公开(公告)号：US20180369193A1

公开(公告)日：2018-12-27

申请号：US16117511

申请日：2018-08-30

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Alex SAUNOIS ,  Caroline BAUDOUIN ,  Sophie LECLERE-BIENFAIT ,  Sebastien GARNIER ,  Philippe MSIKA

IPC: A61K31/353 ,  A23L33/105 ,  A61Q19/00 ,  A23L19/00 ,  A61K9/00 ,  A61K8/49 ,  A61Q19/08 ,  A61Q19/02 ,  A61Q17/00 ,  A61K36/54 ,  A61K8/97 ,  A61Q17/04 ,  A61Q5/12 ,  A61K45/06

Abstract: The invention relates to an avocado extract rich in polyphenols, containing at least 10% by weight of polyphenols, expressed in gallic acid equivalent relative to the dry extract obtained, wherein said polyphenols contain procyanidins, cafeic acid and cafeic acid derivatives, typically in a proportion of at least 70% by weight, expressed in gallic acid equivalent relative to the total polyphenol content by weight. The invention also relates to a composition comprising an extract according to the invention as active agent and a suitable excipient. The invention also relates to such a composition or such an extract for use thereof in preventing or treating disorders or pathological conditions of the skin, the mucous membranes or the superficial body growths. Finally, the invention relates to a cosmetic care process for the skin, the superficial body growths or the mucous membranes, with a view to improving the condition thereof or the appearance thereof, which consists in administering such a composition or such an extract.

公开(公告)号：US20170157019A1

公开(公告)日：2017-06-08

申请号：US15323347

申请日：2015-07-03

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Caroline BAUDOUIN ,  Sophie LECLERE- BIENFAIT ,  Philippe MSIKA ,  Stéphanie BREDIF

IPC: A61K8/64 ,  A61Q19/06

CPC classification number: A61K8/645 ,  A61K8/97 ,  A61K2800/74 ,  A61Q19/06 ,  A61Q19/08

Abstract: The present invention relates to the use of a lupin peptide extract to prevent loss of skin firmness or to increase the firmness of skin. Advantageously, the lupin peptide extract can prevent the appearance of cellulite and/or reduce skin cellulite.

公开(公告)号：US20170326061A1

公开(公告)日：2017-11-16

申请号：US15529694

申请日：2015-11-26

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Philippe MSIKA ,  Caroline BAUDOUIN ,  Stéphanie BREDIF

IPC: A61K8/97 ,  A61Q17/04 ,  A61Q7/00 ,  A61Q19/08 ,  A61K36/79 ,  A61Q19/00 ,  A61K36/00

CPC classification number: A61K8/97 ,  A61K8/9783 ,  A61K36/00 ,  A61K36/79 ,  A61K2800/72 ,  A61K2800/78 ,  A61Q7/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/005 ,  A61Q19/08

Abstract: The present invention relates to the use of a peptide and glycoside extract of Schizandra fruit as a cutaneous neurosensory agent, for improving the response of the cutaneous neurosensory system, in particular for: —improving cutaneous innervation in the basal state, —combatting age-related loss of cutaneous innervation in the basal state, advantageously for preventing loss of the cutaneous sensitivity and/or combatting thinning of the epidermis, and/or—improving cutaneous perception of the environment, more particularly for combatting burns, extreme cold and/or pain.

公开(公告)号：US20200256853A1

公开(公告)日：2020-08-13

申请号：US16624087

申请日：2018-06-21

Applicant: Laboratoires Expanscience

Inventor： Gaelle BELLEMERE ,  Stephanie BREDIF ,  Gaetan BOYER ,  Caroline BAUDOUIN

IPC: G01N33/50 ,  C12N5/071

Abstract: The present invention relates to models of reconstructed sensitive skin reproducing the features of sensitive skin, as well as to processes for obtaining such models. The present invention further relates to in vitro processes for testing formulations or active ingredients for the prevention or treatment of sensitive skin.

