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公开(公告)号：US08367051B2
公开(公告)日：2013-02-05
申请号：US12311673
申请日：2007-10-09
Applicant: Krzysztof Matyjaszewski , Ke Min , Jung Kwon Oh , James Spanswick , Nicolay V. Tsarevsky
Inventor： Krzysztof Matyjaszewski , Ke Min , Jung Kwon Oh , James Spanswick , Nicolay V. Tsarevsky
CPC classification number: C08F293/005 , C08F283/00 , C08F290/00 , C08F290/06 , C08F291/00
Abstract: Functional gel particle formed from a crosslinked polymeric network including a fraction of stable crosslinks and a second fraction of cleavable crosslinks are disclosed. Functional compounds may be chemically or physically encapsulated within and/or released from the gel particle by selective cleavage of the cleavable crosslinks. The functional compounds may be delivered and released to a pre-selected target site. Peripheral or other accessible functionality on the surface of the gel particle allows attachment of a surface reactive agent, thereby modifying one or more surface properties of the gel particle. Processes of preparing the gel particles and processes of delivering the functional compounds to a target site are also disclosed.
Abstract translation: 公开了由交联的聚合物网络形成的功能性凝胶颗粒，其包括稳定的交联部分和可切割交联的第二部分。 官能化合物可以通过选择性裂解可切割交联而化学或物理地包封在凝胶颗粒内和/或从凝胶颗粒释放。 功能性化合物可以被递送并释放到预先选择的靶位点。 在凝胶颗粒表面上的周边或其他可接近的功能允许附着表面活性剂，从而改变凝胶颗粒的一个或多个表面性质。 还公开了制备凝胶颗粒的方法和将功能性化合物递送至靶位点的方法。
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公开(公告)号：US08252880B2
公开(公告)日：2012-08-28
申请号：US12451581
申请日：2008-05-23
Applicant: Krzysztof Matyjaszewski , Ke Min , James Spanswick
Inventor： Krzysztof Matyjaszewski , Ke Min , James Spanswick
IPC: C08F4/00 , C08F2/00 , C08F4/28 , C08F210/00 , C08F36/00
CPC classification number: C08F12/08 , C08F2/14 , C08F2/38 , C08F212/36 , C08F2438/01
Abstract: The present disclosure describes a two-step batch dispersion polymerization process for the preparation of substantially uniformed-sized functional (co)polymer particles. The first step of the process includes polymerizing at least one first radically (co)polymerizable monomer by a free radical polymerization process to form a (co)polymer in a stable colloidal dispersion and the second step includes polymerizing the at first radically (co)polymerizable monomer or an additional radically (co)polymerizable monomer in the stable colloidal dispersion by a living/controlled radical (co)polymerization process.
Abstract translation: 本公开描述了用于制备基本上均匀尺寸的功能（共）聚合物颗粒的两步间歇分散聚合方法。 该方法的第一步包括通过自由基聚合方法聚合至少一种第一自由基（共）可聚合单体，以在稳定的胶态分散体中形成（共）聚合物，第二步包括首先从根本上聚合（共）可聚合 单体或通过活/受控自由基（共）聚合方法在稳定的胶体分散体中的另外的自由基（共）可聚合单体。
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公开(公告)号：US20110286935A1
公开(公告)日：2011-11-24
申请号：US13109256
申请日：2011-05-17
Applicant: Patrick McCarthy , James Spanswick
Inventor： Patrick McCarthy , James Spanswick
CPC classification number: B82Y5/00 , A61K47/6921 , A61K47/6933 , B82Y15/00 , C08F230/08 , C08F2220/281 , C08F2220/286 , C08F2438/01
Abstract: A universal drug delivery platform for monoclonal antibody-based therapeutics is described. This universal platform resolves the problems of immunogenic response associated with the present monoclonal antibody based therapeutics by providing a multifunctional nano-device which comprises a well defined core/shell nano-structure that can function as a drug delivery platform linked to a monoclonal antibody through a single linking group.
