公开(公告)号：US07640060B2

公开(公告)日：2009-12-29

申请号：US11731490

申请日：2007-03-29

申请人： Mark J. Zdeblick

发明人： Mark J. Zdeblick

IPC分类号： A61N1/08

CPC分类号： A61N1/372 ,  A61B5/04011 ,  A61B5/0422 ,  A61N1/056 ,  A61N1/36185 ,  A61N1/368 ,  A61N1/3684 ,  A61N1/3686 ,  A61N1/37211 ,  A61N1/37276 ,  A61N1/37288 ,  A61N2001/0585

摘要： Techniques for controlling one or more modular circuits (“satellites”) that are intended for placement in a subject's body. The one or more satellites are controlled by sending signals over a bus that includes first and second conduction paths. Also coupled to the bus in system embodiments is a device such as a pacemaker that provides power and includes control circuitry. Each satellite includes satellite circuitry and one or more effectors that interact with the tissue. The satellite circuitry is coupled to the bus, and thus interfaces the controller to the one or more effectors, which may function as actuators, sensors, or both. The effectors may be electrodes that are used to introduce analog electrical signals (e.g., one or more pacing pulses) into the tissue in the local areas where the electrodes are positioned (e.g., heart muscles) or to sense analog signals (e.g., a propagating depolarization signal) within the tissue.

摘要翻译： 用于控制用于放置在受检者体内的一个或多个模块化电路（“卫星”）的技术。 通过在包括第一和第二导电路径的总线上发送信号来控制一个或多个卫星。 在系统实施例中还耦合到总线的是诸如提供电力并包括控制电路的起搏器的装置。 每个卫星包括卫星电路和与组织相互作用的一个或多个效应器。 卫星电路耦合到总线，并且因此使控制器与一个或多个效应器接合，这些效应器可以用作致动器，传感器或两者。 效应器可以是用于将模拟电信号（例如，一个或多个起搏脉冲）引入电极定位的局部区域（例如，心脏肌肉）中的组织中或用于感测模拟信号（例如，传播 去极化信号）。

公开(公告)号：US07637867B2

公开(公告)日：2009-12-29

申请号：US11731252

申请日：2007-03-29

申请人： Mark J. Zdeblick

发明人： Mark J. Zdeblick

IPC分类号： A61N1/08

CPC分类号： A61N1/372 ,  A61B5/04011 ,  A61B5/0422 ,  A61N1/056 ,  A61N1/36185 ,  A61N1/368 ,  A61N1/3684 ,  A61N1/3686 ,  A61N1/37211 ,  A61N1/37276 ,  A61N1/37288 ,  A61N2001/0585

摘要： Techniques for controlling one or more modular circuits (“satellites”) that are intended for placement in a subject's body. The one or more satellites are controlled by sending signals over a bus that includes first and second conduction paths. Also coupled to the bus in system embodiments is a device such as a pacemaker that provides power and includes control circuitry. Each satellite includes satellite circuitry and one or more effectors that interact with the tissue. The satellite circuitry is coupled to the bus, and thus interfaces the controller to the one or more effectors, which may function as actuators, sensors, or both. The effectors may be electrodes that are used to introduce analog electrical signals (e.g., one or more pacing pulses) into the tissue in the local areas where the electrodes are positioned (e.g., heart muscles) or to sense analog signals (e.g., a propagating depolarization signal) within the tissue.

摘要翻译： 用于控制用于放置在受检者体内的一个或多个模块化电路（“卫星”）的技术。 通过在包括第一和第二导电路径的总线上发送信号来控制一个或多个卫星。 在系统实施例中还耦合到总线的是诸如提供电力并包括控制电路的起搏器的装置。 每个卫星包括卫星电路和与组织相互作用的一个或多个效应器。 卫星电路耦合到总线，并且因此使控制器与一个或多个效应器接合，这些效应器可以用作致动器，传感器或两者。 效应器可以是用于将模拟电信号（例如，一个或多个起搏脉冲）引入电极定位的局部区域（例如，心脏肌肉）中的组织中或用于感测模拟信号（例如，传播 去极化信号）。