公开(公告)号：US20190234939A1

公开(公告)日：2019-08-01

申请号：US16311378

申请日：2017-06-23

Applicant: Laboratoires Expanscience

Inventor： Caroline BAUDOUIN ,  Stephanie BREDIF

IPC: G01N33/50 ,  C12N5/00 ,  C12N5/071

CPC classification number: G01N33/5064 ,  C12N5/0062 ,  C12N5/0629 ,  C12N2503/06 ,  C12N2513/00 ,  C12Q1/68 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5044 ,  G01N2500/02 ,  G01N2500/10 ,  G01N2800/202 ,  G01N2800/38

Abstract: The invention relates to biomarkers in children's skin, in particular in the skin of infants, the expression of which changes when the skin is affected by atopic dermatitis. Such markers are particularly advantageous in that they allow the skin's response to atopic dermatitis to be monitored. The inventors have developed methods for evaluating the in vitro efficacy of formulations in preventing the effects of atopic dermatitis on a child's skin, using a skin model specifically capable of reproducing the characteristics of children's skin.

公开(公告)号：US20150030550A1

公开(公告)日：2015-01-29

申请号：US14514646

申请日：2014-10-15

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Caroline BAUDOUIN ,  Philippe MSIKA

IPC: A61K8/60 ,  A61K45/06 ,  A61Q7/00 ,  A61Q5/02 ,  A61Q5/00 ,  A23L2/52 ,  A61Q5/12 ,  A61Q5/06 ,  A61K31/7004 ,  A61K36/54 ,  A23L1/164 ,  A61K8/97 ,  A61Q3/00

CPC classification number: A61K8/60 ,  A23L2/52 ,  A23L7/126 ,  A23V2002/00 ,  A61K8/97 ,  A61K9/4858 ,  A61K31/70 ,  A61K31/7004 ,  A61K36/54 ,  A61K45/06 ,  A61K2800/5922 ,  A61K2800/92 ,  A61Q3/00 ,  A61Q5/00 ,  A61Q5/006 ,  A61Q5/02 ,  A61Q5/06 ,  A61Q5/12 ,  A61Q7/00 ,  A61K2300/00

Abstract: The present invention relates to a composition including at least one C7 sugar, or derivative from esterification of said sugar, and a pharmaceutically acceptable carrier for treating alopecia. The present invention also relates to a method for cosmetically treating hair and nails, said method being intended to stimulate the growth thereof and/or slow the loss thereof. According to said method, a cosmetic composition including at least one C7 sugar, or derivative from esterification of said sugar, is administered. The present invention finally relates to a method for cosmetic care of hair and/or eyelashes and/or nails.

Abstract translation: 本发明涉及包含至少一种C 7糖或所述糖的酯化衍生物和用于治疗脱发的药学上可接受的载体的组合物。 本发明还涉及一种美发头发和指甲的方法，所述方法旨在刺激其生长和/或减缓其损失。 根据所述方法，施用包含至少一种C 7糖或所述糖的酯化衍生物的化妆品组合物。 本发明最终涉及用于化妆品护理头发和/或睫毛和/或指甲的方法。

公开(公告)号：US20200085897A1

公开(公告)日：2020-03-19

申请号：US16580826

申请日：2019-09-24

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Alex SAUNOIS ,  Caroline BAUDOUIN ,  Sophie LECLERE-BIENFAIT ,  Sebastien GARNIER ,  Philippe MSIKA

IPC: A61K36/31 ,  A61Q19/08 ,  A61K8/49 ,  A61K8/368 ,  A23L33/105 ,  A61K8/97 ,  A61K31/05 ,  A61K31/197 ,  A61K31/198 ,  A61K31/201 ,  A61K31/341 ,  A61K31/42 ,  A61K31/57 ,  A61K31/585 ,  A61K31/715 ,  A61K31/717 ,  A61K33/30 ,  A61K36/28 ,  A61K36/48 ,  A61K36/54 ,  A61K36/899 ,  A61K38/00 ,  A61K45/00

