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公开(公告)号：US20180045746A1
公开(公告)日：2018-02-15
申请号：US15547978
申请日：2016-02-04
Applicant: BD KIESTRA B.V
Inventor： Jurjen Sinnema , Roger Petri , Martijn Xander Berntsen , Martijn Kleefstra
CPC classification number: G01N35/00732 , C12M23/10 , C12M23/50 , G01N35/021 , G01N35/04 , G01N2035/00752 , G01N2035/0484
Abstract: An apparatus for conveying a plurality of articles (10) includes a transport belt (6), a bumper stopper (14), and a rotator (12). A motor moves the transport belt which is adapted to rotate the rotator as the belt conveys the plurality of articles. The stopper can move between first and second positions relative to the transport belt wherein the bumper stopper guides one article toward the rotator when the bumper stopper is in the first position. The bumper stopper allows the article to be conveyed to another location when the bumper stopper is in the second position. The transport belt can continue to convey other articles while the one article is temporarily held in place by the bumper stopper. The rotator is configured to rotate the article conveyed by the transport belt. The article can remain in contact with the transport belt while the rotator is rotating the article.
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32.发明申请公开(公告)号：US20170307525A1
公开(公告)日：2017-10-26
申请号：US15513448
申请日：2015-09-29
Applicant: BD Kiestra B.V.
Inventor： Brian Reuben Langhoff , William Alan Fox , Kerry Lynn Smith
CPC classification number: G01N21/51 , G01N21/03 , G01N21/253 , G01N2021/0357 , G01N2021/0385 , G01N2021/4726 , G01N2021/513
Abstract: A nephelometer that measures turbidity of low volume suspensions using measurements of light transmitted through and/or scattered by the sample. The sample suspension is placed in a tiered cuvette adapted to facilitate measuring the turbidity of low volume samples. The lower portion of the cuvette has smaller dimensions, in horizontal cross section, than the top portion. Both lower and upper portions have angled surfaces. The lower, smaller portion of the cuvette is interrogated by the nephelometer.
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33.发明申请A SYSTEM AND METHOD FOR IMAGE ACQUISITION USING SUPERVISED HIGH QUALITY IMAGING 审中-公开一种使用高质量图像拍摄的图像采集系统和方法公开(公告)号：US20170013181A1
公开(公告)日：2017-01-12
申请号：US15115715
申请日：2015-01-30
Applicant: BD KIESTRA B.V.
Inventor： Raphael R. Marcelpoil , Cedrick Orny , Didier Morel
IPC: H04N5/235 , G01N33/483 , H04N5/217 , G01N21/27 , G01N21/25
CPC classification number: H04N5/2352 , G01N21/255 , G01N21/274 , G01N33/4833 , G01N2201/12 , H04N5/217 , H04N5/2353
Abstract: An image capture system and method for imaging biological samples disposed in culture media supported by a plate. The system has a calibration module, an image acquisition module and an image presentation module. When the system receives a culture plate for imaging, default values for the culture plate and media are used to begin image acquisition at a given time. The captured image is then used to create a pixel by pixel map of the image. The system inspects the pixel-by-pixel map for saturated pixels and for signal to noise ratio and acquires a new image if the number of saturated pixels is at or above a predetermined threshold or the signal to noise ratio for the pixel is below a predetermined threshold. From this inspection a new value of photon flux and/or exposure time is determined and a new image is captured using the new value and the steps are repeated. Upon a determination that a predetermined threshold signal to noise ratio has been obtained for the non-saturated pixels, or when the predetermined upper threshold for the time interval for image acquisition is elapsed the system provides a final image for the given time.
Abstract translation: 用于成像放置在由板支撑的培养基中的生物样品的成像捕获系统和方法。 该系统具有校准模块，图像采集模块和图像呈现模块。 当系统接收到用于成像的培养板时，使用培养板和培养基的默认值在给定时间开始图像采集。 然后，捕获的图像用于创建图像的逐像素图。 系统检查饱和像素的像素像素映射和信噪比，并且如果饱和像素的数量等于或高于预定阈值或者像素的信噪比低于预定值，则获取新图像 阈。 从该检查中，确定光子通量和/或曝光时间的新值，并使用新值捕获新图像，并重复该步骤。 在已经获得了对于非饱和像素的预定阈值信噪比的确定之后，或者当经过用于图像获取的时间间隔的预定上限阈值时，系统在给定时间内提供最终图像。
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公开(公告)号：US20160032351A1
公开(公告)日：2016-02-04
申请号：US14828956
申请日：2015-08-18
Applicant: BD Kiestra B.V.