Abstract translation: 描述了用于基于单克隆抗体的治疗剂的通用药物递送平台。 该通用平台通过提供多功能纳米装置来解决与本发明的基于单克隆抗体的治疗相关的免疫原性应答的问题，该多功能纳米装置包含明确定义的核/壳纳米结构，其可以作为通过以下方式与单克隆抗体连接的药物递送平台 单链接组。
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公开(公告)号：US20110218306A1
公开(公告)日：2011-09-08
申请号：US13026919
申请日：2011-02-14
Applicant: Krzysztof Matyjaszewski , Lindsay Bombalski , Wojciech Jakubowski , Ke Min , James Spanswick , Nicolay V. Tsarevsky
Inventor： Krzysztof Matyjaszewski , Lindsay Bombalski , Wojciech Jakubowski , Ke Min , James Spanswick , Nicolay V. Tsarevsky
IPC: C08F120/06 , C08F112/08 , C08F118/02 , C08G63/08
CPC classification number: C08F265/04 , C08F4/40 , C08F220/18 , C08F265/00 , C08F291/00 , C08F293/00 , C08F293/005 , C08F2438/01
Abstract: Embodiments of the polymerization process of the present invention are directed to polymerizing free radically polymerizable monomers in the presence of a polymerization medium initially comprising at least one transition metal catalyst and an atom transfer radical polymerization initiator. The polymerization medium may additionally comprise a reducing agent. The reducing agent may be added initially or during the polymerization process in a continuous or intermittent manner. The polymerization process may further comprises reacting the reducing agent with at least one of the transition metal catalyst in an oxidized state and a compound comprising a radically transferable atom or group to form a compound that does not participate significantly in control of the polymerization process. Embodiments of the present invention comprise reacting a reducing agent with at least one of catalyst in an oxidized state and a compound comprising a radically transferable atom or group to initiate and/or maintain catalytic activity throughout the polymerization process.
Abstract translation: 本发明的聚合方法的实施方案涉及在最初包含至少一种过渡金属催化剂和原子转移自由基聚合引发剂的聚合介质的存在下使可自由基聚合的单体聚合。 聚合介质可另外包含还原剂。 还原剂可以以连续或间歇的方式最初或在聚合过程中加入。 聚合方法可以进一步包括使还原剂与氧化态的至少一种过渡金属催化剂和包含可自由基转移的原子或基团的化合物反应，以形成不显着控制聚合过程的化合物。 本发明的实施方案包括使还原剂与氧化状态的催化剂和包含可自由基转移的原子或基团的化合物中的至少一种反应，以在整个聚合过程中引发和/或维持催化活性。
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公开(公告)号：US20110112267A1
公开(公告)日：2011-05-12
申请号：US12926143
申请日：2010-10-27
Applicant: Wojciech Jakubowski , Patrick McCarthy , Nicolay Tsarevsky , James Spanswick
Inventor： Wojciech Jakubowski , Patrick McCarthy , Nicolay Tsarevsky , James Spanswick
IPC: C08F20/06
CPC classification number: C08G83/003 , A61K8/72 , A61K8/8147 , A61K8/8152 , A61K8/90 , A61K2800/10 , A61K2800/48 , A61Q19/00 , C08F265/04 , C08F293/005 , C08F299/04 , C08F299/0492 , C08J2300/206
Abstract: A polymer composition comprising star macromolecules is provided. Each star macromolecule has a core and five or more arms, wherein the number of arms within a star macromolecule varies across the composition of star molecules. The arms on a star are covalently attached to the core of the star; each arm comprises one or more (co)polymer segments; and at least one arm and/or at least one segment exhibits a different solubility from at least one other arm or one other segment, respectively, in a reference liquid of interest.
Abstract translation: 提供了包含星形大分子的聚合物组合物。 每个星形高分子具有核心和五个或更多个臂，其中星形大分子内的臂数在星形分子的组成上不同。 星星上的武器共同附着在星星的核心上; 每个臂包含一个或多个（共）聚合物链段; 并且至少一个臂和/或至少一个区段分别在目标参考液体中显示与至少一个其它臂或另一个区段不同的溶解度。
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Patent Agency Ranking
公开(公告)号：US07893173B2
公开(公告)日：2011-02-22
申请号：US11990841
申请日：2006-08-28
Applicant: Krzysztof Matyjaszewski , Wojciech Jakubowski , James Spanswick
Inventor： Krzysztof Matyjaszewski , Wojciech Jakubowski , James Spanswick
CPC classification number: C08F2/40 , C08F4/04 , C08F4/40 , C08F212/08 , C08F212/10 , Y02P20/584 , C08F220/12
Abstract: Polymerization processes of the present invention comprise low catalyst concentration. Embodiments include a polymerization process comprising polymerizing free radically (co)polymerizable monomers in a polymerization medium comprising one or more radically (co)polymerizable monomers, a transition metal catalyst complex capable of participating in a one electron redox reaction with an ATRP initiator; a free radical initiator; and an ATRP initiator; (wherein the concentration of transition metal catalyst complex in the polymerization medium is less than 100 ppm). Further embodiments include a polymerization process, comprising polymerizing one or more radically (co)polymerizable monomers in the presence of at least one transition metal catalyst complex; and an ATRP initiator; and a reducing agent; wherein the transition metal catalyst complex is present at less than 10″3 mole compared to the moles of radically transferable atoms or groups present on the ATRP initiator.
