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    Kapok Tree Flower Extract, And Cosmetic, Pharmaceutical Or Dermatological Compositions Containing Same
    31.
    发明申请
    Kapok Tree Flower Extract, And Cosmetic, Pharmaceutical Or Dermatological Compositions Containing Same 有权

    公开(公告)号：US20210093685A1

    公开(公告)日：2021-04-01

    申请号：US16956220

    申请日：2018-12-21

    Applicant: Laboratoires Expanscience

    Inventor： Sophie Leclere-Bienfait ,  Stéphanie Bredif

    IPC: A61K36/185 ,  A61K8/365 ,  A61K8/9789 ,  A61Q19/08 ,  A61Q19/00

    Abstract: The invention relates to an extract of flowers, preferably calyxes, from kapok trees, in particular Bombax costatum, to a process for preparing same and to the extract obtainable by said process. The invention also relates to a composition comprising such an extract, the composition being advantageously a cosmetic, pharmaceutical or dermatological composition. The invention also relates to such a composition or such an extract for use in preventing or treating disorders or diseases of the skin, the mucous membranes or keratinous appendages and for use in preventing or treating vascular disorders. The invention finally relates to a cosmetic care process for the skin, the keratinous appendages or the mucous membranes, with a view to improving the condition thereof or the appearance thereof, which process consists in administering such a composition or such an extract.

    DERMATOLOGICAL OR COSMETIC COMPOSITIONS CONTAINING A POLYPHENOL?ENRICHED EXTRACT OF VITEX NEGUNDO
    35.
    发明申请
    DERMATOLOGICAL OR COSMETIC COMPOSITIONS CONTAINING A POLYPHENOL?ENRICHED EXTRACT OF VITEX NEGUNDO 审中-公开

    公开(公告)号：US20190008757A1

    公开(公告)日：2019-01-10

    申请号：US16073728

    申请日：2017-01-27

    Applicant: Laboratoires Expanscience

    Inventor： Sophie LECLERE-BIENFAIT ,  Philippe MSIKA

    IPC: A61K8/9789 ,  A61K8/368 ,  A61K8/37 ,  A61Q19/00 ,  A61Q19/08

    Abstract: The invention relates to a cosmetic or dermatological composition containing a polyphenol-enriched extract of Vitex Negundo, typically a root extract obtained using a PAT plant milking®process. The invention further relates to a composition of this kind for use in the prevention or treatment of disorders and diseases affecting the skin, mucous membranes or skin appendages, for use in the prevention or treatment of vascular disorders and for use in the prevention or treatment of extrinsic or intrinsic skin aging. Lastly, the invention relates to a cosmetic care method for the skin, skin appendages or mucous membranes, with a view to improving the condition or appearance thereof, said method consisting in administering such a composition or such an extract.

    RECONSTITUTED NIPPLE SKIN MODEL
    37.
    发明申请
    RECONSTITUTED NIPPLE SKIN MODEL 审中-公开
    重建鼻孔皮肤模型

    公开(公告)号：US20160326492A1

    公开(公告)日：2016-11-10

    申请号：US15110826

    申请日：2015-01-12

    Applicant: LABORATOIRES EXPANSCIENCE

    Inventor： Stephanie BREDIF ,  Caroline BAUDOUIN ,  Philippe MSIKA ,  Marisa MELONI

    IPC: C12N5/071 ,  G01N33/50 ,  C07K14/78

    CPC classification number: C12N5/0629 ,  C07K14/495 ,  C07K14/52 ,  C07K14/78 ,  C12N5/0698 ,  C12N9/0006 ,  C12N2533/54 ,  G01N33/5082 ,  G01N33/5088 ,  G01N2333/47 ,  G01N2333/495 ,  G01N2333/525 ,  G01N2333/7055 ,  G01N2333/904

    Abstract: A first subject of the invention is a skin model characterized in that it comprises keratinocytes capable of overexpressing filaggrin. A second subject of the invention is a method for evaluating the in vitro activity of a formulation or of at least one active agent on the healing of nipple skin and/or on the reduction of nipple skin inflammation, characterized in that said method comprises at least the following steps: a) bringing said active agent or said formulation into contact with a skin model comprising keratinocytes overexpressing filaggrin and also comprising a lesion; b) measuring the level of production of at least one biological marker in the nipple skin model of step a), characterized in that said biological marker can be chosen from lactate dehydrogenase (LDH), TNFα, filaggrin, TGFβ1 and β1 integrin; c) comparing the level of production of at least one biological marker obtained in step b) with a reference level of production; evaluating the efficacy of said active agent or of said formulation according to the comparison of step c).

