公开(公告)号：US5216178A

公开(公告)日：1993-06-01

申请号：US745623

申请日：1991-08-15

Applicant: Helen H. Ong ,  Vernon B. Anderson ,  James A. Profitt

Inventor： Helen H. Ong ,  Vernon B. Anderson ,  James A. Profitt

IPC: C07D313/14

CPC classification number: C07D313/14

Abstract: Novel aminoalkylthiodibenzoxepins, physiologically tolerable acid addition salts thereof, a method of preparing same, pharmaceutical and veterinary preparations including same and methods of treating by administering same are disclosed. These compounds are useful as analgesic, antidepressant and anticonvulsant agents. A process for selectively reducing olefins by alkaline earth metals in loweralkanols is also disclosed.

Abstract translation: 公开了新的氨基烷基硫代二氧化硫蛋白，其生理上可耐受的酸加成盐，其制备方法，包括其的药物和兽医制剂以及通过施用方法进行治疗。 这些化合物可用作镇痛药，抗抑郁药和抗惊厥药。 还公开了一种通过碱金属在低级烷醇中选择性还原烯烃的方法。

公开(公告)号：US5006664A

公开(公告)日：1991-04-09

申请号：US453872

申请日：1989-12-20

Applicant: Helen H. Ong ,  Vernon B. Anderson ,  James A. Profitt

Inventor： Helen H. Ong ,  Vernon B. Anderson ,  James A. Profitt

IPC: C07D337/14

CPC classification number: C07D337/14

Abstract: Novel aminoalkylthiodibenzothiepins and related compounds, physiologically tolerable acid addition salts thereof, a method of preparing same, pharmaceutical and veterinary preparations including same and methods of treating by administering same are disclosed. These compounds are useful as antidepressant, analgetic, and anticonvulsant agents.

Abstract translation: 公开了新型氨基烷基硫代二苯并硫蛋白及其相关化合物，其生理上可耐受的酸加成盐，其制备方法，包括其的药物和兽用制剂以及通过施用方法进行治疗。 这些化合物可用作抗抑郁药，止痛剂和抗惊厥剂。

公开(公告)号：US4775682A

公开(公告)日：1988-10-04

申请号：US14740

申请日：1987-02-13

Applicant: Helen H. Ong ,  Vernon B. Anderson ,  James A. Profitt

Inventor： Helen H. Ong ,  Vernon B. Anderson ,  James A. Profitt

IPC: C07D337/14 ,  A61K31/38

CPC classification number: C07D337/14

Abstract: Novel aminoalkylthiodibenzothiepins and related compounds, physiologically tolerable acid addition salts thereof, a method of preparing same, pharmaceutical and veterinary preparations including same and methods of treating by administering same are disclosed. These compounds are useful as antidepressant, analgetic, and anticonvulsant agents.

Abstract translation: 公开了新型氨基烷基硫代二苯并硫蛋白及其相关化合物，其生理上可耐受的酸加成盐，其制备方法，包括其的药物和兽用制剂以及通过施用方法进行治疗。 这些化合物可用作抗抑郁药，止痛剂和抗惊厥剂。

公开(公告)号：US4436748A

公开(公告)日：1984-03-13

申请号：US256470

申请日：1981-04-22

Applicant: Helen H. Ong ,  James A. Profitt

Inventor： Helen H. Ong ,  James A. Profitt

IPC: C07D333/52 ,  A61K31/38 ,  A61K31/381 ,  A61P7/10 ,  A61P9/12 ,  C07C45/63 ,  C07C49/80 ,  C07C333/02 ,  C07D333/54 ,  C07D333/56 ,  C07D333/64 ,  C07D333/76

CPC classification number: C07D333/54 ,  C07C309/00 ,  C07C323/00 ,  C07C45/63 ,  C07C49/80 ,  C07D333/56 ,  C07D333/64 ,  C07D333/76 ,  Y10S514/869

Abstract: Novel benzo[b]thiophenes, compositions containing same, process for the preparation thereof and methods of reducing blood pressure and producing diuresis by administration of the compounds and compositions are disclosed.

Abstract translation: 公开了新的苯并[b]噻吩，含有它们的组合物，其制备方法和通过施用化合物和组合物降低血压和产生利尿的方法。

公开(公告)号：US4409229A

公开(公告)日：1983-10-11

申请号：US313169

申请日：1981-10-20

Applicant: Helen H. Ong ,  Vernon B. Anderson ,  James A. Profitt

Inventor： Helen H. Ong ,  Vernon B. Anderson ,  James A. Profitt

IPC: C07D211/52 ,  C07D211/54 ,  C07D495/10 ,  A61K31/445 ,  A61K31/40

CPC classification number: C07D495/10 ,  C07D211/52 ,  C07D211/54

Abstract: Novel substituted 1,3-dihydrospiro[benzo(c)thiophene]s and methods of preparing the same are described. These compounds are useful as antidepressants and tranquilizers and intermediates therefor.

Abstract translation: 描述了新型取代的1,3-二氢螺[苯并（c）噻吩]及其制备方法。 这些化合物可用作抗抑郁药和镇定剂及其中间体。

公开(公告)号：US4209625A

公开(公告)日：1980-06-24

申请号：US936185

申请日：1978-08-23

Applicant: Helen H. Ong ,  James A. Profitt

Inventor： Helen H. Ong ,  James A. Profitt

IPC: C07D211/64 ,  C07D471/10

CPC classification number: C07D471/10 ,  C07D211/64

Abstract: Novel spiro[indoline-3,4'-piperidine]s and related compounds and methods of preparing same are described. These compounds are useful as antidepressants, anticonvulsants and tranquilizers. Also described is a novel method of preparing indoline rings.