Abstract translation: 本发明的聚合方法包括低催化剂浓度。 实施方案包括聚合方法，其包括在包含一种或多种自由基（共）可聚合单体的聚合介质中自由基（共）可聚合单体聚合，能够与ATRP引发剂参与一电子氧化还原反应的过渡金属催化剂络合物; 自由基引发剂; 和ATRP引发剂; （其中聚合介质中过渡金属催化剂配合物的浓度小于100ppm）。 另外的实施方案包括聚合方法，包括在至少一种过渡金属催化剂络合物的存在下聚合一种或多种自由基（共）可聚合单体; 和ATRP引发剂; 和还原剂; 其中与ATRP引发剂上存在的可自由基转移的原子或基团的摩尔数相比，过渡金属催化剂络合物的摩尔数小于10 -3。
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公开(公告)号：US07795355B2
公开(公告)日：2010-09-14
申请号：US10591425
申请日：2005-03-07
Applicant: Krzyszlof Matyjaszewski , Brent S. Sumerlin , Nicolay V. Tsarevsky , James Spanswick
Inventor： Krzyszlof Matyjaszewski , Brent S. Sumerlin , Nicolay V. Tsarevsky , James Spanswick
IPC: C08F8/30
CPC classification number: C08F8/30 , C08F293/005 , C08F2438/01 , C08F2438/03
Abstract: The process of the present invention is directed toward conducting highly selective, high yield post polymerization reactions on polymers to prepare functionalized polymers. An embodiment of the present invention comprises conducting click chemistry reactions on polymers. Preferably, the polymers were prepared by controlled polymerization processes. Therefore, embodiments of the present invention comprise processes for the preparation of polymers comprising conducting a click chemistry reaction on a functional group attached to a polymer, wherein the polymer has a molecular weight distribution of less than 2.0. The functional polymers may be prepared by converting an attached functional unit on the polymer thereby providing site specific functional materials, site specific functional materials comprising additional functionality, or chain extended functional materials. Embodiments of the process of the present invention include functionalization reactions, chain extensions reactions, to form mock copolymer linking reactions, and attaching side chains to form graft copolymers, for example.
Abstract translation: 本发明的方法涉及在聚合物上进行高选择性，高收率的后聚合反应以制备官能化聚合物。 本发明的一个实施方案包括对聚合物进行点击化学反应。 优选地，通过受控聚合方法制备聚合物。 因此，本发明的实施方案包括制备聚合物的方法，包括在连接到聚合物上的官能团上进行点击化学反应，其中聚合物的分子量分布小于2.0。 官能聚合物可以通过在聚合物上转化附着的官能单元来制备，从而提供位点特异性功能材料，包含附加官能团的位点特异性功能材料或链延伸的功能材料。 本发明方法的实施方案包括例如官能化反应，延伸链反应，形成嵌段共聚物连接反应和连接侧链以形成接枝共聚物。
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公开(公告)号：US20100143286A1
公开(公告)日：2010-06-10
申请号：US12311673
申请日：2007-10-09
Applicant: Krzystof Matyjaszewski , Ke Min , Jung Kwon Oh , James Spanswick , Nicolay V. Tsarevsky
Inventor： Krzystof Matyjaszewski , Ke Min , Jung Kwon Oh , James Spanswick , Nicolay V. Tsarevsky
CPC classification number: C08F293/005 , C08F283/00 , C08F290/00 , C08F290/06 , C08F291/00
Abstract: Functional gel particle formed from a crosslinked polymeric network including a fraction of stable crosslinks and a second fraction of cleavable crosslinks are disclosed. Functional compounds may be chemically or physically encapsulated within and/or released from the gel particle by selective cleavage of the cleavable crosslinks. The functional compounds may be delivered and released to a pre-selected target site. Peripheral or other accessible functionality on the surface of the gel particle allows attachment of a surface reactive agent, thereby modifying one or more surface properties of the gel particle. Processes of preparing the gel particles and processes of delivering the functional compounds to a target site are also disclosed.
