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31.发明申请公开(公告)号：US20160274106A1
公开(公告)日：2016-09-22
申请号：US14900060
申请日：2014-06-20
Inventor： Wan-Uk KIM , Daehee HWANG , Eugene C. YI , Min Jueng KANG , Yune Jung PARK , Sung youg YOU
IPC: G01N33/564
CPC classification number: G01N33/564 , G01N2333/4725 , G01N2333/4728 , G01N2333/70596 , G01N2800/102
Abstract: The present invention relates to a composition and kit for rheumatoid arthritis diagnosis or activity evaluation, the composition and kit each including an agent for measuring the concentration of at least one protein selected from a group consisting of soluble CD14 (sCD14), a-1-acid glycoprotein 1 (AGP1), and a-1-acid glycoprotein 2 (AGP2). Further, the present invention relates to a use of the composition for diagnosing rheumatoid arthritis or evaluating activity.
Abstract translation: 本发明涉及用于类风湿关节炎诊断或活性评估的组合物和试剂盒，所述组合物和试剂盒各自包含用于测量选自由可溶性CD14（sCD14），α- 酸性糖蛋白1（AGP1）和α-1酸性糖蛋白2（AGP2）。 此外，本发明涉及该组合物用于诊断类风湿性关节炎或评估活性的用途。
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32.发明申请HUMAN-INDUCED PLURIPOTENT STEM CELLS, AND METHOD FOR PREPARING ANIMAL IN WHICH HUMAN IMMUNE SYSTEM IS EXPRESSED, BY USING SAME 审中-公开人类诱导的大脑干细胞，以及用于制备人免疫系统中的动物的方法，通过使用它们公开(公告)号：US20160205904A1
公开(公告)日：2016-07-21
申请号：US14917246
申请日：2014-09-04
Inventor： Ji Hyeon JU , Young Kyun KIM , Hyo Ju YI , Ju Ryun KIM , Hye Rin JEONG , Yeri A. RIM , Na rae PARK , Sejin YU , Seung Min JUNG
IPC: A01K67/027
CPC classification number: A01K67/0278 , A01K67/0271 , A01K2207/12 , A01K2207/15 , A01K2227/105 , A01K2267/0387 , C12N5/0696 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2506/1392 , C12N2510/00
Abstract: The present disclosure relates to: a method for preparing an animal in which the human immune system is expressed, by using human-induced pluripotent stem cells; and an animal prepared by the method.
Abstract translation: 本公开涉及：通过使用人诱导的多能干细胞来制备人免疫系统表达的动物的方法; 和通过该方法制备的动物。
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33.发明申请COMPOSITION FOR PREVENTING OR TREATING AUTOIMMUNE DISEASE, COMPRISING, AS ACTIVE INGREDIENT, PINK1 PROTEIN OR POLYNUCLEOTIDE ENCODING SAME 有权用于预防或治疗自身免疫疾病的组合物，包含作为活性成分，PINK1蛋白或编码其的多核苷酸公开(公告)号：US20160114007A1
公开(公告)日：2016-04-28
申请号：US14948095
申请日：2015-11-20
Inventor： Mi-La Cho , Hyang-Suk Rhim , Seon-Yeong Lee , Yeong-Mi Mun , Hye-Jin Son , Eun-Ji Yang , Eun-Kyung Kim
IPC: A61K38/45
CPC classification number: A61K38/45 , A61K48/005 , C12N9/12 , C12Y207/11001
Abstract: The present invention relates to a composition for preventing or treating an autoimmune disease comprising, as an active ingredient, PINK1 protein or polynucleotide encoding the same. The PINK1 protein according to the present invention inhibits the activity of Th17, promotes the activity of a regulatory T cell (Treg), and increases autophagy in Treg cells, thereby controlling excessive immune responses. Therefore, the PINK1 protein can be effectively used as a pharmaceutical composition or an immunosuppressant, which is capable of preventing or treating an autoimmune disease, such as arthritis, and the like, caused by dysregulation of various kinds of immune responses.
