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公开(公告)号：US10921336B2
公开(公告)日：2021-02-16
申请号：US15575665
申请日：2016-05-27
Applicant: BD Kiestra B.V.
Inventor： Timothy Roy Hansen , Rick Holtz , Martijn Kleefstra , Raphael R. Marcelpoil , Rick Pierpont , Brent Ronald Pohl , Alyssa Shedlosky , Scott Shindledecker , Edward Skevington , Kerry Lynn Smith , Timothy M. Wiles
Abstract: A method and automated apparatus for locating and selecting a colony of microorganisms on a culture dish and subjecting the obtained sample to a plurality of downstream tests including a test to identify the microorganism and a test to identify the susceptibility of the microorganism to antibiotics. The method includes the automated steps of locating and selecting a colony of microorganisms on a culture dish; obtaining a sample of the selected colony of microorganisms; preparing a suspension of a sample of microorganisms automatically by submerging the pick tool with the sample in a suspension, after which the pick tool is vibrated in at least the vertical direction to release the sample from the pick tool in the suspension. The turbidity of the suspension is monitored to ensure that the concentration of microorganism in suspension is sufficient so that the suspension is used a source for sample for both identification and antibiotic susceptibility of the microorganisms in the sample. The apparatus and system optionally provides for downstream processing of samples prepared for antibiotic susceptibility testing (AST). Such apparatus includes further processing after inoculation of an AST panel for the AST test. Such further processing includes capping and transferring inoculated panels to AST instrument.
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公开(公告)号：US20240361214A1
公开(公告)日：2024-10-31
申请号：US18754887
申请日：2024-06-26
Applicant: BD KIESTRA B.V.
Inventor： Timothy Roy Hansen , Martijn Kleefstra , Michael Bois , Timothy M. Wiles , Charles Chak Cheung Yu
CPC classification number: G01N1/38 , C12Q1/18 , C12Q1/24 , G01N1/40 , G01N2001/386
Abstract: An automated method for preparing a sample suspension. The sample suspension can be used for both MALDI and antimicrobial susceptibility (AST). A suspension is prepared, and a portion of that suspension is removed for a first analysis (e.g. MALDI), leaving a remaining volume. The turbidity of the remaining volume is measured. If the turbidity is below a first threshold, the suspension is not used for a second analysis (e.g. AST) and is subjected to a concentration protocol to raise the turbidity of the suspension. If the turbidity is within a predetermined range, a volume of the suspension is calculated that will deliver a predetermined amount of sample to a vessel for the second analysis. If the turbidity of the suspension is above the predetermined range, and the suspension has not been diluted a predetermined number of times, the suspension is diluted according to a dilution protocol.
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3.发明公开公开(公告)号：US20230383232A1
公开(公告)日：2023-11-30
申请号：US18142764
申请日：2023-05-03
Applicant: BD KIESTRA B.V.
Inventor： Timothy M. Wiles , Raphael R. Marcelpoil
CPC classification number: C12M41/36 , G06T7/0016 , C12Q1/02 , G06V20/695 , G06V20/698 , G06T2207/10056 , G06T2207/30024
Abstract: An imaging system and method for microbial growth detection, counting or identification. One colony may be contrasted in an image that is not optimal for another type of colony. The system and method provides contrast from all available material through space (spatial differences), time (differences appearing over time for a given capture condition) and color space transformation using image input information over time to assess whether microbial growth has occurred for a given sample.
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公开(公告)号：US20200090335A1
公开(公告)日：2020-03-19
申请号：US16681333
申请日：2019-11-12
Applicant: BD KIESTRA B.V.
Inventor： Timothy M. Wiles , Raphael Rodolphe Marcelpoil
IPC: G06T7/00 , C12M1/00 , C12M1/34 , C12M1/36 , G06K9/46 , G06T7/11 , G06T7/13 , G06T7/90 , C12M1/12 , C12Q1/02 , G01N21/27 , G01N33/569 , G06K9/00 , G06K9/62 , G06T3/00 , G06T7/60 , C12M1/22
Abstract: An imaging system and method for microbial growth detection, counting or identification. One colony may be contrasted in an image that is not optimal for another type of colony. The system and method provides contrast from all available material through space (spatial differences), time (differences appearing over time for a given capture condition) and color space transformation using image input information over time to assess whether microbial growth has occurred for a given sample.
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公开(公告)号：US12038359B2
公开(公告)日：2024-07-16
申请号：US17255299
申请日：2019-06-24
Applicant: BD KIESTRA B.V.
Inventor： Timothy Roy Hansen , Martijn Kleefstra , Michael Bois , Timothy M. Wiles , Charles Chak Cheung Yu
CPC classification number: G01N1/38 , C12Q1/18 , C12Q1/24 , G01N1/40 , G01N2001/386
Abstract: An automated method for preparing a sample suspension. The sample suspension can be used for both MALDI and antimicrobial susceptibility (AST). A suspension is prepared, and a portion of that suspension is removed for a first analysis (e.g. MALDI), leaving a remaining volume. The turbidity of the remaining volume is measured. If the turbidity is below a first threshold, the suspension is not used for a second analysis (e.g. AST) and is subjected to a concentration protocol to raise the turbidity of the suspension. If the turbidity is within a predetermined range, a volume of the suspension is calculated that will deliver a predetermined amount of sample to a vessel for the second analysis. If the turbidity of the suspension is above the predetermined range, and the suspension has not been diluted a predetermined number of times, the suspension is diluted according to a dilution protocol.