    Abstract translation: 本发明的第一主题是皮肤模型，其特征在于其包含能够过表达丝聚蛋白的角质形成细胞。 本发明的第二个主题是用于评估制剂或至少一种活性剂对乳头皮肤愈合和/或降低乳头皮肤炎症的体外活性的方法，其特征在于所述方法至少包括 以下步骤：a）使所述活性剂或所述制剂与包含过表达丝聚蛋白并且还包含病变的角质形成细胞的皮肤模型接触; b）测量步骤a）的乳头皮肤模型中至少一种生物标志物的产生水平，其特征在于所述生物标志物可以选自乳酸脱氢酶（LDH），TNFα，丝聚蛋白，TGFβ1和β1整联蛋白; c）将步骤b）中获得的至少一种生物标志物的产量水平与参考生产水平进行比较; 根据步骤c）的比较评估所述活性剂或所述制剂的功效。

    Use of avocado skin for obtaining an avocado unsaponifiable material enriched with saturated aliphatic hydrocarbons and with sterols
    38.
    发明授权
    Use of avocado skin for obtaining an avocado unsaponifiable material enriched with saturated aliphatic hydrocarbons and with sterols 有权
    使用鳄梨皮肤获得富含饱和脂肪烃和甾醇的鳄梨不皂化物质

    公开(公告)号：US09439938B2

    公开(公告)日：2016-09-13

    申请号：US14370892

    申请日：2013-01-14

    Applicant: LABORATOIRES EXPANSCIENCE

    Inventor： Philippe Msika ,  Jacques Legrand ,  Sebastien Garnier

    IPC: A61K36/54 ,  A23L1/30 ,  A23D9/00 ,  A23D9/02 ,  C11B1/08 ,  A61K31/01 ,  A61K31/575

    CPC classification number: A61K36/54 ,  A23D9/00 ,  A23D9/02 ,  A23L33/105 ,  A23L33/11 ,  A23L33/115 ,  A61K31/01 ,  A61K31/575 ,  C11B1/08

    Abstract: The present invention relates to the use of avocado peels in order to obtain avocado unsaponifiable enriched in saturated aliphatic hydrocarbons and in sterols, said avocado peels accounting for 5 to 50% by weight relative to the total weight of avocado used. The invention also relates to a method for obtaining avocado unsaponifiable enriched in saturated aliphatic hydrocarbons and in sterols from at least avocado peels, said avocado peels accounting for 5 to 50% by weight relative to the total weight of avocado used. The invention also relates to an avocado unsaponifiable enriched in saturated aliphatic hydrocarbons and in sterols, obtainable by this method. Lastly, the invention relates to an avocado unsaponifiable enriched in saturated aliphatic hydrocarbons and in sterols, for use as a drug, advantageously in the in the prevention and/or treatment of conjunctive tissue disorders such as arthrosis, articular pathologies such as rheumatism, or periodontal diseases such as gingivitis or periodontitis.

    Abstract translation: 本发明涉及鳄梨皮的使用以获得不可皂化的富含饱和脂肪烃的牛油果和甾醇，所述鳄梨皮相对于所用鳄梨的总重量占5至50重量％。 本发明还涉及一种用于从至少鳄梨皮中获得富含饱和脂肪烃和甾醇的鳄梨不可皂化的方法，所述鳄梨皮相对于所用牛油的总重量计算为5至50重量％。 本发明还涉及可通过该方法获得的不可皂化的富含饱和脂肪烃和甾醇的鳄梨。 最后，本发明涉及不可皂化的富含饱和脂族烃和固醇的鳄梨，用作药物，有利地用于预防和/或治疗结缔组织疾病如关节病，关节病变如风湿病或牙周病 疾病如牙龈炎或牙周炎。

    CORNEODESOMOSOMES AND BARRIER FUNCTION MATURATION
    39.
    发明申请
    CORNEODESOMOSOMES AND BARRIER FUNCTION MATURATION 审中-公开
    CORNEODESOMOSOMES和BARRIER功能成熟

    公开(公告)号：US20160195515A1

    公开(公告)日：2016-07-07

    申请号：US14915702

    申请日：2014-09-03

    Applicant: LABORATOIRES EXPANSCIENCE

    Inventor： Philippe Msika ,  Nadege Lachmann ,  Caroline Baudouin

    IPC: G01N33/50 ,  G01N33/68

    CPC classification number: G01N33/5044 ,  G01N33/5023 ,  G01N33/6881 ,  G01N2333/47

    Abstract: The present invention thus relates to a method for determining the degree of maturation of the skin surface of a subject. In particular, the present invention relates to method for determining whether the skin surface of a subject is mature/immature in its organization/function, said method comprising the steps of taking a skin sample of the said subject; and determining the corneodesmosome distribution within the stratum corneum of the sample.

    Abstract translation: 因此，本发明涉及一种用于确定受试者的皮肤表面的成熟程度的方法。 特别地，本发明涉及用于确定受试者的皮肤表面在其组织/功能中是否成熟/不成熟的方法，所述方法包括以下步骤：摄取所述受试者的皮肤样品; 并测定样品角质层内的角质层分布。

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