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公开(公告)号：US20210395689A1
公开(公告)日：2021-12-23
申请号：US17288674
申请日：2019-11-11
Inventor： Ping DAI , Yukimasa TAKEDA , Yoshinori HARADA , Junichi MATSUMOTO , Ayumi KUSAKA
IPC: C12N5/077 , C12N5/0775
Abstract: It is a main object of the present invention to provide a process for producing an insulin-producing cell from a somatic cell without performing artificial gene transfer, an insulin-producing cell obtained from the process, or a composition comprising a combination of chemical substances that can be used for the process. The present invention can include, for example: a process for producing an insulin-producing cell from a somatic cell by direct differentiation induction, comprising a step of culturing a somatic cell in the presence of an RSK inhibitor; an insulin-producing cell obtained from the process; and a composition for producing an insulin-producing cell from a somatic cell by directly inducing differentiation, comprising an RSK inhibitor. The insulin-producing cells obtained according to the present invention are useful in regenerative medicine and the like.
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公开(公告)号：US20210340482A1
公开(公告)日：2021-11-04
申请号：US17282065
申请日：2019-09-30
Applicant: KATAOKA CORPORATION
Inventor： Junichi MATSUMOTO
Abstract: A cell culture tool configured to be produced in a simple facility to obtain a cell mass having a desired shape. The cell culture tool includes a cell culture base layer that contains a cell culture base. The cell culture base layer has a cell adhesive area to which a cell is adherable and a cell adhesion inhibitory area where cell adhesion is inhibited. The cell adhesion inhibitory area includes a modified product of the cell culture base.
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公开(公告)号：US20210079324A1
公开(公告)日：2021-03-18
申请号：US17103539
申请日：2020-11-24
Inventor： Masami SUZUKI , Norio NISHI , Junichi MATSUMOTO , Kimio SUMARU , Toshiyuki KANAMORI
IPC: C12M1/42 , C12N1/00 , C12M1/00 , C12M1/34 , C12M1/12 , C12M1/32 , C12M1/26 , C12N1/02 , C12N5/00 , C12N13/00
Abstract: A laser processing machine for killing specific cells from a group of cells on a surface of a layer containing an ingredient capable of absorbing laser light, the laser processing machine being configured to: control a laser light source to output laser light at 5 W or less and at a wavelength of 380 nm or greater such that the laser light source is applied to a second area on a second surface of the layer opposed to the first surface; and control an actuator to provide a relative movement between the second area where the laser light is applied and the layer at a rate of 2000 mm/sec or less such that the irradiated second area absorbs energy to generate heat that kills unwanted cells on a first area of the first surface and the laser light does not instantly kill the specific cells on the first area upon irradiation.
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公开(公告)号：US20210071121A1
公开(公告)日：2021-03-11
申请号：US17103597
申请日：2020-11-24
Inventor： Masami SUZUKI , Norio NISHI , Junichi MATSUMOTO , Kimio SUMARU , Toshiyuki KANAMORI
IPC: C12M1/42 , C12N1/00 , C12M1/00 , C12M1/34 , C12M1/12 , C12M1/32 , C12M1/26 , C12N1/02 , C12N5/00 , C12N13/00
Abstract: A cell culture vessel for use with a laser processing machine, including: a layer containing an ingredient that generates heat upon laser irradiation; the layer kills specific cells from among a group of cells cultured on a first surface of the layer when a second surface of the layer is irradiated with laser light having an output of 5W or less at a wavelength of 380 nm or greater and a relative movement between a second area on the second surface where the laser light is applied and the layer is at a rate of 2000 mm/sec or less such that the second area absorbs energy of the laser light to generate heat that kills the specific cells that are present on a first area of the first surface and the laser light does not instantly kill the specific cells on the first area upon irradiation with the laser light.
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公开(公告)号：US20200339934A1
公开(公告)日：2020-10-29
申请号：US16853291
申请日：2020-04-20
Applicant: KATAOKA CORPORATION
Inventor： Junichi MATSUMOTO
Abstract: The present invention provides a cell culture base that avoids contact between a photoresponsive layer and cells. The cell culture base of the present invention includes: a support layer; a photoresponsive layer; and a cell culture layer, wherein the photoresponsive layer is laminated on the support layer, the cell culture layer is laminated on the photoresponsive layer, the photoresponsive layer contains a photoresponsive substance that causes at least one of heat and change in magnetism by light irradiation, and the cell culture layer is capable of culturing cells.