Inventor： Trienko Marten Van Der Kaap , Martijn Kleefstra , Ingela Marie Sofie Edlund Tjernberg , Jetze Botma
IPC: C12Q1/24
CPC classification number: C12Q1/24 , C12M33/02 , Y10T428/2982
Abstract: This invention pertains to the general field of microbiology, and more specifically to transfer, inoculation and/or streaking of micro-organisms, e.g. for the purpose of obtaining individual colonies. Provided is a method for transferring a microbial sample from a first carrier to a second carrier, comprising the steps of: a) contacting at least one ferromagnetic particle with at least part of the sample associated with the first carrier, wherein the particle is a composite bead having a surface roughness (Ra) in the range of 0.1 to 25 μm, a diameter between 2 to 88 mm and a density below 7 g/cm3, and b) applying a magnetic field gradient to allow for magnetically controlled motion of said particle to said second carrier, such that at least part of the sample is streaked onto the second carrier. Also provided is an apparatus for inoculating petri dishes with the sample according to the method and also inoculating slides and/or tubes with a portion of the sample. A container that receives the magnetic composite bead that carries samples from the container when removed is also described.
Abstract translation: 本发明涉及微生物学的一般领域，更具体地涉及微生物的转移，接种和/或条纹，例如微生物。 为了获得个体殖民地的目的。 提供了一种将微生物样品从第一载体转移到第二载体的方法，包括以下步骤：a）使至少一个铁磁颗粒与至少部分与第一载体相关的样品接触，其中所述颗粒是复合材料 表面粗糙度（Ra）为0.1〜25μm，直径为2〜88mm，密度为7g / cm 3以下的珠粒，b）施加磁场梯度以允许所述粒子的磁控制运动 到所述第二载体，使得所述样品的至少一部分划线到所述第二载体上。 还提供了根据该方法用样品接种陪替氏培养皿的装置，并且还用一部分样品接种载玻片和/或管。 还描述了当移除时接收从容器携带样品的磁性复合珠的容器。
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35.发明申请公开(公告)号：US20150299639A1
公开(公告)日：2015-10-22
申请号：US14687400
申请日：2015-04-15
Applicant: BD Kiestra B.V.
Inventor： Martijn Kleefstra , Martijn Xander Berntsen , Jan Bart Van Der Vijver , Tsjerk Nauta , Andrej Girgenson
Abstract: The present invention describes an integrated incubator and image capture module that regulates the incubator atmosphere and obtains high-resolution digital images of sample specimens. The incubator has a cabinet type enclosure that enables the provision of a controlled environment to the contents of the incubator by having at least three ports on one face of the cabinet for the passage of sample containers. Additionally, an image capture module is located immediately adjacent to the incubator. In this regard, using at least three separate access/egress points for the sample containers streamlines operation of the system and enhances preservation of the incubator environment. Furthermore, locating the image capture module directly adjacent to the incubator reduces the amount of time a sample container is exposed to the external environment, thereby reducing the extent to which samples are exposed to potential contaminants and reducing the exchange of the lab and ambient atmospheres.
Abstract translation: 本发明描述了一种综合孵化器和图像捕获模块，其调节培养箱气氛并获得样品样品的高分辨率数字图像。 孵化器具有柜式外壳，其能够通过在柜的一个面上具有用于样品容器通过的至少三个端口来为培养箱的内容物提供受控环境。 此外，图像捕获模块位于孵化器的紧邻处。 在这方面，为样品容器使用至少三个独立的出入口可简化系统的操作并增强保鲜箱环境的保存。 此外，将图像捕获模块直接放置在培养箱附近可减少样品容器暴露于外部环境的时间，从而减少样品暴露于潜在污染物的程度，并减少实验室和环境气氛的交换。
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Patent Agency Ranking
公开(公告)号：US20250127442A1
公开(公告)日：2025-04-24
申请号：US18685588
申请日：2022-09-06
Applicant: BD KIESTRA B.V.