Abstract translation: 本发明涉及用于预防或治疗自身免疫疾病的组合物，其包含作为活性成分的PINK1蛋白或编码该组合物的多核苷酸。 根据本发明的PINK1蛋白抑制Th17的活性，促进调节性T细胞（Treg）的活性，并增加Treg细胞中的自噬，从而控制过度的免疫应答。 因此，可以将PINK1蛋白质有效地用作药物组合物或免疫抑制剂，其能够预防或治疗由各种免疫反应失调引起的自身免疫疾病如关节炎等。
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34.发明申请公开(公告)号：US20160017013A1
公开(公告)日：2016-01-21
申请号：US14761157
申请日：2013-08-20
Inventor： In-Sook KIM , Mi-Kyung OH
IPC: C07K14/47
CPC classification number: C07K14/4717 , A61K38/00 , C07K14/47
Abstract: The present invention relates to a use of mutant haptoglobin having angiogenesis-promoting activity and, more particularly, to a mutant haptoglobin polypeptide, a recombinant vector containing a polynucleotide encoding the polypeptide, or a composition for promoting angiogenesis containing, as an active ingredient, a transformant transformed with the recombinant vector. The mutant haptoglobin according to the present invention includes an amino acid sequence of SEQ ID NO: 1 in which the 143rd amino acid is substituted with an amino acid other than Arg. The mutant haptoglobin according to the present invention has excellent angiogenesis-promoting activity and excellent capillary-like tube formation capability as compared with wild-type haptoglobin, and promotes cell migration, and thus is useful as a therapeutic agent for treating diseases caused by non-angiogenesis.
Abstract translation: 本发明涉及具有血管生成促进活性的突变型触珠蛋白的用途，更具体地说，涉及突变型触珠蛋白多肽，含有编码该多肽的多核苷酸的重组载体，或用于促进血管生成的组合物，其含有作为活性成分的 转化体用重组载体转化。 根据本发明的突变型触珠蛋白包含SEQ ID NO：1的氨基酸序列，其中第143位氨基酸被除Arg以外的氨基酸取代。 与野生型触珠蛋白相比，本发明的突变型触珠蛋白具有优异的血管生成促进活性和优异的毛细管样管形成能力，促进细胞迁移，因此可用作治疗由非 - 血管生成。
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公开(公告)号：US09233128B2
公开(公告)日：2016-01-12
申请号：US14073561
申请日：2013-11-06
Inventor： Jin Hee Shin , Kyung Soo Kim , Il Kyu Lee
IPC: A61K35/28 , A61K31/122 , A61K31/343 , C12N5/077
CPC classification number: A61K35/28 , A61K31/343 , C12N5/0654 , C12N2501/999 , C12N2506/1384
Abstract: Provided are a composition for stimulating differentiation of MSCs into osteoblasts, which includes cryptotanshinone, and an osteogenesis stimulator including cryptotanshinone and MSCs. When the cryptotanshinone is treated to the MSCs, the differentiation into osteoblasts is stimulated, and thus osteogenesis of a patient may be stimulated by directly transplanting the differentiation-induced MSCs to the patient. Accordingly, the composition or osteogenesis stimulator may be used to treat patients having disability requiring stimulation of osteogenesis such as osteoporosis, bone fracture, bone grafting including alveolar bone grafting for implant placement, or other bone defects.
Abstract translation: 提供了用于刺激MSC分化成成骨细胞的组合物，其包括隐丹参酮和包括隐丹参酮和MSC的成骨刺激物。 当将隐丹参酮处理到MSC时，刺激成骨细胞的分化，因此可以通过将分化诱导的MSC直接移植到患者来刺激患者的骨形成。 因此，组合物或成骨刺激剂可用于治疗需要刺激成骨的患者，例如骨质疏松症，骨折，骨移植，包括用于植入物放置的牙槽骨移植或其它骨缺损。
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Patent Agency Ranking
公开(公告)号：US20150374702A1
公开(公告)日：2015-12-31
申请号：US14769056
申请日：2013-10-04
Inventor： Hyo Jeong KUH , Jung Ho KIM
IPC: A61K31/522 , A61K9/127 , A61K31/704 , A61K45/06 , A61K31/7068
CPC classification number: A61K31/522 , A61K9/127 , A61K31/704 , A61K31/7068 , A61K45/06 , C07D473/04 , A61K2300/00
Abstract: The present invention provides an anticancer adjuvant containing pentoxifylline. Pentoxifylline inhibits a collagen synthesis in tumors and consequently increases the distribution of an anticancer drug or sensitivity of cancer cells, which thus provides an improved anticancer treatment effect.