Abstract: The invention relates to an extract of aerial parts of Maca rich in polyphenols, and also to a composition comprising such an extract and, where appropriate, a suitable excipient. The invention also relates to a process for extracting an extract of aerial parts of Maca rich in polyphenols, and also to the extract that can be obtained by means of said process. The invention also relates to such a composition or such an extract for use thereof in preventing or treating disorders or pathological conditions of the skin, the mucous membranes or the superficial body growths and/or for use thereof in preventing and/or treating vascular disorders. Finally, the invention relates to a cosmetic care process for the skin, the superficial body growths or the mucous membranes, with a view to improving the condition thereof or the appearance thereof, which comprises the administration of such a composition or of such an extract.

公开(公告)号：US20190242880A1

公开(公告)日：2019-08-08

申请号：US16062488

申请日：2016-12-16

Applicant: Laboratoires Expanscience

Inventor： Stephanie BREDIF ,  Caroline BAUDOUIN

IPC: G01N33/50 ,  G01N33/68 ,  C12N5/071 ,  C12Q1/6883

CPC classification number: G01N33/5088 ,  C12N5/0698 ,  C12Q1/6883 ,  C12Q2600/148 ,  C12Q2600/158 ,  G01N33/6881

Abstract: The invention relates to biomarkers in children's skin, in particular in the skin of infants, the expression of which changes when the skin is dry. Such markers are particularly advantageous in that they allow the skin's response to dehydration to be monitored. The inventors have developed methods for evaluating the in vitro efficacy of formulations in preventing the effects of dehydration on children's skin, using a skin model specifically capable of reproducing the characteristics of children's skin.

公开(公告)号：US20160326492A1

公开(公告)日：2016-11-10

申请号：US15110826

申请日：2015-01-12

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Stephanie BREDIF ,  Caroline BAUDOUIN ,  Philippe MSIKA ,  Marisa MELONI

IPC: C12N5/071 ,  G01N33/50 ,  C07K14/78

CPC classification number: C12N5/0629 ,  C07K14/495 ,  C07K14/52 ,  C07K14/78 ,  C12N5/0698 ,  C12N9/0006 ,  C12N2533/54 ,  G01N33/5082 ,  G01N33/5088 ,  G01N2333/47 ,  G01N2333/495 ,  G01N2333/525 ,  G01N2333/7055 ,  G01N2333/904

Abstract: A first subject of the invention is a skin model characterized in that it comprises keratinocytes capable of overexpressing filaggrin. A second subject of the invention is a method for evaluating the in vitro activity of a formulation or of at least one active agent on the healing of nipple skin and/or on the reduction of nipple skin inflammation, characterized in that said method comprises at least the following steps: a) bringing said active agent or said formulation into contact with a skin model comprising keratinocytes overexpressing filaggrin and also comprising a lesion; b) measuring the level of production of at least one biological marker in the nipple skin model of step a), characterized in that said biological marker can be chosen from lactate dehydrogenase (LDH), TNFα, filaggrin, TGFβ1 and β1 integrin; c) comparing the level of production of at least one biological marker obtained in step b) with a reference level of production; evaluating the efficacy of said active agent or of said formulation according to the comparison of step c).

Abstract translation: 本发明的第一主题是皮肤模型，其特征在于其包含能够过表达丝聚蛋白的角质形成细胞。 本发明的第二个主题是用于评估制剂或至少一种活性剂对乳头皮肤愈合和/或降低乳头皮肤炎症的体外活性的方法，其特征在于所述方法至少包括 以下步骤：a）使所述活性剂或所述制剂与包含过表达丝聚蛋白并且还包含病变的角质形成细胞的皮肤模型接触; b）测量步骤a）的乳头皮肤模型中至少一种生物标志物的产生水平，其特征在于所述生物标志物可以选自乳酸脱氢酶（LDH），TNFα，丝聚蛋白，TGFβ1和β1整联蛋白; c）将步骤b）中获得的至少一种生物标志物的产量水平与参考生产水平进行比较; 根据步骤c）的比较评估所述活性剂或所述制剂的功效。