Inventor： Daniel James Robertson , Samer Ahmed , John Scott Wheeler
IPC: A61B5/15
Abstract: A blood collection system for determining an accurate blood fill volume in a collection vessel is disclosed herein. The blood collection system includes a flow component and a blood metering device connected to the flow component. The flow component comprises a flow channel having a T-junction. The blood metering device includes a control unit for operating the blood metering device, a barrel configured to align with a neck of a. collection vessel for receiving the neck therewithin. and an adapter including a luer connector at a first end portion thereof for coupling with the control unit and a second end portion thereof for coupling with the barrel. A pressure sensor is disposed in a channel adjacent to and in fluid communication with the T-junction. Methods of determining an accurate blood fill volume in a collection vessel are also disclosed herein.
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37.发明申请公开(公告)号：US20250037483A1
公开(公告)日：2025-01-30
申请号：US18664367
申请日：2024-05-15
Applicant: BD KIESTRA B.V.
Inventor： Raphael Rodolphe Marcelpoil
Abstract: An imaging method for earliest microbial growth detection. The method uses images to determined colony biomass, and the colony biomass determines when the colony can be picked for analysis for identification or antibiotic susceptibility testing. If the sample source is not a pure sample source additional incubation may be required to permit an increase in biomass of the colonies prior to pick.
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公开(公告)号：US20250027961A1
公开(公告)日：2025-01-23
申请号：US18714325
申请日：2022-12-06
Applicant: BD KIESTRA B.V.
Inventor： Tong Zhou
Abstract: An automated platform for inoculating a variety of receptacles with biological samples for testing and analysis. The lab automation system includes a plurality of modules used to automate the inoculation of media for subsequent analysis. In this regard, the lab automation system has one module to enter specimen/‘order information and store an inventory of petri dishes. Another module is used to label the sample receptacles with a unique identifier that associates the receptacles with the sample. Yet another module includes a robot for retrieving sample and inoculating the receptacles. The sample inoculation module also includes an apparatus that will receive slides, inoculate those slides, and further process the slides for analysis. The sample inoculation assembly includes a module that permits a slide to be advanced out of the inoculation module to an operator for expedited processing which module also includes a printer for applying a machine readable code to the slide to associate the slide with the sample to be inoculated onto the slide. Finally, the lab automation system includes a module that streaks the culture media with the sample. Thus, the automated lab system described herein provides consistent samples with minimal input from a lab operator.
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公开(公告)号：US12038359B2
公开(公告)日：2024-07-16
申请号：US17255299
申请日：2019-06-24
Applicant: BD KIESTRA B.V.
Inventor： Timothy Roy Hansen , Martijn Kleefstra , Michael Bois , Timothy M. Wiles , Charles Chak Cheung Yu
CPC classification number: G01N1/38 , C12Q1/18 , C12Q1/24 , G01N1/40 , G01N2001/386
Abstract: An automated method for preparing a sample suspension. The sample suspension can be used for both MALDI and antimicrobial susceptibility (AST). A suspension is prepared, and a portion of that suspension is removed for a first analysis (e.g. MALDI), leaving a remaining volume. The turbidity of the remaining volume is measured. If the turbidity is below a first threshold, the suspension is not used for a second analysis (e.g. AST) and is subjected to a concentration protocol to raise the turbidity of the suspension. If the turbidity is within a predetermined range, a volume of the suspension is calculated that will deliver a predetermined amount of sample to a vessel for the second analysis. If the turbidity of the suspension is above the predetermined range, and the suspension has not been diluted a predetermined number of times, the suspension is diluted according to a dilution protocol.
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公开(公告)号：US20240144629A1
公开(公告)日：2024-05-02
申请号：US18280997
申请日：2022-03-09
Applicant: BD KIESTRA B.V.
Inventor： Franciscus Hermannus Feijen , Brent Ronald Pohl , Craig W. Bark , Jan Bart Van Der Vijver , Timothy Roy Hansen , Jurjen Sinnema , Martijn Kleefstra
CPC classification number: G06V10/14 , G06V10/22 , G06V10/25 , G06V2201/034
Abstract: A system that may automatically and rapidly process blood culture bottles. Such processing includes obtaining an image of a label placed on the cylindrical surface of the blood culture bottle. The system may also determine an amount of blood sample that has been added to the blood culture bottle by comparing a sample level to pre-placed fiducial. The distance between the liquid meniscus in the blood culture bottle and fiducial may be used to determine blood volume. The imaging apparatus may also detect internal conditions of the blood culture bottle such as the presence of foam or the presence of culture media in a neck portion of the blood culture bottle. The image of the label is obtained from one or more images captured by a camera or scanner. The information on the label may be read automatically and therefore the blood culture bottles do not have to be processed manually, increasing throughput of the apparatus.
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