Abstract translation: 公开了由交联的聚合物网络形成的功能性凝胶颗粒，其包括稳定的交联部分和可切割交联的第二部分。 官能化合物可以通过选择性裂解可切割交联而化学或物理地包封在凝胶颗粒内和/或从凝胶颗粒释放。 功能性化合物可以被递送并释放到预先选择的靶位点。 在凝胶颗粒表面上的周边或其他可接近的功能允许附着表面活性剂，从而改变凝胶颗粒的一个或多个表面性质。 还公开了制备凝胶颗粒的方法和将功能性化合物递送至靶位点的方法。
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公开(公告)号：US20090171024A1
公开(公告)日：2009-07-02
申请号：US12158471
申请日：2006-12-20
Applicant: Wojciech Jakubowski , James Spanswick , Laura Mueller , Krzysztof Matyjaszewski
Inventor： Wojciech Jakubowski , James Spanswick , Laura Mueller , Krzysztof Matyjaszewski
IPC: C08L53/00
CPC classification number: C08F293/005 , C08F293/00 , Y02P20/584
Abstract: The present invention is directed towards a polymerization process for the preparation of block copolymers. In an embodiment, the polymerization process may comprise low levels of catalyst in an oxidized state that react with a reducing agent to form an active catalyst. Embodiments of the process surprisingly use low levels of catalysts and allow formation of the all blocks with the same catalyst. The catalyst may be deactivated and reactivated to form each block. In one embodiment of the invention, the catalyst is oxidized to the deactivator state when the desired degree of polymerization of a polymer segment or block is reached. The first monomer may be removed prior to addition of the second monomer. The catalyst may then be reactivated for preparation of a second block. A further embodiment may include addition of second radically polymerizable monomer to provide efficient initiation of the macroinitiator to transition from polymerization of the first block or segment to polymerization of a second block or blocks.
Abstract translation: 本发明涉及制备嵌段共聚物的聚合方法。 在一个实施方案中，聚合方法可以包含处于氧化状态的低水平的催化剂，其与还原剂反应以形成活性催化剂。 该方法的实施方案令人惊讶地使用低水平的催化剂并允许用相同催化剂形成所有嵌段。 可以使催化剂失活并重新活化以形成每个嵌段。 在本发明的一个实施方案中，当达到聚合物链段或嵌段的所需聚合度时，催化剂被氧化成失活状态。 可以在加入第二单体之前除去第一单体。 然后可以将催化剂再活化以制备第二嵌段。 另一个实施方案可以包括添加第二自由基聚合单体以提供大分子引发剂有效引发从第一嵌段或链段的聚合转变为第二嵌段或多嵌段的聚合。
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公开(公告)号：US20070244265A1
公开(公告)日：2007-10-18
申请号：US10591425
申请日：2005-03-07
Applicant: Krzyszlof Matyjaszewski , Brent Sumerlin , Nicolay Tsarvsky , James Spanswick
Inventor： Krzyszlof Matyjaszewski , Brent Sumerlin , Nicolay Tsarvsky , James Spanswick
IPC: C08F8/30 , C08F226/06 , C08F4/619 , C08F8/00
CPC classification number: C08F8/30 , C08F293/005 , C08F2438/01 , C08F2438/03
Abstract: The process of the present invention is directed toward conducting highly selective, high yield post polymerization reactions on polymers to prepare functionalized polymers. An embodiment of the present invention comprises conducting click chemistry reactions on polymers. Preferably, the polymers were prepared by controlled polymerization processes. Therefore, embodiments of the present invention comprise processes for the preparation of polymers comprising conducting a click chemistry reaction on a functional group attached to a polymer, wherein the polymer has a molecular weight distribution of less than 2.0. The functional polymers may be prepared by converting an attached functional unit on the polymer thereby providing site specific functional materials, site specific functional materials comprising additional functionality, or chain extended functional materials. Embodiments of the process of the present invention include functionalization reactions, chain extensions reactions, to form mock copolymer linking reactions, and attaching side chains to form graft copolymers, for example.
Abstract translation: 本发明的方法涉及在聚合物上进行高选择性，高收率的后聚合反应以制备官能化聚合物。 本发明的一个实施方案包括对聚合物进行点击化学反应。 优选地，通过控制聚合方法制备聚合物。 因此，本发明的实施方案包括制备聚合物的方法，包括在连接到聚合物上的官能团上进行点击化学反应，其中聚合物的分子量分布小于2.0。 官能聚合物可以通过在聚合物上转化附着的官能单元来制备，从而提供位点特异性功能材料，包含附加官能团的位点特异性功能材料或链延伸的功能材料。 本发明方法的实施方案包括例如官能化反应，延伸链反应，形成嵌段共聚物连接反应和连接侧链以形成接枝共聚物。
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