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Patent Agency Ranking
公开(公告)号：US20200325432A1
公开(公告)日：2020-10-15
申请号：US16305378
申请日：2017-03-24
Applicant: KATAOKA CORPORATION
Inventor： Junichi MATSUMOTO
Abstract: A cell treatment system includes an analysis unit to calculate the area or size of each of cell aggregates existing on the cell culture vessel based on an image; a display device to show the area or size of each of the cell aggregates on a display; a laser irradiator to emit. laser toward the cell culture vessel so as to kill cells existing on the cell culture vessel; an input device to receive an operation input designating cells to be killed with irradiation of the laser or cells to survive without the irradiation of the laser among the cells existing on the cell culture vessel, or an operation input designating a position to be irradiated with the laser or a position not to be irradiated with the laser on the cell culture vessel; and a control unit to control a position irradiated with the laser,
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公开(公告)号：US20200271913A1
公开(公告)日：2020-08-27
申请号：US16648950
申请日：2018-08-17
Applicant: KATAOKA CORPORATION
Inventor： Shoichi HONDA , Junichi MATSUMOTO , Tadao MORISHITA
Abstract: The present invention provides a phase difference observation apparatus that can reduce the size of the apparatus by not requiring an additional imaging unit and can suppress deterioration of the phase difference image due to the meniscus. The phase difference observation apparatus of the present invention includes a light source; an illumination optical system that guides illumination light from the light source to an observation target object in a cell culture vessel; an imaging optical system that forms an optical image of the observation target object on an image sensor; and a control unit. The illumination optical system includes a spatial modulator that changes an intensity distribution of the illumination light, the control unit contains intensity distribution correction information associating a position of the imaging optical system with respect to the cell culture vessel with an intensity distribution of illumination light at the position of the imaging optical system, the control unit acquires imaging system position information, which is the position of the imaging optical system, and the control unit changes an intensity distribution of illumination light in the spatial modulator on the basis of the imaging system position information and the intensity distribution correction information.
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公开(公告)号：US20200032198A1
公开(公告)日：2020-01-30
申请号：US16485367
申请日：2017-09-20
Applicant: KATAOKA CORPORATION
Inventor： Junichi MATSUMOTO , Shoichi HONDA
Abstract: The present invention provides a cell treatment apparatus capable of treating cells in a cell culture vessel. The cell treatment apparatus 100 according to the present invention includes a first region 1, a second region 3, and a third region 5. The first region 1 and the second region 3 are placed in succession. The first region 1 is a cell treatment chamber for treating cells. The cell treatment chamber can be closed from the outside of the cell treatment chamber and includes a culture vessel placement portion for placing a cell culture vessel. The second region 3 includes: a laser irradiation device capable of irradiating the cell culture vessel placed in the culture vessel placement portion with a laser; and a spot diameter adjustment device that adjusts a spot diameter formed in a portion to be irradiated with the laser in an object to be irradiated. The third region 5 includes a control device that controls at least one device in the cell treatment apparatus 100 and a power supply device 52 that supplies electric power to at least one device in the cell treatment apparatus 100. The culture vessel placement portion is placed to be adjacent to the second region 3 in the cell treatment chamber. An adjacent portion to the second region 3 in the culture vessel placement portion is translucent.
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公开(公告)号：US12018239B2
公开(公告)日：2024-06-25
申请号：US17103539
申请日：2020-11-24
Inventor： Masami Suzuki , Norio Nishi , Junichi Matsumoto , Kimio Sumaru , Toshiyuki Kanamori
IPC: C12M1/34 , C12M1/00 , C12M1/12 , C12M1/26 , C12M1/32 , C12M1/42 , C12N1/00 , C12N1/02 , C12N5/00 , C12N13/00
CPC classification number: C12M1/42 , C12M1/005 , C12M1/3446 , C12M23/20 , C12M25/06 , C12M31/02 , C12M33/06 , C12M33/10 , C12M47/04 , C12N1/00 , C12N1/02 , C12N5/0081 , C12N13/00
Abstract: A laser processing machine for killing specific cells from a group of cells on a surface of a layer containing an ingredient capable of absorbing laser light, the laser processing machine being configured to: control a laser light source to output laser light at 5W or less and at a wavelength of 380 nm or greater such that the laser light source is applied to a second area on a second surface of the layer opposed to the first surface; and control an actuator to provide a relative movement between the second area where the laser light is applied and the layer at a rate of 2000 mm/sec or less such that the irradiated second area absorbs energy to generate heat that kills unwanted cells on a first area of the first surface and the laser light does not instantly kill the specific cells on the first area upon irradiation.
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公开(公告)号：US20240157470A1
公开(公告)日：2024-05-16
申请号：US18421370
申请日：2024-01-24
Applicant: KATAOKA CORPORATION
Inventor： Etsushi KATO , Takeshi YAMAMURA , Keisuke HAYASHI
IPC: B23K26/046 , B23K26/06 , B23K26/073 , B23K26/082 , B23K26/21
CPC classification number: B23K26/046 , B23K26/0604 , B23K26/0648 , B23K26/073 , B23K26/082 , B23K26/21
Abstract: A laser processing device 0 includes a combiner unit 3 configured to superimpose a plurality of laser beams L1 and L2 having different wavelengths on the same optical axis; a focus shifter unit 4 configured to adjust a focal length of the laser beams L1 and L2 superimposed by the combiner unit 3; and a Galvano scanner unit 5 located downstream of the focus shifter unit 4 and configured to change a direction of the optical axis of the laser beams L1 and L2 traveling toward a processing object, and the adjustment in the focal length performed by the focus shifter unit 4 is synchronized with the change in the direction of the optical axis performed by the Galvano scanner unit 5.
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