Abstract translation: 本发明提供含有己酮可可碱的抗癌佐剂。 己酮可可碱抑制肿瘤中的胶原合成，从而增加抗癌药物的分布或癌细胞的敏感性，从而提供改善的抗癌治疗效果。
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37.发明申请CAPSULE ENDOSCOPE FOR PHOTODYNAMIC AND SONODYNAMIC THERAPY USING MAGNETISM 审中-公开使用磁性的光合动力学和SONODYNAMIC治疗的胶囊内窥镜公开(公告)号：US20150374216A1
公开(公告)日：2015-12-31
申请号：US14769589
申请日：2013-12-05
Inventor： Hiun Suk CHAE
CPC classification number: A61B1/041 , A61B1/00158 , A61B1/045 , A61N5/0601 , A61N5/062 , A61N7/00 , A61N2007/0043
Abstract: The present invention relates to a capsule endoscope for a photodynamic and sonodynamic therapy using magnetism. The capsule endoscope for a photodynamic and sonodynamic therapy using magnetism includes: an endoscope body; a light and ultrasonic wave irradiation part provided on an outer surface of the endoscope body, for irradiating light and ultrasonic waves having different wavelengths; and a photodynamic and sonodynamic therapy part connected to an outer surface of the endoscope body and including materials for a photodynamic and ultrasonic therapy, and the endoscope body has a positive electrode part and a negative electrode part having different polarities and is controlled such that the polarities are changed, and the photodynamic and sonodynamic therapy part is activated by photosensitizers leaked from a therapy part connected to the endoscope by light and ultrasonic waves irradiated by the light and ultrasonic wave irradiation part.
Abstract translation: 胶囊内窥镜技术领域本发明涉及一种使用磁性的光动力学和声波动力学治疗的胶囊型内窥镜。 用于使用磁性的光动力学和声力学治疗的胶囊型内窥镜包括：内窥镜体; 光和超声波照射部，其设置在所述内窥镜主体的外表面上，用于照射光和具有不同波长的超声波; 以及连接到所述内窥镜主体的外表面并且包括用于光动力学和超声波治疗的材料的光动力学和声力学治疗部，并且所述内窥镜主体具有正极部分和具有不同极性的负极部分，并且被控制为使得极性 通过光和超声波照射部照射的光和超声波，通过由连接到内窥镜的治疗部分泄漏的光敏剂来激活光动力学和声力学治疗部。
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公开(公告)号：US20150305934A1
公开(公告)日：2015-10-29
申请号：US14436115
申请日：2013-10-18
Inventor： Choun-Ki Joo , Dong Jin Chang , Chong Houn Lee , Dong Kun Lee
IPC: A61F9/007
CPC classification number: A61F9/00736
Abstract: The present invention relates to an anterior capsulotomy guide device for cataract surgery. The present invention relates to an anterior capsulotomy guide device for cataract surgery which is temporarily inserted for anterior capsulotomy during cataract surgery, wherein the anterior capsulotomy guide device comprises a ring-shaped body, and a cut portion is formed by cutting a part of the body. According to the present invention, it is possible to carry out anterior capsulotomy with precise size and shape during cataract surgery, thereby maximizing the effect of cataract surgery.