公开(公告)号：US20090256702A1

公开(公告)日：2009-10-15

申请号：US12398941

申请日：2009-03-05

申请人： Timothy Robertson ,  Mark J. Zdeblick

发明人： Timothy Robertson ,  Mark J. Zdeblick

IPC分类号： G08B1/08 ,  H05K7/00

CPC分类号： H04B5/0062 ,  A61B5/0031 ,  A61B5/073 ,  A61B5/4833 ,  A61B5/4839 ,  A61B5/4848 ,  A61B5/6861 ,  A61B2562/08 ,  A61B2562/162 ,  G06K7/10297

摘要： Aspects of the invention include multi-mode communication ingestible event marker devices. Ingestible event marker devices of the invention include an ingestible component comprising a conductive communication module and at least one additional non-conductive communication module. The non-conductive communication module may be integrated with the ingestible component or at least a portion or all of the non-conductive communication module may be associated with a packaging component of the ingestible event marker device. Additional aspects of the invention include systems that include the devices and one or more receivers, as well as methods of using the same.

摘要翻译： 本发明的方面包括多模式通信可摄取事件标记装置。 本发明的可摄入事件标记装置包括可摄入组件，其包括导电通信模块和至少一个附加的非导电通信模块。 非导电通信模块可以与可摄取组件集成，或者非导电通信模块的至少一部分或全部可以与可摄入事件标记设备的包装组件相关联。 本发明的另外的方面包括包括装置和一个或多个接收器的系统，以及使用该装置的方法。

公开(公告)号：US20080255629A1

公开(公告)日：2008-10-16

申请号：US11718201

申请日：2005-10-31

申请人： Marc Jenson ,  Todd Thompson ,  Olivier Colliou ,  George M. Savage ,  Mark J. Zdeblick ,  Jeremy Frank ,  Lawrence W. Arne ,  Robert White

发明人： Marc Jenson ,  Todd Thompson ,  Olivier Colliou ,  George M. Savage ,  Mark J. Zdeblick ,  Jeremy Frank ,  Lawrence W. Arne ,  Robert White

IPC分类号： A61N1/365 ,  A61B5/02

CPC分类号： A61N1/056 ,  A61B5/1107 ,  A61B5/6851 ,  A61B5/6857 ,  A61B5/6858 ,  A61B5/686 ,  A61B2562/0266 ,  A61N1/08 ,  A61N1/3627

摘要： Methods for evaluating motion of a cardiac tissue location, e.g., heart wall, are provided. In the subject methods, timing of a signal obtain from a strain gauge stably associated with the tissue location of interest is employed to evaluate movement of the cardiac tissue location. Also provided are systems, devices and related compositions for practicing the subject methods. The subject methods and devices find use in a variety of different applications, including cardiac resynchronization therapy.

摘要翻译： 提供了用于评估心脏组织位置例如心脏壁的运动的方法。 在本方法中，采用从与感兴趣的组织位置稳定相关联的应变仪获得的信号的定时来评估心脏组织位置的运动。 还提供了用于实践主题方法的系统，装置和相关组合物。 主题方法和设备可用于各种不同的应用，包括心脏再同步治疗。

公开(公告)号：US07214189B2

公开(公告)日：2007-05-08

申请号：US11219305

申请日：2005-09-01

申请人： Mark J. Zdeblick

发明人： Mark J. Zdeblick

IPC分类号： A61N1/08

CPC分类号： A61N1/372 ,  A61B5/04011 ,  A61B5/0422 ,  A61N1/056 ,  A61N1/36185 ,  A61N1/368 ,  A61N1/3684 ,  A61N1/3686 ,  A61N1/37211 ,  A61N1/37276 ,  A61N1/37288 ,  A61N2001/0585

摘要： Techniques for controlling one or more modular circuits (“satellites”) that are intended for placement in a subject's body. The one or more satellites are controlled by sending signals over a bus that includes first and second conduction paths. Also coupled to the bus in system embodiments is a device such as a pacemaker that provides power and includes control circuitry. Each satellite includes satellite circuitry and one or more effectors that interact with the tissue. The satellite circuitry is coupled to the bus, and thus interfaces the controller to the one or more effectors, which may function as actuators, sensors, or both. The effectors may be electrodes that are used to introduce analog electrical signals (e.g., one or more pacing pulses) into the tissue in the local areas where the electrodes are positioned (e.g., heart muscles) or to sense analog signals (e.g., a propagating depolarization signal) within the tissue.

