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公开(公告)号：US20200379070A1
公开(公告)日：2020-12-03
申请号：US16065302
申请日：2016-12-22
IPC分类号： G01R33/56 , A61K49/10 , A61B5/055 , G01R33/465 , G01R33/48
摘要： The present invention relates to on the use of exogenous agents having a pool of mobile proton(s) in CEST-MR imaging to generate Chemical Exchange Rotation Transfer/based CEST contrast, and to a ratiometric-based CEST-MR procedure that comprises using these exogenous agents to set-up CERT-based concentration-independent CEST MR imaging, and as responsive agents to set-up CERT-based concentration independent responsiveness.
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公开(公告)号：US10781188B2
公开(公告)日：2020-09-22
申请号：US16060577
申请日：2016-12-12
发明人： Luciano Lattuada , Roberta Napolitano , Valeria Boi , Massimo Visigalli , Silvio Aime , Giovanni Battista Giovenzana , Alberto Fringuello Mingo
IPC分类号： C07D257/02 , A61K49/10 , C07D401/06
摘要： The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
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公开(公告)号：US10780184B2
公开(公告)日：2020-09-22
申请号：US16263769
申请日：2019-01-31
摘要： The present invention discloses a solid lipid nanoparticle (SLN) comprising: a) a solid lipid core comprising at least a glyceride and/or at least a fatty acid; b) a mixture of amphiphilic components forming a shell around said core a); c) an alkaline-earth complex with a compound of formula I and/or II: d) at least a fluorescent dye selected from: a cyanine fluorescent dye and/or a polyetherocyclic compound selected from: coumarin, pyrano, quinoline, pyranoquinoline, indole and pyranoindole derivates in acid form or a pharmaceutically acceptable salt thereof. These nanoparticles allow a prolonged blood circulation half-life, show enhanced photostability and improved fluorescence signal. The dye is preserved from degradation and improves the fluorescent quantum yield.
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公开(公告)号：US10682427B2
公开(公告)日：2020-06-16
申请号：US15535937
申请日：2015-12-18
摘要： The present invention relates to the use of a NIR fluorescent probe comprising an aza-bicycloalkane based cyclic peptide labelled with a Cy5.5 dye moiety in the fluorescence-guided surgery of pathologic regions and to an optical imaging method that comprises using this fluorescent probe for the identification and demarcation of tumor margins during the surgical resection.
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公开(公告)号：US10407412B2
公开(公告)日：2019-09-10
申请号：US16060754
申请日：2016-12-12
IPC分类号： A61B5/055 , C07D403/12 , C07D257/02 , A61K49/12 , A61K49/10
摘要： The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.
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公开(公告)号：US20190209713A1
公开(公告)日：2019-07-11
申请号：US16256749
申请日：2019-01-24
发明人： Silvio AIME , Daniela DELLI CASTELLI , Franco FEDELI , Dario Livio LONGO , Enzo TERRENO , Fulvio UGGERI
IPC分类号： A61K49/10
摘要： The present invention relates to the use of non-equivalent mobile protons belonging to NMR distinguishable steroisomers of a CEST agent in a ratiometric based CEST imaging procedure and to Lanthanide (III) complex compounds displaying at least two NMR-distinguishable steroisomers in solution useful as concentration independent CEST responsive agents.
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公开(公告)号：US20180362476A1
公开(公告)日：2018-12-20
申请号：US16060577
申请日：2016-12-12
发明人： Luciano LATTUADA , Roberta NAPOLITANO , Valeria BOI , Massimo VISIGALLI , Silvio AIME , Giovanni Battista GIOVENZANA , Alberto FRINGUELLO MINGO
IPC分类号： C07D257/02 , C07D401/06 , A61K49/10
摘要： The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.5
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公开(公告)号：US20180222840A1
公开(公告)日：2018-08-09
申请号：US15946204
申请日：2018-04-05
发明人： Roberta FRETTA , Pietro DELOGU , Fernanda DI GIORGIO , Alfonso NARDELLI , Stefano SGUASSERO , Carlo Felice VISCARDI
IPC分类号： C07C67/08 , C07C51/44 , C07C67/287 , C07C67/54 , B01D3/00
CPC分类号： C07C67/08 , B01D3/009 , C07B2200/07 , C07C51/44 , C07C67/287 , C07C67/54 , C07C69/63 , C07C69/14 , C07C53/08 , C07C59/08
摘要： The present invention relates to a method for the acetylation of an aqueous solution of lactic acid to (S)-2-acetyloxypropionic acid.The process comprises in particular removing water from the solution of lactic acid and reacting lactic acid with acetic anhydride in the presence of acetic acid.
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公开(公告)号：US20170340755A1
公开(公告)日：2017-11-30
申请号：US15535937
申请日：2015-12-18
摘要： The present invention relates to the use of a NIR fluorescent probe comprising an aza-bicycloalkane based cyclic peptide labelled with a Cy5.5 dye moiety in the fluorescence- guided surgery of pathologic regions and to an optical imaging method that comprises using this fluorescent probe for the identification and demarcation of tumor margins during the surgical resection.
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40.发明授权Class of diazepine derivative chelating agents and complexes with paramagnetic metals thereof as MRI contrast agents 有权二氮杂衍生物螯合剂类及其顺磁金属络合物作为MRI造影剂公开(公告)号：US09259491B2
公开(公告)日：2016-02-16
申请号：US14384414
申请日：2013-03-13
IPC分类号： C07D243/08 , C07F9/645 , A61K49/10
CPC分类号： A61K49/106 , C07D243/08 , C07F9/645
摘要： The present invention relates to a new class of diazepine-derivatives as chelating agents for paramagnetic metal ions, the process for their preparation, and use of such paramagnetic complexes as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis. The present invention refers to a new class of derivatives of formula (I), or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明涉及一类新的二氮杂衍生物作为顺磁性金属离子的螯合剂，其制备方法以及使用这种顺磁络合物作为造影剂，特别适用于磁共振成像（MRI）分析。 本发明涉及一类新的式（I）衍生物或其药学上可接受的盐。
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