告)日：1990-04-17

申请号：US831552

申请日：1986-02-20

Applicant: Gerard Lang ,  Serge Forestier ,  Alain Lagrange

Inventor： Gerard Lang ,  Serge Forestier ,  Alain Lagrange

IPC: C07D263/10 ,  A61K8/00 ,  A61K8/11 ,  A61K8/30 ,  A61K8/365 ,  A61K8/37 ,  A61K8/42 ,  A61K8/46 ,  A61K8/60 ,  A61K31/00 ,  A61K31/045 ,  A61K31/075 ,  A61K31/11 ,  A61K31/12 ,  A61K31/165 ,  A61K31/19 ,  A61K31/215 ,  A61K31/275 ,  A61K31/35 ,  A61K31/357 ,  A61K31/42 ,  A61K31/421 ,  A61K31/495 ,  A61K31/496 ,  A61P17/00 ,  A61P29/00 ,  A61P37/08 ,  A61Q5/00 ,  A61Q7/00 ,  A61Q17/04 ,  A61Q19/00 ,  C07C13/615 ,  C07C27/00 ,  C07C33/38 ,  C07C41/00 ,  C07C43/166 ,  C07C45/00 ,  C07C47/238 ,  C07C47/548 ,  C07C49/252 ,  C07C49/798 ,  C07C51/00 ,  C07C57/42 ,  C07C57/46 ,  C07C57/48 ,  C07C57/50 ,  C07C59/46 ,  C07C63/66 ,  C07C67/00 ,  C07C69/618 ,  C07C69/76 ,  C07C231/00 ,  C07C233/00 ,  C07C233/01 ,  C07C233/02 ,  C07C233/11 ,  C07C233/12 ,  C07C233/64 ,  C07C233/65 ,  C07C253/00 ,  C07C255/32 ,  C07C255/34 ,  C07C323/60 ,  C07D295/18 ,  C07D317/00 ,  C07D493/14 ,  C07H13/04

CPC classification number: A61K8/46 ,  A61K8/365 ,  A61K8/37 ,  A61K8/42 ,  A61K8/602 ,  A61Q19/00 ,  C07C57/48 ,  C07C63/66 ,  C07H13/04 ,  A61Q17/04 ,  A61Q7/00

Abstract: Unsaturated norbornane, 2,2-dimethyl norbornane, adamantane or cyclododecane derivatives exhibit activity in the systemic and topical treatment of dermatologic disorders.

Abstract translation: 不饱和降冰片烷，2,2-二甲基降冰片烷，金刚烷或环十二烷衍生物在全身和局部治疗皮肤病方面表现出活性。

公开(公告)号：US4475144A

公开(公告)日：1984-10-02

申请号：US461496

申请日：1983-01-27

Applicant: Alain Lagrange ,  Alain Beauger

Inventor： Alain Lagrange ,  Alain Beauger

IPC: C04B35/46 ,  C04B35/468 ,  H01B3/12 ,  H01G4/12

CPC classification number: C04B35/4682 ,  H01G4/1227

Abstract: The present invention provides a dielectric ceramic composition having excellent electric properties and able to be sintered at a temperature between 750.degree. and 1000.degree. C.According to the invention, said composition comprises from 90 to 98% by weight of barium titanate, from 0.5 to 2.5% by weight of lithium oxide and 1.5 to 8% by weight of zinc fluoride.

Abstract translation: 本发明提供一种电介质陶瓷组合物，其电性能优异，能够在750〜1000℃的温度下烧结。根据本发明，所述组合物包含90-98重量％的钛酸钡，0.5〜 2.5重量％的氧化锂和1.5-8重量％的氟化锌。