摘要翻译： 用于控制用于放置在受检者体内的一个或多个模块化电路（“卫星”）的技术。 通过在包括第一和第二导电路径的总线上发送信号来控制一个或多个卫星。 在系统实施例中还耦合到总线的是诸如提供电力并包括控制电路的起搏器的装置。 每个卫星包括卫星电路和与组织相互作用的一个或多个效应器。 卫星电路耦合到总线，并且因此使控制器与一个或多个效应器接合，这些效应器可以用作致动器，传感器或两者。 效应器可以是用于将模拟电信号（例如，一个或多个起搏脉冲）引入电极定位的局部区域（例如，心脏肌肉）中的组织中或用于感测模拟信号（例如，传播 去极化信号）。

公开(公告)号：US5399232A

公开(公告)日：1995-03-21

申请号：US179756

申请日：1994-01-07

申请人： Thomas R. Albrecht ,  Shinya Akamine ,  Thomas E. Carver ,  Mark J. Zdeblick

发明人： Thomas R. Albrecht ,  Shinya Akamine ,  Thomas E. Carver ,  Mark J. Zdeblick

IPC分类号： B81C1/00 ,  G01Q70/10 ,  G01Q70/14 ,  G01Q70/16 ,  H01L21/306 ,  H01L21/603

CPC分类号： G01Q60/38 ,  B82Y35/00 ,  G01Q70/10 ,  G01Q70/14 ,  G01Q70/16

摘要： A dielectric cantilever arm stylus with an integrally formed pyramidal tip is provided. The tip is molded in a pyramidal pit etched in a later-removed (100) silicon substrate. An integrally-formed cantilever arm is also formed as the tip is being formed. Various thin film materials form the cantilever arm and the tip. In one embodiment of the invention, the dielectric is silicon nitride. The cantilever arm is anodically bonded to a glass block.

摘要翻译： 提供具有整体形成的金字塔形尖端的介电悬臂臂触针。 尖端被模制在蚀刻在稍后去除的（100）硅衬底中的金字塔形坑中。 当尖端正在形成时，也形成一体形成的悬臂。 各种薄膜材料形成悬臂和尖端。 在本发明的一个实施例中，电介质是氮化硅。 悬臂被阳极结合到玻璃块上。

公开(公告)号：US08558563B2

公开(公告)日：2013-10-15

申请号：US13390866

申请日：2010-08-23

申请人： Mark J. Zdeblick

发明人： Mark J. Zdeblick

IPC分类号： G01R27/08 ,  A61B5/053

CPC分类号： A61B5/150229 ,  A61B5/0002 ,  A61B5/0537 ,  A61B5/14503 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/150305 ,  A61B5/150877 ,  A61B5/150969 ,  A61B5/157 ,  A61B5/6833 ,  A61B5/6846 ,  A61B10/0064 ,  A61B2560/0412

摘要： In a first embodiment, electrodes are coupled to a surface at first, second, and third locations, the first location being further from the third location than from the second location. Impedance is measured at distinct frequencies between pairs of the electrodes. As a result, impedance is measured at differing regions below the surface, one region being deeper below the surface than the other region. In a second embodiment, a microfluidic device carries out an analysis. The analysis may be within a flexible patch adhered to a surface, or may be in a solid device implanted in a body of liquid surrounded by tissue. The analysis may involve pumping a fluid or may involve drawing an analyte electrophoretically through a microfluidic channel.