Abstract translation: 本发明涉及一种用于白内障手术的前囊切开术引导装置。 本发明涉及一种用于白内障手术的前囊膜切开术引导装置，其在白内障手术期间临时插入用于前囊切开术，其中前囊膜切开术引导装置包括环形体，并且切割部分通过切割身体的一部分 。 根据本发明，可以在白内障手术期间进行精确尺寸和形状的前囊切开术，从而最大化白内障手术的效果。
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公开(公告)号：US20150283370A1
公开(公告)日：2015-10-08
申请号：US14440097
申请日：2013-10-31
Inventor： Hiun Suk Chae
CPC classification number: A61M37/0092 , A61B1/00087 , A61B1/041 , A61N5/0601 , A61N5/0603 , A61N5/062 , A61N7/00 , A61N2007/0043
Abstract: The present invention relates to a capsule endoscope for photodynamic and sonodynamic therapy. The present invention comprises: an endoscope body; a light and ultrasonic wave irradiation portion provided on the outer surface of the endoscope body and irradiating light of different wavelengths and ultrasonic waves; and a photodynamic and sonodynamic therapy portion connected to the outer surface of the endoscope body and comprising a material for photodynamic and sonodynamic therapy, wherein the photodynamic and sonodynamic therapy portion can be activated by the light and ultrasonic waves irradiated from the light and ultrasonic wave irradiation portion. According to the present invention, the capsule endoscope can treat local bacterial infection, or diabetes, malignant diseases, chronic colitis and the like caused by a change in the number and type of intestinal floras while passing through the body in addition to carrying out diagnosis, which is the inherent function of a capsule endoscope, and thus there is no need for additional treatment and a patient can comfortably receive therapy.
Abstract translation: 本发明涉及一种用于光动力学和声子动力学治疗的胶囊型内窥镜。 本发明包括：内窥镜体; 设置在所述内窥镜主体的外表面并照射不同波长的光和超声波的光和超声波照射部; 以及连接到所述内窥镜主体的外表面并且包括用于光动力学和声力动力学治疗的材料的光动力学和声力学治疗部分，其中所述光动力学和声力学治疗部分可以被从所述光和超声波辐射照射的光和超声波激活 一部分。 根据本发明，胶囊型内窥镜除了进行诊断之外，还能够通过身体的肠道数量和类型的变化而治疗局部细菌感染，糖尿病，恶性疾病，慢性结肠炎等， 其是胶囊型内窥镜的固有功能，因此不需要额外的治疗，患者可以舒适地接受治疗。
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40.发明申请APPARATUS, METHOD, AND COMPUTER-READABLE RECORDING MEDIUM FOR GENERATING TACTILE SENSATION THROUGH NON-INVASIVE BRAIN STIMULATION USING ULTRASONIC WAVES 有权装置，方法和计算机可读记录介质，用于通过使用超声波的非引发性脑刺激来产生手术感觉公开(公告)号：US20150251023A1
公开(公告)日：2015-09-10
申请号：US14285807
申请日：2014-05-23
Applicant: Center Of Human-Centered Interaction For Coexistence , Korea Institute of Science and Technology , Catholic University Industry Academic Cooperation Foundation
Inventor： Bum Jae You , Sung On Lee , Yong An Chung
IPC: A61N7/00
CPC classification number: A61N7/00 , A61B5/4064 , A61N2007/0021 , A61N2007/0026 , G06F1/00
Abstract: The present invention relates to an apparatus for creating a tactile sensation through non-invasive brain stimulation by using ultrasonic waves. The apparatus includes: an ultrasonic transducer module for inputting the ultrasonic waves to stimulate a specific part of the brain of a specified user non-invasively through at least one ultrasonic transducer unit; a compensating module for acquiring information on a range of tactile perception areas in the brain of the specified user and compensating properties of ultrasonic waves to be inputted to the specified user through the ultrasonic transducer unit by referring to the acquired information thereon; and an ultrasonic waves generating module for generating ultrasonic waves to be inputted to the specified user through the ultrasonic transducer unit by referring to a compensating value decided by the compensating module.
Abstract translation: 本发明涉及一种通过使用超声波通过非侵入性脑刺激产生触感的装置。 该装置包括：超声换能器模块，用于输入超声波，以通过至少一个超声波换能器单元非侵入地刺激指定用户的脑的特定部分; 补偿模块，用于获取关于指定用户的大脑中的触觉感知区域的信息的信息，并且通过参考所获取的信息来补偿要通过超声波换能器单元输入到指定用户的超声波的属性; 以及超声波产生模块，用于通过参考由补偿模块决定的补偿值，通过超声波换能器单元产生要输入到指定用户的超声波。
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