Abstract translation: 描述了新的螺[二氢吲哚-3,4'-哌啶]和相关化合物及其制备方法。 这些化合物可用作抗抑郁药，抗惊厥药和镇定剂。 还描述了制备二氢吲哚环的新方法。

公开(公告)号：US4198420A

公开(公告)日：1980-04-15

申请号：US2350

申请日：1979-01-10

Applicant: Helen H. Ong ,  James A. Profitt

Inventor： Helen H. Ong ,  James A. Profitt

IPC: A61K31/435 ,  A61K31/445 ,  A61P25/04 ,  A61P25/08 ,  A61P25/20 ,  C07D211/64 ,  C07D495/10 ,  A61K31/38 ,  A61K31/55 ,  C07D313/10

CPC classification number: C07D495/10 ,  C07C323/00 ,  C07D211/64

Abstract: Novel spiro[dibenz(b,f)thiepin-piperidine]s and methods of preparing same are described. These compounds are useful as analgetics, tranquilizers and anticonvulsants.

Abstract translation: 描述了新的螺[二苯并（b，f）硫蛋白 - 哌啶]和其制备方法。 这些化合物可用作止痛药，止痛药和抗惊厥药。

公开(公告)号：US08486715B2

公开(公告)日：2013-07-16

申请号：US13608081

申请日：2012-09-10

Applicant: Michael J. Pugia ,  James A. Profitt ,  Lloyd S. Schulman ,  Chris T. Zimmerle ,  Hai-Hang Kuo

Inventor： Michael J. Pugia ,  James A. Profitt ,  Lloyd S. Schulman ,  Chris T. Zimmerle ,  Hai-Hang Kuo

IPC: G01N1/10

CPC classification number: B01L3/0268 ,  B01J2219/0036 ,  B01J2219/00378 ,  B01J2219/00385 ,  B01J2219/00527 ,  B01J2219/00545 ,  B01J2219/00641 ,  B01J2219/00725 ,  B01J2219/0074 ,  B01L2400/0487 ,  G01N33/52 ,  G01N35/1016 ,  G01N2035/00158 ,  Y10T436/144444 ,  Y10T436/2575

Abstract: Biological fluid samples are deposited by methods that produce a uniform layer of the sample over a reagent-containing surface. In one embodiment, a nozzle having multiple openings is used to deposit a sample over the reagent-containing surface simultaneously. In an alternative embodiment, single droplets of the sample are deposited in a pattern on the surface, preferably in a sequence of parallel lines. The reaction between the biological sample and the reagents is read from a spectrographic image of the reagent-containing surface obtained by optical methods.

Abstract translation: 通过在含试剂的表面上产生均匀的样品层的方法沉积生物流体样品。 在一个实施例中，使用具有多个开口的喷嘴同时将试样沉积在含有试剂的表面上。 在替代实施例中，样品的单个液滴以图案沉积在表面上，优选地以一系列平行线沉积。 从通过光学方法获得的含有试剂的表面的光谱图像中读取生物样品和试剂之间的反应。

公开(公告)号：US08263414B2

公开(公告)日：2012-09-11

申请号：US11135928

申请日：2005-05-23

Applicant: Michael J. Pugia ,  James A. Profitt ,  Lloyd S. Schulman ,  Chris T. Zimmerle ,  Hai-Hang Kuo

Inventor： Michael J. Pugia ,  James A. Profitt ,  Lloyd S. Schulman ,  Chris T. Zimmerle ,  Hai-Hang Kuo

IPC: G01N1/10

CPC classification number: B01L3/0268 ,  B01J2219/0036 ,  B01J2219/00378 ,  B01J2219/00385 ,  B01J2219/00527 ,  B01J2219/00545 ,  B01J2219/00641 ,  B01J2219/00725 ,  B01J2219/0074 ,  B01L2400/0487 ,  G01N33/52 ,  G01N35/1016 ,  G01N2035/00158 ,  Y10T436/144444 ,  Y10T436/2575

Abstract: Biological fluid samples are deposited by methods that produce a uniform layer of the sample over a reagent-containing surface. In one embodiment, a nozzle having multiple openings is used to deposit a sample over the reagent-containing surface simultaneously. In an alternative embodiment, single droplets of the sample are deposited in a pattern on the surface, preferably in a sequence of parallel lines. The reaction between the biological sample and the reagents is read from a spectrographic image of the reagent-containing surface obtained by optical methods.

Abstract translation: 通过在含试剂的表面上产生均匀的样品层的方法沉积生物流体样品。 在一个实施例中，使用具有多个开口的喷嘴同时将试样沉积在含有试剂的表面上。 在替代实施例中，样品的单个液滴以图案沉积在表面上，优选地以一系列平行线沉积。 从通过光学方法获得的含有试剂的表面的光谱图像中读取生物样品和试剂之间的反应。

公开(公告)号：US20100093109A1

公开(公告)日：2010-04-15

申请号：US12598141

申请日：2008-03-14

Applicant: Michael J. Pugia ,  James A. Profitt

Inventor： Michael J. Pugia ,  James A. Profitt

IPC: G01N33/544

CPC classification number: B01L3/502738 ,  B01L3/0268 ,  B01L3/50273 ,  B01L2200/0621 ,  B01L2300/0636 ,  B01L2300/0825 ,  B01L2400/0406 ,  B01L2400/0688 ,  B01L2400/086 ,  Y10T436/118339

Abstract: Assays in which samples of biological fluids are dispensed into the inlet port of a microfluidic device are improved in the accuracy and repeatability by dispensing the biological sample and/or associated liquids in small droplets and at timed intervals to control the operation of the microfluidic device.

Abstract translation: 通过以小液滴和定时的间隔分配生物样品和/或相关液体来控制微流体装置的操作，通过将生物流体的样品分配到微流体装置的入口端口的分析物的精度和重复性得到改善。