摘要翻译： 在第一实施例中，电极耦合到第一，第二和第三位置处的表面，第一位置比第二位置更远离第三位置。 电阻之间以不同的频率测量阻抗。 结果，在表面下方的不同区域测量阻抗，一个区域比其他区域更深于表面下方。 在第二实施例中，微流体装置执行分析。 分析可以在粘附到表面的柔性贴片内，或者可以是植入由组织包围的液体体内的固体装置。 分析可以涉及泵送流体，或者可以涉及通过微流体通道电泳分析分析物。

公开(公告)号：US08547248B2

公开(公告)日：2013-10-01

申请号：US12063095

申请日：2006-09-01

申请人： Mark J. Zdeblick ,  Timothy Robertson

发明人： Mark J. Zdeblick ,  Timothy Robertson

IPC分类号： G08C17/00

CPC分类号： A61B5/0022 ,  A61B5/0028 ,  A61B5/0031 ,  A61B5/01 ,  A61B5/0215 ,  A61B5/026 ,  A61B5/0265 ,  A61B5/145 ,  A61B5/14535 ,  A61B5/415 ,  A61B5/418 ,  A61B5/6862 ,  A61B5/6876 ,  A61M5/172 ,  A61N1/37217 ,  A61N1/37223 ,  G06F19/00 ,  H02J50/20 ,  Y02A90/26

摘要： The present invention provides implantable systems that communicate wirelessly with each other using a unique format that enables devices configurations and applications heretofore not possible. Embodiments of the present invention provide communication apparatuses and methods for exchanging information with implantable medical devices. In some embodiments, two implantable devices communicate with each other using quasi-electrostatic signal transmission in a long wavelength/low frequency electromagnetic band, with the patient's body acting as a conductive medium.

摘要翻译： 本发明提供了使用能够使设备配置和应用迄今不可能的唯一格式彼此无线通信的可植入系统。 本发明的实施例提供了与可植入医疗装置交换信息的通信装置和方法。 在一些实施例中，两个可植入装置通过长波长/低频电磁波带中的准静电信号传输彼此进行通信，患者的身体用作导电介质。

公开(公告)号：US08542123B2

公开(公告)日：2013-09-24

申请号：US13564479

申请日：2012-08-01

申请人： Timothy Robertson ,  Mark J. Zdeblick

发明人： Timothy Robertson ,  Mark J. Zdeblick

IPC分类号： G08B23/00

CPC分类号： H04B5/0062 ,  A61B5/0031 ,  A61B5/073 ,  A61B5/4833 ,  A61B5/4839 ,  A61B5/4848 ,  A61B5/6861 ,  A61B2562/08 ,  A61B2562/162 ,  G06K7/10297

摘要： Aspects of the invention include multi-mode communication ingestible event marker devices. Ingestible event marker devices of the invention include an ingestible component comprising a conductive communication module and at least one additional non-conductive communication module. The non-conductive communication module may be integrated with the ingestible component or at least a portion or all of the non-conductive communication module may be associated with a packaging component of the ingestible event marker device. Additional aspects of the invention include systems that include the devices and one or more receivers, as well as methods of using the same.

公开(公告)号：US20120146670A1

公开(公告)日：2012-06-14

申请号：US13390866

申请日：2010-08-23

申请人： Mark J. Zdeblick

发明人： Mark J. Zdeblick

IPC分类号： G01R27/08

CPC分类号： A61B5/150229 ,  A61B5/0002 ,  A61B5/0537 ,  A61B5/14503 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/150305 ,  A61B5/150877 ,  A61B5/150969 ,  A61B5/157 ,  A61B5/6833 ,  A61B5/6846 ,  A61B10/0064 ,  A61B2560/0412

摘要： In a first embodiment, electrodes are coupled to a surface at first, second, and third locations, the first location being further from the third location than from the second location. Impedance is measured at distinct frequencies between pairs of the electrodes. As a result, impedance is measured at differing regions below the surface, one region being deeper below the surface than the other region. In a second embodiment, a microfluidic device carries out an analysis. The analysis may be within a flexible patch adhered to a surface, or may be in a solid device implanted in a body of liquid surrounded by tissue. The analysis may involve pumping a fluid or may involve drawing an analyte electrophoretically through a microfluidic channel.

摘要翻译： 在第一实施例中，电极耦合到第一，第二和第三位置处的表面，第一位置比第二位置更远离第三位置。 电阻之间以不同的频率测量阻抗。 结果，在表面下方的不同区域测量阻抗，一个区域比其他区域更深于表面下方。 在第二实施例中，微流体装置执行分析。 分析可以在粘附到表面的柔性贴片内，或者可以是植入由组织包围的液体体内的固体装置。 分析可以涉及泵送流体，或者可以涉及通过微流体通道电泳分析分析物。