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Patent Agency Ranking
公开(公告)号：US11669971B2
公开(公告)日：2023-06-06
申请号：US17733309
申请日：2022-04-29
Applicant: BD KIESTRA B.V.
Inventor： Timothy M. Wiles , Raphael Rodolphe Marcelpoil
IPC: G06T7/00 , C12M1/00 , C12M1/34 , C12M1/36 , C12M1/22 , G06V10/40 , G06V20/69 , G06F18/214 , G06T7/11 , G06T7/13 , G06T7/90 , C12M1/12 , C12Q1/02 , G01N21/27 , G01N33/569 , G06T3/00 , G06T7/60
CPC classification number: G06T7/0016 , C12M23/10 , C12M23/22 , C12M25/06 , C12M31/02 , C12M41/14 , C12M41/46 , C12M41/48 , C12Q1/02 , G01N21/27 , G01N33/56911 , G06F18/214 , G06T3/0068 , G06T7/11 , G06T7/13 , G06T7/60 , G06T7/90 , G06V10/40 , G06V20/69 , G06V20/693 , G06V20/695 , G06V20/698 , G06T2207/10024 , G06T2207/10056 , G06T2207/10152 , G06T2207/30024
Abstract: An imaging system and method for microbial growth detection, counting or identification. One colony may be contrasted in an image that is not optimal for another type of colony. The system and method provides contrast from all available material through space (spatial differences), time (differences appearing over time for a given capture condition) and color space transformation using image input information over time to assess whether microbial growth has occurred for a given sample.
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公开(公告)号：US11341648B2
公开(公告)日：2022-05-24
申请号：US16875082
申请日：2020-05-15
Applicant: BD KIESTRA B.V.
Inventor： Timothy M. Wiles , Raphael Rodolphe Marcelpoil
IPC: G06T7/11 , G06T7/00 , C12M1/00 , C12M1/34 , C12M1/36 , C12M1/22 , G06V10/40 , G06V20/69 , G06T7/13 , G06T7/90 , C12M1/12 , C12Q1/02 , G01N21/27 , G01N33/569 , G06K9/62 , G06T3/00 , G06T7/60
Abstract: An imaging system and method for microbial growth detection, counting or identification. One colony may be contrasted in an image that is not optimal for another type of colony. The system and method provides contrast from all available material through space (spatial differences), time (differences appearing over time for a given capture condition) and color space transformation using image input information over time to assess whether microbial growth has occurred for a given sample.
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8.发明申请公开(公告)号：US20200283719A1
公开(公告)日：2020-09-10
申请号：US16876518
申请日：2020-05-18
Applicant: BD KIESTRA B.V.
Inventor： Timothy M. Wiles , Raphael R. Marcelpoil
Abstract: An imaging system and method for microbial growth detection, counting or identification. One colony may be contrasted in an image that is not optimal for another type of colony. The system and method provides contrast from all available material through space (spatial differences), time (differences appearing over time for a given capture condition) and color space transformation using image input information over time to assess whether microbial growth has occurred for a given sample.
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公开(公告)号：US10692216B2
公开(公告)日：2020-06-23
申请号：US16681333
申请日：2019-11-12
Applicant: BD KIESTRA B.V.
Inventor： Timothy M. Wiles , Raphael Rodolphe Marcelpoil
IPC: G06T7/00 , C12M1/00 , C12M1/34 , C12M1/36 , G06K9/46 , G06T7/11 , G06T7/13 , G06T7/90 , C12M1/12 , C12Q1/02 , G01N21/27 , G01N33/569 , G06K9/00 , G06K9/62 , G06T3/00 , G06T7/60 , C12M1/22
Abstract: An imaging system and method for microbial growth detection, counting or identification. One colony may be contrasted in an image that is not optimal for another type of colony. The system and method provides contrast from all available material through space (spatial differences), time (differences appearing over time for a given capture condition) and color space transformation using image input information over time to assess whether microbial growth has occurred for a given sample.
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10.发明授权公开(公告)号：US11674116B2
公开(公告)日：2023-06-13
申请号：US16876518
申请日：2020-05-18
Applicant: BD KIESTRA B.V.
Inventor： Timothy M. Wiles , Raphael R. Marcelpoil
CPC classification number: C12M41/36 , C12Q1/02 , G06T7/0016 , G06V20/695 , G06V20/698 , G06T2207/10056 , G06T2207/30024
Abstract: An imaging system and method for microbial growth detection, counting or identification. One colony may be contrasted in an image that is not optimal for another type of colony. The system and method provides contrast from all available material through space (spatial differences), time (differences appearing over time for a given capture condition) and color space transformation using image input information over time to assess whether microbial growth has occurred for a given sample.
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